Wattsschultz0658

We aim to examine effects of collateral status and post-thrombectomy reperfusion on final infarct distribution and early functional outcome in patients with anterior circulation large vessel occlusion ischemic stroke.

Patients with large vessel occlusion who underwent endovascular intervention were included in this study. All patients had baseline computed tomography angiography and follow-up magnetic resonance imaging. Collateral status was graded according to the criteria proposed by Miteff et al and reperfusion was assessed using the modified Thrombolysis in Cerebral Infarction (mTICI) system. We applied a multivariate voxel-wise general linear model to correlate the distribution of final infarction with collateral status and degree of reperfusion. Early favorable outcome was defined as a discharge modified Rankin Scale score ≤2.

Of the 283 patients included, 129 (46%) had good, 97 (34%) had moderate, and 57 (20%) had poor collateral status. Successful reperfusion (mTICI 2b/3) was achieved in 206 (73collateral status-was among the independent predictors of favorable outcome at discharge. Infarction of the lentiform nuclei was observed regardless of collateral status or reperfusion success.

In this cohort of patients with large vessel occlusion stroke, both the collateral status and endovascular reperfusion were strongly associated with middle cerebral artery territory final infarct volumes. Our findings suggesting that baseline collateral status predominantly affected middle cerebral artery border zones infarction, whereas higher mTICI preserved deep white matter and internal capsule from infarction; may explain why reperfusion success-but not collateral status-was among the independent predictors of favorable outcome at discharge. Infarction of the lentiform nuclei was observed regardless of collateral status or reperfusion success.Background Basal release of nitric oxide (NO) from the vascular endothelium regulates the tone of muscular arteries and resistance vasculature. Effects of NO on muscular arteries could be particularly important during exercise when shear stress may stimulate increased NO synthesis. Methods and Results We investigated acute effects of NO synthase inhibition on exercise hemodynamics using NG-monomethyl-l-arginine (l-NMMA), a nonselective NO synthase -inhibitor. Healthy volunteers (n=10, 5 female, 19-33 years) participated in a 2-phase randomized crossover study, receiving l-NMMA (6 mg/kg, iv over 5 minutes) or placebo before bicycle exercise (25-150 W for 12 minutes). Blood pressure, cardiac output (measured by dilution of soluble and inert tracers) and femoral artery diameter were measured before, during, and after exercise. At rest, l-NMMA reduced heart rate (by 16.2±4.3 bpm relative to placebo, P less then 0.01), increased peripheral vascular resistance (by 7.0±1.4 mmHg per L/min, P less then 0.001), mean arterial blood pressure (by 8.9±3.5 mmHg, P less then 0.05), and blunted an increase in femoral artery diameter that occurred immediately before exercise (change in diameter 0.14±0.04 versus 0.32±0.06 mm after l-NMMA and placebo, P less then 0.01). During/after exercise l-NMMA had no significant effect on peripheral resistance, cardiac output, or on femoral artery diameter. Conclusions These results suggest that NO plays little role in modulating muscular artery function during exercise but that it may mediate changes in muscular artery tone immediately before exercise.The aim of the present study is to describe a study protocol to compare different types of analgesic electrical currents on pain intensity and sensory comfort during the application of carboxytherapy for the treatment of cellulite. Seventy five women with the presence of moderate and/or severe gluteal cellulite will be randomly allocated into three groups carboxytherapy plus transcutaneous electrical nerve stimulation, carboxytherapy plus interferential current or carboxytherapy plus Aussie current. Oprozomib mw Pain intensity, which is the primary outcome, will be measured by a numeric rating scale (0-10). The secondary outcome is sensory comfort, which will be measured using the visual analogue scale (0-10). Trial registration Brazilian Clinical Trials Registry ReBEC (RBR-6z82zb) www.ensaiosclinicos.gov.br/rg/RBR-6z82zb/.Back squats are a common strengthening exercise for knee and hip musculature. However, repetitive loaded movements like backs squats result in high patellofemoral joint loading and therefore may contribute to the development of common overuse injuries. Thus, it is important to understand how changing parameters such as squat depth or load influences patellofemoral loading. This study investigated differences in patellofemoral loading when experienced female lifters squatted to three depths (above parallel, parallel, and below parallel) and with three loads (unloaded, 50%, and 85% of depth-specific one repetition maximums). Patellofemoral joint reaction forces (pfJRF) and stresses (pfJS) were calculated from biomechanical models incorporating knee extensor moments (KEM) and joint angles. Peak KEMs displayed a depth-by-load interaction such that within each depth, as load increased so did peak KEM. However, within each load, the effects of depth were different. Peak pfJRF also increased with load and was higher at below parallel than above or parallel depths. Peak pfJS also displayed a depth-by-load interaction, increasing with load within a given depth, and being greatest at the below parallel depths within a given load. If patellofemoral joint loading is a concern, clinicians or coaches should carefully monitor the depth and load combinations being used. Highlights The barbell back squat is one of the most ubiquitous exercise for improving lower extremity strength. While several studies have been performed in males, the interactive effect of squat depth and load on patellofemoral joint kinetics remains relatively unstudied in female lifters. Patellofemoral joint kinetics in female lifters are influenced by both the depth of squat and load used, so if loading of the patellofemoral joint is a concern, clinicians or coaches should carefully monitor the depth and load combinations used in rehabilitation or training.