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The presence of permanent flow was found to be the main driving factor in explaining both rheophilic fish community trends and habitat succession in individual restored channels. We did not observe an effect of habitat heterogeneity on nursery function for rheophilic fish. To create and maintain optimal nursery conditions in restored floodplain channels of strongly anthropogenically influenced rivers such as the river Rhine, we propose a management strategy involving cyclic rejuvenation through human intervention, focusing on restoring permanent flow, with a frequency of on average every 15 years, depending on the rate of aggradation and targeted rheophilic species. We also propose a thorough investigation of the relationship between habitat heterogeneity and nursery success in floodplain channels, as a next step in the identification of suitable nursery areas for rheophilic fishes.Rewilding has been proposed as an opportunity for biodiversity conservation in abandoned landscapes. However, rewilding is challenged by the increasing fire risk associated with more flammable landscapes, and the loss of open-habitat specialist species. Contrastingly, supporting High Nature Value farmlands (HNVf) has been also highlighted as a valuable option, but the effective implementation of agricultural policies often fails leading to uncertain scenarios wherein the effects of wildfire management remain largely unexplored. Herein, we simulated fire-landscape dynamics to evaluate how fire suppression scenarios affect fire regime and biodiversity (102 species of vertebrates) under rewilding and HNVf policies in the future (2050), in a transnational biosphere reserve (Gerês-Xurés Mountains, Portugal-Spain). Rewilding and HNVf scenarios were modulated by three different levels of fire suppression effectiveness. Then, we quantified scenario effects on fire regime (burned and suppressed areas) and biodiversity (habitat suitability change for 2050). Simulations confirm HNVf as a long-term opportunity for fire suppression (up to 30,000 ha of additional suppressed areas between 2031 and 2050 in comparison to rewilding scenario) and for conservation (benefiting around 60% of species). Rewilding benefits some species (20%), including critically endangered, vulnerable and endemic taxa, while several species (33%) also profit from open habitats created by fire. Although HNVf remains the best scenario, rewilding reinforced by low fire suppression management may provide a nature-based solution when societal support through agricultural policies fails.Pyrrolizidine alkaloids (PA)s are natural toxins produced by a variety of plants including ragwort. The PAs present a serious health risk to human and livestock. Nutlin-3 Although these compounds have been extensively studied in food and feed, little is known regarding their environmental fate. To fill this data gap, we investigated the occurrence of PAs in ragwort plants, soils and surface waters at three locations where ragwort was the dominant plant species to better understand their environmental distribution. The concentrations of PAs were quantified during the full growing season (April-November) and assessed in relation to rain events. PA concentrations ranged from 3.2-6.6 g/kg dry weight (dw) in plants, 0.8-4.0 mg/kg dw in soils, and 6.0-529 μg/L in surface waters. Maximum PA concentrations in the soil (4 mg/kg) and water (529 μg/L) were in mid-May just before flowering. The average distribution of PAs in water was approximately 5 g/10,000 L, compared to the average amounts present in ragwort (506 kg/ha), and soil (1.7 kg/ha). In general, concentrations of PAs increase in the soil and surface water following rain events.An increasing number of research shows that long non-coding RNA plays a key role in many important biological processes. However, the number of disease-related lncRNAs found by researchers remains relatively small, and experimental identification is time consuming and labor intensive. In this study, we propose a novel method, namely HAUBRW, to predict undiscovered lncRNA-disease associations. First, the hybrid algorithm, which combines the heat spread algorithm and the probability diffusion algorithm, redistributes the resources. Second, unbalanced bi-random walk, is used to infer undiscovered lncRNA disease associations. Seven advanced models, i.e. BRWLDA, DSCMF, RWRlncD, IDLDA, KATZ, Ping's, and Yang's were compared with our method, and simulation results show that the AUC of our method is more perfect than the other models. In addition, case studies have shown that HAUBRW can effectively predict candidate lncRNAs for breast, osteosarcoma and cervical cancer. Therefore, our approach may be a good choice in future biomedical research.The aim of this article is to analyze the conceptual structure underlying the models of obesity prevention implemented in Argentina, Brazil, and Spain. In their culturally distinct but epidemiologically similar contexts, the three countries have devised strategies that reproduce global diagnoses of the causes of obesity and replicate some of the measures proposed at the global level. While so-called "obesogenic environments" are considered primarily responsible for these tendencies, efforts to raise awareness about food and nutrition tend to promote self-monitoring and behavior rationalization as the main tools for achieving changes in diet and physical activity. Although a variety of measures have been proposed at the local level, they have been less diverse in terms of their nature and scope, barely taking into account the constraints that hinder the adoption of healthy lifestyles. In contexts of social and food precarity, this has meant neglecting the social groups with the highest prevalence of obesity.In Brazil, the provision of mental health care in primary care centers has gained strategic importance, as it ensures that users will be able to attend these services within their communities, and empathy is a key aspect in the development of the doctor-patient relationship. The aim of this study was to identify characteristics related to empathy in physicians who work in primary care centers and who provide care to individuals with mental disorders. Qualitative research was carried out in 2016, based on semi-structured interviews with eight general and family physicians. Material from the interviews was analyzed using content analysis techniques and three categories emerged empathy in the active listening of the physician, strategies that allow for better patient care, and the mobilization of emotions. The use of empathy is intrinsically linked to the resolutive capacity of care, and the characteristics identified were active listening, resource management, and the development of methods to overcome the structural obstacles of daily routines.