Willishay2295

or azithromycin should be considered in patients with AUFI, after ruling out malaria and arboviruses.

Over 40% of returning travelers with AUFI were diagnosed with malaria or dengue, infections that can be easily diagnosed by rapid diagnostic tests. Arboviruses were the most common cause of AUFI (above malaria) and most cases were diagnosed during Aedes spp. high season. This is particularly relevant for those areas at risk of introduction of these pathogens. Empirical antibiotic regimens including doxycycline or azithromycin should be considered in patients with AUFI, after ruling out malaria and arboviruses.

to understand how the contradictions and tensions of neoliberal policy, materialized in precarious work, affect nursing workers' mental health in the context of the COVID-19 pandemic.

this is a study with a qualitative and descriptive approach, analyzed in the light of neoliberal economic policy. Data were collected through virtual means, with the participation of 719 nursing workers, from April to June 2020. To organize the data, the IRaMuTeQ® software and thematic analysis were used.

the reports revealed the lack of value of workers and the loss of social labor rights; the progressive nature of the neoliberal policy, its threats and repercussions on workers' mental health; and recognition by female workers that political and class participation does not occur in isolation, but collectively.

under the aegis of neoliberal policy, the COVID-19 pandemic brought an upsurge precarious work, influencing nursing workers' subjectivity and mental health.

under the aegis of neoliberal policy, the COVID-19 pandemic brought an upsurge precarious work, influencing nursing workers' subjectivity and mental health.In recent years, a rapid development of polymeric hydrogel-based sensors has been witnessed. However, conventional hydrogels often exhibit poor mechanical properties. Additionally, the use of these sensors at temperatures less then 0 °C is limited due to the freezing of the water molecules in the hydrogel matrix. In this study, graphene oxide/poly(acrylamide-co-N-(3-amino propyl)methacrylamide) [poly(AAm-co-APMA)/GO] hydrogels have been synthesized by UV photo-initiation polymerization. Subsequently, the poly(AAm-co-APMA)/GO-Gly (PAAG-Gly) organohydrogels were obtained by glycerol replacement. GO and glycerol had multiple interactions with the polymer chains, which endowed the physically crosslinked organohydrogel with a high fracture stress of up to 782.9 ± 38.6 kPa. Also, the glycerol molecules formed hydrogen bonds with the water molecules, thus inhibiting the formation of ice crystals. After storage at -20 °C for 24 h, the PAAG-Gly organohydrogels retained their superior mechanical properties, adhesion strength, and electrical conductivity. Once the cut surfaces of the organohydrogel were contacted, the conductive path was rapidly self-healed. Moreover, the PAAG-Gly organohydrogels exhibited excellent cytocompatibility. At 100% strain, the gauge factor of the organohydrogel-based sensor reached 4.22. The organohydrogel-based sensor revealed the capability to monitor human motions, such as finger, wrist and knee movements.Guided tissue regeneration (GTR) strategies are an effective approach to repair periodontal defects by using GTR membranes. However, commercial GTR membranes still have limitations in periodontal tissue regeneration owing to lack of antibacterial and osteogenic properties. The development of novel Janus nanofibers with biphasic release characteristics based on the therapeutic needs of GTR is essential to tackle this issue. Here, we developed a multifunctional Janus nanofiber via uniaxial electrospinning, with zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP) loading in the hydrophilic polyvinylpyrrolidone (PVP) part and FK506 embedding in the hydrophobic polycaprolactone (PCL) part. The release of Zn2+ conformed to the Ritger-Peppas kinetics which could effectively prevent bacterial infection, and the release profile of FK506 was fitted to a first-order equation which could provide persistent osteogenic stimulation for osteogenesis. The periodontal tissue regeneration data from a rat periodontitis model revealed that the multifunctional electrospun Janus nanofibers could be used as an effective bioplatform to restore alveolar bone impairment, compared with the control group. In summary, the Janus nanofibers with biphasic release characteristics quickly exert antibacterial function as well as continuously provide a microenvironment beneficial to the osteogenesis process, demonstrating its great potential for GTR treatment in dental clinic applications.The direct synthesis of isocoumarin skeletons has been realized through the Rh(III)-catalyzed [3 + 3] annulation of sulfoxonium ylides with iodonium carbenes. The synthetic protocol was constructed efficiently with broad functional group tolerance and mild reaction conditions. This reaction can be formally viewed as the result of C-H activation, carbene insertion and nucleophilic addition processes. Furthermore, the further conversions of the product and gram-scale reactions were also demonstrate to support the effectiveness of the synthesis protocol.The prenylation of phenolic substrates promoted by magnesium dicarboxylates was developed. An investigation of the scope demonstrated that substrates with electron-donating group(s) gave better yields than those with electron-withdrawing group(s). Although the conversions of all substrates were higher in MeCN than in DMF, DMF was still the favorable solvent for polyphenolic substrates since MeCN would cause the generation of cyclized by-products (6) and reduce the yield of 3. The regio-selectivity of ortho- vs. LF3 cost para-prenylation (3'vs.3) for those para-unoccupied substrates was also solvent dependant. DMF produced mainly ortho-products but with poor conversions. On the other hand, MeCN generated mainly para-products, along with minor ortho-products. Mechanistic study of the prenylation provided evidence for the nucleophilic addition/substitution of the phenolic substrate to the alkyl halide in the presence of the magnesium dicarboxylates. The proto application of this method in the total synthesis of icaritin through the prenylation of 2,4,6-trihydroxyacetophenone, followed by the reaction with benzaldehyde to afford the flavonol, was successful, with a total yield of 33%.Ligand receptor based adhesion is the primary mode of interaction of cellular blood constituents with the endothelium. These adhered entities also experience shear flow imposed by the blood which may lead to their detachment due to the viscous lift forces. Here, we have studied the role of the ligand-receptor bond kinetics in the detachment of an adhered vesicle (a simplified cell model) under shear flow. Using boundary integral formulation we performed numerical simulation of a two dimensional vesicle under shear flow for different values of applied shear rates and time scale of bond kinetics. We observe that the vesicle demonstrates three steady state configurations - adhered, pinned and detached for fast enough ligand-receptor kinetics (akin to Lennard-Jones adhesion). However, for slow bond kinetics the pinned state is not observed. We present scaling laws for the critical shear rates corresponding to the transitions among these three states. These results can help with identifying the processes of cell adhesion/detachment in the blood stream, prevalent features during the immune response and cancer metastasis.Lipidic-liquid crystalline nanostructures (lipidic cubic phases), which are biomimetic and stable in an excess of water, were used as a convenient environment to investigate the transport properties of the membrane antiporter E. coli CLC-1 (EcCLC). The chloride ion transfer by EcCLC was studied by all-atom molecular dynamics simulations combined with electrochemical methods at pH 7 and pH 5. The cubic phase film was used as the membrane between the chloride donor and receiving compartments and it was placed on the glassy carbon electrode and immersed in the chloride solution. Structural characterization of lipidic mesoscopic systems with and without the incorporation of EcCLC was performed using small-angle X-ray scattering. The EcCLC transported chloride ions more efficiently at more acidic pH, and the resistance of the film decreased at lower pH. 4,4-Diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) employed as an inhibitor of the protein was shown to decrease the transport efficiency upon hydrolysis to DADS at both pH 7 and pH 5. The molecular dynamics simulations, performed for the first time in lipidic cubic phases for EcCLC, allowed studying the collective movements of chloride ions which can help in elucidating the mechanism of transporting the ions by the EcCLC antiporter. The protein modified lipidic cubic phase film is a convenient and simple system for screening potential inhibitors of integral membrane proteins, as demonstrated by the example of the EcCLC antiporter. The use of lipidic cubic phases may also be important for the further development of new electrochemical sensors for membrane proteins and enzyme electrodes.Monolayer MoSi2N4 (MoSiN) was successfully synthesized last year [Hong et al., Science369, 670 (2020)]. The MoSiN monolayer exhibited semiconducting characteristics and exceptional ambient stability, calling for more studies of its properties. Here, we conduct first-principle calculations to examine the structural, magnetic, and electronic properties of substitutional doping of MoSiN monolayers with transition metals (TM) at the Mo site (TM-MoSiN). We find that the Sc-, Y-, Ti-, and Zr-MoSiN are metallic systems, while Mn-, Tc-, and Ru-MoSiN are n-type conducting. The Fe-MoSiN is a dilute magnetic semiconductor, and the Ni-MoSiN is a metal (or half-metal). The inclusion of spin-orbit coupling turns them into a half-metal and a semimetal, respectively. We also find that the work function of TM-MoSiN and the bond lengths between the TM and neighbor atoms increase as the atomic radius and electronegativity of the TM atom increase, respectively. The Fe-, Co-, and Ni-MoSiN may be used in spintronic devices, while Mn-, Rh- and Pd-MoSiN could be utilized for spin filter applications.Macroscopically homogeneous mixtures of p-nitroanisole (pNA) and mesitylene (MES) can be selectively heated using microwave (MW) energy. The pNA solutes agglomerate into distinct phase domains on the attoliter-scale (1 aL = 10-18 L), and these agglomerates can be MW-heated selectively to temperatures that far exceed the boiling point of the surrounding MES solvent. Here, a 1  20 mixture of pNA  MES is used as a mixed solvent for aryl Claisen rearrangement of allyl naphthyl ether (ANE). ANE itself does not heat effectively in the MW, but selective MW heating of pNA allows for transfer of thermal energy to ANE to accelerate rearrangement kinetics above what would be expected based on Arrhenius kinetics and the measured bulk solution temperature. This focused study builds on prior work and highlights 1  20 pNA  MES as a mixed solvent system to consider for strategically exploiting MW-specific thermal effects.An inclusion system of embedding ferulic acid into β-cyclodextrin (FACD) with different host-guest stoichiometries was prepared by a co-precipitation method. Then, the physicochemical properties and release kinetics of the FACD were evaluated. The results of thermal analysis, X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy (FTIR) proved the successful embedding of FA into the β-cyclodextrin matrix. Four mathematical models were applied to adjust the ferulic acid release profile and identify preferential kinetics. The results of physicochemical properties confirmed the successful formation of the complexes. The loading capacity (LC) and encapsulation efficiency (EE) of the inclusion complex (1  0.5) were 41.0 ± 3.28 mg g-1 and 52.1 ± 2.31%, respectively, which were significantly higher than other molar ratios. The release behaviour revealed that loaded FA molecules under various host-guest stoichiometries obey different release models. While lower host-guest stoichiometry (1  0.