Winklermonroe3151

Dose-related reductions in T4 were observed for Day 13 pups (not seen on Day 4) but were not accompanied by thyroid weight changes or histopathological findings; further investigations are required to determine the biological relevance of these T4 reductions.Cases of human envenomation by Centruroides pococki are exceptionally reported in human. We report a Class III human envenomation by C. pococki in Guadeloupe, French West Indies, with neuromuscular toxicity that has never been described before. Symptoms resolved within a few hours, without the need for intravenous scorpion-specific antivenom.Metagenomic next-generation sequencing (mNGS) is an emerging sequence-based method that detects genomic information of pathogenic microorganisms from a wide range of clinical specimens. The mNGS has moderate sensitivity and very high specificity for tuberculous meningitis, and the validity of mNGS was higher than that of Xpert MTB/RIF.Sexually experienced male rats show an olfactory preference for estrous female odor compared to male odor. Notably, they also prefer castrated male over gonadally intact male odor. This study examined the role of elevated circulating gonadotropins and gonadotropin-releasing hormone (GnRH) induced by disinhibition of the hypothalamus-pituitary-gonad axis in the castration-induced attractiveness of male rats. Experiment I compared preference of sexually experienced males between odors of castrated males injected with a GnRH antagonist (Cast+Ant), castrated males injected with saline (Cast), and gonadally intact males (Sham). These olfactory preference tests revealed that probe males significantly preferred Cast over Sham and Cast+Ant odors but had no preference between Sham and Cast+Ant odors. Experiment II used hypophysectomy (HPx) to remove the gonadotropin source in place of pharmacologically antagonizing GnRH. Similarly, the probe males preferred Cast (high both GnRH and gonadotropins) over HPx (high GnRH but no gonadotropin) odors, but also preferred HPx than Sham (low both GnRH and gonadotropins) odors. We then examined the effects of exogenous gonadotropins, human chorionic gonadotropin (hCG) and equine chorionic gonadotropin (eCG), to reveal which gonadotropins critically affect on the attractiveness of HPx males. The olfactory preference tests revealed that injecting eCG, but not hCG, significantly increased the probe males` preference compared to HPx male odor, suggesting that the attractiveness is augmented via follicle stimulating hormone (FSH) receptor rather than luteinizing hormone receptor. These results indicate that sexually active male rats show olfactory preference for castrated male rats due to elevated GnRH and FSH blood levels produced by a lack of androgens.Emotional contagion refers to the sharing of emotional states between individuals and can cause depressive behaviors in healthy persons who live with depressed individuals. Negative emotional contagion has been observed in animal models, but the vast majority of studies are short-term and bear little resemblance to long-term human relationships. Thus, the first aim of this study was to establish an animal model of stress-induced negative emotional contagion that develops across time and between pairs. To accomplish this, we tested the hypothesis that sedentary male rats that cohabitate for five weeks with a stress-exposed female will exhibit a depression-like phenotype that is observable on behavioral and physiological measures. In addition, drawing from a comprehensive literature that describes the beneficial effects of prior exercise on stress-related behavior, we tested our second hypothesis that in males that were paired with a stressed female, prior voluntary exercise will diminish the impact of negativel contagion between dyads of male-female rats and support the view that inclusion of exercise programs would be beneficial for persons that may, in the future, be susceptible to negative emotional contagion.Reports of a female advantage in empathy-related measures suggest a role for sex hormones, although the data are inconsistent. Studies also report similar sex differences in human olfactory perception. In rodents, olfaction is involved in detecting and integrating socially relevant information and is modulated by the brain actions of estrogens. We hypothesized that olfaction may untangle the mixed evidence on the relationship between sex hormones and empathy-related measures (cognitive and affective) in humans. To test this, we examined 60 healthy participants in three sex-hormone-status groups free-cycling women tested in cycle phases with higher 17-β estradiol and progesterone, oral-contraceptive users (low estradiol and progesterone), and men. We assessed empathy-related measures, facial mimicry (from zygomaticus and corrugator muscle activity), and odor discrimination ability. In the empathy-related measures and facial mimicry, we did not find overall group effects or meaningful associations with salivary levels of estradiol, progesterone, or testosterone. Free-cycling women only outperformed men in the recognition of emotions from pictures of the eye region, but sex hormones were unrelated to emotion recognition performance. Oral contraceptive users showed higher scores in the affective empathy-related measure when viewing negative emotions, with no relation to hormone levels. Free-cycling women exhibited the strongest facial mimicry (viewing female, but not male protagonists), positively associated with progesterone. Finally, the groups differed in odor discrimination, with free-cycling women outperforming men. However, odor discrimination ability and empathy-related performance were not correlated. Our results support a role of sex hormones in odor perception and in empathy-related measures, to a certain extent. CX-5461 molecular weight However, no common underlying mechanism was found.Firefighter uniforms protect firefighters from exposure to potentially harmful chemicals including a range of semi-volatile organic compounds (SVOCs). Contaminated uniforms can become a secondary source of firefighters' exposure to these chemicals. There is inconsistency on the removal efficiency of SVOCs during the cleaning, laundering and field decontamination of firefighting uniforms. Therefore, this study aims to assess how effective decontamination and laundering processes are in reducing firefighter uniforms as a vector for transport and exposure to SVOCs. Firefighters who had attended a controlled house fire and simulated container burns had their uniforms sampled pre- and post-laundering. Clean station wear was laundered with contaminated uniforms and after a load of contaminated uniforms to assess inter and intra load contamination. Surface wipes were collected from uniforms across 12 fire stations, after they had returned from a laundering provider. Concentrations of 13 polycyclic aromatic hydrocarbons (PAHs), six organophosphate flame retardants (OPFRs) and seven polybrominated diphenyl ethers (PBDEs) were measured in the collected samples.