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coli, samples collected from beach sands uncovered concentrations up to 86,500 times higher than adjacent swimming waters. EGFR signaling pathway Results from this study indicate that foreshore beach sands and other beach proximate FIB sources serve as the major contributing source for swimming zone advisories. The current methodology used by state and federal officials includes impairing entire lake waterbodies for FIB contamination of the swimming area. These impairment listings do not accurately reflect the condition(s) of the larger lake environment outside the swimming area and fail to account for beach proximate conditions in the assessment process. Further, this approach provides potentially misleading information to the public and may undermine implementation strategies deployed by resource managers aimed at addressing FIB contamination at recreational swimming areas. Views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the Iowa Department of Natural Resources. Results from recent studies on associations between blood pressure (BP) and short-term exposure to fine particulate matter (PM2.5) have been inconsistent. Most studies have been evaluations of small geographic areas, with no national study in China. This study aimed to examine the acute BP responses to ambient PM2.5 among the general population of Chinese adults. During 2012-2015, systolic and diastolic BP levels were obtained from a large national representative sample, the China Hypertension Survey database (n = 479,842). Daily PM2.5 average exposures with a spatial resolution of 0.1° were estimated using a data assimilation that combines satellite measurements, air model simulations, and monitoring values. Overall, a 10-μg/m3 increase in daily PM2.5 was associated with a 0.035 (95% confidence interval 0.020, 0.049) mmHg change in systolic BP and 0.001 (-0.008, 0.011) mmHg in diastolic BP after adjustments. Stratified by geographic regions, the systolic and diastolic BP levels varied from -0.050 (-0.109, 0.010) to 0.242 (0.176, 0.307) mmHg, and from -0.026 (-0.053, 0.001) to 0.051 (0.020, 0.082) mmHg, respectively. Statistically significant positive BP-PM2.5 associations were only found in South and North China for systolic levels and in Southwest China for diastolic levels. We further explored the regional study population characteristics and exposure-response curves, and found that the geographic variations in BP-PM2.5 associations were probably due to different population compositions or different PM2.5 exposure levels. Our study provided national-level evidence on the associations between ambient PM2.5 exposure and elevated BP levels. The magnitude of the estimated associations varied substantially by geographic location in China. CLINICAL TRIAL REGISTRATION The Clinical trial registration name was Survey on prevalence of hypertension in China; the registration number was ChiCTR-ECS-14004641. http//www.chictr.org.cn/showproj.aspx?proj=4932. The concentration of dissolved organic matter (DOM) in freshwaters is increasing in large areas of the world. In addition to carbon, DOM contains nitrogen and phosphorus and there is growing concern that these organic nutrients may be bioavailable and contribute to eutrophication. However, relatively few studies have assessed the potential for dissolved organic nitrogen (DON) or dissolved organic phosphorus (DOP) compounds to be bioavailable to natural river phytoplankton communities at different locations or times. Temporal and spatial variations in uptake, relative to environmental characteristics were examined at six riverine sites in two contrasting catchments in the UK. This study also examined how the uptake by riverine phytoplankton of four DON and four DOP compounds commonly found in rivers, varied with concentration. Total nitrogen (TN) and phosphorus (TP) concentrations, the proportion of inorganic nutrient species, and nutrient limitation varied temporally and spatially, as did the potential for DON and DOP uptake. All eight of the DOM compounds tested were bioavailable, but to different extents. Organic nutrient use depended on the concentration of the organic compound supplied, with simple compounds (urea and glucose-6-phosphate) supporting algal growth even at very low concentrations. DON use was negatively correlated with the TN and ammonia concentration and DOP use was negatively correlated with soluble reactive phosphorus (SRP) and dissolved organic carbon (DOC) concentration. The evidence indicates that DOM in rivers has been overlooked as a potential source of nutrients to phytoplankton and therefore as an agent of eutrophication. V.Organic UV filters are of emerging concern due to their occurrence and persistence in coastal ecosystems. Because marine bacteria are crucial in the major biogeochemical cycles, there is an urgent need to understand to what extent these microorganisms are affected by those chemicals. This study deciphers the impact of five common sunscreen UV filters on twenty-seven marine bacteria, combining both photobiology and toxicity analysis on environmentally relevant species. Seven bacteria were sensitive to different organic UV filters at 1000 μg L-1, including octinoxate and oxybenzone. This is the first report demonstrating inhibition of bacterial growth from 100 μg L-1. None of the UV filters showed any toxicity at 1000 μg L-1 on stationary phase cells, demonstrating that physiological state was found to be a key parameter in the bacterial response to UV-filters. Indeed, non-growing bacteria were resistant to UV filters whereas growing cells exhibited UV filter dependent sensitivity. Octinoxate was the most toxic chemical at 1000 μg L-1 on growing cells. Interestingly, photobiology experiments revealed that the toxicity of octinoxate and homosalate decreased after light exposure while the other compounds were not affected. In terms of environmental risk characterization, our results revealed that the increasing use of sun blockers could have detrimental impacts on bacterioplanktonic communities in coastal areas. Our findings contribute to a better understanding of the impact of the most common UV filters on bacterial species and corroborate the importance to consider environmental parameters such as solar radiation in ecotoxicology studies. Crown V. All rights reserved.Water deficit, exacerbated by global population increases and climate change, necessitates the investigation of alternative non-traditional water sources to augment existing supplies. Indirect potable reuse (IPR) represents a promising alternative water source in water-stressed regions. Of high concern is the presence of pathogenic microorganisms in wastewater, such as enteric viruses, protozoa and bacteria. Therefore, a greater understanding of the potential impact to human health is required. The aim of this research was to use a quantitative microbial risk assessment (QMRA) approach to calculate the probability of potential pathogen infection risk to the public in surface waters used for a range of recreational activities under scenarios 1) existing de facto wastewater reuse conditions; 2) after augmentation with conventionally treated wastewater; and 3) after augmentation with reclaimed wastewater from proposed IPR schemes. Forty-four 31 l samples were collected from river sites and a coastal wastewater tnative water supply option selection. As such, this evidence may inform water managers and the public of the potential benefits of IPR and improve acceptance of such practices in the future. Urbanization processes have accelerated over recent decades, prompting efforts to model land use change (LUC) patterns for decision support and urban planning. Cellular automata (CA) are extensively employed given their simplicity, flexibility, and intuitiveness when simulating dynamic LUC. Previous research, however, has ignored the spatial heterogeneity among sub-regions, instead applying the same transition rules across entire regions; moreover, most existing methods extract neighborhood effects with only one data time slice, which is inconsistent with the nature of neighborhood interactions as a long-term process exhibiting obvious spatiotemporal dependency. Accordingly, we propose a hybrid cellular automata model coupling area partitioning and spatiotemporal neighborhood features learning, named PST-CA. We use a machine-learning-based partitioning strategy, self-organizing map (SOM), to divide entire regions into several homogeneous sub-regions, and further apply a spatiotemporal three-dimensional convolneity; while the optimal time steps in 3D CNN generally maintained a positive correlation with the growth rate of built-up areas, which implies longer temporal dependency should be captured for rapidly developing areas. BACKGROUND Predicted temperature rise is likely to increase the risks of development and progression of renal/urologic anomalies for workers engaged in physically exerting and high-heat occupations. METHODS We conducted a cross-sectional study with 340 steelworkers engaged in moderate to heavy labour with ≥3 year's heat exposures and assessed Wet Bulb Globe Temperature (WBGT) and heat-strain indicators. We captured self-reported heat-strain and kidney symptoms using validated questionnaires and subjected 91 workers to renal ultrasound upon referral of an occupational health specialist to detect and confirm any structural renal anomalies/stones. RESULTS The results show that heat exposures (Avg.WBGT = 33.2 °C ± 3.8 °C) exceeded the Threshold Limit Value (TLV) for 220 workers. 95% of the workers reported symptoms of heat strain and dehydration and significant associations between heat exposures, rise in Core Body Temperature (CBT) (p = 0.0001) and Urine Specific Gravity (USG) (p = 0.018) were observed. Of the 91 workers subjected to renal ultrasound, 33% were positive for kidney/ureteral stones (n = 25) & other structural renal anomalies (n = 5). Renal/urologic anomalies were higher in the heat-exposed workers (AOR = 2.374; 95% C.I = 0.927 to 6.077; p = 0.072) 29% of workers were from exposed group and 4% were from unexposed group. Years of exposure to heat (≥5 vs less then 5) were significantly associated with the risk of renal anomalies/calculi. CONCLUSION The preliminary finding concludes that high-heat stress combined with a heavy workload and chronic dehydration are high-risk factors for adverse renal health and calls for the urgent need for cooling interventions, enhanced welfare facilities, and protective labour policies to avert adverse health consequences for few million workers in the climate change scenario. Efficient energy generation device is desired to couple with soft electronics for driving devices. Due to frequent uses of soft electronics in indoor conditions, flexible fiber-shaped dye-sensitized solar cell (FDSC) is regarded as the most promising energy generation device due to high light-to-electricity conversion maintenance under weak dim light. Using gel electrolyte to assemble FDSC cannot only restrict electrolyte leakage but also improve device flexibility and stability especially under bending conditions. In this study, poly(vinylidene fluoride-co-hexafluoropropylene) (PVdF-HFP) gel electrolyte is used to fabricate FDSC composed of curled TiO2 nanotube/Ti wire photoanode and Pt counter electrode. It is the first time to control gel electrolyte configuration by adding different PVdF-HFP concentrations, and to optimize iodine concentration in electrolyte regarding to redox ability and electrolyte transmittance. Configuration of gel electrolyte is carefully analyzed to define porous layer and concrete layer of polymer for accumulating liquid electrolyte and inhibiting leakage and evaporation.