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55%) received respiratory support. Sixteen patients (55.17%) had positive bacterial culture results. Fourteen bacterial strains were detected, most of which were gram-positive (72.72%). Mean LOS was 6.89 ± 14.39 days (range 0.5-73 days), and 24.79 ± 16 days in the hospital. The ICU mortality rate was 10.34%. Compared with LA patients without descending necrotizing mediastinitis (DNM), those with DNM had longer ICU and hospital LOS. The laboratory investigations were higher.
LA patients in ICU were predominantly male, with a wide range age, high incidence of complications, long hospital LOS.
LA patients in ICU were predominantly male, with a wide range age, high incidence of complications, long hospital LOS.
Inhibition of bone resorption is essential for periodontal treatment. Recently, it has been suggested that boric acid suppresses periodontitis, but the mechanism of this inhibition is still not well understood. Therefore, to analyze the cellular response to boric acid administration, we histologically evaluated alveolar bone in experimental periodontitis of rats administered boric acid.
5-0 silk ligatures were placed around the cervix of the second maxillary molars of 4 week-old rats treated with or without boric acid. Five and 14 days after ligature placement, the periodontal tissues between first and second molars were investigated histologically and immunohistochemically using antibodies to CD68, cathepsin K, and α-smooth muscle actin (SMA).
Five days after the beginning of the experiment, many CD68-positive cells appeared in the periodontal tissues with ligature placement without boric acid administration. Also, the number of cathepsin K-positive osteoclasts had increased on the surface of alveolar bone. However, boric acid administration prevented severe bone resorption and reduced the number of cells positive for CD68 and cathepsin K. At day 14 post treatment, cells positive for α-SMA were seen in the periodontal tissues after boric acid administration, whereas no such cells were found around the alveolar bone without the administration of boric acid.
Boric acid inhibited the inflammation of ligature-induced periodontitis. This agent might reduce bone resorption by inhibiting osteoclastogenesis and also could accelerate osteoblastogenesis.
Boric acid inhibited the inflammation of ligature-induced periodontitis. This agent might reduce bone resorption by inhibiting osteoclastogenesis and also could accelerate osteoblastogenesis.
No study has previously investigated and compared whether resin coating could prevent the effect of dehydration on flexural strengths and porosities of high powder-liquid and resin-modified glass ionomer cements (HPL-GIC and RM-GIC). The purpose of this study is to investigate the effect of resin coating on flexural strengths and porosities of HPL-GIC and RM-GIC under a dry condition.
HPL-GIC (
) or RM-GIC (
) was mixed and loaded into a mold to create a bar-shaped specimen, n = 12 of each. The specimens were randomly divided into two groups,
and
, n = 6 of each. In the
group, a resin coating agent (
) was applied and light cured for 20 s. After 72 h, each specimen was dried and scanned to detect porosities (% volume) using micro-computed tomography. After scanning, flexural strength (MPa) of the specimen was tested using a three-point bending method.
Porosities of HPL-GIC were significantly higher than RM-GIC, either
group (
). Flexural strengths of
and
HPL-GIC were 41.47 ± 0.89 and 15.32 ± 1.15 MPa that were significantly lower than those of RM-GIC at 104.77 ± 3.97 and 52.90 ± 2.17 MPa (
). Flexural strengths of
GICs were significantly higher than
GICs (
).
Resin coating increased flexural strengths of GICs under dry condition. HPL-GIC had higher porosities and lower flexural strength than RM- GIC.
Resin coating increased flexural strengths of GICs under dry condition. HPL-GIC had higher porosities and lower flexural strength than RM- GIC.
Hyperparathyroidism-jaw tumor syndrome is a rare autosomal dominant disease characterized by parathyroid tumors and ossifying fibroma of the jaw. Disease-causing mutations have been localized in the tumor suppressor gene CDC73. This study is designed to highlight the importance of genetic testing in the diagnosis of ossifying fibroma related to this syndrome.
The Clinical, histopathological, radiographical, familial and genetic features of 24 patients with Hyperparathyroidism-jaw tumor syndrome were collected by searching the electronic literature PubMed, Medline, Embase, and Science Direct databases combining the MeSH heading terms "Hyperparathyroidism jaw tumor syndrome", with the words "Ossifying fibroma" and "CDC73". The collected features were simply assessed and analyzed.
The average age was 28.68 years old (age range 10-66), with 12 male and 12 female patients (11 M/F ratio). Hyperparathyroidism results from parathyroid adenoma in 16/24 cases (66.666%) and parathyroid carcinome in 5/24 (20.833%). Bone pathology occurred most often in the mandible (16/24 cases; 66.666%), while 5/24 cases were in the maxilla (20.883%) and 3 cases in both (12.5%). In 5/24 cases, ossifying fibroma was the first to occur before hypercalcemia. Genetic mutation of CDC73 were positive in 19/24 cases (79.166%).
Since the jaw lesions in Hyperparathyroidism-jaw tumor syndrome could proceed the cardinal signs of hyperparathyroidism, its accurate diagnosis needs to depend on clinical, histological, radiographical, family history and most of all the genetic testing for CDC73 gene.
Since the jaw lesions in Hyperparathyroidism-jaw tumor syndrome could proceed the cardinal signs of hyperparathyroidism, its accurate diagnosis needs to depend on clinical, histological, radiographical, family history and most of all the genetic testing for CDC73 gene.
Even after surgical orthodontic treatment, the level of masticatory function in patients with jaw deformities is still lower than that of healthy subjects. The purpose of this study was to evaluate the effects of functional training program using gum chewing exercise after orthognathic surgery on masticatory function in patients with mandibular prognathism.
The study subjects were 16 patients with mandibular prognathism who underwent orthognathic surgery and 8 individuals with normal occlusion. Patients were divided into two groups (training group and non-training group; n = 8 per group). Functional training included gum chewing exercise and patient-education about masticatory function. selleck chemicals The training; gum chewing exercise of 5 min twice a day for 90 days, started at 3 months after surgery. For each subject, electromyographic activities of masseter and temporalis muscles during maximum voluntary clenching (MVC) and jaw movement during gum chewing were recorded before and after surgical orthodontic treatment. Two parameters; activity index (AI ratio of activity of masseter and temporalis muscles) and error index (EI ratio of the number of abnormal chewing patterns), were used.
In the training group, the AI value during MVC increased significantly and the EI value during gam chewing decreased significantly after surgical orthodontic treatment (AI p < 0.01; EI p < 0.01), indicating the improvement of activity balance of masseter and temporalis muscles and conversion of the jaw movement from abnormal to normal pattern (p < 0.01).
Our findings suggested that functional training using the gum chewing and patient-education exercise improved masticatory function in patients with mandibular prognathism.
Our findings suggested that functional training using the gum chewing and patient-education exercise improved masticatory function in patients with mandibular prognathism.
The use of cavity treatments may help in the reduction of bacteria remaining in dentinal tubules after selective carious tissue removal. This study aimed to investigate the effect of selective carious tissue removal and treatment with either 35% phosphoric acid +0.12% chlorhexidine or dentine conditioner on the residual intratubular bacteria in coronal dentine of deep carious lesions.
Thirty carious human molars were randomly divided into three groups; group 1 untreated carious teeth (positive control), group 2 carious teeth treated with 35% phosphoric acid and chlorhexidine disinfectant after selective carious tissue removal and group 3 carious teeth treated with dentine conditioner after selective carious tissue removal. Another six non-carious teeth was used as negative control. The presence of bacteria and depth of bacteria remaining in dentinal tubules were determined by scanning electron microscopy (SEM). Chi square test and one-way, repeated-measures analysis of variance were used for statistical analysis.
Using SEM, coronal dentine of group 1, 2 and 3 revealed cocci, rod and filamentous bacteria within dentinal tubules. Positive rates of bacteria detection in coronal dentine of group 1 were significant higher than those of group 2 and 3 (
< 0.05). The distance of bacteria remaining in the dentinal tubules in group 1, 2 and 3 were 1149.14 ± 384.44, 707.98 ± 357.19 and 869.25 ± 470.75 μm, respectively.
Both treatment groups had similar ability to reduce the number of intratubular bacteria in coronal dentine of carious teeth, but not complete elimination.
Both treatment groups had similar ability to reduce the number of intratubular bacteria in coronal dentine of carious teeth, but not complete elimination.
Sucrose has been considered as a cariogenic substrate due to large amounts of acid production after fermentation by certain oral bacteria, thus sugar alcohols are often used to replace sucrose. The aims of this study were to investigate the effect of maltitol on the growth and acid production of
and
-SD11 compared to various sugars, and to examine whether the fermented milk containing a potential probiotic
-SD11 with maltitol could reduce
The acid production of tested sugars by cariogenic
was measured using pH meter. In a clinical trial, 123 children were recruited and randomly assigned to either the probiotic- or control-fermented milk, once daily for 4 weeks. The target bacteria levels in the saliva were examined using a real-time PCR at baseline, 4 and 8 weeks. The oral examination was recorded at the baseline and 8 weeks.
The results showed that maltitol exhibited less acid production than simple sugars. In the clinical trial, a significant reduction of salivary total streptococci and
occurred, while the levels of salivary lactobacilli significantly increased in the probiotic group compared to the control group after receiving the probiotic fermented milk.
The daily consumption of the fermented milk containing
-SD11 with maltitol had beneficial effects on oral health by reducing salivary
Thus, the substitution of simple sugars by maltitol in dairy products containing
-SD11 may be an alternative way to prevent the risk of caries.
The daily consumption of the fermented milk containing L. rhamnosus-SD11 with maltitol had beneficial effects on oral health by reducing salivary S. mutans. Thus, the substitution of simple sugars by maltitol in dairy products containing L. rhamnosus-SD11 may be an alternative way to prevent the risk of caries.
