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In 2019, there were only two scientific publications on COVID-19. In 2020, the largest amount, 228 manuscripts, were published in Q1 journals, followed by 210 manuscripts in Q3 journals, and only 194 manuscripts were published in Q4 journals.

Currently, there is a notable increase in global academic production in Scopus on the impact of COVID-19 in dentistry, whereas Brazil is the only South American country with three highly productive universities.

Currently, there is a notable increase in global academic production in Scopus on the impact of COVID-19 in dentistry, whereas Brazil is the only South American country with three highly productive universities.

The aim of this article is to establish a comprehensive nation-wide prevalence of malocclusion traits on the sagittal, vertical, and transverse planes of space in Saudi Arabia.

A systematic search was conducted in three databases (Medline via PubMed, Embase, and Web of Science) and complemented with a manual search of Google Scholar and the reference list of included studies. Original studies of Saudi Arabian healthy individuals at any age were included. The quality and the risk of bias of the included studies were assessed using the Joanna Briggs Institute's appraisal tool. The data about the selected malocclusion traits on the sagittal, vertical, and transverse planes of space were extracted and pooled.

Out of 7163 identified titles, 11 studies were finally included. The risk of bias was high in two studies, moderate in eight studies, and low in one study. The studied age groups were from early childhood to late adulthood, with a total sample size of 19,169 participants. The majority of the studies reg with increased overjet and overbite, were among the most common malocclusion traits occurring in Saudi Arabia.

The purpose of this study was to establish a formula for cervical vertebral bone age (CVBA) based on the morphological changes of cervical vertebrae on cephalometric radiographs in Vietnamese subjects between 7 and 18 years of age.

This study included 180 children and adolescents (92 boys, 88 girls), between 7 and 18 years of age, selected from the craniofacial morphology studies of the Faculty of Odonto-Stomatology, Ho Chi Minh University of Medicine and Pharmacy. The cephalometric and hand-wrist radiographs of each subject were taken simultaneously and evaluated. Eleven hand-wrist skeletal maturity indicators of Fishman were grouped into five stages initiation and acceleration, transition, deceleration, maturation, and completion stage. A multivariate regression analysis was conducted to assess the correlation between the stages of hand-wrist BA and the morphological characteristics of the second, third, and fourth cervical vertebrae on the cephalometric radiographs.

A formula for CVBA was proposed as follows CVBA = 1.92+ 0.04 *

2 + 0.03 *

4 -1.12*AB3/BC3 + 3.17 * h4/w4, where

2 and

4 are anteroinferior border angles of C2 and C4; AB3/BC3 is the ratio of inferior to anterior dimension of C3; h4/w4 is the ratio of height to width of C4. The means and standard deviations of five stages of CVBA will be as follows CVBA I= 1.527 ± 0.906; CVBA II= 2.732 ± 0.568; CVBA III= 3.762 ± 0.589; CVBA IV= 5.077 ± 0.840; and CVBA V= 5.820 ± 0.661.

The quantitative CVBA method could be useful to assess the level of skeletal maturation in orthodontic and orthopedic treatments.

The quantitative CVBA method could be useful to assess the level of skeletal maturation in orthodontic and orthopedic treatments.

Several factors influence the development of white spot lesions (WSLs), and one of these is fixed orthodontic appliances. This study aims to evaluate the awareness, preventive strategies, and management of WSLs among a group of Orthodontists.

A qualitative methodology was applied; four focus groups made up a purposive sample from Orthodontists with various training backgrounds while working within the same healthcare services.

Three main themes emerged awareness and ability to diagnose WSLs, perceived influences on the development of WSLs, and prevention and management strategies and barriers to care delivery. All focus groups agreed that there is a need for continuous prevention and preventive strategies of WSLs, particularly among orthodontic patients. There was also a consensus that orthodontic treatment should be delayed until WSLs are managed appropriately.

Within the limitation of this study, WSLs were collectively agreed to be a significant issue during fixed orthodontic therapy, and continuous professional development for Orthodontists should include risk factors evaluation, diagnosis, prevention, and management of WSLs.

Within the limitation of this study, WSLs were collectively agreed to be a significant issue during fixed orthodontic therapy, and continuous professional development for Orthodontists should include risk factors evaluation, diagnosis, prevention, and management of WSLs.

A 10-year-old male neutered domestic shorthair cat from Quilmes (Province of Buenos Aires, Argentina) presented at the Infectious Diseases and Parasitology Unit with a hyperpigmented nodule of 5 cm diameter on the nasal plane with a small ulceration of more than 1 year's evolution. A scaly and hyperpigmented alopecic lesion of 3 cm in diameter was found on the lower edge of the tail. The patient was under immunosuppressive therapy with corticosteroids for lymphoplasmacytic duodenitis. Samples of the lesion present on the nasal plane were taken under a surgical procedure. In the wet mount preparations, pigmented irregular hyphae were observed. They developed dark colonies when cultured on Sabouraud medium. On micromorphology, structures compatible with

species were identified. PCR and sequencing of

(ITS1-5.8S-ITS2) confirmed

as the etiologic agent. A therapeutic scheme that included a combination of itraconazole oral solution (1.5 mg/kg PO q12h) with terbinafine (30 mg/kg PO q24h) was indicated for a period of 10 months. The patient died of complications resulting from its underlying disease.

As far as the authors are aware, this is the first study to report

as an etiologic agent of phaeohyphomycosis in cats. In this case study, the species was identified using molecular tests.

As far as the authors are aware, this is the first study to report P americana as an etiologic agent of phaeohyphomycosis in cats. In this case study, the species was identified using molecular tests.

A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy. Physical examination revealed pale pink mucous membranes and peripheral lymphadenomegaly. Haematology showed a regenerative anaemia (haematocrit 19.3%, reticulocyte count 118.08 ×10

/l), and saline agglutination was positive. Infectious disease screening was negative and lymph node cytology was consistent with reactive lymphoid hyperplasia. ISX-9 research buy A diagnosis of phenobarbital-induced reactive lymphoid hyperplasia and immune-mediated anaemia was suspected. Complete resolution of the lymphadenomegaly and anaemia was documented within 4 weeks of phenobarbital discontinuation.

There are limited case reports of phenobarbital-induced haematological changes and lymphadenomegaly; however, the combination has not previously been reported in cats and is similar to the rare but significant syndrome in humans known as 'anticonvulsant hypersensitivity syndrome'. Anticonvulsant hypersensitivities should be considered as a potentially serious, yet reversible, sequela to phenobarbital treatment that may be mistaken for more severe illness such as neoplasia.

There are limited case reports of phenobarbital-induced haematological changes and lymphadenomegaly; however, the combination has not previously been reported in cats and is similar to the rare but significant syndrome in humans known as 'anticonvulsant hypersensitivity syndrome'. Anticonvulsant hypersensitivities should be considered as a potentially serious, yet reversible, sequela to phenobarbital treatment that may be mistaken for more severe illness such as neoplasia.As a result of the COVID-19 pandemic, individuals with neurodevelopmental disabilities (NDD) are engaging more with others in virtual group formats for social, educational, and professional reasons. This study extends prior research by evaluating the efficacy of common behavioral interventions, including behavioral skills training, provided via group video conferencing to teach skills that are important when interacting with others in a virtual format. Four adults with NDD were taught to use their cameras and microphones appropriately and to make encouraging statements to one another while discussing current events and social skills-based lessons via Zoom™. Two of the three skills increased and maintained for all participants even after the experimenter faded the contingencies for appropriate responding. The third skill maintained after the experimenter arranged for the response to produce natural consequences. Tests for generalization across group leads and activities yielded promising results. Findings suggest that adults with NDD benefit from group-based telehealth services to improve skills needed to interact successfully with others in a virtual format.The Covid-19 pandemic has highlighted global knowledge about, but lack of equitable access to, life-changing medicines, and other innovative medical products by populations in African low and middle income countries. The World Health Organization (WHO) and other international non-profit foundations and organizations are constantly striving to address inequity. In the 1970s, WHO initiated a regularly updated essential medicines list, together with the concept of national medicines policies (NMPs) to ensure access and availability, affordability, rational, and effective use of medicines which are considered essential in addressing predominant population health issues and disease burden. We studied the NMPs of Ghana, South Africa, Uganda and Zimbabwe to highlight some of the important issues that these countries experience in the safe and effective use of medical products. Thailand is an example of how health technology assessment (HTA) can provide a country with an internationally supported, clearly defined and transparent process to broaden access to medicines and services. These medical services can add considerable value in accordance with local values and priorities. Involvement of civil society adds democratic legitimacy to such processes. Community health workers and patient advocacy groups are important in raising awareness and knowledge of safety issues and the effective use of quality medicines. They can apply pressure for increased funding to improve access to healthcare. Medicines and services that contribute to supported self-care are of benefit in any setting. Joint efforts across African countries such as with the African Medicines Agency are important in addressing some of the major health issues.Health technology assessment (HTA) aims to be a systematic, transparent, unbiased synthesis of clinical efficacy, safety, and value of medical products (MPs) to help policymakers, payers, clinicians, and industry to make informed decisions. The evidence available for HTA has gaps-impeding timely prediction of the individual long-term effect in real clinical practice. Also, appraisal of an MP needs cross-stakeholder communication and engagement. Both aspects may benefit from extended use of modeling and simulation. Modeling is used in HTA for data-synthesis and health-economic projections. In parallel, regulatory consideration of model informed drug development (MIDD) has brought attention to mechanistic modeling techniques that could in fact be relevant for HTA. The ability to extrapolate and generate personalized predictions renders the mechanistic MIDD approaches suitable to support translation between clinical trial data into real-world evidence. In this perspective, we therefore discuss concrete examples of how mechanistic models could address HTA-related questions.

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