Wilderlundqvist9947

Cd was found to promote PINK1/Parkin expression, which was proportional to the Cd dose. In conclusion, Cd activates PINK1/Parkin-mediated mitophagy in a dose-dependent manner. Mitophagy blockade likely aggravates Cd toxicity, leading to the dual role of inducing liver injury and inhibiting the progression of early liver cancer.Constituting the host-parasite interface and playing a censorious role in host immune response modulation and parasite survival, tegument represents a crucial target for many antischistosomal drugs. Sphingomyelin forms a stable outer leaflet of tegumental membrane-lipid bilayer. Neutral magnesium‏-dependent sphingomyelinase (Mg2+-nSMase) is a key enzyme in sphingomyelin breakdown was identified in schistosomes. We investigated the in vivo efficacy of ubiquinol, a natural inhibitor of Mg2+-nSMase, in free and niosomes-encapsulated forms, through five-day and 15-day regimens on the early and late Schistosoma mansoni parasitic stages, respectively, compared to PZQ. Oral administration of 300 mg/kg/day ubiquinol-encapsulated niosomes (U-N) showed significant deterioration of the parasitic growth and development in the term of reduction of lung schistosomula burden (39.12%), adult worm burden (50.81%), hepatic and intestinal tissue-egg counts (80.89% and 75.54%, respectively). PZQ and free ubiquinol regimens reported reductions in lung schistosomula counts (45.36% and 22.90%, respectively) and total worm burdens of 86.28% and 24.58%, respectively. U-N therapy revealed worms de-pairing and remarkable diminution in female worms' perimeters and fecundity. Scanning electron microscope revealed disruption of tegumental ridges with excessive longitudinal corrugation. Transmission electron microscope showed testicular and ovarian parenchymal degeneration, signs of immaturity and cell apoptosis. Indirect immunofluorescence assay approved parasite's tegumental changes. Remarkable reduction of granulomas size with amelioration of hepatic pathology and fibrosis were assumed to be attributed to the anti-inflammatory and anti-oxidant properties of ubiquinol. These findings with the drug safety profile suggest that U-N could be a promising candidate for a new antischistosomal drug development.In this study, three cadmium (Cd)-resistant fungal strains, temporarily named as F1, F2 and F3 were isolated from the roots of Cd-tolerant soybean cultivars, rhizosphere and bulk soils, respectively, in contaminated sites. Cd-resistant strains F1, F2 and F3 were characterized for their effect on biomass, Cd uptake and translocation of two soybean cultivars (Liaodou36 and Liaodou33) grown in Cd-contaminated soils. The results showed that Cd concentration decreased significantly in Cd-supplemented culture solutions inoculated with strains F1, F2 and F3 compared to non-inoculated controls, while cell counts significantly increased during the incubation. The increase in shoot biomass of two soybean cultivars inoculated with strains F1, F2 and F3 ranged from 13% to 29%, 16%-27% and 15%-32%, respectively, compared to controls. Strain F2 had a higher potential to reduce the water-soluble Cd content (23% and 40%) and EDTA-extractable Cd content in the rhizosphere soil of Liaodou36 and Liaodou33 seedlings compared to strains F1 and F3. A significant decrease of Cd contents was observed in the root and shoot of Liaodou33 inoculated with strain F2 compared to non-inoculated controls, and inoculation with strain F2 significantly reduced the TF and BCF of Liaodou33 in comparison with controls. Based on ITS rRNA gene sequence analyses, the strains F1, F2 and F3 were identified as Mucor circinelloides (similarity 99.81%), Curvularia lunata (similarity 99.31%) and Clonostachys rosea (similarity 99.17%). The results of our study demonstrated that the strain F2 had a higher Cd biosorption and immobilization potential than strains F1 and F3. The strain F2 promoted the growth and reduced Cd uptake and translocation of Liaodou33 in Cd-polluted soils. It is worth noting that our results might provide an effective technical support for Cd immobilization remediation and safe soybean production by inoculating moderate Cd-accumulating soybean cultivars with strain F2 in Cd-contaminated soils.This research paper employed an innovative electrochemical electrode to simultaneously determine topotecan (TPT) and mitomycin (MMC) as anticancer agents. For this purpose, a novel nanocomposite was synthesized using a hydrothermal procedure. The nanocomposites were characterized using FTIR, STEM, FESEM, mapping analysis, EDX, and XRD methods. The novelty of this work is the successful synthesis of Fe3O4 decorated on the surface of CuCo2S4 (Fe3O4@CuCo2S4) nanocomposites showed two separate anodic peaks at 0.8 V for TPT and 1.0 V for MMC with potential separation of 0.2 V. This was enough for the simultaneous electrochemical determination of topotecan and mitomycin on a glassy carbon electrode (GCE), simultaneously. At optimized conditions, the developed electrode exhibited linear responses with TPT and MMC concentration in the ranges of 0.01-0.89 and 0.89-8.95 μM for topotecan and 0.1-19.53 μM for mitomycin. The detection limits were observed as 6.94 nM and 80.00 nM for topotecan and mitomycin, respectively. The fabricated Fe3O4@CuCo2S4/GCE showed high sensitivity, long-term stability, and repeatability towards the sensing of TPT and MMC simultaneously and can be utilized in real samples. The obtained results confirmed that the fabricated Fe3O4@CuCo2S4/GCE nanocomposites can be utilize in the simultaneous electrochemical determination of topotecan and mitomycin in real samples.The textile industry is one of the most valuable industries, especially in developing countries, because it employs a large portion of the workforce. However, the development of the textile industry has led to increasing concern about environmental issues. Wastewater from the textile industry has a high COD and an undesirable color. Color is one of the problems with the wastewater due to its toxicity and low biodegradability. Color in textile wastewater mainly originates from the dyestuff used during the dyeing or printing process. Amongst all of available technology for color removal, advanced oxidation processes (AOPs) are considered one of the best and the most potential technology. However, the understanding of AOPs reaction mechanism to degrade dyestuff is still limited. In general, dyes degradation mechanism will vary and mainly depend on the chemical structure of the dyes itself. Some reaction pathway that seems less favorable thermodynamically can still happen during the process. Understanding the mechanism will be beneficial for future dyes improvement, especially on developing the moiety of the aromatic compound in order to produce easily degraded dyes while maintaining the fastness quality.Although previous meta-analyses have shown that prenatal PFASs exposure is associated with reduction in birth weight, effects of prenatal PFASs exposure on birth outcomes have not been fully explored. We conducted a meta-analysis of 23 eligible studies searched from Embase, PubMed, and Web of Science before March 21, 2021 to analyze the association between prenatal PFASs exposure and birth outcomes, including premature birth (PTB), low birth weight (LBW), small for gestational age (SGA) and miscarriage. Odds ratio (OR) and corresponding confidence intervals were extracted for analysis. According to the heterogeneity of the included studies, fixed-effects (I2 ≤ 50%) and random-effects (I2 > 50%) models were applied respectively. The significant associations between PFOS and PTB (pooled OR = 1.54, 95% CI 1.20-1.98), PFOA and miscarriage (pooled OR = 1.40, 95% CI 1.15-1.70), and PFOS and LBW (pooled OR = 1.52, 95% CI 1.19-1.94) were obtained. There were differences between included studies with different study regions, sampling time, and samples type used for PFASs assessment. These findings may provide insight in risk assessment and decision-making in producing products that contain PFASs.Hazardous oil sludge (OS) poses a great challenge to the environment, whereas conventional treatment methods (i.e., incineration or pyrolysis-incineration) are relatively less value-added and will bring about air pollution problems. To realize the high-value utilization of OS, catalytic co-pyrolysis with waste biomass to produce platform chemicals was studied using TG-FTIR and Py (pyrolyzer)-GC/MS methods. Results showed that for the non-catalytic co-pyrolysis of RH (rice husk) and OS, the main synergy on weight loss was the greatly lowered initial pyrolysis temperature of RH (for ∼55 °C) at the lower temperatures and the reduced weight loss ratio of OS (∼10-18 wt%) within the higher temperature range. ZSM-5 catalyst promoted the degradation of OS and RH mixtures at less then 150 °C, yet showed minor effects on their weight loss at higher temperatures. The oxygenated and aliphatic compounds from non-catalytic co-pyrolysis were efficiently converted, resulting in an increased relative yield of aromatics to the highest of 46% and an elevated selectivity to BTX (as high as 60%). Despite the relatively short carbon chain length of OS components, ZSM-5 was proved effective to activate the OS pyrolysis products, thus enhancing the further aromatization reactions with biomass pyrolysis intermediates. This study provides a novel method for value-added co-utilization of hazardous OS waste and abundant biomass waste, and thus is beneficial to producing renewable chemicals while reducing the environment pollutant.Cellulose-based aerogels have considerable potential for various application due to renewable, low cost, and high availability. However, mechanical robustness and functionalization remain major challenges. Here, we synthesized a compressible, recoverable cellulose nanofiber (CNF)/carboxymethyl cellulose (CMC)/branched polyethyleneimine (BPEI) aerogel via electrostatic-modulated interfacial covalent crosslinking and freeze-drying process. The porous BPEI@CNF/CMC aerogel possessed excellent mechanical compression and high-density metal-chelating groups, which exhibited fast adsorption kinetics and high adsorption capacity (452.49 mg g-1) in static copper adsorption process. Furthermore, BPEI@CNF/CMC aerogels displayed excellent recyclability and could still reach 85% after 10 cycles. N-Ethylmaleimide Cysteine Protease inhibitor The integrated analyses of ATR-FTIR and XPS suggested that the predominant adsorption mechanism included electrostatic interaction, ion-exchange and chelation. This strategy provides a sustainable route to fabricate efficient biomass-based adsorbents for selective copper removal from water.The Society for Maternal-Fetal Medicine seeks to ensure excellence in obstetrical outcomes for all people who desire or experience pregnancy, including people with diverse sexual and gender identities. The Society commits to the use of practices in clinical and research settings that affirm the sexual and gender identities of all people, encourages the development of undergraduate and graduate medical education curricula and training programs that address diverse pathways to pregnancy and support clinicians with diverse sexual and gender identities, and promotes the use of inclusive language that is accurate and, when possible, specific.