Tonnesenmalone3180
A systematic review and meta-analysis were performed to compare the effects of high-flow nasal oxygen cannula (HFNC) and noninvasive ventilation (NIV) in extubated patients with respiratory insufficiency.
The Cochrane Library, PubMed, and ClinicalTrials.gov were searched from inception to 28 February 2021, to identify randomized controlled trials. The primary outcome was reintubation within 24-72hours after a planned extubation. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
Six articles with1746 patients were included. The effect of HFNC on the reintubation rate was noninferior to that of NIV (OR= 1.11, 95% CI 0.85-1.44). The rate of treatment failure was 20.40% with HFNC versus 20.92% with NIV; this difference was nonsignificant (OR= 0.97, 95% CI 0.72-1.32,
= 0.85). HFNC reduced the rates of skin lesion occurrence (10.28% versus 23.82%, OR= 0.37, 95% CI 0.26-0.53,
< 0.00001) and post-extubation respiratory failure (23.76% versus 25.56%, OR= 0.64, 95% CI 0.46-0.88,
= 0.006), compared with NIV.
In extubated patients, HFNC was noninferior to NIV in the rate of reintubation and treatment failure. Compared with NIV, HFNC decreased the occurrence of skin lesions and post-extubation respiratory failure.
In extubated patients, HFNC was noninferior to NIV in the rate of reintubation and treatment failure. Compared with NIV, HFNC decreased the occurrence of skin lesions and post-extubation respiratory failure.2β,3α,19-Triacetoxy-17-hydroxyspongia-13(16),14-diene (1), a novel acetoxy diterpenoid, and 18-nor-2,17-hydroxyspongia-1,4,13(16),14-quaien-3-one (2), belonging to the rare 18-nor-spongian carbon skeleton, together with six related known metabolites (3‒8), were isolated from the aquaculture Spongia officinalis Linnaeus, 1759. Their structures were elucidated by comprehensive spectroscopic analysis, quantum chemical calculation of NMR parameters, and electronic circular dichroism (ECD). Compounds 3, 4, and 5 exhibited moderate inhibition against STAT3/NF-κB, HIF-1, Wnt signalling pathways. Compounds 1, 3, and 5 showed cytotoxicity activities against K562 cell line with IC50 values of 7.3, 3.5, and 6.4 μM, respectively.
Until the late 1980s, acute promyelocytic leukemia (APL) was the most rapidly fatal leukemia; however, nowadays, it is a curable disease with survival rates exceeding 90-95%. The improvement of APL outcome is mainly due to two agents, which target the typical translocation t(15;17) and its fusion transcript
α responsible for initiating and maintaining the disease all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). The story of APL represents a pioneering model for the development of precision medicine and curative chemotherapy-free approaches for acute leukemia.
The authors examine the major advances in the treatment of patients with APL focusing on three different eras 1) the pre-ATRA era; 2) the ATRA era; 3) the ATO era.
The combination of ATRA and ATO is effective and curative for the majority of APL patients. It has been approved for low/intermediate risk cases while an experimental trial with a minimal addition of chemotherapy for high-risk ones is ongoing. Disease relapse is infrequent and can be cured with ATRA-ATO rechallenging, with or without subsequent transplantation depending on the interval between complete remission and relapse. New therapeutic landscapes contemplate the use of an oral chemo-free ATRA-ATO combination, implementing treatment as outpatient care, thus increasing quality of life and decreasing medical costs.
The combination of ATRA and ATO is effective and curative for the majority of APL patients. It has been approved for low/intermediate risk cases while an experimental trial with a minimal addition of chemotherapy for high-risk ones is ongoing. Disease relapse is infrequent and can be cured with ATRA-ATO rechallenging, with or without subsequent transplantation depending on the interval between complete remission and relapse. New therapeutic landscapes contemplate the use of an oral chemo-free ATRA-ATO combination, implementing treatment as outpatient care, thus increasing quality of life and decreasing medical costs.Two new coumarin glycosides, named 7-methoxy isoarnottinin 4'-O-β-ᴅ-glucopyranoside and 7-methoxy isoarnottinin 4'-O-rutinoside (1 and 2) along with six known compounds (3-8) were isolated from the roots of Prangos heyniae, an endemic plant of Turkey. Navoximod chemical structure 1-methylethyl 6-O-D-apio-β-ᴅ-furanosyl-β-ᴅ-glucopyranoside (7) and cnidioside A (8) have been obtained from the genus Prangos for the first time. Structures of isolated compounds were established using spectroscopic methods (1 D and 2 D NMR, HR-MS, UV and IR). Moreover, all extracts and isolated compounds were evaluated for their cytotoxic activity against NIH/3T3, HK-2, A-549, MCF-7, PC-3 and SH-SY5Y cell lines by WST-1 method. One of the new coumarin glycosides, 7-methoxy isoarnottinin 4'-O-β-ᴅ-glucopyranoside (1) exhibited selective cytotoxic activity against SH-SY5Y cells with IC50 value of 31.41 ± 1.04 μM.Soil salinity is considered one of the main types of soil degradation in semiarid environments around the globe. This work aims to evaluate the effectiveness of soil conditioners to enhance the growth and salt extraction ability of Salicornia ramosíssima for different soil moisture contents. Salicornia plants were cultivated in pots in which the soils were treated with the following conditioners control; gypsum + organic matter; elemental sulfur + organic matter; and gypsum + elemental sulfur + organic matter. Salicornia plants were subjected to two soil moisture rates - at 35 and 85% field capacity. Soil conditioners associated with higher contents of soil moisture promoted significant increases, compared to control, in fresh (6.20 - 11.13 g) and dry matter (1.20 - 2.07 g), relative biomass (100 - 179%) as well as significantly increased the concentrations of Na+ (56.09 - 65.64 mg kg-1) and Cl- (110.83 - 150.0 mg kg-1) in plant tissues. Soil conditioners significantly increased salt extraction ability under the two moisture levels, mainly by promoting higher values for both transfer factor and phytoremediation potential. The best performance of Salicornia in terms of plant yield and salt extraction, regardless of the moisture level, was the gypsum + organic matter.Novelty statementThere are no studies in the literature relating the use of conditioners as a strategy to enhance Salicornia's ability to extract salts.This work contributes to the management of salinized areas around the globe in two main aspects. The first is that many of these salt-degraded areas are desertified and through this study, it is possible to revegetate and recover them. The second one is that, since Salicornia is a plant with economic value, this can serve as an incentive for farmers to grow Salicornia in saline areas.
Deep lesions located in lateral and third ventricles can be accessed thorough interhemispheric transcallosal or transcortical trans-ventricular approaches. Traditional brain retractors are made by 'non-cerebral engineered' spatulas, which do not equally distribute pressure on surrounding structures damaging brain. In this paper, we present a series of 20 intraventricular tumours resected through a MRI/US-navigated microscopic transcortical endoportal approach.
Between January 2014 and December 2017, 20 patients underwent US-MRI neuronavigated (Esaote
, Genova, Italy) transcortical endoportal (Vycor
Viewsite Brain Access System TC Model, Vycor
Medical Inc., Boca Raton, FL) surgery for intraventricular deep-seated lesions with the intent to reach maximal safe resection.
Gross total removal was achieved in 14 patients (70%). The only prognostic factor that resulted in statistical significance related to surgical radicality from multivariate analysis was white matter infiltration (
= 0.043), regardle surgery, although further prospective multicentre studies with larger number of patients, evaluation of pre- and post-operative neuropsychological outcomes and achievement of postoperative DTI and f-MRI are needed to confirm our results.
The objective of this study was to investigate the relationship between maternal functions including self-care and adjustment and maternal attachment during the postpartum period.
Mothers adapt to their new role during the postpartum period by recognising both their baby and their physical, emotional, and social recovery. link2 During this period, a mother's interaction with her baby supports attachment.
The study design was planned as a descriptive-relational type. The study was performed in two Family Healthcare Centres located in Antalya city, Turkey country. The population of the study consisted of 250 mothers aged 18-45years who had a postpartum period between 8 and 11weeks. A simple sampling method was used. Data were collected using the mothers' identification forms, the Barkin Index of Maternal Function, and the Maternal Attachment Inventory. The forms were administered to mothers via the face-to-face interview method. Numerical, percental, and relational statistical methods as well as arithmetic means were used in the data analysis.
The mean score of the Barkin Index of the Maternal Function was 76.97±10.19 and the mean score of the Maternal Attachment Inventory was 100.92±3.17. There was a positive, low, and significant relationship between maternal function and maternal attachment (
=0.22,
=0.00). There was a positive, low, and significant relationship between maternal attachment and self-care, maternal psychology, infant care, social support, and maternal adjustment scores.
The maternal attachment level was found to be high in women with high maternal function. To develop the relationship between functional status and maternal attachment, mothers may provided with social support and, if necessary, psychological support.
The maternal attachment level was found to be high in women with high maternal function. To develop the relationship between functional status and maternal attachment, mothers may provided with social support and, if necessary, psychological support.Mycotoxins have several toxicological implications. In the present study, we evaluate the presence of aflatoxin B1 (AFB1), ochratoxin A (OTA), and fumonisin (FB1) in paddy rice, polished rice, and maize from the fields and markets in Nayarit State (Mexico). The results indicated the presence of AFB1 in 21.21% of paddy rice samples and 11.11% of market maize samples. link3 OTA was present in only 3.03% (one sample) of paddy rice samples. FB1 was detected in 87.50% and 88.88% of maize samples from field and market, respectively. The estimated human exposure was calculated for FB1 using the probable daily intake (PDI), which suggested that FB1 could contribute to the development of diseases through the consumption of contaminated maize. Positive samples indicated that some rice and maize samples were not suitable for human consumption. Further efforts are needed to continue monitoring mycotoxins and update national legislation on mycotoxins accordingly.
Patient-reported outcomes (PROs) on adverse drug reactions (ADRs) are increasingly used in cohort event monitoring (CEM) to obtain a better understanding of patients' real-world experience with drugs. Despite the leading role for patients, little is known about their perspectives on CEM systems.
In a cross-sectional open survey following the rationale of the Technology Acceptance Model, we aimed to obtain insight in patients' perspectives on the perceived usefulness, ease of use and attitude toward using a PRO-based drug safety monitoring system for ADRs attributed to biologics.
Patients considered structural reporting of ADRs in web-based questionnaires as useful and not burdensome. It was preferred to link the questionnaire frequency to regular hospital consultations or the biologic administration schedule. Various respondents were interested in sharing questionnaires with their medical specialist (49.0%) or pharmacist (34.2%), and suggested to minimize the questionnaire frequency in case of an unaltered situation or absence of ADRs.
