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Despite the expectation that nurses utilize research to provide excellent patient care, students often fail to recognize the value of learning about evidence-informed practice. Experiential, creative pedagogical approaches are needed to engage undergraduate nursing students in evidence-informed practice. In two undergraduate courses, we implemented an innovative assignment in which students created an arts-based multimedia knowledge translation presentation to communicate systematic review findings to patients.

To evaluate how the assignment affected nursing students' satisfaction, learning, and anticipated behaviour changes regarding evidence-informed practice and to assess what factors influenced their evaluation of the assignment.

Kirkpatrick's Evaluation Model and Groff's Theory of Whole-Mindedness informed our study, incorporating an observational cross-sectional survey design. We recruited a convenience sample of nursing students (N = 242) from two baccalaureate programs. We collected data with anerience of the assignment. These results provide valuable insights to inform effective implementation of arts-based assignments in nursing education.

Creative approaches that contextualize research findings hold potential to deepen students' understanding of evidence-informed practice. This study identified key factors that influenced students' evaluation and experience of the assignment. These results provide valuable insights to inform effective implementation of arts-based assignments in nursing education.The use of explosive devices in war and terrorism has increased exposure to concussive blasts among both military personnel and civilians, which can cause permanent hearing and balance deficits that adversely affect survivors' quality of life. Significant knowledge gaps on the underlying etiology of blast-induced hearing loss and balance disorders remain, especially with regard to the effect of blast exposure on the vestibular system, the impact of multiple blast exposures, and long-term recovery. To address this, we investigated the effects of blast exposure on the inner ear using a mouse model in conjunction with a high-fidelity blast simulator. Anesthetized animals were subjected to single or triple blast exposures, and physiological measurements and tissue were collected over the course of recovery for up to 180 days. Auditory brainstem responses (ABRs) indicated significantly elevated thresholds across multiple frequencies. Limited recovery was observed at low frequencies in single-blasted mice. Distortir ear and cause basal OHC loss despite middle ear dysfunction caused by TM rupture, (3) blast exposure may result in synaptopathy in humans, and (4) balance deficits after blast exposure may be primarily due to traumatic brain injury, rather than damage to the peripheral vestibular system.Anthocyanins, which are natural pigments and nutraceuticals, can be extracted from plant materials using enzyme-assisted methods. However, the enzymes used are often expensive, fragile, and hard to recover/reuse. In this study, cellulase and α-amylase were immobilized on amino-functionalized magnetic nanoparticles to prepare a magnetic nanobiocatalyst. The enzymes in this nanobiocatalyst exhibited higher stability and greater catalytic activity than free enzymes, including good thermal stability (50 to 70℃) and pH stability (pH 4.5-7.5). Nanobiocatalyst efficacy was demonstrated by extracting anthocyanins from black rice, with a maximum yield of 266 mg anthocyanin/100 g black rice obtained. After six reuse cycles, cellulase and α-amylase retained around 70% and 64% of their activity, respectively. Immobilization also increased their reusability. In summary, a novel magnetic nanobiocatalyst was developed for extracting anthocyanins from black rice, which may also have other applications within the food industry.Lysimachia ramosa has been used as a traditional medicine among the tribal population of Meghalaya, northeast India, for the control of helminthosis. The anthelmintic efficacy of L. ramosa has been documented earlier. In the present study, the active compound from L. ramosa has been isolated and identified using mass and NMR spectra. It's in vitro anthelmintic activity was evaluated against Raillietina echinobothrida, one of the most pathogenic cestode of domestic fowl. The isolated active compound was characterized to be a kaempferol derivative which showed potent anthelmintic activity against R. echinobothrida by changing surface ultrastructure and also inhibiting the activity of two neurotransmitter enzymes acetyl cholinesterase (AChE) and nitric oxide synthase (NOS), both of which are known to perform dynamic roles in the intracellular communication mediated through neuromuscular system. Motility reduction, deformation in the surface architecture, extensive ultrastructural alterations and reduced histochemical stain intensity in both AChE and NOS was observed in the treated parasites. Biochemical result also revealed alteration in the enzyme activities in the treated parasites. Further, depletion in the nitric oxide (NO) production in the bioactive component exposed tissues of R. echinobothrida was also detected. The results provided evidence that the bioactive compound could be further explored to control helminthosis at a large scale.Trypanosoma evansi infects a wide range of hosts to cause huge economic losses in livestock industry. In recent years, it has been demonstrated that neutrophils extracellular traps (NETs) play a critical role in combating parasite infections. However, the role of NETs in the resistance to T. evansi infection is still unclear. In this study, T. evansi induced NETs were observed and their components were determined. The effect of NETs on the viability and motility of T. evansi were estimated. The production of reactive oxygen species (ROS) and Lactate dehydrogenase (LDH) activity in the process of T. evansi-induced NETs formation were detected. The effect of ERK1/2 signaling pathway, neutrophil elastase (NE), myeloperoxidase (MPO), store-operated Ca(2+) entry (SOCE) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase on T. evansi triggered NETs formation were determined. The results showed that neutrophils could release ETs after being stimulated with T. evansi and the structures of NETs mainly consisted of DNA decorated with histone 3 (H3), NE, and MPO. NETs could reduce the parasite motility without affecting the parasite viability. T. evansi-induced NETs formation was dose and time-dependent and was accompanied by ROS production. Inhibitor assays suggested that the formation of NETs induced by T. evansi was dependent on MPO, NE and ERK1/2 signaling pathway but independent on NADPH oxidase and SOCE. In addition, there was no significant changes in LDH activity during NETs formation. This study is the first report of T. evansi-induced NETs formation.The present study uses agent-based modeling (ABM) to examine the effectiveness of a nudge policy for improving recycling behavior. In our simulation, agents' recycling behavior is computed by components of the Theory of Planned Behaviour (i.e., attitudes, perceived behavioral control, social norms) and influenced by other agents as well as their surrounding (i.e., amount of waste in the area). The simulation, based on real data from a Taiwan community district, confirms realistic recycling trends and demonstrates the usefulness and reliability of ABM as a method to examine the effectiveness of waste management policies. An additional step in our simulation was to manipulate the amount of waste in the community to test the effect of a nudge policy based on social norms. Results showed that the policy increases recycling activity, but predominantly in low waste scenarios. This suggests that nudges, in the form of norm-based policies, can be an effective solution to enhancing people's recycling behavior under specific circumstances.The plant residues of tomato bring pressures to the environment and composting provides a feasible method to treat such agricultural waste. However, little is known about the succession and associations of the dominant lignocellulose degraders in the compost system. Elenbecestat To further accelerate the process by inoculating key functional microorganisms, a compost pile composed of tomato stalk with maize straw addition was constructed, and the whole community structure and functions of the dominant were investigated by applying the integrated mata-omics. Results showed that Actinobacteria, Firmicutes, and Ascomycota dominated and drove the assembly of the co-occurrence network. In the thermophilic stage, Thermobifida was the exclusive degrader of cellulose, and Thermobifida fusca was the most important cellulolytic actinomycete. Saccharomonospora viridis, Planifilum fulgidum, Thermobacillus sp. and the dominant ascomycota of Aspergillus sclerotialis participated in hemicellulose decomposing. In the cooling phase, functional microorganisms became more diverse, with Nocardiopsis flavescens, Glycomyces artemisiae, Glycomyces sambucus, Streptomyces rubrolavendulae and Streptomyces vietnamensis joining the cellulose-degrading rank, and Chaetomium thermophilum emerging as the main hemicellulose degrader. More than two thirds of the bacteria-bacteria interactions and all the fungi-fungi associations were positive, while, both competition (for the same substrate of hemicellulose) and synergy (preference for cellulose and hemicellulose) coexisted in the bacteria-fungi interactions. In conclusion, these findings provide useful information for understanding the biodegradation of tomato plant residues better, and effects of the functional agents identified on composting process should be further studied.

Anti-gravity straining maneuver (AGSM) helps to reduce the occurrence of gravity-induced visual disturbances and loss of consciousness. An objective assessment of the AGSM is still missing during ground training. This study evaluated the feasibility of using electrical impedance tomography (EIT) to assess the performance of AGSM.

Eight undergraduates and eight teachers majoring in aerospace medicine were included in the study. An experienced professor from the department of aerospace medicine reviewed the key points of AGSM with each subject. EIT measurement was performed during AGSM. The global and regional ventilation were used to investigate the characteristics of AGSM. The professor and the subjects rated the performance of AGSM according to the maneuver requirements of AGSM (maximum 16 points) before and after reviewing the ventilations from EIT.

For global ventilation, the relative depth of gas exchange and duration of exhalation of the teachers were larger than those of the students (p<0.01), the maneuver details of AGSM, which might provide a potential tool for real-time assessment of AGSM quality in an objective manner.Because of its simplicity and effectiveness, fuzzy K-nearest neighbors (FKNN) is widely used in literature. The parameters have an essential impact on the performance of FKNN. Hence, the parameters need to be attuned to suit different problems. Also, choosing more representative features can enhance the performance of FKNN. This research proposes an improved optimization technique based on the sine cosine algorithm (LSCA), which introduces a linear population size reduction mechanism for enhancing the original algorithm's performance. Moreover, we developed an FKNN model based on the LSCA, it simultaneously performs feature selection and parameter optimization. Firstly, the search performance of LSCA is verified on the IEEE CEC2017 benchmark test function compared to the classical and improved algorithms. Secondly, the validity of the LSCA-FKNN model is verified on three medical datasets. Finally, we used the proposed LSCA-FKNN to predict lupus nephritis classes, and the model showed competitive results. The paper will be supported by an online web service for any question at https//aliasgharheidari.