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Using principal component analysis, we confirmed that the AGEs formation inhibitory property and AGEs-collagen cross-links breaking activity were closely correlated with total phenolic and the condensed tannin contents contained in SWEs. Therefore, the bioactive substances such as phenolics and condensed tannins in seaweeds can be used as predictive indices in selecting compounds for the development of a therapeutic agent that prevents diabetic complications related to the AGEs. In addition, our results suggest that brown algae species, which contains more bioactive substances than green and red algae species, can be utilized as a promising natural resource for the prevention and alleviation of AGEs-related diabetic complications as AGE inhibitor and cross-links breaker.This study examines the potential defending effects of the diatom, Amphora coffeaeformis, as a feed additive versus the deleterious effects (mainly on gonads) caused by microplastics (MPs) in Nile tilapia, Oreochromes niloticus. Groups of male tilapia were pre-fed diets with four different supplementation levels of A. coffeaeformis (0%, 2.5%, 5%, and 7.5%) for 70 days, then exposed to 10 mg/L MPs for 15 days. Thereafter, samples were taken from the four experimental groups and the control fish group, for evaluating blood picture, erythrocytes alterations, biochemical parameters, catalase (CAT), superoxide dismutase (SDO), and total antioxidant capacity (TAC). In addition, male reproductive performance was assessed by quantifying the follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T), also testicular sections and GSI% were also assessed. The results showed that the number of leucocytes were significantly (p less then 0.05) higher, but the number of red blood cells (RBCs), the level of Hemoglobin (Hb), the percentage of Hematocrit (Ht), the number of platelets, and the eosinophil percentages were significantly decreased (p less then 0.05) when fish exposed to MPs. Biochemical parameters (ALP, glucose, uric acid, albumin, and A/G ratio) were significantly increased after MP exposure compared with the control group. Furthermore, MPs induced a significant decline in both serum LH and T levels. Testicular, histological, degenerative changes and testis-ova were found in the MP-exposed fish. Thus, A. coffeaeformis supplementation displayed ameliorative properties that detoxified the negative effects of MPs. This study provides a better understanding of the reproductive injuries caused by MPs exposure and evidence for the use of A. coffeaeformis as a natural remedy in freshwater tilapia.During the pandemic outbreak of COVID-19, the important role of plastic becomes evident since vital equipment such as respirators have plastic parts, as well as personal protective equipment (PPE), which avoids the transmission of the SARS-CoV-2 virus, is made of plastic. So, plastic during a pandemic is considered a life savior in the struggle against the virus. However, the same material that is a protector becomes a polluter when inadequately disposed of in the environment, generating or worsening socio-environmental problems, such as pollution of water bodies by plastic. This work proposes a reflection about the role and the importance of plastic in our society, bringing an overview of its main applications and consequences during the COVID-19 pandemic, correlating its use with aspects related to environmental problems and public health. Some questions revolving around the concerns caused by plastic pollution are posed, and some possible solutions to the problems are outlined.The presence of substances of emerging concern-pharmaceuticals-in marine environments has been studied to a lesser extent compared to fresh and wastewaters. This is the first study of pharmaceutical distribution in the Russian part of the Baltic Sea. Among 18 pharmaceuticals previously detected in influent waters of Saint-Petersburg WWTPs, 7 compounds (caffeine [81% of samples], carbamazepine [81%], ketoprofen [60%], diclofenac [23 %], ciprofloxacin, trimethoprim, and clarithromycin) were recorded in seawater samples in a range of measured concentrations from 0.1 to 4452 ng L-1. Antibiotics were presented in trace concentrations. In sediment samples, 6 pharmaceuticals (0.1-66.2 ng g-1) were detected. The most common was carbamazepine (80%). The remaining compounds were located in decreasing frequency as follows ketoprofen, trimethoprim, drotaverine, tetracycline, and ciprofloxacin. Some specific features of the Gulf of Finland affecting the distribution of pharmaceutical concentrations were highlighted-among the most important, the megapolis of St. Petersburg with its population over 5 million and freshwater input by the Neva River (high urbanization of the territory with a potent dilution factor). We discussed the suitable set of anthropogenic markers for the Russian part of the Gulf of Finland.The material discarded by past mining extractive activities is exposed to the action of different environmental agents and constitutes the beginning of a problem that, inevitably, involves the population and the conditions of the environment where it is deposited. selleck chemicals Bearing this in mind, a study of the Copaquilla-Chile valley was carried out with a focus on the socio-environmental conflict produced by the accumulation of abandoned mining waste in its vicinity. The objectives were to identify the role of the different actors and the main causes that originated the conflict and to characterize the physical-natural factors that conditioned the susceptibility and physical vulnerability of the studied environment. The methodological approach combined a set of qualitative and quantitative techniques, using participatory action research techniques (PAR) and multi-criteria evaluation models (MCE) through a geographic information system (GIS). The evaluation of the study area revealed quite severe levels in terms of the indices of susceptibility to processes of mass removal and vulnerability of the aquifer, which led us to infer that the morpho-climatic and hydrogeological characteristics of the sector generated the appropriate conditions to produce large damage to the complex socio-ecological system of the Copaquilla territory. This study generated participatory material, a chronology of the conflict, a database of the physical environment of the Copaquilla valley interpreted in thematic cartographies, and physicochemical soil and water samples to monitor contamination levels.