Winklerkehoe5118

EPZ-6438 (5μM) suppressed cell migration and gel contraction in CFs. RNA sequencing results revealed that antifibrotic genes were activated after EZH2 inhibition to suppress corneal myofibroblast activation.

Inhibition of EZH2 suppresses corneal myofibroblast activation and ECM protein synthesis, and could serve as a novel therapeutic target for preventing corneal scarring.

Inhibition of EZH2 suppresses corneal myofibroblast activation and ECM protein synthesis, and could serve as a novel therapeutic target for preventing corneal scarring.

To estimate the heritability of ocular biometric and anterior chamber morphologic parameters and to determine predictors of angle closure concordance in South Indian probands with angle closure and their siblings DESIGN Prospective observational cohort study METHODS Subjects received a standardized ophthalmic examination, A-scan ultrasonography, pachymetry, and anterior segment optical coherence tomography (ASOCT) imaging. Heritability was calculated using residual correlation coefficients adjusted for age, sex, and home setting. Concordant sibling pairs were defined as both proband and sibling with angle closure. Predictors of angle closure concordance among siblings were calculated using multivariable logistic regression models.

A total of 345 sibling pairs participated. All anterior chamber parameters were highly heritable (P < .001 for all). Similarly, all iris parameters, axial length, lens thickness (LT), central corneal thickness, anterior lens curvature, lens vault (LV), spherical equivalent, are older or have a shallower ACD may need more careful disease monitoring.

To investigate the effects of preoperative Lipiflow (Johnson & Johnson, USA) treatment prior to cataract surgery on meibomian gland dysfunction (MGD) and dry eye induced by surgery.

Prospective, randomized controlled study METHODS This study comprised 124 eyes of 124 patients with planned surgery for senile cataract. Participants were randomly allocated into control and Lipiflow groups based on administration of Lipiflow treatment three weeks prior to cataract surgery. For meibomian gland (MG) evaluation, MG atrophy, degree of gland expressibility, and quality of gland secretions were examined at the baseline visit and one and three months postoperatively. Ocular surface parameters of tear film break-up time (TBUT), Oxford corneal staining score, and tear film lipid layer thickness (LLT) were measured at each visit. Ocular Surface Disease Index (OSDI) and Dry Eye Questionnaire (DEQ) were also assessed.

The control group exhibited a significant decrease in MG expressibility, worsened meibum quality, y be a safe and effective intervention for relieving MGD and dry eye induced by surgery. It might be recommended, not only for the patients with preoperative MGD, but also for those without baseline MGD, to prevent the development of MGD and dry eye induced by ocular surgeries.

To identify demographic and disease-related characteristics predictive of Lost-to-Follow-Up (LTFU) status in amblyopia treatment and create a risk model for predicting LTFU status.

Retrospective cohort study METHODS Setting Single-center, ophthalmology department at Boston Children's Hospital (BCH).

2037 patients treated for amblyopia at BCH between 2010 and 2014.

LTFU was defined as patients who did not return after initial visit, excluding those who came for second opinion. Multiple variables were tested for association with LTFU status.

Odds ratio of LTFU risk associated with each variable. Multivariate logistic regression was used to create a risk score for predicting LTFU status.

A large proportion of patients (23%) were LTFU after first visit. Older age, nonwhite race, lack of insurance, previous glasses or atropine treatment, and longer requested follow-up intervals were independent predictors of LTFU status. A multivariable risk score was created to predict probability of LTFU (area under the curve 0.68).

Our comprehensive amblyopia database allows us to predict which patients are more likely to be LTFU after baseline visit and develop strategies to mitigate these effects. These findings may help with practice efficiency and improve patient outcomes in the future by transitioning these analyses to an electronic medical record that could be programmed to provide continually updated decision support for individual patients based on large data sets.

Our comprehensive amblyopia database allows us to predict which patients are more likely to be LTFU after baseline visit and develop strategies to mitigate these effects. selleck kinase inhibitor These findings may help with practice efficiency and improve patient outcomes in the future by transitioning these analyses to an electronic medical record that could be programmed to provide continually updated decision support for individual patients based on large data sets.

To quantify the association of visual field (VF) damage on physical activity away-from-home, per away-from-home excursion, and at home.

Prospective cohort study.

Among 229 participants with glaucoma or suspected glaucoma, severity of VF damage was defined as average sensitivity within the integrated VF (IVF). Participants wore accelerometers and GPS trackers for seven days to measure physical activity and characterize activity location. Multivariable negative binomial regressions were used to test whether away-from-home activity per day, physical activity per away-from-home excursion, and at home activity per day varied by severity of VF damage.

Each 5-dB decrement in IVF sensitivity was associated with a lower amount of away-from-home activities per day [18% less Moderate & Vigorous Physical Activity (MVPA) minutes/day, 95% CI, 0.69 to 0.97], and physical activities per away-from-home excursion (20% less MVPA minutes/excursion, 95% CI, 0.65, 0.98). Similar findings were noted for other away-from- activity, when leaving the home amongst patients with glaucoma.

To describe an open-source, reproducible, step-by-step method to design sum-of-segments thick-lens intraocular lens (IOL) calculation formulas, and to evaluate a formula built using this methodology.

Retrospective, multi-center case series METHODS A set of 4242 eyes implanted with Finevision IOLs (PhysIOL, Liège, Belgium) was used to devise the formula design process and build the formula. A different set of 677 eyes from the same center was kept separate to serve as a test set. The resulting formula was evaluated on the test set as well as another independent dataset of 262 eyes.

The lowest SD of prediction errors on set n°1 were obtained with the PEARL-DGS formula (±0.382 D), followed by K6 and Olsen (± 0.394 D), EVO 2.0 (±0.398 D), RBF 3.0 and BUII (± 0.402 D). The formula yielding the lowest SD on set n°2 was the PEARL-DGS (± 0.269 D), followed by Olsen (± 0.272 D), K6 (± 0.276 D), EVO 2.0 (± 0.277 D) and BUII (± 0.301 D).

Our methodology achieved an accuracy comparable to other state-of-the-art IOL formulas.