Wisepiper9760

ts and worse cosmetic outcome. In this series, even among those deemed cautionary or unsuitable for APBI by ASTRO criteria, we demonstrated a low rate of IBTR.

To investigate the risk factors and to construct a nomogram for the prediction of postoperative neck tilt (PNT) in Lenke I and II adolescent idiopathic scoliosis (AIS) patients.

A total of 95 Lenke I and II AIS patients who underwent posterior segmental spinal instrumentation and fusion between the years 2010 and 2018 (with an average 2-year follow-up) at a single institution were retrospectively investigated. The full spine X-rays of patients were measured preoperatively, postoperatively and at the final follow-up. Variables were compared between the PNT (n = 33) group and the non-PNT group (n = 62), and univariate and multivariate logistic regressions were performed to identify the independent predictors for the occurrence of PNT. The discrimination and calibration of the nomogram were validated by receiver operating characteristic (ROC) curve and calibration curve.

Variables including the preoperative neck tilt, postoperative upper instrumented vertebrae (UIV) imbalance, postoperative T1 tilt and decrease values in main thoracic curve (ΔMTC) minus decrease values in proximal thoracic curve (ΔPTC) (ΔMTC - ΔPTC) were identified as the predictors for nomogram. The area under the ROC curve (AUC) was 0.900 (95% CI, 0.857 to 0.932). Meanwhile, the calibration curve revealed good agreement, and the Hosmer and Lemeshow test determined that the model was well fitted.

Preoperative neck tilt, postoperative UIV imbalance, postoperative T1 tilt and ΔMTC - ΔPTC are predictors for the nomogram. The nomogram can provide surgeons with a simple and effective tool to predict the occurrence and development of PNT in Lenke I and II AIS patients.

Preoperative neck tilt, postoperative UIV imbalance, postoperative T1 tilt and ΔMTC - ΔPTC are predictors for the nomogram. The nomogram can provide surgeons with a simple and effective tool to predict the occurrence and development of PNT in Lenke I and II AIS patients.The paper uses clinical neuropsychological testing methods and resting state functional MRI technology to investigate whether chemotherapy can cause cognitive impairment and/or changes in local brain activity in breast cancer patients. In the thesis, 21 breast cancer patients (stage Ⅰ-Ⅲ) who had not undergone radiotherapy and adjuvant chemotherapy were confirmed by clinical surgery and pathology, with an average age of (50.14±13.12) years. Perform 6 neuropsychological tests before chemotherapy and 1 month after chemotherapy, conventional horizontal axis T2-weighted fluid attenuation inversion recovery (T2-FLAIR) sequence, plane echo imaging blood oxygen level dependent (EPI-Bold) functional sequence collection. DPARSF software package was used to analyse the low frequency amplitude (ALFF) of resting functional MRI data. The SPSS17.0 software package was used for statistical analysis. One month after the completion of chemotherapy, the Stroop word test and interference test scores, digit span back test, auditory word learning delay 5min memory scores of breast cancer patients were significantly different than those before chemotherapy. One month after chemotherapy, the brain areas with increased ALLF in breast cancer patients include left inferior temporal gyrus, right middle temporal gyrus, left middle temporal and upper gyrus, and bilateral praecuneus. In breast cancer patients, memory, attention, executive function and processing speed are reduced in the short term after conventional chemotherapy. Chemotherapy changes the neural activity of the resting local brain areas, mainly the increased activity of the bilateral anterior cuneiform and middle temporal gyrus, which is the brain area that constitutes the default network (DMN).

Although intensity-modulated radiation therapy (IMPT) is dosimetrically superior to passive scattering proton therapy (PSPT) for locally advanced non-small cell lung cancer (LA-NSCLC), direct comparisons of clinical outcomes are lacking. Here, we compare toxicity profiles and clinical outcomes after IMPT vs. PSPT for LA-NSCLC.

This is a non-randomized, comparative study of two independent cohorts with LA-NSCLC (stage II-IIIB, stage IV with solitary brain metastasis) treated with concurrent chemotherapy and proton beam therapy. Toxicity (CTCAE v4.0) and outcomes were prospectively collected as part of a clinical trial (NCT00915005) or prospective registry (NCT00991094).

Of 139 patients, 86 (62%) received PSPT and 53 (38%) IMPT; median follow-up times were 23.9 and 29.0 months, respectively. IMPT delivered lower mean radiation doses to the lungs (PSPT 16.0Gy vs. IMPT 13.0Gy, P < 0.001), heart (10.7Gy vs. 6.6Gy, P = 0.004) and esophagus (27.4Gy vs. 21.8Gy, P = 0.005). Consequently, the IMPT cohort had llmonary toxicity; additional clinical studies will be needed to assess potential differences in survival between the two techniques.Senile hypertension affects the life quality of aged population. Dietary intervention plays a pivotal role in the prevention of hypertension. There are few reports concerning the effects and mechanisms of green tea supplementation preventing aged related hypertension. The current study investigated the effect and mechanism of dietary supplement of Huangshan Maofeng green tea (HSMF) on prevention of hypertension induced by deoxycorticosterone acetate (DOCA) and salt in old C57BL/6 mice. Our results showed that HSMF dose-dependently prevented the increase of systolic blood pressure and diastolic blood pressure induced by DOCA plus salt (DS) at 51 week old mice. And HSMF significantly reduced the agonists stimulated contraction of mesenteric arteries isolated from the old mice. The expression of vasoconstrictor genes and inflammatory cytokines in aorta were suppressed observably by HSMF supplementation compared with DS group. The protein expression of PKCα in the aorta was dose-dependently decreased by HSMF compared to DS group. The phosphorylation level of MYPT1, CPI-17and MLC20 was also restrained by HSMF in the aorta. Furthermore, HSMF protected kidney by maintaining integrity of glomeruli and tubules and remarkably decreased the NGAL level in plasma. HSMF also suppressed the kidney inflammation by decreasing inflammatory cytokines expression and the macrophage infiltration. Our results proved that dietary supplement of HSMF remarkably improved the vascular functions and protected kidney injury, and thus prevented hypertension induced by DS in older C57BL/6 mice. Our data indicated that the dietary supplement of HSMF may potentially be used as a food additive for preventing hypertension for aged people.

Because of the enormous demand for personal protective equipment and especially respiratory protective devices (respirators) during the initial phase of the corona pandemic shortages arose. Sterilisation of used respirators can reduce these shortages. In our study, respirator testing was carried out after only one sterilisation cycle.

To determine if steam sterilisation and reuse could be safely applied for used respirators.

In a cabinet an aqueous solution of NaCl (0.02% w/v) was nebulized and passed through a sample of the material of a respirator. Passing particle concentrations were measured directly from the cabinet and via the filter material of the respirator for particles ≥ 0.3 μm, ≥ 0.5 μm and ≥ 1.0 μm.

only three out of ten steam sterilised respirators met the requirements of 94% filtration efficiency.

The results prove that heat sterilisation cannot be generically applied for reuse of respirators safely.

The results prove that heat sterilisation cannot be generically applied for reuse of respirators safely.The reaction time-based concealed information test (RT CIT) typically uses three types of stimuli 1) probe (i.e., crime-related item), 2) irrelevant (i.e., crime-unrelated item) and 3) target (i.e., an irrelevant item assigned a unique response so as to ensure attention to the test). Lukács, et al., (2017) introduced familiarity-related filler items to the RT CIT, enhancing the efficacy of the test for both single and multiple probe (per block) protocols. Our study aims to A) replicate the effects of familiarity-related filler items on the RT CIT, B) use P300 to investigate the mechanisms of the fillers-related enhancement effect on the RT CIT, C) investigate whether these fillers can enhance the efficacy of the typical P300-based CIT, and D) explore the effects of fillers on the semantic and episodic versions of the P300 and RT CITs. We replicated a clear fillers-related enhancement of the RT CIT (N = 38 for Fillers, N = 37 for No Fillers). Semantic and Episodic experiments were enhanced equally-well by filler items. No effect of fillers was observed on P300 amplitude for CIT stimuli, however, an interaction involving P300 latency suggests that fillers facilitated the processing of Semantic information over Episodic information. ESI-09 mw Our study independently replicates a valuable improvement of the traditional RT CIT, investigates the potential mechanisms of this enhancement effect, and demonstrates important differences between the P300 and RT CITs.Consumption of Cassia occidentalis (CO) seeds, a ubiquitously distributed weed plant, is responsible for a pathological condition known as hepato-myo-encephalopathy (HME). The toxicity of CO seeds is largely attributed to the presence of anthraquinones. Here, we report that Emodin, a CO anthraquinone, inhibits the enzymatic activity of NADPH-Quinone reductase, which is an intracellular enzyme fundamentally involved in the detoxification of quinone containing compounds. Emodin binds to the active site of the enzyme and acts as a competitive inhibitor with respect to 2, 6-Dichlorophenolindophenol, a known substrate of NADPH-Quinone reductase. Moreover, our in-vitro study further revealed that Emodin was cytotoxic to primary rat hepatocytes.

This study evaluates the impact of a novel model of care called Geriatric Comanagement of Older Vascular surgery inpatients on clinical outcomes.

A pre-post study of geriatric comanagement, comparing prospectively recruited preintervention (February-October 2019) and prospectively recruited postintervention (January-December 2020) cohorts. Consecutively admitted vascular surgery patients age ≥65years at a tertiary academic hospital in Concord and with an expected length of stay (LOS) greater than 2days were recruited.

A comanagement model where a geriatrician was embedded within the vascular surgery team and delivered proactive comprehensive geriatric assessment based interventions.

Primary outcomes of incidence of hospital-acquired geriatric syndromes, delirium, and LOS were compared between groups using univariable and multivariable logistic regression analyses. Prespecified subgroup analysis was performed by frailty status.

There were 150 patients in the preintervention group and 152 patients in implementing geriatric comanagement. These benefits were also demonstrated in the frail subgroup.

This is the first prospective study of inpatient geriatric comanagement for older vascular surgery patients. Reductions in hospital-acquired geriatric syndromes including delirium, and cardiac and infective complications were observed after implementing geriatric comanagement. These benefits were also demonstrated in the frail subgroup.