Thorupneergaard4717

There are several technologies and techniques available when developing indoor positioning systems (IPS). Recently, the development of positioning systems based on optical signals has aroused great interest, mainly those using visible light from the lighting infrastructure. In this work, we analyze which techniques give better results to lay the foundations for the development of a Visible Light Positioning system (VLP). Working only with a receiver, it is analyzed what the result of determining the position of different emitters is when they emit simultaneously and without any synchronism. The results obtained by Frequency Division Multiple Access (FDMA) (with digital bandpass filters, I/Q demodulation, and FFT) and Code Division Multiple Access (CDMA) are compared. The interference between signals when emitted simultaneously from multiple emitters is analyzed as well as the errors they cause and how these effects can be mitigated. As a result of the research, the advantages and disadvantages using different multiple-access determination techniques are determined. In addition, advantages and disadvantages of using FDMA and CDMA techniques as well as hardware requirements that make one more feasible than the other are presented. The system behavior, in terms of errors, is established using FDMA and different configurations such as I/Q, RMS, or FFT. The work also determines the error rates that can be obtained with the different FDMA and CDMA configurations, considering different error scenarios and integration time. Synthetic emulations and empirical tests were performed, which concluded that IPS systems based on optical signals and PSD sensors can achieve very high measurement accuracies and a high measurement rate. Obtained positioning errors in a room of 3 m height are less than 1 cm when working in noisy environments.Comprehensive oncology research suggests an important role of phytochemicals or whole plant foods in the modulation of signaling pathways associated with anticancer action. The goal of this study is to assess the anticancer activities of Cinnamomum zeylanicum L. using rat, mouse, and cell line breast carcinoma models. C. zeylanicum (as bark powder) was administered in the diet at two concentrations of 0.1% (w/w) and 1% (w/w) during the whole experiment in chemically induced rat mammary carcinomas and a syngeneic 4T1 mouse model. After autopsy, histopathological and molecular evaluations of mammary gland tumors in rodents were carried out. Moreover, in vitro analyses using MCF-7 and MDA-MB-231 cells were performed. The dominant metabolites present in the tested C. zeylanicum essential oil (with relative content over 1%) were cinnamaldehyde, cinnamaldehyde dimethyl acetal, cinnamyl acetate, eugenol, linalool, eucalyptol, limonene, o-cymol, and α-terpineol. The natural mixture of mentioned molecules demonstratedc changes in rat tumor cells in vivo showed a significant decrease in lysine methylation status of H3K4m3 and H3K9m3 in the high-dose treated group, a dose-dependent increase in H4K16ac levels (H4K20m3 was not changed), down-regulations of miR21 and miR155 in low-dose cinnamon groups (miR22 and miR34a were not modulated), and significant reduction of the methylation status of two out of five gene promoters-ATM and TIMP3 (PITX2, RASSF1, PTEN promoters were not changed). In vitro study confirmed results of animal studies, in that the essential oil of C. zeylanicum displayed significant anticancer efficacy in MCF-7 and MDA-MB-231 cells (using MTS, BrdU, cell cycle, annexin V/PI, caspase-3/7, Bcl-2, PARP, and mitochondrial membrane potential analyses). As a conclusion, C. zeylanicum L. showed chemopreventive and therapeutic activities in animal breast carcinoma models that were also significantly confirmed by mechanistic evaluations in vitro and in vivo.Under the rapid development of urbanization, fire service becomes one of the biggest contributive factors to personal health and property safety. A reasonable plan of fire services should first address the issue of service area delimitation for fire emergency facilities. Specifically, there are two key factors for fire services including rescue efficiency and load balancing, which are usually handled by the space partitioning methods (e.g., Voronoi diagram). The traditional methods tend to model the space in a homogeneous plane with Euclidean distance, while in reality, the movement of rescuing is constrained by the street network. In addition, the built environment is complex by its variation of fire risk across places. Therefore, we propose a novel constrained Voronoi diagram for fire service area delimitation by adding the datasets of street network and historical fire incidents. Considering the prior knowledge that a fire engine is expected to reach the location of incident within five minutes, which is also called Golden 5 min, we propose a network partitioning algorithm which is able to increase the five-minute coverage of fire stations. find more Through a case study in Nanjing, China, we demonstrate the practicability of the proposed method in delimitating service areas of fire stations across time.Preterm infants born before 32 weeks gestation have increased risks for neurodevelopmental impairment at two years of age. How brain function differs between preterm infants with normal or impaired development is unknown. However, abnormal spontaneous motor behavior at 12-15 weeks post-term age is associated with neurodevelopmental impairment. We imaged brain blood oxygen level-dependent signals at term-equivalent age in 62 infants born at less then 32 weeks gestation and explored whether resting state functional connectivity (rsFC) differed with performances on the General Movement Assessment (GMA) at 12-15 weeks, and Bayley III scores at two years of corrected age. Infants with aberrant general movements exhibited decreased rsFC between the basal ganglia and regions in parietal and frontotemporal lobes. Infants with normal Bayley III cognitive scores exhibited increased rsFC between the basal ganglia and association cortices in parietal and occipital lobes compared with cognitively impaired children. Infants with normal motor scores exhibited increased rsFC between the basal ganglia and visual cortices, compared with children with motor impairment.