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Aromatase inhibitors (AIs) are indicated in the treatment of hormone-receptive breast cancer in postmenopausal women in various settings. Studies have shown that they are effective when used as adjuvant therapy to chemotherapy and surgery in metastatic estrogen-dependent breast cancer. Their use in preventative and adjuvant therapies for other conditions is currently under investigation.Adenoid cystic carcinoma (ACC) is a rare malignancy arising from the secretory glands, most commonly seen involving the salivary glands. It accounts for approximately 1% of all malignancies of the head and neck region. However, it is the most common tumor of the minor salivary glands and the second most common tumor of the major salivary glands. Overall, it accounts for 10% of all salivary gland tumors. The tumor is typically slow-growing compared to other carcinomas and has a tendency for perineural invasion as well as hematogenous spread to distant organs and is most commonly seen in the elderly. Due to its rarity, limited data is available regarding the predisposing risk factors and the management of patients with advanced disease.The white dot syndromes constitute a group of inflammatory chorioretinopathies in which the common, defining clinical feature is the presence of multiple, discrete, white lesions located at the deeper levels of the retina and choroid. Several of the white dot syndromes are associated with a viral prodrome, and an etiology is lacking for these conditions. Typically seen in young, otherwise healthy adults, the white dot syndromes most often present with symptoms of photopsia, floaters, decreased night vision, blurred vision, and visual field loss. These conditions can be acute in onset, or transient without long-term visual consequence. White dot syndromes share many similar clinical features, including the "tell-tale" chorioretinal lesions, several distinct clinical features and findings on diagnostic testing allow for additional characterization. Commonly recognized white dot syndromes include Multiple evanescent white dot syndrome (MEWDS), acute retinal pigment epitheliopathy (ARPE), acute posterior multifocal placoid pigment epitheliopathy (APMPPE), multifocal choroiditis and panuveitis (MCP), acute zonal occult outer retinopathy (AZOOR), birdshot chorioretinopathy, serpiginous choroidopathy, and punctate inner choroidopathy (PIC). These conditions are conventionally recognized as distinct identities, and some suggest that they represent a spectrum of chorioretinal disease.Zafirlukast is an orally available drug (available in 10 mg and 20 mg tablets and chewable tablets), which is FDA-approved for the management of chronic asthma in adults and children ≥ 5 years old. It is used off-label for the management of chronic urticaria, prevention of exercise-induced bronchospasm, and those with asthma and allergic rhinitis.Immunocompromised patients have an impaired immune system leading to decreased resistance to infections. The immunocompromise can be innate; however, acquired immunodeficiency is far more common due to the recent advances in cancer chemotherapy, hematopoietic stem cell and solid organ transplantation, use of immunomodulatory drugs and AIDS. These recent developments have led to an increase in the number of immunocompromised patients. Pulmonary infections are quite common in immunocompromised patients owing to the respiratory tract’s constant environmental exposure. Besides the common pathogens capable of infecting an immunocompetent individual, immunocompromised patients are also at risk of infection from opportunistic pathogens. The type of pathogen involved and the severity of infection depend on the type, duration, and degree of immunodeficiency. Types of common immunodeficiencies are It is important to remember that various infections can be present simultaneously in an immunocompromised patient.Vinca alkaloids, which belong to a class of cell cycle phase M specific anti-tubulin agents, are one of the first plant alkaloids to be developed for use as anti-cancer agents in humans. This class of drugs derived from Vinca rosea (Catharanthus roseus) consists of first-generation (vincristine, vinblastine) and second-generation semi-synthetic derivatives (vinorelbine, vinflunine, and vindesine). Vinflunine, the newest fluorinated anti-microtubule agent, has been advocated to have a higher potency and lesser frequency of adverse events when compared to the older agents. They are usually used in combination with other chemotherapeutic agents (as part of multi-drug combination regimens) since they have been shown to potentiate the anti-cancer effects of these agents and are also known to be well tolerated with manageable adverse effects. These agents are highly lipophilic and attain very high intracellular concentrations, making overproduction of P-glycoprotein, which is an efflux transporter protein, a plausible mechanism of development of acquired drug resistance. Mutations in beta-tubulin with overexpression of different isotypes have also shown to correlate with the production of altered drug effects, leading to the development of resistance.Talipes equinovarus (TEV) is a congenital disorder affecting a large portion of the global population leading to decreased quality of life, disability, and mobility limitations. TEV is characterized by deformities of the foot, including cavus midfoot arch, adduction of the forefoot, hindfoot varus, and equinus. It is estimated to have an overall incidence of 1-2 in 1000 live births. Left untreated, TEV will persist into adulthood, causing loss of mobility and decreased quality of life. Currently, no known cause exists for TEV, though multiple genetic associations have been found. TEV has an increased risk associated with a family history of TEV and maternal smoking. However, studies have not shown associations with TEV and oligohydramnios, the season of birth, parental age, or parity. GSK-3 activity Typical management of TEV is non-operative and utilizes serial manipulation, casting, and bracing following the Ponseti method. For cases unresponsive to non-surgical methods, a variety of surgical approaches may be used to address TEV.