Watsonsosa3864

Benefitting from narrow band gap nonfullerene acceptors, continually increasing power conversion efficiency (PCE) endows organic solar cells (OSCs) with great potential for commercial application. Fabricating high-performance OSCs with potential for large-scale coating and nonhalogenated solvent processing is a necessity. Herein, we have proposed the use of nonhalogenated solvents combined with high-temperature blade coating to prepare a PM6 (poly[(2,6-(4,8-bis(5-(2-ethylhexyl-3-fluoro)thiophen-2-yl)benzo[1,2-b4,5-b']dithiophene))-alt-(5,5-(1',3'-di-2-thienyl-5',7'-bis(2-ethylhexyl)benzo[1',2'-c4',5'-c']dithiophene-4,8-dione)])Y6 (2,2'-((2Z,2'Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,34',5']thieno[2',3'4,5]pyrrolo[3,2-g]thieno[2',3'4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene)))blend active layer. The resultant OSCs deliver a PCE of 15.51% when the PM6Y6 active layer is blade-coated at 90 °C in nonhalogenated o-xylene (o-XY) host solvent containing 1,2-dimethylnaphthalene (DMN) additive. It is found that high-temperature blade coating and nonhalogenated solvent additive DMN can suppress excessive aggregation of Y6 and enhance the crystallinity of PM6 and Y6 by regulating the dynamic process of active layer formation. Finally, an optimized blend morphology with nanofibrous phase separation and enhanced crystallinity are achieved for the PM6Y6 active layer prepared with high-temperature blade coating and nonhalogenated o-XYDMN solvents, which not only shortens the film-drying time but also leads to increased charge generation, transport, and collection efficiency. The 1.00 cm2 OSCs prepared with high-temperature blade coating and nonhalogenated solvents exhibit a high PCE of 13.87%. This approach shows great potential for large-area fabrication of OSCs.The article presents the data of the latest domestic and foreign original studies, the results of a number of meta-analyses, conclusions of randomized clinical trials (RCTs), and other scientific studies that prove the effectiveness and necessity of mandatory inclusion in the treatment of chronic pain syndrome of the stage of non-invasive non-pharmacological therapy. One of the promising areas of pharmacotherapy for degenerative-dystrophic joint lesions is the use of chondroprotectors (CP), in particular chondroitin sulfate (CS). According to new Clinical Recommendations of Ministry Health (MH) of the Russian Federation (RF) «Chronic pain in patients of elderly and senile age» (2020), according to which the purpose of CS is recommended for patients older than 60 years with joint pain and contraindications to non-steroidal anti-inflammatory drugs (NSAIDs) or senile asthenia for the purpose of pain relief and the prevention of exacerbations of pain. selleck inhibitor A high level of reliability and persuasiveness of the recommendations was noted (1A) of CS use. Most of the CS is available in the form of forms for oral use, the bioavailability of which, according to clinical studies, is 13-38% due to the destruction of the CS molecules in the gastrointestinal tract. Intramuscular (i/m) administration of the drug can increase the bioavailability of CS, which can not only increase the effectiveness of therapy, but also lead to a more rapid development of the symptomatic effect. In Russia available parenteral forms of CS (Chondroguard) pharmaceutical quality, efficacy has been proven in randomized clinical trial (RCT) MH RF. To relieve pain in the joints, it is recommended to use parenteral forms of CS (Chondroguard) at a dose of 100-200 mg per day, every other day, the total duration of the course of treatment is 25-30 injections.The use of pulmonary rehabilitation reduces symptoms, improves life quality and exercise tolerance. The article presents indications for physical training, their characteristics and assessment of their effectiveness in the rehabilitation of patients with chronic lung diseases. It was noted that the execution of exercise tests (a monitoring with a progressive load increase on a bicycle ergometer or treadmill, a test with a constant load, a 6-minute walk test, a shuttle test with an increasing load and a shuttle test with a constant load) is appropriate for physical training before rehabilitation course. Physical endurance training programs are an essential component of pulmonary rehabilitation. Strength training, flexibility training and upper limb exercises give a good additional effect. To assess the effectiveness after rehabilitation programs, it is advisable to perform tests with physical activity. link2 To assess the effectiveness of rehabilitation, the constant load exercise test and the constant load shuttle test are more sensitive to changes than the increasing load tests.An analytical review of the methods of cancer patients' rehabilitation with peripheral polyneuropathy induced by cytostatics (PNPIC) was carried out. Studies from electronic databases were investigated Scopus, Web of Science, MedLine, World Health Organization, The Cochrane Central Register of Controlled Trials, ScienceDirect, US National Library of Medicine National Institutes of Health, PubMed Cancer, eLIBRARY, CyberLeninka. Despite the improvement of anticancer therapy and an increase in patients' life expectancy, the emerging peripheral polyneuropathy remains an urgent problem, since it significantly affects both the patients' life quality and the selection of adequate therapy. The frequency of detection of PNPIC is 90%, after discontinuation of treatment; symptoms of damaged peripheral nerve fibers remain in 30% of patients. The clinical symptoms of PNPIC are varied and most often include numbness in the extremities and / or increased sensitivity to thermal or mechanical stimuli, neuropathic pain. link3 Curren it is not possible to carry out a comparative analysis of the results of these rehabilitation types and to give an unambiguous answer about their effectiveness. As the analysis has shown, peripheral PNPIC is well known all over the world, however, the search for methods of its treatment is far from complete.Moscow in modern borders is the largest metropolitan area in the country with a fairly high and unevenly distributed population density. This predetermines the need to address environmental regulation of urbanization in order to create the most comfortable living conditions for the population. Health care and the maintenance of health of all age groups are the leading role in the list of the most important tasks to ensure the social well-being of citizens. In the bowels of the Moscow region there are natural therapeutic resources low-mineralized (M 3-5 g/l) sulfate sodium-magnesium-calcium drinking mineral water and chloride sodium bromine brine. The article presents the characteristics of the natural therapeutic resources of the Moscow region, the area of their therapeutic use, justified the possibility of wider use based on the available scientific data on the effect on the body of these waters and their analogues. All this provides an opportunity to achieve the main goal of medical resortology - the use of mineral water as a means of therapy, rehabilitation and prevention of most existing human diseases.Metabolic syndrome (MS) is a complex of interrelated metabolic disorders leading to the development of abdominal obesity, hyperglycemia, insulin resistance, and dyslipidemia. To develop new methods for the prevention and treatment of MS, it seems appropriate to simulate this disease using a high-calorie diet that induces many of its symptoms. As a therapeutic and prophylactic agent, it is promising to use low-intensity electromagnetic radiation (EMR) of ultra-high frequency (UHF), which can have a stimulating effect on metabolic and regenerative processes and strengthen the mechanisms of their regulation.Purpose of the study. To reveal the features of the effect of low-intensity microwave EMR/UHF on the development of adaptive metabolic and ultrastructural changes in the liver and blood of rats at an early stage of MS development.

The work was carried out on 40 nonlinear male rats weighing 180-220 g. In the experimental group, the rats were kept on a high-calorie diet for 2 months; in the control group, onlyt is advisable to use EMR/UHF in more adequate modes.Purpose of the study. To carry out a comparative analysis of the intake effect of mineral waters (MW) of various physicochemical compositions, including those ones enriched in selenium, on the pathogenesis of metabolic syndrome (MS) in the experiment.

The experiment was carried out on 68 male white rats aged 3 months, which were divided into 5 groups. Control groups CG1 - 10 animals without exposure; CG2 - 14 animals with MS, received only drinking water. Experimental groups EG1 - 14 rats with MS, received MW1 of chloride-sulfate sodium composition (Ivanovo region); EG2 - 15 animals, received MW2 of chloride-hydrocarbonate-sodium composition (Essentuki No. 4); EG3 - 15 animals, received MW2 enriched with selenium. MS was modeled by double injection of streptozotocin, intraperitoneally, 30 μg/kg, after 60 days of finding the animals on a hypercaloric diet.

According to the oral glucose tolerance test (GTT) in animals with MS, two variants of the glycemic response were identified, according to which two subggnal was restored to varying degrees and the increased activity of blood α-amylase decreased.

In animals with MS, a decrease in the sensitivity of β-cells to the stimulating effect of glucose and the involvement of the exocrine pancreas in the pathological process was determined. Under the influence of therapeutic course drinking MW of different physicochemical composition in animals with MS in the experiment, the sensitivity of tissues to the stimulating hyperglycemic signal was restored to varying degrees and the increased activity of blood α-amylase decreased.Arthrogryposis is one of the most severe congenital orthopedic diseases, characterized by multiple joint contractures, hypoplasia or aplasia of the skeletal muscles of the extremities, as well as severe motor disorders. The use of compensatory strategies allows patients to improve the ability to self-care.

To study the compensatory strategies in children with arthrogryposis with absent of active flexion in the elbow joint and estimate their dynamic after surgical treatment.

We performed a clinical examination of 236 patients with arthrogryposis with deformities of the upper extremities due to arthrogryposis at the age of 10 months to 16 years. The examination was carried out before the operation, as well as at various times (from 1 month to 8 years) after. In 87 cases (67 patients), restoration of active elbow flexion was performed by transposition of latissimus dorsii or pectoralis major to the biceps position. The activity of the muscles involved that most commonly used in compensatory strategies (synergeservation of passive flexion in the elbow joint are diverse. They depend on the amplitude of passive and active movements in the shoulder, the function of the hand and deformities of the lower extremities. These strategies in children with arthrogryposis are unstable and completely disappear when active movements in the elbow joint are restored in the functional range.