Vossgarrison3924

Participants identified likes and dislikes in regard to dental hygiene and dental treatment as well as daily self-care practices. Individuals reported that improvements in communication were needed; some indicated not wanting to disclose their ASD diagnosis with their oral care providers. Multiple auditory, visual, and tactile sensory challenges were experienced while waiting in the reception area and during the provision of oral health care treatment. Participants made recommendations to improve oral health care experiences.Conclusions Results from this study offered insight into the oral care experiences of young adults with ASD and the challenges they encounter. Additional research is needed to further explore this phenomenon from the perspective of non-verbal individuals with ASD and from the standpoint of oral health care professionals who are working with young adults with developmental disabilities.Purpose Interprofessional collaboration in health care is needed for comprehensive patient care and improved health outcomes. The purpose of this study was to assess dental hygienists' attitudes and behaviors on past interprofessional education experiences to determine how those experiences influence the ways they collaborate with other health care professionals.Methods Licensed dental hygienists in the United States were recruited to participate in this mixed methods study via social media sites and through the constituents of the American Dental Hygienists' Association. The survey instrument consisted of 23 items incorporating quantitative Likert-style, multiple-choice and qualitative open-ended questions designed to measure participants' attitudes towards interprofessional collaboration (IPC) and interprofessional education (IPE), IPC behaviors in practice and previous IPE experiences.Results Of the 184 participants who opened the survey, 165 respondents met the inclusion criteria and completed the survey (n=165). Most of the participants indicated the belief that IPC was important (90%, n=147) and felt confident collaborating with other health care professionals (81%, n=133). While two-thirds of the respondents did not report previous IPE experience (66%, n=109), the majority reported collaborating with other health care professionals within the past six months (63%, n=102). Respondents who reported prior IPE, collaborated with other health care professionals more frequently, on average, than those without IPE experience. Most IPE experiences were case studies and on- and off-campus clinical rotations.Conclusion Findings suggest dental hygienists appreciate the importance of IPC and collaborate with other health care providers based on those attitudes, regardless of prior IPE experiences. read more Further research examining the best practices of IPE experiences could enrich the value of future collaborations between dental hygienists and other health care providers.Purpose Orofacial manifestations of Lyme disease can affect head and neck anatomical structures that are frequently examined by dental professionals. The purpose of this systematic review was to examine the literature for types and frequencies of orofacial manifestations documented in populations in the United States (US) with Lyme disease.Methods Four electronic databases (Dentistry and Oral Sciences, PubMed, Cinahl Plus, and Medline) were systematically searched during the summer of 2019 using keywords and MeSH terms to identify relevant studies. Search term alterations and synonyms were cross-checked using the US National Library of Medicine Unified Medical Language System Metathesaurus. Full-text, English language studies were included if they reported on US populations with Centers for Disease Control and Prevention confirmed cases of Lyme disease. The review followed guidelines set forth in Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Quality was assessed with a modified ded so this medical condition can be better understood by oral health care providers and result in improved health outcomes for infected patients.Purpose Workplace violence (WPV) and inappropriate patient sexual behavior (IPSB) have become increasingly prevalent in the United States. Previous research has shown health care professionals are at a 16-times higher risk of experiencing WPV and IPSB than other occupations, however, there is a lack of research in the field of dental hygiene. The purpose of the study was to examine the experiences of dental hygienists with IPSB in the workplace.Methods A cross-sectional survey research design was used with a purposive sample of clinical dental hygienists recruited through social media sites (n=471). The validated survey was comprised of demographic and IPSB-related questions, with one open-ended question to expand on experiences with IPSB. Descriptive statistics, Pearson's correlation, t-tests and multiple regression analysis were used to analyze the data.Results The survey completion rate was 49% (n=232). Career occurrence of IPSB was 85.8% and occurrence within the last 12-month period was 63.5% among the respondents. Participants who experienced all three categories of IPSB severity had the lowest median number of years in clinical practice (Md.=5.0) as compared to those who reported two categories (Md.=7) and those with only one category (Md.=10), p=0.01. Themes from the open-ended questions included types of patient perpetrating IPSB; type of IPSB behavior; and approaches to management of the IPSB.Conclusion The high prevalence of IPSB events among dental hygienists in this study warrants increased practitioner education, improved workplace policy and support for management of IPSB.Purpose The percentage of men entering the dental hygiene profession has increased from less than 1% of the workforce in 1999 to 6.1% in 2020. However, little is known about the experiences of male dental hygienists. The purpose of this study was to explore and better understand the experiences of male dental hygienists.Methods A qualitative phenomenological research design was used with a purposive sample of male dental hygienists (n=19) recruited via social media groups. Virtual focus groups were conducted and participants were asked open-ended questions to assist in data collection. The data analysis was conducted both manually and with qualitative analysis software. Two investigators independently identified emergent themes and a sub-set of participants participated in member checking of the themes identified.Results The following major themes were identified stereotype, "not just because I'm a guy, I'm a dental hygienist," discrimination, reverse discrimination/special treatment, and bringing balance to the work setting. In addition to the major themes, there were also several minor themes identified with the most common being the need for increased male representation in the profession.Conclusion The findings of this study were consistent with nursing literature regarding the experience of males in female dominated professions. These findings may serve to enhance the positive experiences of being a male in dental hygiene and highlight the need to address the negative experiences such as discrimination to encourage more men to join the profession. Minor themes suggested the need to enhance male representation to make the profession more appealing to men.Purpose The development of allogeneic chimeric antigen receptor (CAR) T cell therapies for off-the-shelf use is a major goal yet faces two main immunological challenges, namely the risk of graft-versus-host-disease (GvHD) induction by the transferred cells and the rejection by the host immune system limiting their persistence. In this work we assessed the direct and indirect antitumor effect of allogeneic CAR-engineered invariant natural killer T (iNKT) cells, a cell population without GvHD-induction potential that displays immunomodulatory properties. Experimental Design After assessing murine CAR iNKT cells direct antitumor effects in vitro and in vivo, we employed an immunocompetent mouse model of B-cell lymphoma to assess the interaction between allogeneic CAR iNKT cells and endogenous immune cells. Results We demonstrate that allogeneic CAR iNKT cells exerted potent direct and indirect antitumor activity when administered across major MHC-barriers by inducing tumor-specific antitumor immunity through host CD8 T cell cross-priming. Conclusions In addition to their known direct cytotoxic effect, allogeneic CAR iNKT cells induce host CD8 T cell antitumor responses resulting in a potent antitumor effect lasting longer than the physical persistence of the allogeneic cells. The utilization of off-the-shelf allogeneic CAR iNKT cells could meet significant unmet needs in the clinic.

Programmed cell death receptor-1 (PD-1) inhibitors are front-line therapy in advanced melanoma. Severe immune-related adverse effects (irAEs) often require immunosuppressive treatment with glucocorticoids (GCCs), but GCC use and its correlation with patient survival outcomes during anti-PD-1 monotherapy remains unclear.

In this multicenter retrospective analysis, patients treated with anti-PD-1 monotherapy between 2009 and 2019 and detailed GCC use data were identified from five independent cohorts, with median follow-up time of 206 weeks. IrAEs were tracked from the initiation of anti-PD-1 until disease progression, initiation of a new therapy, or last follow-up. Correlations between irAEs, GCC use, and survival outcomes were analyzed.

Of the entire cohort of 947 patients, 509(54%) developed irAEs. In the MGH cohort (irAE(+)n=90), early-onset irAE (within 8 weeks of anti-PD-1 initiation) with high-dose-GCC use (greater than or equal to60mg prednisone equivalent qd) was independently associated with pe randomized control clinical trials designed to explore alternative irAE management options are warranted.

amplification is associated with poor prognosis in advanced gastric cancer and its subclonal heterogeneity has been revealed. Here, we examined whether circulating tumor DNA (ctDNA) was useful for detecting

amplification and co-occurring resistance mechanisms in advanced gastric cancer.

We assessed genomic characteristics of

-amplified advanced gastric cancer in a nationwide ctDNA screening study. We also analyzed

amplification status in paired tissue and plasma samples with advanced gastric cancer. In addition, we examined patients with

-amplified advanced gastric cancer identified by ctDNA sequencing who received FGFR inhibitors.

amplification was more frequently detected by ctDNA sequencing in 28 (7.7%) of 365 patients with advanced gastric cancer than by tissue analysis alone (2.6%-4.4%).

amplification profiling of paired tissue and plasma revealed that

amplification was detectable only by ctDNA sequencing in 6 of 44 patients, which was associated with a worse prognosis. Two patiener.

Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathological response to immunotherapy in locally-advanced non-small cell lung cancer (NSCLC).

In this study, next-generation TCR sequencing was performed in peripheral blood and tissue samples of 40 NSCLC patients, before and after neoadjuvant chemoimmunotherapy (NADIM clinical trial, NCT03081689), considering their complete pathologic response (CPR) or non-CPR. Beyond TCR metrics, tissue clones were ranked by their frequency and spatiotemporal evolution of top 1% clones was determined.

We have found a positive association between an uneven TCR repertoire in tissue samples at diagnosis and CPR at surgery. Moreover, TCR most frequent-ranked clones (top 1%) present in diagnostic biopsies occupied greater frequency in the total clonal space of CPR patients, achieving an AUC ROC to identify CPR patients of 0.967 (95% CI, 0.897 to 1.000; p=0.001), and improving the results of PD-L1 TPS (AUC 0.767; p=0.