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Furthermore, LbL coating on droplets utilizing the presented strategy is implemented in the parallel coating-chemical and washing streams to obtain multiple layers of microcapsules. The linearly increasing fluorescence intensity of the coated droplets with each subsequent fluorescent coating demonstrates the capability of the tilted-angle dielectrophoretic medium exchanger for on-chip generation of LbL microcapsules on demand. The presented medium exchange strategy, together with its unique features of simple geometric configuration, facile control and multifunctionality, can provide a refined alternative for further expanding the utility scope in functional particles and cells.A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host-guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.Ammonia is one of the most useful chemicals for the fertilizer industry and is also promising as an important energy carrier for fuel cell application, and is currently mostly produced by the traditional Haber-Bosch process under high temperature and pressure conditions. This energy-intensive process is detrimental to the environment due to the dependence on fossil fuels and the emission of significant greenhouse gases (such as CO2). Ammonia production via the electrochemical nitrogen reduction reaction (ENRR) has been recognized as a green sustainable alternative to the Haber-Bosch process in recent years. Current ENRR research mainly focuses on the catalyst for ammonia selective production and the enhancement of faradaic efficiency at high current density; however, these have not been explored well due to the unavailability of highly efficient and cheap catalysts. Herein, this review provides information on the ENRR process along with (i) theoretical background, (ii) experimental methodology of the electrocatalytic process and (iii) computational screening of promising catalysts. The impact of active sites and defects on the activity, selectivity, and stability of the catalysts is deeply understood. Telaglenastat Furthermore, we demonstrate the mechanistic understanding of the ENRR process on the surface of catalysts, with the aim of boosting the improvement of the ENRR activities. The ammonia detection methods are also summarized along with thorough discussion of control experiments. Finally, this review highlights prevailing problems in existing ENRR methods of ammonia production along with technical advancements proposed to address these issues and concludes with comments on opportunities and future directions of the ENRR process.We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and controlled toward Darwinian evolution in RNA reaction networks.Understanding the relationship between charge mobilities and the molecular stacking structures of π-conjugated organic semiconducting materials is essential for their development. In this study, a quantum mechanics (QM)-derived state-specific polarizable force field (SS-PFF) is applied to explicitly estimate the external reorganization energies (λext) during electron transfer (ET) or hole transfer (HT) processes using our recently proposed two-point model (J. Phys. Chem. A, 2018, 122, 8957-8964). Different from the Marcus two-sphere model, the application of the explicit two-point model produces a notably asymmetric λext for ET and HT processes in oligoacene crystals. For the same charge transfer channels, the λext of ET is 7-10 times higher than that of HT, which results in a larger intrinsic hole mobility. This successfully rationalizes why acenes are prone to be p-type conducting materials. Perfluorination can change the polarity of the molecular surface electrostatic potential (ESP). Thus, perfluorination is a possible approach to reduce the external reorganization energies for ET reactions, which can be used to tune the order of λext of ET and HT processes. The two-point model with the SS-PFF, therefore, opens the door to revisit the intrinsic mobilities of electrons and holes in organic semiconductors.Cell membranes - primarily composed of lipids, sterols, and proteins - form a dynamic interface between living cells and their environment. They act as a mechanical barrier around the cell while selectively facilitating material transport, signal transduction, and various other functions necessary for the cell viability. The complex functionality of cell membranes and the hierarchical motions and responses they exhibit demand a thorough understanding of the origin of different membrane dynamics and how they are influenced by molecular additives and environmental cues. These dynamic modes include single-molecule diffusion, thermal fluctuations, and large-scale membrane deformations, to name a few. This review highlights advances in investigating structure-driven dynamics associated with model cell membranes, with a particular focus on insights gained from neutron scattering and spectroscopy experiments. We discuss the uniqueness of neutron contrast variation and its remarkable potential in probing selective membrane structure and dynamics on spatial and temporal scales over which key biological functions occur. We also present a summary of current and future opportunities in synergistic combinations of neutron scattering with molecular dynamics (MD) simulations to gain further understanding of the molecular mechanisms underlying complex membrane functions.Correction for 'Engineering strategies for rational polyketide synthase design' by Maja Klaus et al., Nat. Prod. Rep., 2018, 35, 1070-1081, DOI 10.1039/C8NP00030A.