Tysoncobb9985

Hepatocellular carcinoma (HCC), a common type of human malignancies, leads to increasing incidence and fairly high mortality. read more An increasing number of studies have verified that long noncoding RNAs (lncRNAs) played key roles in the development of multiple human cancers. As a biomarker, SLC16A1-AS1 has been reported in non-small cell lung cancer (NSCLC) and oral squamous cell carcinoma (OSCC). Thus, we decided to investigate whether SLC16A1-AS1 exerts its biological function in HCC. In this study, we discovered that SLC16A1-AS1 was obviously downregulated in HCC tissues and cells. Overexpression of SLC16A1-AS1 inhibited HCC cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) process as well as promoted cell apoptosis. Moreover, SLC16A1-AS1 was confirmed to enhance the radiosensitivity of HCC cells. Molecular mechanism exploration suggested that SLC16A1-AS1 served as a sponge for miR-301b-3p and CHD5 was the downstream target gene of miR-301b-3p in HCC cells. Rescue assays implied that CHD5 knockdown could recover the effects of SLC16A1-AS1 overexpression on HCC cellular processes. In brief, our study clarified that SLC16A1-AS1 acted as a tumor suppressor in HCC by targeting the miR-301b-3p/CHD5 axis, which may be a promising diagnostic biomarker and provide promising treatment for HCC patients.Biomass waste contributes 14% of the total global energy. And 15-20% of the coal-fine waste from coal mines are deposited in the rivers, ponds, etc., unused, which leads to resource wastage and environmental pollution. The present study aims utilizing biomass and coal-fine waste for producing biomass-coal briquettes without using a binding material. Three different average sizes 50, 134.3, and 199.7 μm of biomass mixture (bagasse, groundnut shell, and woodchips) and coal-fines were used to make different ratios of biomass and coal mixture briquettes. Then, it is subjected to proximate, scanning electron microscope/elemental (SEM/EDX) and thermo-gravimetric analysis (TGA) to understand its property. Proximate analysis results revealed that the biomass waste has the low ash, sensible fixed carbon, and high volatile matter content. A briquette of biomass coal = 71 ratio 50-μm particle size case was chosen for SEM/EDX and TGA analysis since it holds reasonable fixed carbon value comparatively. SEM analysis revealed irregular surfaces, cracks, cavities and longitudinal cracks, veins distribution all around, ups and shallows on the surface and it is the most favorable condition for fuel combustion since oxidant reaches the core of the fuel with less resistant. TGA reconfirms the spontaneous burning characteristics of the entire volatiles and fixed carbon. EDX analysis shows that the carbon and potassium are the two major elements present in the tested briquettes.This study attempts to construct an econometric model using China's natural disaster losses and macro-industry development data from 1980 to 2017 to explore the macroeconomic fluctuations caused by natural disasters. The structural vector autoregressive (SVAR) and the seemingly unrelated regression (SUR) models are employed in estimating the impact of natural disasters on China's macroeconomy and how the disasters specifically affect the three sectors of the economy primary, secondary, and tertiary. This study concludes that even though natural disasters in China do not significantly affect the overall real GDP, they have adverse impacts on the production in the primary industry, causing a sudden reduction in the means of production in the market and directly affecting various industries, but the impact on the secondary and tertiary industries is weak. This study also shows that the effect of natural disasters on the primary sector reduced significantly following industry restructuring after China's accession to the World Trade Organization (WTO). The impact of natural disasters on the primary industry could be reduced by adjusting the industrial structure to deal with macroeconomic shocks caused by natural disasters in order to promote macroeconomic stability of both regional and national economies. Finally, national aid policy should focus on the primary industry since that sector is significantly affected by natural disasters shocks.Metalloids are a subset of particular concern to risk assessors and toxicologists because of their well-documented potential hazards to plant system. Most of the metalloids are major environmental contaminants which affect crop productivity when present in high concentrations in soil. Metalloids are coupled with carrier proteins of the plasma membrane and translocated to various organs causing changes in key metabolic processes, damages cell biomolecules, and finally inhibit its growth. Phytoremediation-based approaches help in understanding the molecular and biochemical mechanisms for prerequisite recombinant genetic approaches. Recent advancements in proteomics and plant genomics help in understanding the role of transcription factors, metabolites, and genes in plant system which confers metal tolerance. The present review summarizes our current status of knowledge in this direction related to various physiological responses, detoxification mechanisms, and remediation strategies of metalloids in crop plants in relation to plant-metalloid tolerance. Further, the role of various transcription factors and miRNAs in conferring metal tolerance is also briefed. Hence, the present review mainly focused on the alterations in the physiological activities of plants due to metalloid toxicity and the various mechanisms which get activated inside the plants to mitigate their toxic effects.Ecotoxicological bioassays have been widely applied to evaluate the toxicity of substances in standardized test organisms. Nevertheless, the main challenge for researchers is the use of native species to express the effects of pollutants on aquatic biota. Thirty years ago, Smith and collaborators evaluate the possible use of Pristina longiseta (as Pristina leidyi) in acute toxicity test, developing some experiments using cadmium and vanadium as toxicants. The present work aimed to update the use of P. longiseta, in acute bioassays, presenting the occurrence and general characteristics of the species; adaptation of cultivation to tropical conditions; sensitivity tests using potassium chloride (KCl) and copper sulfate (CuSO4) as reference substances standardized by OECD, USEPA, and ABNT; and acute exposure to zinc chloride (ZnCl2). The results showed a successful use of this species as tropical test organism, which presented easy laboratory rearing and responded to the classical ecotoxicological index. The present study can increase the utilization of P.