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t women with influenza vaccine to prevent unvaccinated infants and pregnant/postpartum women from influenza-associated disease in Japan can be cost-effective from societal perspective, under the WHO-suggested "cost-effective" criteria (1-3 times of GDP).Integrins are transmembrane receptors that transduce biochemical and mechanical signals across the plasma membrane and promote cell adhesion and migration. In addition, integrin adhesion complexes are functionally and structurally linked to components of the intracellular trafficking machinery and accumulating data now reveal that they are key regulators of endocytosis and exocytosis in a variety of cell types. Here, we highlight recent insights into integrin control of intracellular trafficking in processes such as degranulation, mechanotransduction, cell-cell communication, antibody production, virus entry, Toll-like receptor signaling, autophagy, and phagocytosis, as well as the release and uptake of extracellular vesicles. We discuss the underlying molecular mechanisms and the implications for a range of pathophysiological contexts, including hemostasis, immunity, tissue repair, cancer, and viral infection.

To identify events and experiences of adolescent mothers relevant to their own care and the care of their children so as to support the elaboration of a future Event History Calendar (EHC) tool.

Qualitative study was conducted based on the Grounded Theory, from the constructivist perspective. Data were collected through in-depth interviews with 11 Brazilian adolescent mothers. Initial and focused coding was applied in the data analysis.

The results present events that demarcate the adolescent mothers' perspectives of child care. Self-care and child care are related to everyday learning, ways of coping, strengthening of various support sources, mastery of gaps in health care, and sensory events.

The different events for adolescents are related to the transience of life, strategies of the moment, and the process of support for pregnancy-motherhood, which is dependent on a network of people and institutions that provide cooperation and participation in the reengagement of the adolescents while encouraging quality of life and development. The events identified can contribute to a list of relevant elements to structure a tool using EHC to guide the clinical practice of nurses so as to strengthen the adolescent's self-care and child care.

In the context of fragility in the communicative process between adolescent mothers and nurses, the strategy of an EHC can contribute to the expansion of nursing care, aid in developing new coping strategies addressing vulnerabilities, recognize multidimensional needs, strengthen the potentialities and confidence of mothers, and encourage involvement, advocacy and empowerment.

In the context of fragility in the communicative process between adolescent mothers and nurses, the strategy of an EHC can contribute to the expansion of nursing care, aid in developing new coping strategies addressing vulnerabilities, recognize multidimensional needs, strengthen the potentialities and confidence of mothers, and encourage involvement, advocacy and empowerment.Our aim was to evaluate the functional outcomes and complications of mandibular condylar fractures managed surgically and non-surgically. Patients were identified retrospectively from audit data and clinical records from 2005-2018, and functional outcomes were evaluated based on the development of complications at clinical follow up. Patients were categorised into three treatment groups conservative (management with soft diet, analgesia, and monitoring), closed (management with intermaxillary fixation), and open reduction and internal fixation (ORIF). A total of 358 patients were included with a median age of 33 years (mean 38), and a malefemale ratio of 2.71. A total of 72 patients (20%) were treated conservatively, 177 (49%) were treated with closed management, and 109 (31%) with ORIF. The ORIF group demonstrated better outcomes than the closed group in terms of reduced protrusive and lateral excursive movements, and temporomandibular joint (TMJ) pain; and in terms of occlusal derangement when compared with the conservative group. check details The ORIF group had poorer outcomes than both the closed and conservative groups in terms of maximum mouth opening, and temporary facial nerve injury occurred in 5/109 (5%) and condylar resorption in 2/109 (2%) of patients in the ORIF group. There was no incidence of permanent facial nerve injury, Frey syndrome, or paraesthesia of the auricular nerve. The trend that favours ORIF can be justified, as it offers improved functional outcomes in severe or displaced condylar fractures. However, this must be evaluated against the risk of potential surgical complications. Careful case selection is therefore necessary to optimise management of these injuries.

The German Cancer Society ("Deutsche Krebsgesellschaft"; DKG) certifies on a volunteer base colorectal cancer centers based on, among other things, minimum operative amounts (at least 30 oncological colon cancer resections and 20 oncological rectal cancer resections per year). In this work, nationwide hospital mortality and death after documented complications ('Failure to Rescue'=FtR) were evaluated depending on the fulfillment of the minimum amounts.

This is a retrospective analysis of the nationwide hospital billing data (DRG data, 2012-2017). Categorization is based on the DKG minimum quantities (fully, partially or not fulfilled).

Of 287,227 patients analyzed, 56.5% were operated in centers that met the DKG minimum amounts. The overall hospital mortality rate was 5.0%. In centers which met the minimum quantities, it was significantly lower (4.3%) than in hospitals which partially (5.7%) or not (6.2%) met the minimum quantities. The risk-adjusted hospital mortality rate for patients in hospitals who meet the minimum amount was 20% lower (OR 0.80; 95% CI [0.74-0.87], p<0.001). For complications, both surgical and non-surgical, there was an unadjusted and adjusted lower FtR in hospitals that met the minimum amounts (e.g. anastomotic leak 11.2% vs. 15.6%, p<0.001; pulmonary artery embolism 21.3% vs. 28.2%, p=0.001).

There is a 1/3 lower mortality and FtR rate after surgery for a colon or rectal cancer in centers fulfilling the DKG minimum amounts. The presented data implicate that there is an urgent need for a nationwide centralization program.

There is a 1/3 lower mortality and FtR rate after surgery for a colon or rectal cancer in centers fulfilling the DKG minimum amounts. The presented data implicate that there is an urgent need for a nationwide centralization program.