Vindhirsch3900

Environmental factors affect daily milk production in dairy animals. The aim of this study was to quantify the effects of environmental factors, specifically mean temperature (°C), relative humidity (%), temperature-humidity index (THI), solar radiation (°), pluvial precipitation (mm) and lunar calendar (full moon, waxing quarter, waning quarter, new moon), on milk production (kg/d). The analysis was based on 96,195 morning and evening milking records documented on 109 consecutive days, from 869 Lacaune ewes. PX-12 Ewes were housed in groups of 174 individuals. The analysis was performed in two independent procedures, a Pearson correlation analysis and a multivariate analysis of the ewe's interrelationships, which was based on the total variance estimate and a Varimax-rotated factorial analysis. Milk yield (kg/d) was significantly (p  less then  0.05) negatively correlated with mean temperature (-0.24), relative humidity (-0.16), THI (-0.24), and radiation (-0.18), which suggests that the higher these environmental factors, the lower the milk yield. Lunar calendar had a significant (p  less then  0.01) effect on milk production yield; specifically, yields were higher on the full moon and new moon (2.25 ± 0.05 kg/day) than they were on the crescent or waning moon (2.17 ± 0.05 kg/day). In conclusion, ewes that had been exposed to higher mean temperature, relative humidity, THI and solar radiation had the lowest milk yield, and milk yields are highest on full and new moons. The results of this work may be helpful in making predictions for milk production in Lacaune ewes in the Mediterranean region throughout the year.Migrant youth are vulnerable and face a risk of internalised disorders such as depression. This qualitative meta-synthesis explores migrant adolescents' experience of depression. 14 studies (7 qualitative studies and 7 case reports) were selected after a systematic search of PubMed, Embase, Scopus and PsycInfo. Their quality was assessed with the Critical Appraisal Tool (CASP) for qualitative studies and the Joanna Briggs Institute (JBI) checklist for case reports. The analysis identified six themes describing the experience of depression among migrant adolescents (1) the vulnerability factors underlying depressive distress, before, during and after migration; (2) the subjective experience of depression, combining symptoms associated with a form of depression common in the West with symptoms more common in other cultures; (3) two types of aetiological hypotheses to make sense of their distress; (4) attitudes adopted in response to distress; (5) experience of care, especially reasons discouraging investment in care; and (6) impairment of identity construction by breaks in cultural transmission and intergenerational conflicts. The threat of losing their connections both at the interpersonal (connection to family, peers and community) and intrapsychic levels (construction of identity) is inherently linked to migrant adolescents' experience of depression. We propose to adapt Brandenberger's 3C model (communication, continuity of care, and confidence) for the care of young migrants to promote a therapeutic alliance, foster construction of a coherent bicultural identity, and support the family.

Despite the widespread use of multivitamin/mineral supplements, the effects of multivitamin/mineral on cardiovascular disease (CVD) remain inconclusive. We aimed to prospectively investigate how multivitamin/mineral use is associated with CVD.

This population-based cohort study included 465,278 men and women who participated in the UK Biobank and were free from CVD at baseline. Participants were enrolled between 2006 and 2010 and followed-up until the end of 2018. Data on supplement use including multivitamin/mineral were collected using self-reported questionnaires. Cox proportional hazards models were used to estimate the hazard ratios of CVD events in relation to multivitamin/mineral use.

During the follow-up, we identified 25,772 cases of CVD events, 4754 cases of CVD mortality, 18,728 cases of coronary heart disease, 6726 cases of myocardial infarction, and 4561 cases of stroke. The multivariable-adjusted hazard ratios associated with multivitamin/mineral use were 0.96 (95% CI 0.93, 0.99) for CVD events, 0.92 (0.86, 1.00) for CVD mortality, 0.96 (0.93, 0.99) for coronary heart disease, and 0.92 (0.86, 0.97) for myocardial infarction. Subgroup analysis suggested that multivitamin/mineral use was associated with a significantly lower risk of CVD events in participants aged < 60years and in former and current smokers (P for interaction ≤ 0.01). Sensitivity analyses showed no substantial change in the results when we excluded participants who developed CVD events during the first 2years of follow-up.

Multivitamin/mineral supplementation was associated with very modest reductions in CVD events. Age and smoking might modify these associations.

Multivitamin/mineral supplementation was associated with very modest reductions in CVD events. Age and smoking might modify these associations.

Papillary thyroid carcinoma (PTC) spreads early to lymph nodes (LN). However, prophylactic central (CND) and lateral neck dissection (LND) is controversially discussed in patients with clinically negative nodes (cN0). The preoperative prediction of LN metastasis is desirable as re-operation is associated with higher morbidity and poor prognosis. The study aims to analyse possible benefits of a systemic bilateral diagnostic lateral lymphadenectomy (DLL) for intraoperative LN staging.

Preoperative prediction of LN metastasis by conventional ultrasound (US) was correlated with the results of DLL and intra-/postoperative complications in 118 consecutive patients with PTC (cN0) undergoing initial thyroidectomy and bilateral CND and DLL.

Lateral LNs (pN1b) were positive in 43/118 (36.4%) patients, including skip lesions (n = 6; 14.0%). Preoperative US and intraoperative DLL suspected lateral LN metastasis in 19/236 (TP 8.1%) and 54/236 (TP 22.9%) sides at risk, which were confirmed by histology. Sixty-seven out of 236 (FN 28.4%) and 32/236 (FN 13.6%) sides at risk with negative preoperative US and intraoperative DLL lateral LN metastasis were documented. DLL was significantly superior compared to US regarding sensitivity (62.8% vs 22.1%; p < 0.002), positive predictive value (100% vs 76.0%), negative predictive value (82.4% vs 68.2%), and accuracy (86.4% vs 69.1%), but not specificity (100% vs 96.0%; p = 0.039). DLL-related complications (haematoma) occurred in 6/236 [2.5%] sides at risk, including chylous fistula in 2/118 [1.7%] patients.

DLL can be recommended for LN staging during initial surgery in patients with PTC to detect occult lateral LN metastasis not suspected by US in order to plan lateral LN dissection.

DLL can be recommended for LN staging during initial surgery in patients with PTC to detect occult lateral LN metastasis not suspected by US in order to plan lateral LN dissection.

Immunosuppressive dosing of corticosteroids at the start of treatment impairs immune checkpoint inhibitor (ICI) efficacy in advanced non-small cell lung cancer (NSCLC). Previous cumulative dose and intake modality of corticosteroids may result in different levels of immunosuppression. We sought to determine whether these aspects could predict disease control and survival in NSCLC patients receiving ICIs.

We conducted a retrospective single-center study, including patients treated with ICI as second-line therapy at our institution between July 2015 and February 2021. A prednisone equivalent threshold of 700mg defined low (LCD) or high (HCD) cumulative dosing during the 90days before starting ICIs. At least one 5-day course of ≥ 10mg prednisone equivalent determined whether the intake was pulse (PCD, ≤ 5days) or continuous (CCD, > 5days).

We included 113 consecutive patients. Durable control benefit and no clinical benefit (NCB) were reported in 53 (47%) and 60 (53%) of the cases, respectively. ECOG PS 1-2, negative PD-L1 expression, HCD, and CCD were significantly related to NCB in multivariate analysis. The median PFS was 4.6months (95%CI 3.9-6.3) and median OS was 6.9months (95% CI 6.0-8.9) after a median follow-up time of 43.5months (95% CI 32.6-54.4). Multivariate analysis of survival confirmed ECOG PS 1-2 (p = 0.005), negative PD-L1 expression (p = 0.002), and CCD (p = 0.001) significantly correlated with an increased risk of mortality.

These findings imply that immunosuppressive corticosteroid dosing before ICIs, even of short duration, might affect survival. The constraints of this study and lack of reliable comparisons suggest a hypothesis-generating value of these results.

These findings imply that immunosuppressive corticosteroid dosing before ICIs, even of short duration, might affect survival. The constraints of this study and lack of reliable comparisons suggest a hypothesis-generating value of these results.Maximal oxygen uptake (VO2max) is associated with cardiovascular and metabolic health in the general population. The heart rate (HR) ratio method (HRratio) is a valid, easy and accessible method for estimating VO2max in well-trained subjects. This study examined the validity of using the HRratio to estimate VO2max in recreational football players in the untrained and trained states. Sixty-six participants (age 39.3 ± 5.8 years) were tested pre-training and 28 after 12 weeks, for VO2max assessment, running on a treadmill alternating speed (1 km h-1) and inclination (1%) increments every 30 s until exhaustion. Maximal HR (HRmax) was assessed directly with a multiple approach and estimated with selected equations. Resting HR (HRrest) was measured in supine position, after 15 min of rest. The HRratio method considers the product of HRmax/HRrest ratio by a theoretical proportionality factor (15 ml kg-1 min-1, TPF) to estimate VO2max. This population-specific proportionality factor (SPF) was 14.6 ± 2.6 ml kg-1 min-1. In the untrained state (n = 66), participants' actual VO2max (41.3 ± 6.2 ml kg-1 min-1) was moderately lower (~ 2 ml kg-1 min-1) than the estimated VO2max using the TPF. A nonsignificant difference (0.7 ml kg-1 min-1) was found when the VO2max was estimated using the SPF. When using HRmax equations and the TPF, a small nonsignificant difference (~ 1.5 ml kg-1 min-1) was reported between actual and estimated VO2max. In the trained state (n = 28), the estimated VO2max values were not significantly different from the actual VO2max (44.2 ± 5.2 ml kg-1 min-1), with large effect sizes when considering TPF and estimated HRmax. The results of this study provide evidence of the applicability of HRratio in estimating VO2max in male adult/middle-aged recreational football players.Microplastics (MPs) in environmental studies have revealed that public sewage treatment plants are a common pathway for microplastics to reach local surroundings. Microplastics are becoming more of a worry, posing a danger to both marine wildlife and humans. These plastic items not only contribute to the macrocosmic proliferation of plastics but also the scattering of microplastics and the concentration of other micropollutant-containing objects, increasing the number of pollutants identified. Microplastics' behavior, movement, transformation, and persistence mechanisms, as well as their mode of action in various wastewater effluent treatment procedures, are still unknown. They are making microplastics made from wastewater a big deal. We know that microplastics enter wastewater treatment facilities (WWTPs), that wastewater is released into the atmosphere, and that this wastewater has been considered to represent a threat to habitats and ground character based on our literature assessment. The basic methods of wastewater and sewage sludge, as well as the treatment procedure and early characterization, are covered throughout the dissection of the problematic scientific conceptualization.