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PURPOSE To evaluate and compare plasma osteopontin (OPN, a candidate prostate cancer biomarker) levels in prostate cancer patients receiving radiotherapy or combined radiotherapy or hormone therapy. METHODS OPN levels were determined by ELISA in 40 prostate cancer patients eligible for radiotherapy (n=18 radiotherapy alone, n=22 combined radiotherapy and hormone therapy) before the start of irradiation, during treatment, and one month after its completion. RESULTS OPN levels were significantly higher (p=0.02) in prostate cancer patients after receiving radiotherapy compared to baseline. In a subgroup analysis, there were no differences in OPN levels before and after treatment in patients undergoing radiotherapy alone, but OPN levels were significantly higher in patients after radiotherapy with hormone therapy compared to baseline (p=0.04) and in patients during radiotherapy compared to baseline (p=0.03). CONCLUSIONS Radiotherapy can increase plasma OPN concentrations in patients with prostate cancer, and radiotherapy may interact with hormone therapy to increase OPN concentrations. These differences suggest that OPN is worthy of further study as a predictive biomarker.PURPOSE Studies on patients undergoing esophagectomy for esophageal cancer have shown that thoracic and abdominal surgery may be performed safely in patients without an uppermost age cut-off. The aim of this study was to evaluate the morbidity and mortality of radical minimally invasive esophagectomy for cancer in patients over 80 years old. METHODS A retrospective analysis of prospectively collected data over a period of 4 years was conducted. During the study period 184 esophagectomies were performed. A total of 12 octogenarians that underwent Minimally Invasive Esophagectomy (MIE) for cancer were included in the study. Our results were compared to the UK national outcomes as presented in the National Esophago-Gastric Cancer Audit (NOGCA) 2017 report. RESULTS Median overall survival (OS) was 16.5 months (range 6-38) and progression-free survival (PFS) 14.5 months (tange3-38). 30-and 90-day postoperative mortality was zero. Postoperative complications included chest infection (CI) in 4 (33.3%) patients, anastomotic leakage (AL) in 3 (25%) and atrial fibrillation in 2 (16.7%). CONCLUSIONS MIE should therefore be considered as an effective treatment strategy even in elderly patients over 80 years of age.PURPOSE This study aimed to compare the efficacy of laparoscopic and conventional left hemicolectomy for treating colon cancer and their effects on stress response and quality of life of patients. METHODS 92 patients with colon cancer were selected. Forty three patients in the study group were treated with laparoscopic left hemicolectomy, and 49 patients in the control group were treated with conventional left hemicolectomy. The surgery, postoperative recovery, intraoperative and postoperative complications were compared between the two groups. The enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL1β and IL-6. The quality of life of patients after surgery was analyzed by the Functional Assessment of Cancer Therapy-Lung (FACT-L). RESULTS The operation time and intraoperative blood loss of the study group were statistically lower than those of the control group (p less then 0.05). The postoperative exhaust time and hospitalization time of the study group were statistically shorter than those of the control group (p less then 0.05). Serum IL-1β and IL-6 levels in the study group were significantly lower than those in the control group (p less then 0.05). In the two groups, the overall scores of quality of life after surgery were significantly lower than those before surgery (p less then 0.05). After surgery, the overall score of quality of life in the study group was significantly higher than that in the control group (p less then 0.05). CONCLUSION The laparoscopic left hemicolectomy with surgical approaches on the surgical plane has high safety and marked efficacy.PURPOSE Diosgenin - a steroidal saponin- has been shown to exhibit wonderful anticancer potential. https://www.selleckchem.com/GSK-3.html However, the antiproliferative effects of diosgenin have not been examined against the optic nerve sheath meningioma cells. In the current research work, the anticancer potential of diosgenin was evaluated in optic nerve sheath meningioma cells along with evaluating its effects on cancer cell invasion, migration, apoptotic cell death, autophagy and cell cycle progression. METHODS The WTS-1 assay was used to determine the viability of HBL-52 cells. https://www.selleckchem.com/GSK-3.html Autophagy was detected by transmission electron microscopy and western blot. The cell migration and invasion of HBL-52 cells was determined by wound healing and transwell assays. Apoptotic and effects on cell cycle were studied by fluorescence microscopy, western blot and flow cytometry. RESULTS The results showed that diosgenin decreased the viability of the HBL-52 considerably and exhibited an IC50 of 15 µM. The antiproliferative effects were found to be due to the activation of the autophagy in the HBL-52 cells. The autophagy was also accompanied by upregulation of LC3 II and Beclin 1 expression. Diosgenin also triggered cell cycle arrest of the HBL-52 at the sub-G1 phase of the cell cycle. The cell migration and invasion of the HBL-52 cells was also suppressed by diosgenin. Diosgenin also triggered mitochondrial-dependent apoptotic cell death. CONCLUSIONS The results of the current study clearly indicate that diosgenin has anticancer potential in optic nerve sheath meningioma cells under in vitro conditions and can be a potential drug candidate provided further studies are carried out in this direction. Key words diosgenin, optic nerve sheath meningioma, apoptosis, autophagy, cell cycle.PURPOSE Esophageal gastrointestinal stromal tumors (GISTs) compose a very rare clinical entity, representing 0.7% of all GISTs. Therefore, the clinicopathological factors that affect mortality are currently not adequately examined. We reviewed individual cases of esophageal GISTs found in the literature in order to identify the prognostic factors affecting mortality. METHODS MEDLINE, EMBASE, and the Cochrane Library were systematically searched to identify clinical studies and case reports referring to esophageal GISTs. The clinicopathological features were recorded and evaluated. RESULTS A total number of 105 patients were found. The median age of patients was 58 years (mean 52.4%). The majority of patients (71.6%) presented with tumor-associated symptoms. Tumors were mostly located at the lower esophagus (72.9%), and the median tumor size was 7 cm. Esophagectomy was the most common surgical approach (54.3%), followed by tumor enucleation (45.7%). The median follow-up period was 34 months; tumor recurrence occurred in 18 cases (18.