Wilhelmsenbowles9019

0%; OR = 19.0; 95% CI = 17.3, 20.9), and bots (8.8%; OR = 5.4; 95% CI = 4.7, 6.3).Conclusions. A small proportion of vaccine-critical information that reaches active US Twitter users comes from bots.Objectives. To understand changes in how Facebook pages frame vaccine opposition.Methods. We categorized 204 Facebook pages expressing vaccine opposition, extracting public posts through November 20, 2019. We analyzed posts from October 2009 through October 2019 to examine if pages' content was coalescing.Results. Activity in pages promoting vaccine choice as a civil liberty increased in January 2015, April 2016, and January 2019 (t[76] = 11.33 [P  less then  .001]; t[46] = 7.88 [P  less then  .001]; and t[41] = 17.27 [P  less then  .001], respectively). The 2019 increase was strongest in pages mentioning US states (t[41] = 19.06; P  less then  .001). Discussion about vaccine safety decreased (r s [119] = -0.61; P  less then  .001) while discussion about civil liberties increased (r s [119] = 0.33; Py  less then  .001]). Page categories increasingly resembled one another (civil liberties r s [119] = -0.50 [P  less then  .001]; alternative medicine r s [84] = -0.77 [P  less then  .001]; conspiracy theories r s [119] = -0.46 [P  less then  .001]; morality r s [106] = -0.65 [P  less then  .001]; safety and efficacy r s [119] = -0.46 [P  less then  .001]).Conclusions. The "Disneyland" measles outbreak drew vaccine opposition into the political mainstream, followed by promotional campaigns conducted in pages framing vaccine refusal as a civil right. Political mobilization in state-focused pages followed in 2019.Public Health Implications. Policymakers should expect increasing attempts to alter state legislation associated with vaccine exemptions, potentially accompanied by fiercer lobbying from specific celebrities.The author examined experiences of Commercial Sex Workers (CSWs) in Accra, Kumasi and Kasoa metropolises following Ghana's imposition restrictive ACT since 21 March 2020. Three trained male field assistants posing as mystery clients, purposively selected and interviewed 35 CSWs using a combination of face-to-face and telephone interviews with consenting CSWs in the study area. Findings show declined activity and patronage of CSWs due to fear of contracting COVID-19. With no savings or other reliable sources of income, some CSWs have however devised various strategies to work safely and implored the government to support them financially during this crisis.

This study aimed to assess the economic burden of subsequent fracture in osteoporosis patients with incident fracture.

The authors conducted a retrospective cohort analysis of the South Korean national health insurance claims data. Study subjects included osteoporosis patients aged ≥50 with incident fracture (July 1, 2014-June 30, 2015). Fracture-related 1-year healthcare cost was evaluated after incident fracture for patients with and without subsequent fracture, defined as a fracture occurring within 2 years from incident fracture at a different site or at the same site after 6-months washout period. Per-patient-per-month (PPPM) cost was calculated by dividing each patient's cumulative healthcare cost until subsequent fracture with time-to-subsequent-fracture. For the patients without subsequent fracture, PPPM cost equaled 1-year monthly cost. A generalized linear model (GLM) was used to estimate the ratio of increase in healthcare cost to assess the economic impact of subsequent fracture.

A total of s.Objective Our study was designed to determine if the TRPM1 gene is associated with any of three mental disorders. The project included a cross disorder meta-analysis and association analysis including 141701 cases and 175248 controls. Materials and Methods We genotyped eight tag single nucleotide polymorphisms (SNPs) in 1248 unrelated schizophrenia (SCZ) patients, 1056 major depressive disorder patients, 1344 bipolar disorder patients, and 1248 normal controls. We then performed a meta-analysis of 10 GWASs to identify common genetic factors among these three mental disorders. Finally, we performed a meta-analysis of six GWASs to explore the role of rs10162727 in SCZ. Result Although two haplotypes of the TRPM1 gene, rs1035706-rs10162727 and rs10162727-rs3784599, were identified in the control group, as well as all three disease groups, none of the eight tag SNP associations remained significant after correction for multiple tests. In this cross-disorder meta-analysis of the three diseases, none of the tag SNPs were confirmed to be common among the diseases. In addition, in the meta-analysis conducted for the rs10162727 locus in SCZ, there was no significant association (p-value = 0.84, odds ratio = 1.02 [95% CI = 0.87-1.19]). Conclusion In the Han Chinese population, no significant evidence was found linking variants of the TRPM1 gene with any of the mental disorders examined.The study aimed to measure serum fatty acids (FAs) composition in HIV carrier patients and compare it with non-HIV carrier patients. The FAs composition was measured by gas chromatography as follows four saturated FAs myristic acid (140), palmitic acid (160), stearic acid (180), and docosanoic acid (220); four monounsaturated FAs 7-hexadecenoic acid (161 n-9), palmitoleic acid (161 n-7), oleic acid (181 n-9), and vaccenic acid (181 n-7); and three polyunsaturated FAs linoleic acid (182 n-6), dihomo-γ-linolenic acid (203 n-6), and docosahexaenoic acid (DHA, 226 n-3). We reported herein lower (P  less then  .05) DHA concentration (by 40%) in the serum of HIV carrier patients than in non-HIV carrier patients. This FA has a pivotal role as a precursor of anti-inflammatory molecules with beneficial effects on metabolism, cardiovascular system, and immunological system. Even though most clinical studies reported beneficial effects of DHA supplementation in HIV carrier patients, this issue remains under debate. Further investigations then require to fully clarify the role of DHA in preventing or alleviating the comorbidities associated with HIV infection.Objective A review of current meta-analyses examining the relationship between maternal use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and congenital anomalies. Methods PubMed was searched for meta-analyses published in English language between January 2010 and April 2020 by using the following combinations of key words meta-analysis, pregnancy, antidepressant, SSRI, citalopram, escitalopram, fuloxetine, paroxetine, sertraline, fluvoxamine, neonatal outcome, birth outcome, congenital malformation, congenital anomaly, birth defect, cardiac malformation and heart defect.Results A total of 15 meta-analyses met the search criteria. These meta-analyses consistently suggested a significant positive association between the use of SSRIs in general and paroxetine and fluoxetine in particular and the risk of major congenital anomalies. The data also showed a consistency in increased cardiovascular defects in infants due to maternal use of paroxetine. The risk of cardiovascular defects in infants of women using SSRIs in general and fluoxetine and sertraline in particular was controversial. Conclusion Further large-scale prospective observational studies and meta-analyses on the effects of individual SSRIs other than paroxetine, especially escitalopram and fluvoxamine, are required to reach definitive conclusions.The Dof transcription factor is a plant-specific transcriptional regulator that plays important roles in plant development and acts as a mediator in plant external stress responses. However, Dofs have previously been identified in several plants but not in alfalfa (Medicago sativa L.), one of the most widely cultivated forage legumes. In the present study, a total of 40 MsDof genes were identified, and the phylogenetic reconstruction, classification, conserved motifs, and expression patterns under abscisic acid (ABA), cold, heat, drought and salt stresses of these Dof genes were comprehensively analyzed. The Dof genes family in alfalfa could be classified into eight classes. Gene ontology (GO) and tissue-specific analysis indicated that most MsDof genes may be involved in biological functions during plant growth. Moreover, the expression profiles and quantitative real-time PCR analysis indicated that eight candidate abiotic tolerance genes were induced in response to four abiotic stresses. This study identified the possibility of abiotic tolerance candidate genes playing various roles in stress resistance at the whole genome level, which would provide new information on the Dof family in alfalfa.

This study evaluated the effects of cerebellar tDCS on motor learning for swallowing.

In a double-blind RCT, 39 healthy adults received either sham, anodal tDCS, or cathodal tDCS in two sessions on two consecutive days. Following 20 min cerebellar tDCS (2 mA) or sham, they underwent swallowing skill training that targeted control of timing and magnitude of submental muscle activation during swallowing. Linear mixed models were used to identify the effects of stimulation on timing and magnitude accuracy as measured by the change in task performance for each training session, and for skill retention on days 3 and 10 post-intervention.

Only the sham group had a reduced temporal error from baseline to all following timepoints. When compared to error changes in the sham group, changes from baseline in temporal errors were higher at all timepoints post-intervention for the anodal group, and higher at both retention assessments for the cathodal group. Amplitude errors were smaller for all conditions at all tim in swallowing. For the tDCS parameters used in this study, there is no support for use of tDCS to facilitate swallowing rehabilitation. Trial Registry Number (https//www.anzctr.org.au/) ACTRN12615000451505. IMPLICATIONS FOR REHABILITATION Cerebellar tDCS, in combination with motor skill training, has been demonstrated to increase motor skill learning in healthy individuals and neurologically impaired patients. In this study, cerebellar tDCS applied prior to swallowing skill training adversely affected timing measures of submental muscle activation during swallowing. In contrast to published outcomes in the corticospinal literature, both anodal and cathodal tDCS resulted in a relative inhibitory effect on motor skill learning in swallowing when compared to the sham condition. Swallowing skill training without tDCS produced increased accuracy in outcomes.A combination of positively and negatively worded items (termed a mixed-format design) has been widely adopted in personality and attitude assessments. While advocates claim that the inclusion of positively and negatively worded items will encourage respondents to process the items more carefully and avoid response preference, others have reported that negatively worded (NW) items may induce a nuisance factor and contaminate scale scores. The present study examined the extent of the impact of the NW-item feature and further investigated whether a mixed-format design could effectively control acquiescence and the preference for extreme response options using two datasets (Attitude toward Peace Walls, and International Personality Item Pool). A proposed multidimensional item response model was implemented to simultaneously estimate the impact of item feature and response preference. The results suggested that NW items induced an impact on item responses and that affirmative preference was negligible, regardless of the proportion of NW items in a scale. However, participants' extremity preference was large in both balanced and imbalanced mixed-format designs. It concludes that the impact of the NW-item feature is not negligible in a mixed-format scale, which exhibits good control of acquiescence but not extremity preference.

Multiple prognostic models are available to predict mortality in alcoholic hepatitis (AH) which are of modest benefit, but the best model remains unexplored.

This is a retrospective analysis (2012-2015) of AH patients. Conventional prognostic scoring systems viz. Maddrey's Discriminant Function (mDF), Age Bilirubin International Normalized Ratio and Creatinine (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), and the Model for End-stage Liver Disease score (MELD), were compared with Model for AH to Grade the Severity in an Asian patient cohort (MAGIC) score, using area under the ROC curves for ascertaining 30/90-day mortality.

Eighty-eight patients (100% male); mean (SD) age of 45.6 (7.6) years with a follow-up of 80.7 (45.1) days were included. The 30 and 90-day mortality were 21 (23.9%) and 42 (47.7%), respectively; the commonest cause being sepsis in 22 (48.9%) patients. Survival probabilities for mDF < 32 and mDF > 32 were 100% and 42.25% ± 4.46%, respectively (

= .001). The mean (SD) scores of mDF, MELD and GAHS were significantly higher in deceased patients 70.8 (26.5), 23.4 (5.2), 8.1 (1.01), respectively, as compared to those who survived 40.8 (23.1), 18.9 (5.1), 7.3 (0.9), respectively;

 = .001. ABIC and MAGIC scores were higher among the deceased, but were not significant. mDF had the best predictive AUROC value 0.872, followed by MELD 0.772, and MAGIC 0.626, respectively. mDF was significantly superior in comparison to MAGIC score (

 < .001).

This study showed that mDF had a better predictive performance than other scoring systems in patients with AH.

This study showed that mDF had a better predictive performance than other scoring systems in patients with AH.

Interventions are needed to address chronic health conditions, such as obesity and diabetes, faced by adults with traumatic brain injury (TBI). The objective of this narrative is to present the justification for and an exemplar of an active attention control condition as a needed comparison group in clinical trials for intensive lifestyle interventions after TBI.

Narrative review.

N/A.

Despite the historical use in scientific research, integration of appropriate control conditions to account for not only the placebo effect, but also to isolate the "active ingredients" of behavioural interventions, remains a challenge. This is particularly true for intensive lifestyle interventions, especially with the increasing use of mobile health (mHealth) to augment these interventions. Herein we describe the design, content, and implementation of a group-based, attention control condition, referred to as the Brain Health Group, as an exemplar active comparison to an intensive lifestyle intervention for weight-loss among individuals with TBI (GLB-TBI).

Intervention studies should incorporate strong scientific designs and active control conditions to assess effectiveness and aid in replication. Following recommended guidelines, we provide an active control condition for future group-based intensive lifestyle interventions post-TBI.

Intervention studies should incorporate strong scientific designs and active control conditions to assess effectiveness and aid in replication. Following recommended guidelines, we provide an active control condition for future group-based intensive lifestyle interventions post-TBI.Coptisine, extracted from rhizoma coptidis, has been shown to inhibit a variety of cancers. However, the underlying mechanism by which coptisine regulates hepatocellular carcinoma (HCC) progression remains unknown. MTT assay, transwell invasion assay, and TUNEL assay were employed to examine cell viability, invasion, and apoptosis. In vivo tumor growth was determined by xenograft experiment. Reverse transcription-quantitative PCR was used to detect circCCT3 and HK2 gene expression. We utilized glucose consumption and lactate production assay to examine glucose metabolism state. Conditioned medium of coptisine-treated cancer-associated fibroblast (CAF) suppressed cell viability and invasion of HepG2 and Huh-7, whereas increased cell apoptosis. Coptisine significantly inhibited tumor growth of HepG2 cells in immunodeficient mice. Mechanistically, coptisine blocked secretion of exosomal circCCT3 from CAF. More notably, circCCT3 was upregulated in clinical HCC tumors. Moreover, circCCT3 was confirmed to affect glucose metabolism of HCC cells. We identified HK2 as a key downstream effector for circCCT3-modulated HCC tumorigenesis. In summary, our research revealed novel molecular mechanism of coptisine-blocked HCC progression, thereby providing solid rationale for using coptisine to treat HCC.

Ravulizumab, engineered from eculizumab, provides sustained C5 inhibition in atypical hemolytic uremic syndrome (aHUS) while reducing dosing frequency (every 8 vs 2 weeks, respectively). Treatment choice often carries significant financial implications. This study compared the economic consequences of ravulizumab and eculizumab for treating aHUS.

A cost-minimization model compared direct medical costs for ravulizumab and eculizumab in treating aHUS, assuming equivalent efficacy and safety, and took a US payer perspective, a lifetime horizon, and a 3.0% cost discount rate. The base case modeled adult and pediatric treatment-naïve populations, with characteristics based on clinical trials, and treatment patterns (duration, discontinuation, re-initiation) derived from eculizumab studies with long-term follow-up. Treatment costs (2019 US$) were based on wholesale drug acquisition costs, Centers for Medicare & Medicaid fee schedules, and published disease management studies. Sensitivity analyses were condus with aHUS, ravulizumab provided cost reductions of 32.4-35.5% vs eculizumab, with a reduced dosing frequency for ravulizumab. The magnitude of reductions was consistent across sensitivity analyses.

In US patients with aHUS, ravulizumab provided cost reductions of 32.4-35.5% vs eculizumab, with a reduced dosing frequency for ravulizumab. The magnitude of reductions was consistent across sensitivity analyses.

More and more premature infants were born worldwide that are suffering from various complications, vaccination for whom is often delayed in China. We aim to describe current vaccination recommendations in practice, immunization status, and vaccination safety for premature infants in Zhejiang.

The demographic information, medical records of treatments, and adverse events following immunization (AEFI) history were collected from infants' parents by questionnaire in the Vaccination Consultation Clinic(VCC). Vaccination data were retrieved from Zhejiang Provincial Immunization Information System. The information of AEFI was collected from the Chinese National Adverse Event Following Immunization Information System.

A total of 1515 premature infants visiting the VCC were included in the study. The majority (65.94%) of them were under 7months. 47.59% of premature infants were advised to receive normal vaccinations, while 45.94% were advised to defer a specific vaccination and 6.47% were advised to defer all vaccinations. A total of 807 infants received 7187 vaccine doses were administered and only seven cases experienced mild and self-limiting adverse reactions (9.74/10,000). No uncommon or serious side effects were reported.

Most premature infants visiting the VCC did not receive vaccines on time. The majority of them can be safely vaccinated according to the national-recommended schedule.

Most premature infants visiting the VCC did not receive vaccines on time. The majority of them can be safely vaccinated according to the national-recommended schedule.Few studies have compared interference-based forgetting between item versus associative memory. The memory-system dependent forgetting hypothesis (Hardt, Nader, & Nadel, 2013) predicts that effects of interference on associative memory should be minimal because its hippocampal representation allows pattern separation even of highly similar information. In contrast, there should be strong interference effects on extra-hippocampally represented item memory. We tested this prediction in behavioral data from 3 experiments using continuous recognition paradigms. Given older adults' greater deficits in associative than item memory, we also compared younger and older adults to test whether this associative deficit extends to greater interference susceptibility in older adults' associative memory. Experiment 1 examined item-item associative memory with participants studying unrelated word pairs continuously intermixed with item (single words) and associative (intact vs. recombined pairs) recognition tests across interference-filled lags. Experiments 2 and 3 examined item-context (i.e., source) associative memory with participants studying words in different spatial positions continuously intermixed with source-monitoring tests (presented on top vs. on bottom vs. new?) across interference-filled lags (Experiment 3 controlling for delay/decay-based effects). In all experiments, item memory declined from the first lag on. In contrast, associative memory initially remained stable, with strong evidence for null effects of interference even in older adults, but showed some declines at later lags. The data supports Hardt et al.'s proposal of differential interference-based forgetting in item versus associative memory. The results further show that the age-related associative memory deficit does not extend to greater interference-based forgetting in older adults' associative memory. (PsycInfo Database Record (c) 2021 APA, all rights reserved).One core question in studies of language processing is the extent to which interlocutors engage in real-time communicative perspective-taking. Current evidence suggests that both children and young adult listeners are able to draw on common ground (shared knowledge) to guide referential interpretation. However, less is known about older listeners, who are often described as experiencing age-related cognitive declines that could affect their capacity to integrate perspective cues online. In the present study, we examined the extent to which younger and older listeners used common ground to guide the interpretation of temporarily ambiguous descriptions. Participants followed instructions from a Director to click on displayed objects. The target object (e.g., hat with blue feathers) was accompanied by a competitor (e.g., hat with pink feathers) or a control object (e.g., stapler). We manipulated whether the competitor/control was mutually visible (common ground) or not (privileged ground). The results revealed that, although listeners used perspective information to differentiate the target from the competitor in the common ground condition, this pattern was notably weaker in older adults. Whereas measures of executive function showed significant group differences in inhibitory control and working memory, no differences were found in theory of mind. Thus, age-related changes in communicative perspective-taking are not likely due to general declines in mentalizing ability. Furthermore, strict screening criteria for vision and hearing ability allowed us to rule out explanations involving age-related sensory decline. Together, the results advance our understanding of how younger and older adults integrate common ground during real-time referential processing. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Studies have demonstrated that listeners can retain detailed voice-specific acoustic information about spoken words in memory. A central question is when such information influences lexical processing. According to episodic models of the mental lexicon, voice-specific details influence word recognition immediately during online speech perception. Another view, the Time-Course Hypothesis, claims that voice-specific details influence word recognition only when processing is slow and effortful. The present study investigates the latter proposal by employing reaction time (RT)-distributional analyses. A long-term repetition priming experiment was conducted using an auditory lexical-decision task. In 2 blocks, participants made speeded responses to existing and nonexisting spoken words. In the second block, stimuli consisted of items that had not been presented in the first block and of items that were either repeated in the same voice or in a different voice. Ex-Gaussian and Vincentile analyses of the RT distributions in the second block revealed that voice-specific priming is reflected in distributional shifting rather than in distributional skewing. This indicates that voice-specific priming is not limited to very slow responses but that it affects both fast and slow responses. This finding is inconsistent with a strict version of the Time-Course Hypothesis, which claims that voice-specific priming occurs only during offline processing. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Two masked priming experiments investigated the impact of prime lexicality (word vs. nonword) and the pseudo-morphological structure of prime stimuli (pseudosuffixed vs. nonsuffixed) on embedded word priming effects. In the related prime conditions, target words were embedded at the beginning of prime stimuli and were followed either by a derivational suffix (e.g., corner-corn; cornry-corn) or a nonsuffix but orthographically legal word ending (e.g., dragon-drag; dragip-drag). Lexical decisions to target words were facilitated by related pseudosuffixed primes compared with unrelated primes, and this occurred to the same extent for word primes (corner-corn) and nonword primes (cornry-corn). On the other hand, target word recognition was inhibited by related nonsuffixed word primes (dragon-drag), and no priming was found with nonsuffixed nonword primes (dragip-drag). Conditional suffix probability-the probability that a string-initial embedded word will be followed by a derivational suffix in a lexicon of all uninflected morphologically simple and derived words - determined the size of priming effects obtained with nonsuffixed primes. Two main conclusions are drawn on the basis of these findings (a) the presence of a pseudo-morphological structure in words such as corner limits the impact of lateral inhibitory influences on embedded word priming, and (b) in the absence of a pseudo-morphological structure, one possible factor determining embedded word priming is the likelihood that the embedded word will be followed by a derivational suffix. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Reports an error in "Criterion validity and relationships between alternative hierarchical dimensional models of general and specific psychopathology" by Tyler M. Moore, Antonia N. Kaczkurkin, E. Leighton Durham, Hee Jung Jeong, Malerie G. McDowell, Randolph M. Dupont, Brooks Applegate, Jennifer L. Tackett, Carlos Cardenas-Iniguez, Omid Kardan, Gaby N. Akcelik, Andrew J. Stier, Monica D. Rosenberg, Donald Hedeker, Marc G. Berman and Benjamin B. Lahey (Journal of Abnormal Psychology, Advanced Online Publication, Jul 16, 2020, np). In the article (http//dx.doi.org/10.1037/abn0000601), an acknowledgment is missing from the author note. The missing acknowledgement is included in the erratum. (The following abstract of the original article appeared in record 2020-50590-001.) Psychopathology can be viewed as a hierarchy of correlated dimensions. Many studies have supported this conceptualization, but they have used alternative statistical models with differing interpretations. In bifactor models, every symptom loads indicated that all factors in both bifactor and second-order models exhibited at least adequate construct reliability and estimated replicability. The factors defined in bifactor and second-order models were highly to moderately correlated across models, but have different interpretations. All factors in both models demonstrated significant associations with external criterion variables of theoretical and clinical importance, but the interpretation of such associations in second-order models was ambiguous due to shared variance among factors. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Quality of life (QOL) and delay discounting (preference for smaller, immediate rewards) are significantly associated with substance use status, severity, and treatment outcomes. Associations between delay discounting and QOL among individuals in recovery from substance use have not been investigated. In this 2-study investigation, using data collected from The International Quit & Recovery Registry, we examined the association between QOL, discounting rates, and remission status among individuals in recovery from SUD. Study 1 (N = 166) investigated the relationship between delay discounting and QOL among individuals in recovery from SUD. Study 2 (N = 282) aimed to validate and extend the results of Study 1 by assessing the association between the remission status, delay discounting, and QOL among individuals in recovery from alcohol use disorder (AUD). In both studies, delay discounting was a significant predictor of QOL domains of physical health, psychological, and environment even after controlling for age, gender, race, ethnicity, education, and days since last use. In Study 2, a mediation analysis using Hayes's methods revealed that the association between the remission status and QOL domains of physical health, psychological and environment were partially mediated by the discounting rates. The current study expands the generality of delay discounting and indicates that discounting rates predict QOL and remission status among individuals in recovery from substance use disorders. This finding corroborates the recent characterizations of delay discounting as a candidate behavioral marker of addiction and may help identify subgroups that require special treatment or unique interventions to overcome their addiction. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Heroin intake decreases markedly during proestrus in normally cycling female rats; however, it is not known whether estradiol, progesterone, or both hormones are responsible for these decreases in heroin intake. The purpose of the present study was to examine the roles of estradiol and progesterone in heroin intake by artificially inducing a proestrus state in ovariectomized rats. To this end, ovariectomized female rats were implanted with intravenous catheters and trained to self-administer heroin (0.0075 mg/kg/infusion) on a fixed ratio (FR1) schedule of reinforcement. After 1 week of training, rats were tested at weekly intervals with estradiol (0.005 mg, sc) or vehicle 22 hr before a test session and progesterone (0.125 mg, sc) or vehicle 0.5 hr before a test session to artificially mimic the naturally occurring hormone concentrations characteristic of late proestrus. Administration of estradiol 22 hr prior to testing and progesterone 0.5 hr prior to testing significantly reduced heroin intake relative to the previous training day and vehicle control. It is interesting that this same effect was observed when only estradiol, but not progesterone, was administered. These data suggest that estradiol but not progesterone is responsible for the proestrus-induced decreases in heroin intake previously reported in normally cycling female rats. These findings differ from those reported previously with stimulants and suggest that estrogen-based pharmacotherapies may be of value to women with opioid use disorder. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Behavioral processes underlying sexual behavior are important for understanding normal human functioning and risk behavior leading to sexually transmitted infections (STIs). This systematic review examines delay and probability discounting in human sexual behavior through synthesis of 50 peer-reviewed, original research articles. Sixteen studies focusing exclusively on monetary delay discounting found small effect size positive correlations with sexual risk behaviors. Eleven studies examined delay or probability discounting of sexual behavior itself using tasks that varied duration, frequency, or quality of sex to determine value. Results show delay and uncertainty of sex causes systematic decreases in value. These studies also show consistent medium effect size relationships between sexual discounting measures and sexual health and substance use, supporting utility above and beyond monetary discounting. Twenty-three studies have modeled clinically relevant decision-making, examining effects of delay until condom availability and STI contraction probability on condom use. Observational and experimental designs found condom-use discounting is elevated in high-risk substance use populations, is sensitive to context (e.g., partner desirability), and is more robustly related to sexual risk compared with monetary discounting or condom use decisions when no delay/uncertainty was involved. Administering cocaine, alcohol, and, for some participants, methamphetamine increased condom-use discounting with minimal effect on monetary discounting or condom use when no delay/uncertainty was involved. Reviewed studies robustly support that sexual behavior is highly dependent on delay and probability discounting, and that these processes strongly contribute to sexual risk. Future research should exploit these systematic relationships to design behavioral and pharmacological approaches to decrease sexual risk behavior. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Females are uniquely sensitive to drugs of abuse at specific points in their reproductive cycle. Females' endogenous opioid system contributes to both reward-related processes and maternally relevant physiological functions, yet less is known about how adolescent opioid exposure impacts females' future behavior, ranging from parental caregiving to opioid preference. The present study explores 2 questions (a) are there sex differences in response to adolescent oxycodone exposure, spontaneous withdrawal, and oxycodone preference in adulthood, and (b) to what extent does this pregestational opioid exposure alter females' future maternal caregiving behavior? Female and male mice received 12d of oxycodone or saline injections during mid/late adolescence, and drug was then withheld. Some females were then mated and experienced a drug-free pregnancy. Following parturition, females' maternal behavior and motivation were assessed. All mice then underwent a place conditioning procedure to assess the incentive value of oxycodone during adulthood. Mice displayed similar behavioral responses to oxycodone (e.g., sensitization) and patterns of withdrawal behaviors, independent of sex. Mice showed strong group preferences for the oxycodone-paired chamber, and the strength of these preferences did not differ by sex or maternal status. Postpartum females' maternal behavior and motivation were also similar despite adolescent drug history. Together, results did not suggest overt sex differences in response to adolescent oxycodone exposure and that, in females, a range of motivated behaviors may be relatively resilient to such perturbations during adolescence. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Cigars are available in a variety of flavors that may impact uptake and use, but little is known about how different flavors affect abuse liability. This study used 3 behavioral economic tasks to examine abuse liability of Black & Mild cigars differing in flavor among young adult cigarette smokers. Participants were 25 cigar-naïve young adults (aged 18-25 years) who smoked ≥ 5 cigarettes/day. In 5 Latin square-ordered laboratory visits, participants completed 3 abuse liability tasks (drug purchase task, cross-price purchase task, and multiple-choice procedure) for each of 4 cigar flavors (original, cream, wine, or apple) and own-brand cigarettes. In the drug purchase task, relative to own-brand cigarettes, all cigar flavors were associated with lower abuse liability using most measures (intensity, breakpoint, maximum total tobacco expenditure for 1 day [ps less then .05]), although only wine-flavored cigars scored significantly lower using 1 measure (price at maximum total tobacco expenditure for 1 day). When cigars and cigarettes were available concurrently in the cross-price purchase task, all cigar flavors functioned as substitutes for cigarettes. Using the multiple-choice procedure, crossover points for wine- (mean = $0.61) and apple-flavored cigars (mean = $0.71) were significantly lower than own-brand cigarettes (mean = $0.86) and original-flavored cigars (mean = $1.00); no significant differences existed between own-brand cigarettes and original-flavored cigars. Thus, whereas abuse liability may be highest for participants' own-brand cigarette, young adult smokers may be willing to use flavored cigars. Furthermore, abuse liability varies by cigar flavor, with original- and cream-flavored cigars appearing to have the highest abuse liability. Characterizing flavors and flavor additives in cigars represent an important tobacco regulatory target. (PsycInfo Database Record (c) 2020 APA, all rights reserved).As cannabis policy changes, there is an urgent need to understand interactions between cannabis and alcohol couse. An online sample of 711 adult past-month cannabis and alcohol users completed both single-item hypothetical purchasing tasks for cannabis and alcohol and cross-commodity purchasing tasks assessing adjusting-price cannabis with concurrently available, fixed-price alcohol, and vice versa. Participants provided information about cannabis and alcohol use patterns, and completed the Alcohol and Cannabis Use Disorder Identification Tests (AUDIT and CUDIT, respectively). Group data showed that cannabis and alcohol served as complements (as the price of the adjusting-price commodity increased, consumption of both commodities decreased). However, individual data showed substantial variability with nontrivial proportions showing patterns of complementarity, substitution, and independence. More negative slopes (greater complementarity) for fixed-price cannabis and alcohol were both associated with greater self-reported drug consumption and CUDIT and AUDIT scores. The negative relation between cross-price slope and CUDIT/AUDIT score indicates that individuals who treat cannabis and alcohol more as complements are more likely to experience disordered use. Based on these cross-commodity purchasing data, when both cannabis and alcohol are concurrently available at low prices, both may be used at high levels, whereas limiting consumption of one commodity (e.g., through increased price) may reduce consumption of the other. These data show the importance of examining individual participant analyses of behavioral economic drug interactions and suggest that manipulation of cost (e.g., through taxes) or cosale restrictions are potential public health regulatory mechanisms for reducing alcohol and cannabis use and couse behaviors. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Experts have better memory for items within their domain of expertise. Critically, this does not depend on more efficient use of language. However, this conclusion is based mainly on findings from experts in visual and auditory domains. Olfactory experts constitute an interesting potential counterexample since language has been implicated to be critically involved in odor memory in previous studies. We examined the role language plays in odor recognition memory for wine experts, who typically display better wine odor memory than novices and who are also able to name odors better than lay people. This suggests wine experts' superior recognition memory for odors may be verbally mediated. In 2 experiments, recognition memory for wine odors, wine-related odors, and common odors was tested in wine experts and novices. The use of language was manipulated in Experiment 1 with an overt naming versus no-naming condition, and in Experiment 2, with a verbal interference task inhibiting covert verbalization. Across the two experiments the results showed wine experts have better recognition memory for wines, but not for wine-related or common odors, indicating their memory advantage is expertise specific. Critically, this effect was not verbally mediated, as there was no relationship between experts' ability to name wines and their memory for them. Likewise, directly inhibiting online use of verbalization did not affect memory for wine odors in experts. In sum, once expertise has been acquired, language does not play a causal role in recognition memory for odors. (PsycInfo Database Record (c) 2021 APA, all rights reserved).People vary in their self-awareness of their own emotions, and this may predict psychological well-being. Evidence suggests that emotional self-awareness is diminished in autism, but these findings may be biased by self-report or confounded by verbal intelligence. To address this issue, we developed the emotional consistency (EC) task, measuring emotional self-awareness through consistency in emotional decision-making. In the EC-Task, we showed participants pairs of emotional images, asking them to judge which evoked the more intense emotional experience. The logical consistency of decision making, based on transitive relationships between stimuli, reflects precision of judgment of experience of emotional intensity, which in turn reflects emotional self-awareness. Emotional consistency significantly correlated with lower self-reported alexithymia but not autistic traits. Instead, autistic traits predicted greater discrepancy between EC-Task performance and self-reported difficulties identifying feelings. Participants with higher autistic traits were more likely to underestimate their emotional self-awareness, possibly because of greater metacognitive difficulties and negative self-beliefs. Our study suggests emotional self-awareness is not diminished in autism and provides a novel method to investigate this issue. (PsycInfo Database Record (c) 2020 APA, all rights reserved).We used insights from machine learning to address an important but contentious question Is bilingual language experience associated with executive control abilities? Specifically, we assess proactive executive control for over 400 young adult bilinguals via reaction time (RT) on an AX continuous performance task (AX-CPT). We measured bilingual experience as a continuous, multidimensional spectrum (i.e., age of acquisition, language entropy, and sheer second language exposure). Linear mixed effects regression analyses indicated significant associations between bilingual language experience and proactive control, consistent with previous work. Information criteria (e.g., AIC) and cross-validation further suggested that these models are robust in predicting data from novel, unmodeled participants. These results were bolstered by cross-validated LASSO regression, a form of penalized regression. However, the results of both cross-validation procedures also indicated that similar predictive performance could be achieved through simpler models that only included information about the AX-CPT (i.e., trial type). Collectively, these results suggest that the effects of bilingual experience on proactive control, to the extent that they exist in younger adults, are likely small. Thus, future studies will require even larger or qualitatively different samples (e.g., older adults or children) in combination with valid, granular quantifications of language experience to reveal predictive effects on novel participants. (PsycInfo Database Record (c) 2021 APA, all rights reserved).There is significant variation in lay people's beliefs about the nature of intelligence Some believe that intelligence is relatively fixed and innate, whereas others view intelligence as more malleable and affected by experience. However, most studies in this domain do not explicitly define intelligence when probing about beliefs about intelligence and aptitude. Thus, variation in beliefs may reflect variation in how intelligence is defined. To address this issue, we conducted 3 studies examining individuals' beliefs about fluid versus crystallized intelligence. Study 1 used a modified version of Dweck's (1999) mindset questionnaire and found that people have more fixed views about fluid intelligence than either crystallized intelligence or intelligence in general. Study 2 used a switched-at-birth paradigm and found that individuals hold more essentialist beliefs about fluid intelligence than crystallized intelligence. Study 3 added a survey that probed participants' beliefs about mathematics achievement. It found that when reasoning about mathematics achievements, participants' attributions of ability and effort were differentially associated with their crystallized and fluid mindset beliefs. Specifically, mindsets of fluid intelligence were more associated with effort for professional-level mathematics achievements, whereas mindsets of crystallized intelligence were more associated with elementary-level mathematics achievements. Together, the present studies highlight the importance of considering the definition of intelligence when assessing related beliefs about malleability, inheritance, and achievement. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Culture has an extraordinary influence on human behavior, unparalleled in other species. Some theories propose that humans possess learning mechanisms biologically selected specifically for social learning, which function to promote rapid enculturation. If true, it follows that information acquired via observation of another's activity might be responded to differently, compared with equivalent information acquired through one's own exploration, and that this should be the case in even very young children. To investigate this, we compared children's responses to information acquired either socially or from personal experience. The task we used allowed direct comparison between these alternative information sources, as the information value was equivalent across conditions, which has not been true of previous methods used to tackle similar questions. Across two 18-month- to 5-year-old samples (recruited in the United Kingdom and China), we found that children performed similarly following information acquired from social demonstrations, compared with personal experience. Children's use of the information thus appeared independent of source. Furthermore, children's suboptimal performance showed evidence of a consistent bias driven by motivation for exploration as well as exploitation, which was apparent across both conditions and in both samples. Our results are consistent with the view that apparent peculiarities identified in human social information use could be developmental outcomes of general-purpose learning and motivational biases, as opposed to mechanisms that have been biologically selected specifically for the acquisition of cultural information. (PsycInfo Database Record (c) 2020 APA, all rights reserved).The present research explores decision making in multitasking, investigating how people make optimal decisions between tasks. Empirical evidence suggests that difficulties in task performance (i.e., response conflict within a task) can bias decision making. Here we investigate whether also conflict between task representations can tune choices away from conflict-associated tasks. Using a combined forced/free-choice task-switching design, we tested whether task conflict that arises because of proactive interference of previously activated tasks biases task choice. We compared free-choice decisions between 3 tasks after forced-choice sequences that instigated either high task conflict (task sequences of type ABA, in which persisting inhibition needs to be overcome because one switches back to a just-abandoned task) or low task conflict (task sequences of type CBA). Results of 2 experiments (N = 16; N = 32, preregistered) showed that participants were more likely to switch away from the previously performed task after high than after low task conflict. Furthermore, participants preferably selected the task that suffered least from task conflict and/or proactive interference. In addition, a third experiment (N = 32) confirmed that this bias in task selection could not be explained in terms of randomness heuristics. These results suggest a close link between decision making and performance in multitasking. (PsycInfo Database Record (c) 2020 APA, all rights reserved).In a world where ideas flow freely across multiple platforms, people must often rely on others' advice and opinions without an objective standard to judge whether this information is accurate. The present study explores the hypothesis that an individual's internal decision confidence can be used as a signal to learn the accuracy of others' advice, even in the absence of feedback. According to this "agreement-in-confidence" hypothesis, people can learn about an advisor's accuracy across multiple interactions according to whether the advice offered agrees with their own initial opinions, weighted by the confidence with which these initial opinions are held. We test this hypothesis using a judge-advisor system paradigm to precisely manipulate the profiles of virtual advisors in a perceptual decision-making task. We find that when advisors' and participants' judgments are independent, people can correctly learn advisors' features, like their accuracy and calibration, whether or not objective feedback is available. However, when their judgments (and thus errors) are correlated-as is the case in many real social contexts-predictable distortions in trust can be observed between feedback and feedback-free scenarios. Using agent-based simulations, we explore implications of these individual-level heuristics for network-level patterns of trust and belief formation. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Response errors often cause individuals to slow down their subsequent reactions (posterror slowing [PES]). Despite intensive investigations on PES, the adaptive nature of PES remains unresolved. Here, we systematically examined this issue by manipulating response-stimulus intervals (RSIs) and examining their influence on behaviors and neural dynamics of PES. Behavioral and electrophysiological (EEG) measures were recorded while male and female human participants performed a four-choice flanker task as RSIs were manipulated. Behaviorally, PES showed maladaptive features at short RSIs but some adaptive features at long RSIs. EEG results indicated that RSIs did not affect basic error-related processing, indexed by the same pattern in the contrasts between flanker errors and correct responses on the error-related negativity (ERN), error positivity (Pe), or theta band, no matter at short or long RSIs. However, RSIs significantly influenced postflanker error attentional adjustment, motor inhibition, and sensory sensitivity.