Zimmermannjonsson4497

BACKGROUND Turkish has a rich system of noun suffixes, and although its complex suffixation system may seem daunting, it can actually present a learning opportunity for children. Despite its unique features, Turkish has not been studied extensively, especially in the case of children with language deficits, such as developmental language disorder (DLD). Most of the extant studies are focused on bilingual children, and the results are somewhat mixed. AIMS To focus on the noun morphology system of Turkish-speaking preschoolers with DLD and compare their use with that of two groups of typically developing (TD) children. Moreover, to investigate the nature of their noun suffix errors in detail. METHODS & PROCEDURES We report data from a total of 80 monolingual children, 40 children with DLD (age range = 4;0-7;10), 20 TD age-matched children (4;0-7;3) and 20 younger mean length of utterance (MLU)-matched children (2;0-4;3). The data for this study came from language samples obtained from children in individual cliophonology. These children would benefit from treatment that focuses on how to attach different allomorphs to different open-class words. Because factors such as morphophonological complexity operate in other languages, the findings have broader clinical implications. In particular, regardless of the target language, clinicians should consider the possibility that these broader factors, rather than language-specific details, are the basis for a child's difficulty. © 2020 Royal College of Speech and Language Therapists.AIM To report the first study of temelimab, a monoclonal antibody neutralizing the pathogenic human endogenous retrovirus type W envelope, in patients with type 1 diabetes (T1D). MATERIALS AND METHODS This double-blind, placebo-controlled, randomized clinical trial recruited adult patients with T1D within 4 years postdiagnosis and remaining C-peptide secretion. Menin-MLL Inhibitor mouse Sixty-four patients were randomized (21) to monthly temelimab 6 mg/kg or placebo during 24 weeks, followed by a 24-week, open-label extension, during which all patients received temelimab. The primary objective was the safety and tolerability of temelimab. The secondary objective was to assess the pharmacodynamics response such as C-peptide levels, insulin use, HbA1c, hypoglycaemia and autoantibodies. RESULTS Temelimab was well tolerated without any group difference in the frequency or severity of adverse events. Concerning exploratory endpoints, there was no difference in the levels of C-peptide, insulin use or HbA1c between treatment groups at weeks 24 and 48. The frequency of hypoglycaemia events was reduced with temelimab (P = 0.0004) at week 24 and the level of anti-insulin antibodies was lower with temelimab (P less then  0.01); the other autoantibodies did not differ between groups. CONCLUSIONS Temelimab appeared safe in patients with T1D. Pharmacodynamics signals (hypoglycaemia and anti-insulin antibodies) under temelimab were observed. Markers of β-cell functions were not modified by treatment. These results need to be further explored in younger patients with T1D with earlier disease onset. © 2020 John Wiley & Sons Ltd.The capacity of phytoplankton to utilize dissolved organic phosphorus (DOP) plays an important role in their competition for resources when the availability of dissolved inorganic phosphorus (DIP) is low in the aquatic systems. Here, we explored the physiological and molecular responses of a globally distributed marine diatom, Skeletonema costatum, in utilizing adenosine-5'-triphosphate (ATP) based on incubation experiments under ATP, DIP-replete, and DIP-depleted conditions. The results show that ATP supports the growth of S. costatum as efficiently as DIP. The pathway of S. costatum involved in utilizing ATP is not related to alkaline phosphatase (AP), an important DOP hydrolase, although extracellular hydrolysis is involved. The transcriptome analysis revealed several transcripts related to the hydrolase activity (e.g. NAD+ diphosphatase), which were significantly upregulated in the ATP culture group, indicating their possible involvement in ATP hydrolysis. Meanwhile, ATP-grown S. costatum exhibited downregulation of the genes related to a series of metabolic activities (e.g. purine metabolism), apparently to adapt to ATP condition. © 2020 Society for Applied Microbiology and John Wiley & Sons Ltd.OBJECTIVE To describe the diagnosis, management, and outcome of a ferret with spontaneous hemoperitoneum with surgical intervention and xenotransfusion of type A feline packed red blood cells (pRBCs). CASE SUMMARY A domestic ferret diagnosed with a spontaneous hemoperitoneum secondary to a hepatic mass received isotonic crystalloids, hypertonic saline, and an allogenic blood transfusion perioperatively. Postoperatively, the ferret developed progressive anemia and tachycardia refractory to fluid therapy and, given a lack of additional allogenic blood sources, received a xenotransfusion of feline pRBCs. The ferret was hospitalized for 4 days postoperatively and developed a presumed delayed transfusion reaction characterized by transient hyperbilirubinemia. At a 6-month recheck, the ferret was doing well clinically. NEW OR UNIQUE INFORMATION PROVIDED This is the first reported case of successful xenotransfusion of feline pRBCs in a ferret. Although xenotransfusion of ferrets with feline blood products is not recommended as a routine procedure, it remains a viable option in critical situations in which ferret blood is unavailable. © Veterinary Emergency and Critical Care Society 2020.Advances in microelectronic system technology have necessitated the development and miniaturization of energy storage devices. Supercapacitors are an important complement to batteries in microelectronic systems; and further reduction of the size of micro-supercapacitors is challenging. Here, a novel strategy is demonstrated to break through the resolution limit of micro-supercapacitors by preparing nano-supercapacitors (NSCs) with interdigital nanosized electrodes using focused ion beam technology. The minimization of the size of the NSCs leads to a large increase in capacitance, with a high areal capacitance of 9.52 mF cm-2 and a volumetric capacitance of 18 700 F cm-3 , far superior to those of other reported works. Size reduction and the narrowing of the physical separation between nanoelectrodes are proved to be the most crucial factors in the enhancement of capacitive performances. New charge-storage mechanisms are discovered with a remarkable nonfaradaic double-layer capacitance that exists due to the considerable inner electric field force at the nanoscale.