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artum; biopsies do not provide advantages with regard to hygienic conditions.

The aim of this study was to analyze antimicrobial usage (AMU) in fattening pig farms that took part in the SuisSano/Safety + Health Programme in Switzerland over the year 2020 and to discuss the potential for further improvement. Usage was examined according to the antimicrobial's class and indication for use, with emphasis on highest priority critically important antimicrobials (HPCIAs).

Data on AMU from 1411 farms, reported in an electronic treatment journal, was used. AMU was quantified through treatment incidence (TI) based on Swiss Defined Daily Doses (DDDch). Indication of use for each antimicrobial class was analyzed with particular focus on HPCIAs.

The total TI of all antimicrobials used in the farms corresponds to 8.9 DDDch per 1000 pig-days at risk, of which HPCIAs represented 2.6 %. A total of 140 farms (9.9 %) partake in HPCIAs usage, with tylosin (73.8 % of total HPCIA TI) and colistin (22.8 % of total HPCIA TI) being the most frequently antimicrobials used. The most common indication for  Of the recorded treatments, HPCIA's represented only 2.6 % of the total TIs used in fattening pigs. Since many farms do not use any HPCIAs, knowledge can be obtained from these farms to identify practices which can further reduce or even stop HPCIAs usage. Moreover, information concerning indications for HPCIAs usage provide input concerning where treatment options other than HPCIAs should be explored by both farmers and veterinarians.This cross-sectional study compared hospital staff who had received influenza or COVID-19 vaccination or who had refused COVID-19 vaccination in terms of attitudes towards each vaccination, uptake of influenza vaccination and reasons for refusing COVID-19 vaccination. COVID-19 vaccine refusers rated the risk of infection for themselves and in general and the effectiveness of the vaccination lowest and the vaccination risk highest compared to the other two groups. They also reported the lowest past uptake of influenza vaccination. Perceived pressure to vaccinate proved to be a relevant barrier. Future vaccination campaigns should maintain a balance between information on vaccines, the need for vaccination, and voluntary uptake.

The proximal humeral fracture is one of the most common fractures in the elderly. While epidemiological factors have been well studied, the influence of a proximal humeral fracture on morbidity, mortality and associated costs has not yet been adequately analysed.

On a basis of 4.1 million insurance holders of the German public health insurance (GKV), patients with (study population, SP) and without (comparison group, VG) a proximal humeral fracture (pHF) were compared with regard to comorbidity, rehospitalisation, mortality, drug and aid needs as well as number of physician contacts. Study period was between 2012 and 2016.

6068 patients of the SP met the inclusion and exclusion criteria (age 69.4±14.3 years; male female =28.2% 71.8%). 4781 patients (78.8%) received surgical, 1287 patients (21.2%) conservative treatment of the pHF. Rehospitalisations and visits to the general practitioner occurred more frequently in the SP vs. VG (p<0.01). Contacts with specialists after pHF varied according to specracture. Preventive examinations and treatments are rarer. In the future, care concepts for patients with proximal humeral fractures should not only be optimised with regard to functional scores and reduced complication rates, but also with regard to quality of life and preservation of general health.

In order to prevent implant failure and secondary fracture dislocation, it is often recommended that patients perform partial weight-bearing after surgery of the lower extremity. Previous examinations showed that patients are often not able to follow these instructions. In this study, patients who had undergone surgery of the lower extremity were studied in order to analyze whether incorrect loading influenced the number and severity of complications.

Fifty-one patients were equipped with electronic shoe insoles, which measure loading and other parameters. The measurement period was 24 to 102 hours. Median duration of follow-up was 490 days. The primary outcome parameter was postoperative complications leading to revision surgery. Statistical analysis was performed using the chi-square and Fisher exact tests with significance set at a p<0.05.

Seven out of fifty-one patients had postoperative complications. Four wound complications, one implant failure, chronic instability after fracture of the tibia,efore, we should continue with measurements and reevaluate the "partial weight-bearing doctrine".Not applicable.If mediastinal tumours cause symptoms these are related to their anatomical localization or a paraneoplastic syndrome. The differential diagnosis is based on the clinical situation with finding the lesion, and, furthermore, taking into account the age and sex of the patient, and the mediastinal compartment where the lesion is located. Cross-sectional radiographic diagnostic is essential for defining the therapeutic strategy. The anterior mediastinum is dominated by thymic tumours, mediastinal lymphomas, germ cell tumours and ectopic mediastinal poiters. The middle mediastinal compartment is the most frequent place of mediastinal cystic tumours, whereas the posterior mediastinum is the domain of neurogenic tumours. For selected cases a tissue biopsy is required. Surgery is the mainstay for most mediastinal tumours. Median sternotomy is the most frequent conventional surgical technique while minimally invasive surgery with thoracoscopic and above all robot assisted operation techniques are increasingly frequent. Combined chemotherapy and modern radiotherapy are essential components of the comprehensive treatment for mediastinal tumours.

In sophisticated surgical procedures, e.g. colectomy, cardiac surgery, arterial reconstruction and liver resection, the individual surgeon is a major influence on postoperative morbidity. For the everyday procedure of cholecystectomy, clear data on the morbidity related to the individual surgeon are lacking.

To assess the individual impact on the outcome of cholecystectomy in a cohort of experienced surgeons.

The analysis covered n=710 consecutive patients who had received cholecystecomy between January 2014 and December 2018 - performed by experienced surgeons (> n=300 cholecystectomies before entry in the study and >5 years after specialty registration). In a univariate analysis, the influence of patient characteristics, laboratory findings and surgical data on postoperative morbidity were investigated. Variables with statistical significance were entered into a multivariate logistic regression.

Mortality was 5/710 (0.7%), and morbidity was 58/710 (8.2%), including 37/710 patients with surgicaeach surgeon should be measured as a basis of targeted improvement programs.A 3-month old male Shar-Pei was presented for lethargy, fever and cutaneous edema. Further investigations revealed superficial pyoderma with Streptococcus canis and an acute neutrophilic vasculitis. Symptomatic and antibiotic treatment in combination with immunosuppressive treatment (initially prednisolone, later cyclosporine) treatment was performed. In the course of the disease complications such as dyspnea, anemia, skin ulceration, skin necrosis and secondary bacterial skin infection with multiresistant bacteria occurred. After intensive care treatment the dog was discharged from the hospital 38 days later. Within the following weeks the dosage of the immunosuppressants were reduced and the drugs were discontinued after 4 months.A 2-year old cross-breed dog presented due to acute vomiting and progressive lethargy following ingestion of the owner's anti-gout medication (colchicine, 0.35 mg/kg) 1-3 hours prior to presentation.The dog developed signs of all 3 stages of colchicine poisoning (gastrointestinal phase, multi-organ phase, recovery phase) and the clinical course was complicated by the presence of multi-organ dysfunction syndrome (MODS) and numerous negative prognostic factors.This case report describes the clinical and laboratory effects of colchicine poisoning and represents the first successful treatment of an accidental colchicine ingestion in a dog in Europe.

Tissue Doppler imaging (TDI) is a new technique to measure the myocardial velocities of the avian heart. Using this technique, the present study investigated the influence of isoflurane anesthesia on the systolic and diastolic longitudinal myocardial velocities in racing pigeons.

Racing pigeons (n = 40) were anesthetized with isoflurane with a semi-open anesthesia system with an anesthetic mask and spontaneous breath. The echocardiographic examination was performed during the stage of surgical anesthesia with the failure of the toe pinch and wing twitch reflexes and with deep regular breaths. Echocardiographic measurements were taken in conscious and anesthetized pigeons in the right parasternal longitudinal horizontal heart view.

The results demonstrated a significant decrease in heart rate, systolic and diastolic A' wave myocardial velocities. The diastolic E' wave velocities were less influenced by anesthesia and significantly decreased only for some heart wall segments. The systolic myocardial veloctrioventricular delay during anesthesia could be determined. There is a significant increase in IVR and atrioventricular delay during anesthesia CONCLUSION AND CLINICAL RELEVANCEN A higher heart rate in anesthesia should be interpreted as a compensation for reduced heart performance. The results of the present study indicate the necessity for establishing normal heart values in conscious and anesthetized pigeons.

Epilepsy is one of the more common chronic neurological diseases in cats in which MRI plays a key role in the diagnostic work-up. Hippocampal MRI changes are common in cats, however it is unclear whether these changes represent the reason or the consequence of the disease.The goal of the present study was the retrospective analysis of the MRI findings in a large cohort of epileptic cats.

In total, 143 cats of 3 age groups (< 1 year, 1-6 years, and > 6 years) were included in the study. MRI findings were divided into 4 categories normal, with extrahippocampal lesions, and hippocampal signal alterations with or without contrast enhancement. The prevalence and frequency of these MRI findings in the age groups were examined using chi-quadrat test and nominal regression model.

In approximately one half of the cats (49 %), MRI displayed normal findings. Extrahippocampal changes occurred in 18 % of the animals. read more Hippocampal alterations were present in 33 % of the cats. Hippocampal sclerosis was found histopathologically in all four MRI categories.

Brain MRI was normal in approximately 50 % of the epileptic cats. Extrahippocampal changes are expected mostly in cats older than 6 years. The etiology of the hippocampal alterations is unclear in most cases. Further investigations are needed for a better understanding of the hippocampal signal alterations.

Brain MRI was normal in approximately 50 % of the epileptic cats. Extrahippocampal changes are expected mostly in cats older than 6 years. The etiology of the hippocampal alterations is unclear in most cases. Further investigations are needed for a better understanding of the hippocampal signal alterations.

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