Vasquezbeard5453
0013), 0.32 in TV+ (p = 0.41), 0.45 in coinfection (p = 0.55). RR for progression was 1.92 in GV + and/or TV+ (p = 0.22), 1.34 in GV+ (p = 0.68), 1.16 in TV+ (p = 0.91), 8.39 in coinfection (p = 0.0002). In conclusion, GV infection may be a risk factor for CIN1/L-SIL persistence. TV infection alone does not significantly affect the risk of persistence or progression of such lesions, while it may greatly increase the risk of progression when associated with GV infection.
COVID-19 severity and mortality are elevated in individuals with diabetes. During the pandemic, interventions recommended globally for people with diabetes were to keep blood glucose on target whilst staying at home to curb the spread of the virus. In Brazil, similar measures were proposed. The aim of our observational study was to assess whether these measures achieved their objectives.
An anonymous and untraceable survey was shared from April 22nd to May 4th. States with more than 30 respondents were included in the analysis and Fisher's exact test was performed to identify associations, with p<0.05 considered significant.
Type 1 diabetes and female participants were prevalent, 60.76% and 76.12% respectively. 10 out of 26 states were included, in addition to the Federal District (1562 responses). Only in three states (Bahia, Goiás and Pernambuco) less than 50% of the respondents experienced higher glycemia or higher variability during the pandemic. Goiás state, where almost half of the respondents (49.12%) have private insurance, presented the highest percentage of individuals receiving medicines for three months (35.48%) and one of the lowest percentages of blood glucose deterioration (47.17%). In the large states of Minas Gerais, Rio de Janeiro and São Paulo, consultations and/or lab exams were postponed by 37.14%, 34.33% and 40.88%, respectively.
The decentralized measures implemented by states in Brazil left most people with diabetes unprotected. Many were forced to venture outside to collect or to purchase their medical supplies monthly and reported increased glycemic levels and/or variability.
The decentralized measures implemented by states in Brazil left most people with diabetes unprotected. Many were forced to venture outside to collect or to purchase their medical supplies monthly and reported increased glycemic levels and/or variability.This paper describes the fabrication of antifouling surfaces by the combination of topography and peptide chemistry. The topography of the surface mimics the skin of the shark that can resist biofouling by having a certain microtopography. A peptide-based coating that resists fouling self-assembles on these surfaces. In biofilm formation assays, performed under static conditions, the resulting combination (micropattern with peptide coating) has superior antifouling properties against the Gram-negative and Gram-positive strains tested (Escherichia coli and Staphylococcus epidermidis, respectively) when compared to both micropatterned and peptide-coated surfaces. The same behavior was observed in dynamic assays performed in a parallel plate flow chamber (PPFC) setup, where E. coli could not attach to the micropatterned surface coated with peptide during the 30 min of initial adhesion. These assays, mimicking physiological shear stress conditions, suggest that the peptide-coated surface with micropatterned topography may be promising in reducing adhesion and subsequent biofilm formation in biomedical devices such as urinary catheters and stents, and cardiovascular, dental and orthopedic implants.
Peptide receptor radionuclide therapy (PRRT) has been proven to be effective in gastro-entero-pancreatic neuroendocrine tumours (NETs) using
Yttrium (
Y)- or
Lutetium (
Lu)-based somatostatin peptides, with
Lu-DOTATATE recently licensed. There is less published evidence of PRRT in metastatic bronchial NETs.
The aim of this study was to evaluate the efficacy, safety and toxicity of PRRT in patients with bronchial NETs, to expand the evidence base in this rare type of tumour.
This was a retrospective analysis of all patients with moderate to well-differentiated typical or atypical bronchial NETs treated at the Royal Free Hospital Nuclear Medicine Department with at least two cycles of
Y-DOTA-OCTREOTATE and/or
Lu-DOTA-OCTREOTATE between 2009 and 2020. Response rates, progression free survival (PFS), overall survival and toxicity were evaluated. Factors associated with treatment response were evaluated.
Of the 25 patients with bronchial NETs treated with PRRT in our department between 2009-2020, 7 (28 %) had
Y-DOTATATE and 18 (72 %) had
Lu-DOTATATE. 44 % of patients had PRRT as third, fourth of fifth line treatment. 72 % of patients had liver metastases and 76 % skeletal metastases at baseline. Median progression-free survival (PFS) was 17 months (
Lu-DOTATATE = 18 months;
Y-DOTATATE = 12 months) and the median overall survival was 42 months. High proliferation rate (ki-67 > 20) and low somatostatin receptor (SSR) uptake (score of 2) were associated with shorter PFS.
PRRT appears to be a safe treatment in somatostatin receptor positive bronchial NETs, even in patients who have been heavily pre-treated. The efficacy of PRRT is comparable with if not favourable to other systemic therapeutic options.
PRRT appears to be a safe treatment in somatostatin receptor positive bronchial NETs, even in patients who have been heavily pre-treated. The efficacy of PRRT is comparable with if not favourable to other systemic therapeutic options.
This national cross-sectional survey aimed to assess the iodine status in pregnant women and their offspring, and also to demonstrate regional differences by measuring urinary iodine concentration (UIC). For each woman and her newborn a questionnaire was prepared with basic facts as age, parity number or birth weight and additional information regarding thyroid diseases, use of iodized salt in the household, extra iodine supplementation during pregnancy, education level and wage income.
The target population represented 1444 pregnant women who gave birth between January 1 st, 2018 and 2019, and their offspring. Iodine deficiency for pregnant women and their offspring were defined as urine iodine level <150 μg/L and <100 μg/L, respectively. Results are given as median (25th-75th percentile).
The median UIC in the group of pregnant woman was 94 (52-153) μg/L. Within the sample of 1444 pregnant women, UIC indicative of mild iodine deficiency (100-149 μg/L) was present in 21 % (n = 306), moderate defi drastic measures should be taken to decrease these important iodine deficiencies, both in pregnant women and in their offspring.
Our findings suggest that iodine deficiency is still an important public health problem in Turkey. More drastic measures should be taken to decrease these important iodine deficiencies, both in pregnant women and in their offspring.The gonadotropin compound, PG600, is used to induce estrus in prepubertal gilts, but responses can be variable. This study was conducted to evaluate PG600 effects on follicles, estrus, ovulation and estrogen production. Prepubertal gilts (n = 50) were treated with PG600. Gilts were evaluated for estrus while daily boar exposure was occurring. A sub-population of gilts (n = 12) were slaughtered on Day 3 to assess cytochrome P450 aromatase (CYP19) immunohistochemical staining in ovarian antral follicles. Ovaries of the remaining gilts (n = 38) were evaluated on Day 3 using ultrasonography and blood samples were collected for quantifying estradiol-17β. On Day 3 following administration of PG600, 94.0 % of gilts had large follicles, but only 76.3 % had expressed behavioral estrus by Day 6. Furthermore, 92.1 % of gilts had ovulations, with 16.6 corpora lutea/gilt. There was no association of number of large follicles on Day 0 or 3 with occurrence of estrus or ovulation (P > 0.05). Estradiol-17β concentrations on Day 3 did not differ (P > 0.05) in anestrus compared to estrual gilts and varied in gilts with large antral follicles. Immuno-detection of CYP19 on Day 3 was greater (P less then 0.01) in large and medium compared to small follicles, (64.3 %, 34.2 % and 14.7 %, respectively). Results validate there is a dissociation of large follicle development with estrogen production on Day 3 in gonadotropin-treated gilts. These results indicate failure to express estrus may be due to follicle variation in estrogen production or response to estrogen feedback at the hypothalamus.This study was conducted to assess effects of different doses of pFSH on follicular recruitment, superovulatory response, ova/embryo recovery, and embryo yield in lactating ewes. check details Ewes (n = 24) had a superovulation treatment regimen imposed. All ewes were implanted with a progesterone intravaginal device for 9 d, and administered either 100 (G-100) or 200 (G-200) mg pFSH, proportioned into six doses administered at 12-h intervals, starting 60 h before device removal. At 7 days subsequent to progesterone device removal, there were non-surgical embryo recoveries (NSER) from ewes having three or more corpora lutea. At the time of the first pFSH injection, number of antral follicles were similar (P 0.05). Viable embryo numbers and ova/embryo recovery rate were greater (P less then 0.05) in ewes of the G-200 (6.9 ± 1.1 and 67.8 %) than G-100 (1.0 ± 0.5 and 27.6 %) group. A dose of 200 mg pFSH was more effective in inducing a superovulatory response and embryo yield after NSER in ewes, however, the 100 mg dose was insufficient for these purposes.Harmful algal blooms produced by the phytoplankton species Karenia brevis and its associated neurotoxin, brevetoxin (PbTx), occur throughout the Gulf of Mexico and have had devastating impacts on co-occurring populations of bottlenose dolphins (Tursiops truncatus), an important marine sentinel species. The majority of documented impacts, however, are from the eastern Gulf of Mexico, with a critical lack of information on the degree and frequency of PbTx exposure in bottlenose dolphins from Texas coastal waters. This study documents PbTx exposure in Texas bottlenose dolphins between 2007 and 2017 and their association with co-occurring K. brevis blooms. PbTx was detected in 60% (n = 112) of the animals tested. Liver tissue samples had the highest frequency of detection (62%), followed by feces (41.4%) and gastric contents (30.4%). PbTx was not detected in urine or intestinal tissue. The concentration ranges of PbTx detected in feces (1.2-216, mean 38.4 ng/g), gastric contents (3.3-1016, mean 158 ng/g) and liver (0.6-52.4, mean 8.5 ng/g) samples were an order of magnitude less than values reported for Florida dolphins for the same sample types. The proportion of dolphins recovered within 4 weeks of a bloom that tested positive for PbTx ('Bloom' group; 75%) was significantly higher compared to those that were recovered 5-8 weeks after termination of a bloom ('Post-Bloom' group; 36%; p = 0.004). The proportion of PbTx-positive animals with no observed bloom association ('Baseline' group; 60%) was also significantly greater than the Post-Bloom group (p = 0.012). No significant difference in proportion of PbTx-positive animals was detected between Bloom and Baseline groups (p = 0.242). No significant differences in liver PbTx concentrations were observed between any pairwise combinations of the 3 exposure groups (p = 0.261). Overall, these findings suggest persistent PbTx exposure for many individuals in these populations, although the health impacts of such exposure are not known.
