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the total number of cases were 18; eight males and ten females, the age range was between three months and 12 years. Of the eight HLH-2004 diagnostic criteria, all patients met at least five criteria. We detected PRF1 gene mutation in 38.9% (7 patients) with nine previously unreported mutations. Sixteen patients (88.9%) received HLH-2004 treatment protocol and the remaining two patients died before initiation of treatment. The overall mortality was 72.2% (13 patients).

our results increase the awareness of clinical and laboratory characterizations of pediatric HLH patients and the prevalence of PRF1 gene mutations among those patients.

our results increase the awareness of clinical and laboratory characterizations of pediatric HLH patients and the prevalence of PRF1 gene mutations among those patients.Congenital hernia of the diaphragmatic dome (CDC) is a congenital embryopathy where all or part of the diaphragmatic dome fails to form. Its rate is 1/3500 live births with a male predominance. This study reports a case of Bochdalek hernia as well as data in the literature and highlights the diagnostic and therapeutic challenges in this disease. Diagnosis and antenatal management are essential to reduce patient's mortality and morbidity. Prognosis is poor and depends on the presence and degree of pulmonary hypoplasia and on the association with congenital malformations.

HIV, hepatitis B and hepatitis C pose a public health challenge in sub-Saharan Africa and there are only few studies on co-infection of these viruses done in rural areas in Northern Nigeria. This study provides a rural perspective on HIV-hepatitis co-infection in a Northern Nigerian community.

this cross-sectional study was carried out amongst people living with HIV/AIDS (PLWHA) in a rural community hospital over a three-month period. Socio-demographic data and other relevant information were obtained from the participants and case notes using an interviewer-administered questionnaire. Hepatitis B surface antigen and antibody to Hepatitis C virus were assayed from serum using enzyme-linked immunosorbent assay (ELISA) kits developed by LabACON®. Chi-square test was used to compare categorical variables and logistic regression modelling was used to determine correlates of co-infection in the population.

a total of 281 individuals participated in the study. The prevalence of Hepatitis B co-infection, Hepats include lack of formal education and being married. There is need for provider-initiated routine counselling and screening of PLWHA for viral hepatitis, with adequate follow-up and treatment of co-infected individuals and Hepatitis B vaccination for those without co-infection.

intravenous thrombolysis with recombinant tissue plasminogen activator (rTPA) is an approved treatment for acute ischaemic stroke (AIS). However, its use remains low. We aimed to assess the eligibility of thrombolysis for our patients with AIS before implementing this treatment method in our teaching hospital.

we conducted a prospective cross-sectional study in the emergency department of Casablanca University Hospital. We included every patient admitted for a stroke-related symptom. Delays between symptom-onset and admission and delays regarding the in-hospital evaluation of patients were recorded. IRAK-1-4 Inhibitor I cell line Patients eligible for intravenous thrombolytic therapy were identified according to American Heart Association guidelines.

in all, 463 patients were included. Only 8.42% of patients were eligible for thrombolysis; 74% of patients were ineligible because of an onset-to-thrombolysis delay longer than 4.5 hours. Mean onset-to-thrombolysis time was 27.2 hours. Patients were admitted with a mean delay of 24.9 hou general public to the neurovascular unit.

fever is the primary symptom of most childhood illnesses and a cause of concern to their caregivers. The antipyretics commonly used to treat fever are ibuprofen and paracetamol. Most studies on the effectiveness of ibuprofen and paracetamol in treating fever in under-fives were conducted in Europe and North America with very few in African children. This study was aimed at assessing the effectiveness and safety of a single dose therapy of ibuprofen versus paracetamol for treating childhood fever in Nigeria.

a randomized, controlled clinical trial was conducted in the University of Calabar Teaching Hospital, in Nigeria. A total of 140 eligible children aged 6-59 months with tympanic temperature of 38°C-40°C were enrolled, and 70 of them were assigned to one arm that received a single dose of ibuprofen (10mg/kg) and 70 had paracetamol (15mg/kg). After drug administration, the children were admitted and observed in the hospital for six hours during which period a half-hourly temperature measurement and monitoring for adverse events were done.

the overall result showed that ibuprofen had a better fever reducing effect compared to paracetamol. The proportion of afebrile children in the ibuprofen versus paracetamol group at 1.5-2.5 hours of administration of the drugs was statistically significant (p = 0.04). The adverse events of both drugs were mild and quite comparable with vomiting being the commonest.

ibuprofen is more effective in the treating fever in under-fives compared to paracetamol. The adverse events of both drugs were mild and comparable.

ibuprofen is more effective in the treating fever in under-fives compared to paracetamol. The adverse events of both drugs were mild and comparable.Condylomata acuminata are sexually transmitted lesions caused by human papillomavirus. They mainly occur in the anogenital area and exceptionally in the nasal cavity. We here report a new case of uncommon detection. The study involved a HIV-positive female patient with recurrence of vulvar condylomata acuminata treated in the department of gynecology. She was referred to our department with pink masses in the nasal cavity preventing nasal breathing and evolving over several weeks. Clinical examination and computerized tomography (CT) scan suggested condylomata. Surgical treatment was performed under general anesthesia and endoscopic control; the histological examination showed condylomata acuminata. The postoperative course was simple, with no recurrence after 6 months of follow-up. Condylomata acuminata in the nasal cavity are rare or even exceptional; only very few cases have been described in the literature. They commonly affect young subjects with or without HIV infection, having sexual risk behavior and can occur in several areas, in particular in the genital area. In this case, nasal lesions could result from hand-mediated transfer. Surgical treatment is effective and long-term follow-up is essential to treat possible recurrences.Advanced liver disease is associated with several haemostatic alterations which can lead to either thrombosis or bleeding complications. Spontaneous muscle haematomas although a rare complication of liver cirrhosis is increasingly being described in the literature and hyperfibrinolysis is an emerging plausible pathophysiological mechanism. We describe a patient who presented with a life threatening spontaneous haematoma in his gastrocnemius muscle that required treatment with antifibrinolytic therapy to control further bleeding.

episiotomy induced inflammatory signs like redness, edema, ecchymosis and pain may remain beyond the period of hospitalization and can be objectively measured using redness, edema, ecchymosis, discharge and apposition (REEDA) scale. Pain in the postpartum period is a common problem and can be measured using the numerical pain scale (NPS). Episiotomy is normally poorly executed and poorly repaired with little attention to the subtle pain-free scar. Postpartum perineal pain has been found to affect more people with episiotomy compared to spontaneous perineal tears or contusion in the first two weeks. This study was aimed at comparing NPS and REEDA scores in the first two weeks of postpartum among primiparous parturients with or without episiotomy in Mulago National Referral Hospital.

a prospective cohort study conducted by recruiting primiparous women systematically on the first postnatal day and categorizing them into episiotomy and no episiotomy group. NPS and REEDA scale were taken at baseline and 2 weeks postpartum.

the mean total REEDA score for primiparous women among the episiotomy group was significantly higher both on day 1 and day 14 with p-values <0.0001 and <0.0001 respectively as well as the day 14 mean NPS p-value 0.001.

episiotomy, a traumatic obstetric procedure, that heals slowly and with persistent perineal pain compare to spontaneous perineal contusion or tears.

episiotomy, a traumatic obstetric procedure, that heals slowly and with persistent perineal pain compare to spontaneous perineal contusion or tears.

complete joint fractures of the lower end of the humerus are rare and severe injuries in adults, affecting the functional prognosis of a narrow and complex joint such as the elbow. Multiple therapeutic options are available, but osteosynthesis is widely used provided that it can recover stable, mobile, and painless joint. The purpose of our study was to describe the epidemiological, clinical, radiological and therapeutic features of these fractures, as well as to evaluate functional outcomes in our patients.

we conducted a 3-year prospective study (January 2014-December 2016) of 38 patients older than 16 years admitted with complete sub- and intercondylar joint fracture of the lower extremity of the humerus (classified as type C according to the AO classification). They underwent surgery via transolecranian posterior approach with fixation of one or two screw plates based on anatomopathological diagnosis. Patients were followed-up for a mean period of 34 months.

these conditions had bimodal distribution subjects on the other. The main cause of fractures was road accidents (78%). During the follow-up period, one case had superficial surgical site infection and there were no cases of dismantling of equipment or pseudarthrosis. No complications after osteosynthesis for olecranon fractures were recorded in our case series. Stiffness at the elbow-joint was defined as bending/extension arc less than 50°; elbow stiffness was found in 25% of patients. Functional results were assessed using the Mayo-Clinic or Mayo-Clinic Elbow Performance Score (MEPS) with an average score of 86. Conclusion based on our results, transolecranon posterior approach is the best option for these fractures, since it allows good joint exposure. This is essential for perfect anatomical restitution and stable osteosynthesis in order to undertake early and adapted rehabilitation.

intimate partner violence (IPV) is a global public health problem of human rights concern. It is a global issue, regardless of social, economic, religious or cultural group. Ever experienced IPV is a risk factor for many acute and chronic diseases and or stress-related conditions among women. This study determined the prevalence and predictors of lifetime IPV among women in an urban community in Lagos, Nigeria.

a descriptive cross-sectional study was conducted among 400 respondents from April to September 2019. An interviewer-administered questionnaire was used to obtain information from respondents. Data analysis was done using SPSS Version 22. Descriptive analyses were performed. Associations were explored with Chi-square test; multivariate analysis was done with logistic regression at p≤5% level of significance (95% CI).

a total of 400 adult women aged 18-73 years who have been in an intimate relationship for at least 1 year participated in this study. The mean ± SD age of the respondents was 36.72 ± 11.