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5 × 10-4 M-1 and 0.80 μM, respectively. The sensing mechanism is that the excitation energy absorption of Fe3+ ions reduces the energy transfer efficiency from the ligand to Tb3+ ions.Molecularly imprinted polymers - MIPs - denote synthetic polymeric structures that selectively recognize the molecule of interest against which MIPs are templated. A number of works have demonstrated that MIPs can exceed the affinity and selectivity of natural antibodies, yet operating by the same principle of "lock and key". In contrast to antibodies, which have certain limitations related to the minimal size of the antigen, nanoMIPs can be fabricated against almost any target molecule irrespective of its size and low immunogenicity. Furthermore, the cost of MIP production is much lower compared to the cost of antibody production. Excitingly, MIPs can be used as nanocontainers for specific delivery of therapeutics both in vitro and in vivo. The adoption of the solid phase synthesis rendered MIPs precise reproducible characteristics and, as a consequence, improved the controlled release of therapeutic payloads. These major breakthroughs paved the way for applicability of MIPs in medicine as a novel class of therapeutics. In this review, we highlight recent advances in the fabrication of MIPs, mechanisms of controlled release from the MIPs, and their applicability in biomedical research.Platycodon grandiflorus (Jacq.) A. DC. is widely cultivated across the south and north of China. Its root, Platycodonis radix, is commonly used as a vegetable, functional food, and traditional herbal medicine with various biological benefits. It is critical to fully clarify the chemical composition of Platycodonis radix for the sake of the food industry and traditional herb markets. In this study, a strategy of metabolome and lipidome profiling based on ultra-high performance liquid chromatography coupled to ion mobility-quadrupole time of flight mass spectrometry (UPLC-IM-QTOF-MS) was developed to reveal the overall chemical composition of Platycodonis radix. IN particular, comprehensive lipidome profiling was first performed for Platycodonis radix, in which 170 lipid molecular species including 55.9% glycerophospholipids, 31.2% glycerolipids, and 12.9% sphingolipids were identified. Platycodonis radix from two major production regions in China, Inner Mongolia and Anhui province, were collected and analyzed by the MS based approach combined with multivariate statistical analysis from both the metabolome and lipidome aspects. This study threw focus on the profiling investigations of Platycodonis radix from different growing regions and provided new potential in the lipidome analysis of medicinal food.In this work, we have successfully prepared core-shell nanoparticles (Fe3O4@PDA) wrapped with Ag using a simple and green synthesis method. Without an external reducing agent, silver nanoparticles (Ag NPs) with good dispersibility were directly reduced and deposited on a polydopamine (PDA) layer. Fe3O4@PDA@Ag showed excellent catalytic activity and recyclability for 4-nitrophenol, and also exhibited good catalytic selectivity for organic dyes (MO and MB). This simple and green synthesis method will provide a platform for other catalytic applications.The advances of biomedicine and biotechnology demand new approaches to enrich biological nanoparticles, such as viruses, viral vectors and nanovesicles, in an easy-to-operate fashion. Conventional methods, such as ultracentrifugation and ultrafiltration, require bulky instruments and extensive manual operation. Inspired by recent research of thermophoresis of biomolecules and bio-nanoparticles in aqueous solutions, we present a microfluidic design that directly focuses nanoparticles in a label-free and flow-through process by coupling an engineered swirling flow and a moderate, one-dimensional temperature gradient. Enrichment of polystyrene particles, HIV and bacteriophage samples was quantitatively determined, indicating the compatibility of the microfluidic approach with synthetic and biological samples. The focusing results are well predicted using a numerical model. As thermophoresis is ubiquitous, the microfluidic approach can be applied broadly to bio-nanoparticle enrichment without the necessity of labeling, buffer exchange, or sheath fluids, permitting continuous retrieval of concentrated species in a simple, controlled flow with little infrastructure needs.The conversion of Al-substituted goethite (Al-goethite) to hematite in gibbsitic bauxite is conducive to alumina extraction during the Bayer process and the enrichment of iron minerals in red mud. In this work, mineralogical characteristics of gibbsitic bauxite were identified by AMICS analysis, and the low-temperature thermal conversion behavior of both synthetic Al-goethite and natural Al-goethite in gibbsitic bauxite were investigated through thermal gravity analysis, phase transformation, and microstructure studies. Results show that the proportion of aluminum in Al-goethite reached 12.68% of the total aluminum content in gibbsitic bauxite. The conversion of synthetic Al-goethite to hematite starts at ∼280 °C, while that of natural Al-goethite starts at ∼320 °C, and the addition of NaOH can accelerate the conversion. The formed hematite inherits the needle-like appearance of the original Al-goethite, has many holes on the surface due to dehydroxylation, and no migration of aluminum elements occurs during d.Nanoparticles are like magic bullets and nanomaterials exhibit appealing properties. Their size and morphology can be switched by dopants for certain biological activities. Nanoparticles in combination with certain drugs enhance the antibiotic effects and may be valuable in combating bacterial resistance. The antimicrobial potency of nanoparticles depends upon their ability to bind to the surface of microbial cell membranes resulting in modulation of basic cell functions such as respiration. We report herein the antibacterial, antifungal and antioxidant activities of pure TiO2 and TiO2 doped with 4% Cu, Ni and Cr. The performance of pure and doped nanoparticles has been compared with reference compounds. A comparison of the antifungal activities of the samples doped with TiO2 reveals that Cu-TiO2 exhibits improved performance against A. fumigatus but lower antifungal activity against Mucor sp. and F. solani. Cu-TiO2 and Ni-TiO2 showed good antibacterial action against B. bronchiseptica, while Cr-TiO2 nanoparticles displayed better activity against S. typhimurium as compared to pure TiO2. Moreover, pristine TiO2 and Ni-TiO2 nanoparticles were found to demonstrate maximum total antioxidant capacity.Caries is the most common chronic infectious disease in the human oral cavity and the existing anti-caries agents may lead to drug resistance and microecological imbalance. A novel urea derivative, 1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea, has a potentially prominent antibacterial effect on cariogenic bacterial strain Streptococcus mutans UA159. In this study, we encapsulated the water-insoluble urea derivative in poly(lactic-co-glycolic acid) (PLGA) nanoparticles, performed physicochemical characterizations and explored its potential as a caries-preventive agent. The results showed that the drug-loaded PLGA nanoparticles exhibited satisfying surface morphology, particle size, size distribution and stability. With an optimized theoretical drug loading (10%), the drug-loaded PLGA nanoparticles exhibited negligible cytotoxicity against human oral squamous cell carcinoma cells. We noticed a biphasic drug release in vitro and the rate and cumulative release was higher in an acidic environment (pH 4.5) compared to a neutral environment (pH 7.4). The drug-loaded PLGA nanoparticles significantly inhibited the growth and lactic acid production of planktonic S. mutans as well as S. mutans biofilms. Our results indicate that the novel urea derivative-loaded PLGA nanoparticles serve as a promising anti-caries agent with remarkable pharmaceutical characteristics, low cytotoxicity, and satisfying antimicrobial effect.Ethanol content is an important indicator reflecting the yield of simultaneous saccharification and fermentation (SSF) of cassava. This study proposes an innovative method based on a colorimetric sensor technique to determine the ethanol content during the SSF of cassava. First, 14 kinds of porphyrin material and one kind of pH indicator were used to form a colorimetric sensor array for collecting odor data during the SSF of cassava. Then, the ant colony algorithm (ACO) and the simulated annealing algorithm (SA) were used to optimize and reconstruct the input color feature components of the support vector regression (SVR) model. The differential evolution algorithm (DE) was used to optimize the penalty factor (c) and the kernel function (g) of the SVR model. The results obtained showed that the combined prediction model of SA-DE-SVR had the highest accuracy, and the coefficient of determination (R P 2) in the prediction set was 0.9549, and the root mean square error of prediction (RMSEP) was 0.1562. Dynasore supplier The overall results reveal that the use of a colorimetric sensor technique combined with different intelligent optimization algorithms to establish a model can quantitatively determine the ethanol content in the SSF of cassava, and has broad development prospects.Heat-conductive silicone grease (HCSG), one of the most common composite thermal interface materials (TIMs) used in many advanced applications, is limited by its low thermal conductivity (TC). Different surface modification agents are required to improve the dispersion of TC additives and the interfacial compatibility with the silicone matrix. In this study, MQ silicone resin (MQ) was used to modify two kinds of self-made spherical boron nitrides (SBNs), with different particle sizes, using the sedimentation method. The amount of filler content allowed within the SBNs increased owing to the similar polarity of the MQ and the silicone matrix, and a HCSG with a TC of 1.22 W (m-1 K-1) and a thermal resistance (TR) of 0.49 °C W-1 was obtained, respectively. In addition, the TC pathway was formed more easily with the 15 μm SBNs than with the 5 μm SBNs. In order to verify its potential application in battery thermal management, the HCSG was assembled on the surface of the liquid-cooling plate in the 18 650-battery module, and it was found that the maximum temperature of the battery module could be maintained below 42 °C, and the temperature difference could be controlled within 5 °C. Thus, with these excellent performances, the MQ silicone resin reported here, with respect to the assembly methods, will provide insights into the thermal management and energy storage fields.Solid polymer electrolytes (SPE) are considered a key material in all-solid Li-ion batteries (SLIBs). However, the poor ion conductivity at room temperature limits its practical applications. In this work, a new composite polymer solid electrolyte based on polyurethane (PU)/LiTFSI-Al2O3-LiOH materials is proposed. By adding a few inert fillers (Al2O3) and active agents (LiOH) into the PU/LiTFSI system, the ion conductivity of the SPE reaches 2 × 10-3 S cm-1 at room temperature. Exploiting LiFePO4 (LFP)‖Li as electrodes, the PU-based composite lithium battery is prepared. The experimental result shows that the LFP|SPE|Li displays high specific discharge capacity. The first specific discharge capacities at 0.2C, 0.5C, 1C and 3C are 159.6, 126, 110 and 90.1 mA h g-1 respectively, and the Coulomb efficiency is found to be stable in the region of 92-99% which also shows a desirable cyclic stability after 150 cycles.