Toddmurphy1577

The aim Determination of cardioprotective effect of interval normobaric hypoxia in medical rehabilitation of patients with COPD.

Materials and methods 123 patients with COPD who received basic drug therapy were examined and were divided into 2 groups. Patients of the main group (93 persons) additionally received 2 courses of 20 sessions of interval normobaric hypoxia. All patients underwent echocardiographic examination at the beginning and after 1 year of follow-up.

Results Prior to treatment, all patients had changes in the myocardium of both ventricles, due mainly to hypoxic and inflammatory effects and to a lesser extent to increased pulmonary artery pressure. Interval normobaric hypoxytherapy caused adaptive-adaptive reactions of the cardiovascular system, which manifested a positive effect on the state of both left and right ventricles increase in stroke volume and expulsion fraction, decrease in E-DV and E-SV of the left and right ventricular E-DS, elimination of myocardium. However, the result is more effective in patients with GOLD 1 and GOLD 2 compared to GOLD 3.

Conclusions The use of interval normobaric hypoxytherapy in the rehabilitation of COPD, initiated by ischemic preconditioning, is pathogenetically justified because it triggers endogenous mechanisms of cardioprotection and metabolic adaptation.

Conclusions The use of interval normobaric hypoxytherapy in the rehabilitation of COPD, initiated by ischemic preconditioning, is pathogenetically justified because it triggers endogenous mechanisms of cardioprotection and metabolic adaptation.

The aim To investigate the relationship between serum bilirubin level and the presence of the APS in women with a history of spontaneous miscarriages.

Materials and methods Fifty six women aged 22-38 (median 27) years with a history of spontaneous miscarriages were divided into two groups 33 women with the APS and 23 without. Patients were tested for the presence of lupus anticoagulant, anticardiolipin, anti-β2-glycoprotein 1, antiphospholipid antibodies and genetic thrombophilic defects.

Results Groups were comparable by age, blood pressure, BMI, co-morbidity (anemia, heart abnormality, thyroid disease, overweight). Median serum total bilirubin levels were 7,2 μmol/L (interquartile range [5,8-9,7]) in women with the APS and 10,5 μmol/L (interquartile range [7,5-15,1]) in control group, p=0.005. The chance of detecting a total bilirubin level of less than 8 μmol/L is 4.1 times higher in the APS patients than in the control group (OR 4,1; 95% CI 1,274-13,213). Logistic regression analysis found a statistically significant association between total bilirubin and the presence of the APS (odds ratio, 0.856; 95% CI, 0.734-0.997, p =0.046). Patients with the APS had elevated serum C-reactive protein (medians 2,3 vs 1,1 mg/L, p=0.01) and fibrinogen (medians 2,8 vs 2,5 g/L, p=0.006) levels compared with controls. Correlation analysis revealed a significant correlation between all types of bilirubin and inflammatory markers.

Conclusions All types of serum bilirubin (total, direct and indirect) are significantly reduced in women with APS, associated with higher inflammatory markers and lower levels of 25-hydroxyvitamin D, which may be the result of oxidative stress.

Conclusions All types of serum bilirubin (total, direct and indirect) are significantly reduced in women with APS, associated with higher inflammatory markers and lower levels of 25-hydroxyvitamin D, which may be the result of oxidative stress.

The aim Scientific work aims at determining the frequency and nature of disorders in psycho-emotional and autonomic systems in patients with combined trauma of the middle face.

Materials and methods Examination included 112 patients with combined trauma of the middle face.Their psycho-emotional state was assessed using the Impact of Event Scale (IES) and the Hospital Anxiety and Depression Scale (HADS). All patients were tested using questionnaires developed by Wayne A.M.. The Kerdo index was used to assess autonomic tone, while autonomic reactivity was determined using a Czermak-Gering carotid sinus test. Biochemical markers of stress - adrenocorticotropic hormone (ACTH), cortisol and anti-stress system - β-endorphins,and Garkavi L.Kh. adaptation index.

Results Patients with severe traumatic brain injury - 26.78%, and severe fractures of the facial bones - 48.21%. The consequence of traumatic events is the appearance of post-traumatic stress disorders in their mental function. Post-traumatic stress is ortisol) and an insignificant increase in anti-stress factors in the blood. Insufficient stress-limiting function of the hypothalamic-pituitary system slows down the healing process and requires appropriate correction.

The aim The assessment of clinical effectiveness the cervical perforated pessary (CPP) used for prevention of preterm labor.

Materials and methods Caucasian women with prior SPL who were randomized to receive a CPP (clinical group) or without pessary (control group) was conducted at the Vinnytsya maternal hospital №1, from 2014 through 2018. Eligible women were those referred to the institution for a diagnosis of cervical incompetence between 16 weeks and 18 weeks +6 days. Outcomes will be PTL before 28, 32, 35, and 37 weeks of gestation; a composite of poor perinatal outcomes.

Results The incidence of SPL at less than 37 weeks of gestation was occurred in 14,1% vs 29,3% (RR 0,48, 95% CI, 0,23-0,99), lower rate of SPL at less than 35 weeks of gestation (RR 0,30, 95% CI, 0,10-0,88), longer gestational age (Dif. -1,4, 95% CI, -2,30 to -0,50), higher birth weight (Dif. -197,9, 95% CI, -307,6 to -88,15), lower incidence of adverse composite perinatal outcome (RR 0,28, 95% CI, 0,1-0,81) from the pessary and control group respectively. The participants pessary clinical group had a higher rate than the control group of increased vaginal discharge (RR 1,31, 95% CI, 1,01-1,69), but no differences in pelvic discomfort (RR 0,54, 95% CI, 0,14-2,18), chorioamnionitis (RR 0,30, 95% CI, 0,06-1,44).

Conclusions The women with prior SPL use of a CPP, resulted in a lower rate of SPL. The component in the successful results of preventive strategy SPL is consideration of vaginal microbiota and role of special trained staff for installation and care cervical pessary.

Conclusions The women with prior SPL use of a CPP, resulted in a lower rate of SPL. The component in the successful results of preventive strategy SPL is consideration of vaginal microbiota and role of special trained staff for installation and care cervical pessary.

The aim The purpose of the work was to study the peculiarities of blood supply the pancreatic islet of the 24-month-old rat, and its restructuring during the initial periods of experimental diabetes mellitus.

Materials and methods The work was performed on 20 white outbred rats - males weighing 340-420g. 24 months of age, kept in standard vivarium conditions in compliance with all accepted ethical rules. Experimental streptozotocin diabetes mellitus was simulated in 16 animals. The material was taken on the 14th and 28th day of the experiment.

Results Reorganization of the endocrine part of the pancreas in the early stages of experimental diabetes is characterized by a decrease in the number and area of pancreatic islets, a decrease in the diameter of the lumen of arterioles, precapillaries, postcapillaries compared to the control group of animals by 7% and 5%. The diameter of the capillaries decreases by 16% and reaches 3.8 ± 0.62 μm2, and the diameter of the venules increases by 12%. In some blood vessels there are phenomena of desolation and edema of perivascular connective tissue, which is manifested by a decrease in optical density and stratification of collagen fibers.

Conclusions Thus, the reorganization of the circulatory system of the endocrine part of the pancreas of 24-month-old rats in the early stages of experimental diabetes mellitus is characterized by a decrease in the number and area of pancreatic islets.

Conclusions Thus, the reorganization of the circulatory system of the endocrine part of the pancreas of 24-month-old rats in the early stages of experimental diabetes mellitus is characterized by a decrease in the number and area of pancreatic islets.

The aim Presentation of a single-center experience of cardiac surgery with cardiopulmonary bypass (CPB) in pregnant women with critical cardiac pathology. The possibility of minimally invasive technique in this group of patients were presented.

Materials and methods The present study included 19 cases of multidisciplinary care with CPB surgery in pregnant women in single center from December 2013 to December 2020. Biocytin ic50 8 patients underwent J-form median mini-sternotomy. Maternal and neonatal outcomes depending on the type of surgery (urgent or elective) were reviewed.

Results There were no negative maternal consequences; there were 4 perinatal losses (21%) three after urgent and one after elective interventions. All other pregnancies (n=15) finished successfully with the birth of healthy newborns. We compared some values in two groups (urgent and elective) of patients who underwent CPB surgery during pregnancy. Despite the variability in some parameters the difference between the groups was not significant. Follow-up was from 5 to 72 months (39.7±16.9) without negative consequences.

Conclusions Multidisciplinary team management is an effective strategy for pregnant women with cardiac pathology. Elective cardiac surgery in expert centers during pregnancy is a safe and effective option. Urgent CPB cardiac surgery during pregnancy increases the risk for the fetus. J-form median mini-sternotomy is a good option during pregnancy in high-experienced centers.

Conclusions Multidisciplinary team management is an effective strategy for pregnant women with cardiac pathology. Elective cardiac surgery in expert centers during pregnancy is a safe and effective option. Urgent CPB cardiac surgery during pregnancy increases the risk for the fetus. J-form median mini-sternotomy is a good option during pregnancy in high-experienced centers.

The aim The aim of the work was to determine the leading epidemiological, diagnostical features, disturbance of spirometric indices, changes in the immune system in servicemen with COPD, who take part in Joint Forces Operation (JFO).

Materials and methods 89 male patients were examined, who sought medical help for COPD, group B. They were divided into two groups. 1 group (42 patients) - with COPD, who took part in the JFO not more than 6 month, the 2 group consisted of 47 patients with COPD, who took part in the JFO during the period more than 6 month.

Results The patients in the group 2 had veraciously more points of cough and sputum expectoration in daily amount of 30 and more ml. The type of sputum in 53.2% patients was predominantly mucus-pus. There were also more percentage of patients with feeling short of breath and the high point, achieved at CAT. There were significant differences in systolic and diastolic blood pressure levels, LV mass index between two groups.

Conclusions It was found that servicemen who took part in JFO for more than 6 months had a more severe course of COPD with a higher score in the CAT and probably lower obstructive ventilatory indices, in a probably higher percentage of cases there were detected such a concomitant pathology as AH stage II and GERD. They had Th17 immune response predomination with significant elevation of IL-17, TGF-β, IL-6 concentrations in serum and high concentration of soluble adhesion molecules.

Conclusions It was found that servicemen who took part in JFO for more than 6 months had a more severe course of COPD with a higher score in the CAT and probably lower obstructive ventilatory indices, in a probably higher percentage of cases there were detected such a concomitant pathology as AH stage II and GERD. They had Th17 immune response predomination with significant elevation of IL-17, TGF-β, IL-6 concentrations in serum and high concentration of soluble adhesion molecules.