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This case highlights optic neuritis as a presenting feature of H1N1 infection.Although acute psychotic symptoms are often reduced by antipsychotic treatment, many patients with schizophrenia are impaired in daily functioning due to the persistence of negative and cognitive symptoms. Raloxifene, a Selective Estrogen Receptor Modulator (SERM) has been shown to be an effective adjunctive treatment in schizophrenia. Yet, there is a paucity in evidence for raloxifene efficacy in men and premenopausal women. We report the design of a study that aims to replicate earlier findings concerning the efficacy of raloxifene augmentation in reducing persisting symptoms and cognitive impairment in postmenopausal women, and to extend these findings to a male and peri/premenopausal population of patients with schizophrenia. The study is a multisite, placebo-controlled, double-blind, randomised clinical trial in approximately 110 adult men and women with schizophrenia. Participants are randomised 11 to adjunctive raloxifene 120 mg or placebo daily during 12 weeks. The treatment phase includes measurements at three time points (week 0, 6 and 12), followed by a follow-up period of two years. The primary outcome measure is change in symptom severity, as measured with the Positive and Negative Syndrome Scale (PANSS), and cognition, as measured with the Brief Assessment of Cognition in Schizophrenia (BACS). Secondary outcome measures include social functioning and quality of life. Protein Tyrosine Kinase inhibitor Genetic, hormonal and inflammatory biomarkers are measured to assess potential associations with treatment effects. If it becomes apparent that raloxifene reduces psychotic symptoms and/or improves cognition, social functioning and/or quality of life as compared to placebo, implementation of raloxifene in clinical psychiatric practice can be considered.A Twice-FFT demodulation method for signal distortion state is proposed and experimentally demonstrated in an optical fiber Fabry-Perot (FP) acoustic sensor. Here the fiber FP acoustic sensor element is build with fiber end face and combination of diaphragms which is composed of a small round aluminum foil and a polymer PET film. The hypotenuse intensity demodulation method is applied to acquire the acoustic signal in time domain assisted with a Photodetector (PD) and an oscilloscope. The first Fast Fourier transform (FFT) processing results show harmonic distortion on the frequency domain spectrum. To demodulate the acoustic frequency and amplitude information, twice-FFT processing is preformed. Experimental results reveal an accuracy up to 95.6% of acoustic signal in the frequency range 2-100 Hz. Our scheme provides a new option for signal demodulation of optical fiber acoustic sensors (OFAS).Past research regarding the emotional characteristics of kibbutz children raised with communal sleeping arrangements (CSA) showed inconsistent findings for emotional difficulties, such as insecure attachment and lowered ability for intimacy. Only little research has examined these children's emotional characteristics in their adulthood. Trait emotional intelligence (trait EI) is a new concept measuring a constellation of correlated emotional traits that capture a person's typical way of processing emotional information and reacting to it. The present study examined if difficulties in intimacy and trait EI characterize adults who had been raised in CSA kibbutzim (Hebrew plural of kibbutz). Participants comprised 1185 adults, aged 30-79, of whom 735 were raised in CSA kibbutzim, and the rest did not grow up in a Kibbutz at all. The participants completed three self-report questionnaires Schutte's Self-Report Emotional Intelligence Test (SSEIT) to measure trait EI; the Revised Adult Attachment Scale to measure adult attachment; and the Rosenberg Self-Esteem Questionnaire to measure self-esteem. Results showed that most of the kibbutz CSA participants revealed levels of intimacy and trait EI comparable to the non-kibbutz group. However, a significant difference was found among adults with low self-esteem and poor attachment quality For these participants, trait EI and intimacy were significantly lower for the CSA kibbutz group than for the non-kibbutz group. Furthermore, the CSA kibbutz group reported poorer non-verbal communication skills than the non-kibbutz group. We suggest that a minority of the CSA kibbutz children were less resilient to the kibbutz ecology. These children might have been more vulnerable to the effects of limited social options, decreased parental support, and the kibbutz education's ideological demands. For these children, the effects of communal upbringing on intimacy and attachment appear to be long-lasting, extending throughout their adulthood.Plasma fibroblast growth factor 21 (FGF21) levels and hepatic FGF21, serotonin 2a receptor (htr2a), and stromal cell-derived factor 2 like 1 (Sdf2l1) expression are increased in insulin-resistant C57BL6J mice fed a high-fat diet. Here we show that plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression were decreased in 6-week-old db/db mice compared with C57BL6J mice, whereas they were increased in 6-week-old KKAy mice compared with KK mice. Expression of hepatic htr2b was increased in db/db mice and KKAy mice compared with controls. Treatment with the selective htr2b antagonist SB204741 suppressed the hyperglycemia in either db/db mice or KKAy mice. Treatment with SB20471 reversed the decreases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in db/db mice, whereas it suppressed the increases in plasma FGF21 levels and hepatic FGF21, Sdf2l1, and htr2a expression in KKAy mice. Moreover, treatment with SB204741 increased plasma FGF21 levels and expression of hepatic FGF21, htr2a, and Sdf2l1 in C57BL6J mice, whereas it decreased plasma FGF21 levels and hepatic FGF21 expression in KK mice. These findings suggest that pharmacologic inhibition of htr2b ameliorates the hyperglycemia and altered expression of hepatic FGF21, Sdf2l1 and htr2a in obese and diabetic db/db and KKAy mice.With the advent of Covid-19, health workers have been under constant physical and psychological pressure. Italy was among the first countries to face the health emergency in a period of great uncertainty about the virus and the ways to treat patients. The present study aims to analyse the levels of emotional distress (ED) and psychosomatic symptoms (PS) of Italian frontline health workers during the Covid-19 emergency, and their relationship with the evaluation of the institutional responses received. A survey was available online during the peak of health system overload. Health workers' ED, PS and perceived overall wellbeing were assessed, along with the perceived adequacy of the emotional support, hygiene and safety measures, and protection received from the national government, regional administration and local hospital. A total of 103 questionnaires were collected [Women 51.5%; mean age, 41.8 years; SD ±10,7; high-risk zone 41.7%]. Correlation analyses were applied to investigate the relationship between the measures of emotional distress and psychosomatic symptoms; ANOVA was applied to compare these measures among groups from different risk zones and with different perceived emotional and safety protection.