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OBJECTIVE The aim of this study was to assess the existence of ductal changes in diabetics using sialendoscopy. STUDY DESIGN Twenty patients and 10 volunteers received bilateral parotid diagnostic sialendoscopy. Group I included 10 patients with uncontrolled diabetes (UCD); group II, 10 patients with controlled diabetes (CD); and group III, 10 nondiabetic controls (CG). Expected ductal changes were examined in 3 proposed distinct zones. A χ2 test was used to compare groups. RESULTS Ductal pathologic conditions were significantly higher in diabetic patients in all zones. Abnormalities were classified as stenosis, hyperemia, or others. In UCD, stenosis percentage was 55%, 90%, and 100% in zones 1, 2, and 3, respectively, compared with 30%, 40%, and 55% in CD and 5%, 5%, and 0% in CG (P less then .01). Hyperemic changes in UCD were 90%, 90%, and 40% compared with 50%, 50%, and 20% in CD (P less then .01) and 0% in CG. Comparing zones in UCD and CD indicated that stenosis increased significantly toward the proximal end, whereas hyperemia prevailed toward the distal end. CONCLUSIONS Significant ductal abnormalities were detected in the parotids of UCD and CD patients compared with CG. Ductal changes were higher in UCD compared with CD. BACKGROUND A well-established impaired top-down network for effortful emotion regulation (ER) in major depressive disorder (MDD) includes the dorsal and ventromedial prefrontal cortex (PFC) and the amygdala. Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that has been used successfully to induce mood changes in MDD. Despite reliable findings, little is known regarding the precise effects of tDCS on cortical excitability in vivo in depression and how such changes relate to ER. Here, we addressed this question by combining-for the first time in a psychiatric sample-tDCS with functional magnetic resonance imaging in a single-blind randomized design. METHODS We applied anodal tDCS over the left PFC (area F3 per the 10/20 system) together with cathodal tDCS over the right PFC (F4) or sham tDCS during functional magnetic resonance imaging in patients with moderate to severe MDD (n = 20) and gender- and age-matched control subjects (n = 20). Participants performed 2 runs of an ER task prior to tDCS and 2 runs of the task during tDCS, which was administered at 1.5 mA with 5-cm × 5-cm electrodes. RESULTS Whole-brain, region of interest, and connectivity analyses revealed an impaired ER network in patients with MDD prior to stimulation. Active anodal tDCS over the left (with concurrent cathodal stimulation of the right) PFC during reappraisal of negative stimuli upregulated activity in ventromedial PFC, which was predictive of gains in reappraisal performance during stimulation for the patients with MDD. CONCLUSIONS The results of this study offer insights into the mechanisms of action of tDCS and support its potential as a treatment for depression. BACKGROUND Deficient extinction learning has been suggested as an important mechanism involved in the etiology of posttraumatic stress disorder. A key feature of posttraumatic stress disorder, reexperiencing the trauma in form of intrusions, may be linked to deficient extinction learning. This link is investigated in a novel, functional magnetic resonance imaging-compatible fear conditioning procedure that uses trauma films. Based on previous results, we expected deficient fear extinction indexed by exaggerated responding in the anterior insula and dorsal anterior cingulate cortex to predict subsequent intrusions. METHODS A total of 58 healthy participants underwent acquisition and extinction learning with faces as conditioned stimuli (CS) and highly aversive 16-second films depicting interpersonal violence as unconditioned stimuli. During the subsequent 3 days, participants reported intrusive memories on their smartphone. RESULTS Successful fear acquisition was evidenced by differential (CS+ > CS-) activity (threat cues associated with trauma films > cues paired only with neutral films) of a widespread network, including the anterior insula and dorsal anterior cingulate cortex, whereas extinction was characterized exclusively by differential anterior insula activity. Differential conditioned responding during late extinction in the anterior insula and dorsal anterior cingulate cortex was positively related to intrusive memory frequency independent of unconditioned stimuli responding. Ki16198 solubility dmso Exploratory analysis also revealed intrusion sensitivity of the hippocampus, rostral anterior cingulate cortex, and ventromedial prefrontal cortex, among others. CONCLUSIONS Results support the role of extinction learning in intrusive memory formation; a failure to uncouple conditioned emotional responding from external threat cues was associated with subsequent intrusive memories, representing a potential risk marker for developing posttraumatic stress disorder symptomatology after trauma. OBJECTIVE To compare the skeletal and dentoalveolar changes in Angle Class II malocclusion subjects treated with the banded Mandibular Anterior Repositioning Appliance (Ba-MARA) and crowned MARA (Cr-MARA). MATERIALS AND METHODS This retrospective cohort study included 40 consecutively treated pubertal adolescents with Class II division 1 malocclusion who received full-fixed orthodontic appliances with a phase of orthopedic treatment using Ba-MARA (n=20) or Cr-MARA (n=20). The samples were compared with 20 untreated Class II controls obtained from the Michigan Growth Study. Lateral cephalograms were obtained pre-treatment (T1), post-MARA removal (T2), and post-full-fixed orthodontic treatment (T3). RESULTS After MARA removal (T2-T1), the total mandibular length increased only in the Cr-MARA group compared to controls (Co-Gn=5.4mm; post-hoc P=0.042). Overall dentoskeletal changes were less significant during the T3-T2 timepoint. After full-fixed orthodontic treatment (T3-T1), and after controlling for normal growth, both Ba- and Cr-MARA groups increased the total mandibular length by 3.1mm and 3.8mm respectively. Overjet decreased by 2.2mm in Ba-MARA and 2.9mm in Cr-MARA. The mandibular molars erupted and moved mesially in both treatment groups. The mandibular incisors proclined significantly in the Cr-MARA group in comparison to controls (IMPA=7.1o, post-hoc P=0.002). CONCLUSIONS Both MARA designs were effective in correcting the malocclusion by a combination of small skeletal and dental changes. Although significant differences in dentoskeletal outcomes were observed between the MARA groups and the controls, the differences between the two MARA designs were small and did not achieve statistical/clinical significance.