Websterpilegaard4356

Moreover, p53 was overexpressed in 4 cases. None of them showed Olig2 expression. Two patients showed disease progression after surgery at 18 months and 24 months, respectively. The latter of the two deceased 3 months after tumor progression. Conclusions The clinicopathological and molecular genetics features of high-grade gliomas with H3 G34R mutation have relatively similar clinicopathological and genetic features, and more commonly seen in young adults (vs. older adults). Thus, these tumors may be discussed further as a distinct tumor entity.Objective To study the clinicopathologic features, immunophenotype, molecular genetics and differential diagnosis of biphenotypic sinonasal sarcoma (BSNS), and to evaluate the role of PAX3 and PAX8 immunohistochemical (IHC) antibodies in the diagnosis of BSNS. Methods Nasal sinus spindle cell tumors surgically treated at the Jinling Hospital from 2000 to 2019 were collected, including three cases of BSNS, 10 cases of acinar rhabdomyosarcoma, eight cases of schwannoma, five cases of hemangiopericytoma, three cases of fibrosarcoma, and one case of triton tumor. The cases were evaluated by histology, IHC by EnVision for PAX3 and PAX 8 (including PAX8 murine monoclonal antibody, clone number OTI6H8, hereinafter referred to as PAX8-OTI6H8 antibody; PAX8 rabbit monoclonal antibody, clone number EP298, hereinafter referred to as PAX8-EP298 antibody) molecular genetic tests. Results All three BSNS patients were elderly women with clinical manifestations of nasal congestion and bleeding. Imaging showed a soft tissue dion. FISH detection showed that PAX3 break apart in the tumor cells from all three patients (four specimens). Conclusions BSNS is a distinct sinonasal low grade malignancy with dual differentiation which could be readily confused with a variety of spindle cell tumors encountered in the sinonasal cavity. The molecular genetics of PAX3 gene break is the gold standard for diagnosis of this tumor. IHC marker monoclonal PAX3 is 100% expressed in BSNS, while the specificity is limited. PAX8-OTI6H8 is also expressed in BSNS due to the cross reaction with PAX3 antibody, while PAX8-EP298 is all negative for these tumors.Objective To analyze the clinico pathological features, differential diagnosis and prognosis of metastatic renal cell carcinomas. Methods The clinical data, histology, immunophenotype and follow-up data of 196 patients with metastatic renal cell carcinoma diagnosed from 1994 to 2017 at the Department of Pathology, Changhai Hospital, Naval Military Medical University, Shanghai, China were analyzed retrospectively. Results There were 142 males and 54 females, with a median age of 61 years. The top three metastatic sites for the 196 cases of metastatic renal cell carcinoma were lung (31.1%, 61/196), bone (29.1%, 57/196) and digestive system (19.4%, 38/196). Among the pathological subtypes of metastasis, the proportion of clear cell renal cell carcinoma was 94.4% (185/196) and that of type II papillary renal cell carcinoma was 3.6% (7/196). The TFE3 translocated renal cell carcinoma and congestive tubular carcinoma were rare, with 3 cases and 1 case, respectively. CK, vimentin, CAⅨ and CD10 were expressed in all metastatic clear cell renal cell carcinomas. CK7, CD10 and P504s were expressed in papillary renal cell carcinomas. TFE3 was expressed in TFE3 translocated renal cell carcinoma. The collecting duct carcinoma was positive for HCK. Conclusions Lung metastasis and bone metastasis are still the most frequent metastatic sites of renal cell carcinoma. Five years after primary lesion resection may be the high risk time for metastasis. Most of the metastases are solitary when they are first identified. To better diagnose and identify the renal origin of a metastatic renal cell carcinoma, one should consider morphological characteristics, clinical history information of the metastasis and the combined immunohistochemistry of CK, vimentin, CD10, CK7, TFE3, PAX2 and PAX8.Objective To investigate the clinicopathological characteristics and molecular genetics of atypical renal cysts. Methods Six cases of atypical renal cysts were collected from Zhejiang Provincial People's Hospital, Hangzhou, China, between February 2014 and February 2019. The clinicopathological characteristics and disease progression were analyzed. The 3p deletion and trisomy of chromosomes 7 and 17 were detected using fluorescence in situ hybridization (FISH). Results All of the 6 patients were male, aged 43-63 years (median 52 years). Preoperative Bosniak classification showed 4 cases of grade Ⅱ, 1 case of grade Ⅰ and 1 of grade Ⅲ. Histologically, atypical renal cysts appeared as unilocular or multilocular cysts, lined by multilayered flattened or cuboidal-shaped clear or eosinophilic cells. They often showed short papillary projections, and lacked solid or nodular growth of the lesional cells within the wall or septa of the cysts. Histologically, these cysts could be classified into three categories acquir of currently known renal cell carcinomas. Extensively sampling and careful observation of the histological characteristics of the cyst wall are important for distinguishing atypical renal cysts from extensively cystic renal cell carcinomas.Objective To investigate the clinicopathological characteristics of eosionphilic Chromophobe renal cell carcinoma (eChRCC), and differences in morphology, immunophenotype and clinical prognosis betweeneChRCC, renal oncocytoma(RO) and classic Chromophobe renal cell carcinoma (cChRCC). Methods The clinicopathologic data of 17 patients diagnosed as eChRCC from the Affiliated Hospital of Qingdao University (13 cases) and 971 Hospital of PLA Navy (4 cases) from October 2006 to February 2019 were collected. Immunohistochemical analysis was carried out to compare the immunophenotypes between 17 cases with ChRCC, 27 cases with RO and 30 cases with cChRCC. Resuls Among the 17 patients, seven were males and ten were females, and the age ranged from 40 to 75 years (median 54 years). Clinically, 15 cases of 17 were found accidentally by physical examination. this website The tumor size ranged from 1.8 cm to 10.0 cm (average 5.7 cm) and the cut surface of 15 cases were solid, one case was solicl and cystic, and one was cystic. Most shtive expression of cyclin D1, S100A1 are helpful to the diagnosis and differential diagnosis of eChRCC. The prognosis of eChRCC after complete surgical resection is excellent and few cases may have long-term metastasis. There is no significant difference in prognosis between eChRCC and cChRCC, but eChRCC shows better outcome than RO.Ancient medical books have the names of drugs such as "xinghe" (, apricot pit), but there is only the name "xingren" (, almond) in modern medical books. On the basis of checking Chinese dictionary, exegetical books and ancient literature, it is believed that the ancients could clearly distinguish the difference between "he" (, pit) and "ren" (, nut) in actual use, and realized that the pit and the nut are different parts. This article takes almonds as the center to explore the similarities and differences of concepts and essences between the "he" (, pit) and "ren" (, nut) in ancient prescriptions. By investigating the usage of ancient medical literature, it can be seen that the actual medicinal part of the medicine "xinghe" (, apricot pit) means still almonds. And due to the imperfect market of ancient medicinal materials, there is no perfect medicinal materials processing industry, and it is necessary for doctors to remove part of the non-medicinal parts after obtaining the medicinal materials. Therefore, in ancient times, the "xinghe" (, apricot pit) and "xingren" (, almond) are actually different names for the same medicinal part.Yi Zang Shu Mu(, The List of Medicine Books), written by Yin Zhongchun, is China's earliest medical bibliographer. The years of birth and death of Yin Zhongchun was unknown. By text research, it is confirmed that Yin Zhongchun was born in the 20th Year of Jiajing in Ming Dynasty (1541) and died in the First Year of Tianqi(1621). The only currently existing block-printed edition of Yi Zang Shu Mu is the Fan Xingzhun Qi Fen Shi edition in the library of China Academy of Chinese Medical Sciences. The copies in Japan lack the words " Proofread by Yun Jian Chen Jiru Meigong" , but have an extra preface written by Chen Yidian. This fact indicates that the original of the Japanese copy might be different from the Chinese edition.Yi Lüe Zheng Wu Gai Lun(, Introduction of Corrections to Summaries on Medicine) was written around 1545, the 24th year during Emperor Jiajing's reign in the Ming Dynasty, now it has the only copy extant. Some errors and mistakes happened about this book name and its author in some history books and bibliographies some reference books describe Yi Lüe Zheng Wu Gai Lun and Yi Lüe Zheng Wu (, Corrections to Summaries on Medicine) as two different books, with their own writer Li Xiang and Li Hanyi respectively. In fact, there is only one book, Yi Lüe Zheng Wu Gai Lun and Yi Lüe Zheng Wu is same book. The author is Li Xiang, but Hanyi is his courtesy name that misunderstood as a different person.Some features in the medical prescriptions of western Han dynasty on the wooden slips unearthed in Hujia Pasture were interpreted, and the words were annotated and translated. The study found that this recipe with male magpie excrement treatment epileptic disease is the first moxibustion combined with drugs to treat epilepsy. This is the earliest recorded treatment. The drug is still administered to lactate children by applying it to the mother's nipple and making the child to suck, and it is the earliest recorded of its kind.Rugao and Haian belonging to First Branch of Su-Wan Liberated Area found fulminant cholera in 1946. The fulminant cholera spread throughout the Su-Wan Liberated Area in a short period of time. Thus, local mass and military led by CPC actively launched the Movement of Epidemic Prevention. They took some actions to clear up the circumstance, eliminate the pathogen, prevent the food contamination and cut off the route of transmission. Vaccination was carried out on a large scale. As a result of these measure, the fulminant cholera was efficiently controlled.From 1927 to 1949, the National Government promulgated at least 74 epidemic-related acts and regulations, including 38 national acts and regulations issued by the Ministry of Health, the Ministry of the Interior, the National Economic Commission and other central agencies, 5 industrial acts and regulations, and 31 acts and regulations issued by local governments. These acts and regulations make the epidemic prevention and control of the Republic of China gradually transition from socialization to legalization, thus laying the foundation of the legal system of modern epidemic prevention in China, and playing a positive role in promoting the modernization of epidemic prevention in China. At the same time, the epidemic-related acts and regulations of the Republic of China also show that they attach importance to quarantine of traffic ports, seasonal epidemic prevention, strengthen health and epidemic prevention in remote areas, and pay attention to health care, health and epidemic prevention personnel qualification assessment and guarantee, increase health and epidemic prevention technology application and research and development of the overall characteristics.