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Kaplan-Meier curves were constructed to compare rates of VTE recurrence over time based on the presence or absence of MetS and its individual components. RESULTS A total of 72,936 patients were included in this analysis. The most common MetS component was hypertension with a prevalence of 59%, followed by hyperlipidemia (41%), diabetes mellitus (24%) and obesity (22%). 69% of patients had at least 1 comorbid component of MetS. The overall incidence of VTE recurrence was 17%, increasing stepwise with each additional MetS component and ranging from 6% in patients with 0 components to 37% in those with all 4. AG221 Logistic regression analysis yielded an adjusted OR of 3.03 (95% CI 2.90 to 3.16) for the effect of composite "+MetS" diagnosis on VTE recurrence. CONCLUSIONS The presence of comorbid MetS in patients with PE is associated with significantly higher rates of VTE recurrence, supporting the importance of recognizing these risk factors and initiating appropriate therapies to reduce recurrence risk.We assessed energy compensation, appetite and reward value of foods during a 14-day military expedition in Greenland realized by 12 male French soldiers during which energy compensation was optimized by providing them with easy-to-eat palatable foods in excess. Although daily energy expenditure (estimated by accelerometry) stayed relatively constant throughout the expedition (15 ± 9 MJ.d-1), energy intake (EI estimated by self-reported diaries) was 17% higher during the D8-D14 than D1-D7 period, leading to a neutral energy balance (EB). Body fat mass (BFM) significantly decreased (-1.0 ± 0.7 kg, p less then 0.001) but not body mass (BM). Neither hunger scores (assessed by visual analog scales), nor components of the reward value of food (explicit liking [EL] and food preference) were significantly altered. However, changes in EL at D10 positively correlated with changes in BM (r=0.600, p less then 0.05) and BFM (r = 0.680, p less then 0.05) and changes in hunger with the EI of the relevant period (r=0.743, p less then 0.01 for D1-D7, r=0.652, p less then 0.05 for D8-14). This study shows that the negative EB and BM loss can be attenuated by an appropriate food supply and that subjective components of eating behaviour, such as hunger and EL, may be useful to predict the magnitude of energy compensation.Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating, and progressive lung disease which is characterized by fibrosis and respiratory failure. IPF holds high morbidity and poor prognosis and still faces with considerable problems of reliable diagnosis and valid prognosis. A growing body of literatures have reported changes in the level of various biomarkers in IPF patients, which means that they are expected to become a new tool for clinical practice of IPF.Areas covered We reviewed the recent literature about biomarkers and focus on the role they play in IPF. We systematically searched Medline/PubMed through February 2020. Many literatures have showed that a variety of biomolecules and genomics played multiple roles in the diagnosis or differential diagnosis, prognosis, and indication of acute deterioration of IPF and so on.Expert opinion Significant advances have been made in the role of biomarkers for IPF these years, however, current data indicate that a single biomarker is unlikely to have a transformative effect on clinical practice, therefore, the combined effect of various biomarkers can be considered to improve the accuracy of diagnosis and prognosis. Further research of biomarkers may provide new insights for the diagnosis, prognosis and even therapy of IPF.Isomerization dynamics involving the migrations, proton transfer reaction, and catalytic actions of water molecules upon vertical ionization of the formamide (FA)-(H2O)2 cluster is investigated by the infrared spectroscopy and theoretical reaction path search calculation. The infrared spectroscopic result indicates the [FA-(H2O)2]+ cation has the hydrogen-bonded structure of the enol isomer cation of formamide and the water dimer. This structure is formed by proton transfer from the CH bond to the carbonyl group through the catalytic action of the water molecules. The isomerization paths involving this enolization in ionized FA-(H2O)2 are explored by using the anharmonic downward distortion following method. We found multiple enolization paths which accompany proton exchanges among the formamide moiety and water molecules through the catalytic actions of the water molecules.Exohedral cuprofullerenes with 6-, 12-, or 24-nuclearity were obtained by utilizing fluorocarboxylic/dicarboxylic acid under solvothermal conditions. The 24-nuclear molecule presents a C60@Cu24 core-shell structure with a rhombicuboctahedron Cu24 coated on the C60 core, representing the highest nuclearity in metallofullerene. The resultant complexes show an efficient absorption of visible light as opposed to the pristine C60. TD-DFT calculations revealed the charge transfer from Cu(I) and O atoms to the fullerene moiety dominates the photophysical process.Dense arrays of high-aspect-ratio (HAR) vertical nanostructures are essential elements of microelectronic components, photovoltaics, nanoelectromechanical, and energy storage devices. One of the critical challenges in manufacturing the HAR nanostructures is to prevent their capillary-induced aggregation during solution-based nanofabrication processes. Despite the importance of controlling capillary effects, the detailed mechanisms of how a solution interacts with nanostructures are not well understood. Using in situ liquid cell transmission electron microscopy (TEM), we track the dynamics of nanoscale drying process of HAR silicon (Si) nanopillars in real-time and identify a new mechanism responsible for pattern collapse and nanostructure aggregation. During drying, deflection and aggregation of nanopillars are driven by thin-liquid-film instability, which results in much stronger capillary interactions between the nanopillars than the commonly proposed lateral meniscus interaction forces. The importance of thin-film instability in dewetting has been overlooked in prevalent theories on elastocapillary aggregation. The new dynamic mechanism revealed by in situ visualization is essential for the development of robust nanofabrication processes.