Wootensong7262

Objective　An increasing incidence of disuse syndrome is commonly observed in areas affected by large-scale natural disasters. Consequently, the fall risk is high in such populations, necessitating adequate attention to fall prevention measures. It is important to identify factors associated with falls to prevent deterioration in functional ability. We investigated the risk factors associated with falls among elderly survivors in disaster-stricken areas using longitudinal data from the Research project for the prospective Investigation of health problems Among Survivors of the Great East Japan Earthquake (RIAS) Study.Methods　Of all data obtained from the RIAS Study, we used the data of 1,380 survivors who were aged ≥65 years, were not diagnosed with cancer or cardiovascular disease, did not need supportive care, and could participate in the annual survey between 2011 and 2016. Self-administered questionnaires were distributed, and anthropometric and grip tests were performed during the 2011 survey to obtain innd a history of smoking (OR 4.30, 95%CI 1.08-17.14) were significantly associated with falls. In women aged ≥75 years, partial housing damage (OR 7.93, 95%CI 1.85-33.91) and psychological distress (OR 2.83, 95%CI 1.09-.7.37) were also significantly associated with falls.Conclusion　This study suggests that cognitive dysfunction in both sexes and insomnia, dyslipidemia, and a history of smoking in women were significantly associated with falls, and partial housing damage and psychological distress were risk factors for falls in women aged ≥75 years. Fall prevention after large-scale natural disasters warrants close attention to known risk factors and environmental and mental health changes.Objective　This study aimed to examine whether there is any remaining association between grandparental poverty and grandchildren's body mass index (BMI) and depression, after controlling for parental poverty and other parental characteristics.Methods　Data used in this study were gathered through the Child Living Standard Survey (Kodomo no Seikatsu Jittai Chosa) conducted by the Tokyo Metropolitan government in 2016. The survey questionnaires were mailed to all children in grades five, eight, and eleven who lived in four districts of Tokyo. Data for grades five and eight were used for analysis. First, the children were divided into four groups according to their grandparents' and mothers' poverty status, and their BMI and depression were compared. Then, structural equation modeling was used to fit a model where grandparental poverty was associated with parental poverty and parental BMI and depression, and they, in turn are associated with grandchildren's BMI and depression, as well as directly associated with ession. To combat this, it is necessary to not only adopt the "3-generation approach" which focuses on child and parent's current conditions, but also to implement policy to assist children when they become parents in the future. As for BMI, effective policies should be put into place to combat parents' and children's current weight problems.Objectives　Approximately 40% of new fitness club (FC) members drop out within the first six months; however, the factors associated with FC membership resignation are largely unknown. This study aimed to identify the association between psychological attitudes toward exercise and FC membership resignation.Methods　We conducted a cohort study enrolling participants from 17 FCs. All individuals who became members at FCs between April 1st, 2015 and March 31st, 2016 (n=5,421) were invited to participate in the study, and those who agreed to participate completed a self-administered baseline questionnaire (n=2,934). We excluded participants aged less then 20 years (n=167) and those with missing values (n=702). Psychological factors were evaluated using the short version of the perceived benefit and barriers to exercise scale. Participants were followed until September 30th, 2016, at which time we assessed the FC membership drop-out rate. Cox proportional-hazards models were used to evaluate the association betweenfit were less likely to resign their memberships, as were women with higher lack of motivation to exercise scores and who perceived lack of motivation as a barrier to exercise (HR for social benefit, 0.84 [0.74-0.97]; HR for lack of motivation, 0.85 [0.73-0.99]). Among both male and female participants aged ≥60 years, higher self-improvement scores, indicating that peer recognition was perceived as a benefit of exercise, was associated with higher HR for drop-out (men, 2.52 [1.10-5.81]; women, 1.31 [1.00-1.72]).Conclusions　The results revealed gender and age differences in the association between the perceived benefits/barriers of exercise and FC membership dropout. Implementing programs based on enrollees' characteristics and psychological factors may contribute to preventing FC dropout in the future.Objectives　To develop and assess the reliability and validity of a scale measuring subjective quality of life (QOL), which encompasses the "strength and ability" to live positively through the three dimensions of biological life, everyday life, and overall course of life, in order to support QOL in older adults.Methods　We reviewed related literature and conducted interviews with patients with chronic diseases. Participants rated their QOL on a seven-point scale using the visual analog scale. Interviewer-administered questionnaires were used to collect data from 100 older adults living in their own homes. The participants were between the ages of 70 and 84, and were recruited from comprehensive community support centers or from among hospital outpatients. We assessed scale reliability using Cronbach's α, item-total (I-T) correlation analysis, and calculation of α coefficient-if-item-deleted. We examined content validity by analyzing the content of the free response items. To evaluate construct validity, we carh subjective QOL. These results are consistent with past research and therefore confirm construct validity.Conclusion　This study sufficiently confirmed the reliability and validity of the scale, and consequently its usability.Objective　To elucidate information on people's consumption of seasonings with a higher sodium content than those of other food groups.Methods　This study used the data of 503 persons aged≥20 years who participated in the 2014 Yamanashi Prefecture Nutrition Survey; survey responses connected with the consumption of seasonings were analyzed. Using the Japanese Standard Tables of Food Composition, the amount of salt intake per person was calculated based on the total household intake and apportioning. Dishes were classified into eight categories rice, noodle, soup, grilled, deep-fried, simmered, marinated, and other. The proportion of participants who consumed salt-containing seasonings for breakfast, lunch, and dinner was first calculated. Then, the proportion of those who consumed salt-containing seasonings was calculated according to dish category. Finally, the proportion of those who consumed salt-containing seasonings was calculated according to dish category and age group.Results　The following seasonings werelationship between age group and dish category according to salt intake showed that while salt intake from marinated dishes increased significantly with increasing age (P=0.008), that from deep-fried dishes decreased significantly (P less then 0.001).Conclusion　Through analyzing the proportion of people of whom seasonings were their main source of salt intake according to age in the Yamanashi Prefecture, it was shown that the consumption of soups and marinated dishes increased significantly with increasing age; in contrast, young people often consumed grilled and deep-fried dishes.The metabolic sensor sirtuin 1 (SIRT1) also functions as a checkpoint in inflammation, and SRT1720 is a highly active and selective SIRT1 activator shown to alleviate inflammatory injury in several recent experimental studies. In the present study, the potential effects and underlying mechanisms of SRT1720 on lipopolysaccharide (LPS)-induced fulminant hepatitis in D-galactosamine (D-Gal)-sensitized mice were investigated. The results indicated that treatment with SRT1720 inhibited LPS/D-Gal-induced elevation of ALT and AST, alleviated the histological abnormalities, suppressed the induction of TNF-α and IL-6, mitigated the phosphorylation of JNK, downregulated the activities of caspase 8, caspase 9 and caspase 3, decreased the level of cleaved caspase 3, reduced the TUNEL-positive cells, and improved the survival rate of the LPS/D-Gal-exposed mice. These data indicated that treatment with the SIRT1 activator SRT1720 alleviated LPS/D-Gal-induced fulminant hepatitis, which might be attributed to the suppressive effects of SRT1720 on TNF-α production and the subsequent activation of the apoptosis cascade.Immature neurons undergo morphological and physiological maturation in order to establish neuronal networks. During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ezh1, a component of Polycomb repressive complex 2 (PRC2), increases during neuronal maturation in mouse neocortical culture. In addition, conditional knockout of Ezh1 in post-mitotic excitatory neurons leads to downregulation of a set of genes related to neuronal maturation. Moreover, the locus encoding Cpg15/Neuritin (Nrn1), which is regulated by neuronal activity and implicated in stabilization and maturation of excitatory synapses, is a direct target of Ezh1 in cortical neurons. Together, these results suggest that elevated expression of Ezh1 contributes to maturation of cortical neurons.

Few registries have provided precise information concerning incidence rates for acute heart failure syndrome (AHFS) in Japan.Methods and ResultsAll hospitals with acute care beds in Awaji Island participated in the Kobe University heart failure registry in Awaji Medical Center (KUNIUMI Registry), a retrospective, population-based AHFS registration study, enabling almost every patient with AHFS in Awaji Island to be registered. From 1 January 2015 to 31 December 2017, 743 patients with de novo AHFS had been registered. Mean age was 82.1±11.5 years. Selitrectinib Using the general population of Japan as of 2015 as a standard, age- and sex-adjusted incidence rates for AHFS were 133.8 per 100,000 person-years for male and 120.0 for female. In 2015, there were an estimated 159,702 new-onset patients with AHFS, which was predicted to increase to 252,153 by 2040, and reach a plateau. The proportion of patients aged >85 years accounted for 42.6% in 2015, which was predicted to increase up to 62.5% in 2040. The proportion of patients with heart failure with preserved ejection fraction was estimated at 52.0% in 2015, which was predicted to increase gradually to 57.3% in 2055.

The present analysis suggested that the number of patients with de novo AHFS keeps increasing with progressive aging in Japan. Establishment of countermeasures against the expanding burden of HF is urgently required.

The present analysis suggested that the number of patients with de novo AHFS keeps increasing with progressive aging in Japan. Establishment of countermeasures against the expanding burden of HF is urgently required.