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This is vital information when one wants to examine individual differences in infant ERPs related to face-categorization.Over recent decades, the use of geothermal energy for heating supply and power generation has increased significantly across the world, owing to its low carbon emissions. However, a series of emerging environmental risks from geothermal energy development and operation have been drawing increasing attention from governments and the publics. In this context, the present study provides an overview of methods for quantitatively assessing the environmental risks of geothermal energy. These include seismic hazards, human health, ecological damage and economic loss. The constraints on constructing assessment frameworks are also discussed. Furthermore, a preliminary concept for an integrated framework is proposed to assess environmental risks of geothermal energy comprehensively from multiple perspectives. #link# To enhance the accuracy and reliability of the proposed framework, a data-sharing platform needs to be built to develop multi-disciplinary modeling further.

To evaluate the evidence reporting gene expression array data of human in vitro cultured periodontal ligament cells (PDLCs) submitted to static mechanical loading compared to a control group.

Systematic searches were performed in MEDLINE/PubMed, Scopus, Web of Science, Virtual Health Library, The Cochrane Library and the System for Information on Grey Literature in Europe up to June 2019. A narrative synthesis was performed to summarize differentially expressed genes (DEGs). These were grouped according to the culture method (2D or 3D), force type (compression or tension) and observation time. Additionally, gene ontology (GO) analysis was performed using the Database for Annotation Visualization and Integrated Discovery. The risk of bias (RoB) and certainty of evidence (CoE) were assessed using a modified CONSORT checklist and the GRADE tool, respectively.

Of eight studies included (all rated as having moderate RoB), only two provided the complete list of DEGs and four studies performed GO, gene networkNR4A3, NAMPT, PGK1, and REDD1 are suggested as novel biomarkers for orthodontic tooth movement. Limited amount of evidence on the complete gene expression profile and the high heterogeneity in methodologies make it impossible to obtain definite conclusions. New studies following standardized and well-designed in vitro model and reporting complete gene expression datasets are needed.Functional carbon nanodots (FCNs) with multiple chemical groups have great impact on the growth regulation of plants. To understand find more of the chemical groups, FCNs were reduced from the raw material by pyrolysis method and hydrolysis method. The chemical structure of these materials were characterized by using TGA, TEM, FT-IR, XPS, Raman and elementary analysis. The raw and reduced FCNs were used as plants growth regulators in culture medium of Arabidopsis thaliana. Our results indicate there is a strong correlation between the physiological responses of plants and the surface chemistries (especially carboxyl group and ester group) of the nanomaterials. The quantum-sized FCNs with multiple carboxyl groups and ester groups show better aqueous dispersity and can induce various positive physiological responses in Arabidopsis thaliana seedlings compared with the FCNs decorated without carboxyl and ester as well as aggregated FCNs. link2 The raw FCNs present higher promotion capacity in plants biomass and roots length, and the quantum-sized FCNs are easier to be absorbed by plants and generate more positive effects on plants.Background OBJECTIVE To investigate the effects of peripheral muscle training (PMT) and different inspiratory muscle training (IMT) methods on respiratory functions, exercise capacity, and biochemistry parameters in coronary artery disease patients with metabolic syndrome.

This prospective, single-blind, randomized-controlled study included 60 patients of stable coronary artery disease with metabolic syndrome (New York Heart Association [NYHA] Class I-II, left ventricular ejection fraction >40%). Patients were randomly divided into three groups neuromuscular electrical stimulation (NMES) plus PMT group (NMES+PMT group, n=20), IMT plus PMT group (IMT+PMT group, n=20) and PMT group (PMT group, n=20). Treatment continued for six weeks for all groups. The NMES was applied to rectus abdominis, IMT was applied with 30% of maximal inspiratory pressures, and PMT was applied at home. Spirometry, maximal inspiratory and expiratory pressure, dyspnea scores, exercise stress test, and biochemistry parameters were measured before and after training.

There were significant improvements in spirometric tests, respiratory muscle strength, dyspnea scores, exercise capacity, fasting blood glucose, and antistreptolysin O after treatment in all groups (p<0.05). Significant improvements in C-reactive protein and erythrocyte sedimentation rate were observed in NMES+PMT and IMT+PMT groups (p<0.05). link3 Among the groups, there was a significant difference in maximal inspiratory pressure (p=0.02) and erythrocyte sedimentation rate (p=0.037) in favor of NMES+PMT group (p<0.05).

Our study results showed significant improvements in respiratory functions, exercise capacity, and biochemistry markers in all groups. Different IMT methods can be used in cardiopulmonary rehabilitation to improve exercise intolerance in coronary artery disease patients with metabolic syndrome.

NCT03523026.

NCT03523026.

Neoplasms of the sacrum and pelvis are challenging to manage due to their complex vascularity and size and are at high risk of bleeding during resection. Intra-aortic balloon occlusion (IABO) has been used in trauma to control massive blood loss, but its efficacy and safety in oncologic sacral and pelvic surgery are unknown. The primary objective of this systematic review and meta-analysis was to assess the effectiveness of IABO in providing hemorrhage control during resection of sacral and pelvic tumors.

This PROSPERO pre-registered study meta-analyzed all studies reporting on the use of IABO in the setting of pelvic and sacral tumour resection, in accordance with the PRISMA guidelines. The primary outcome of the meta-analysis was intraoperative blood loss, with secondary outcomes consisting of transfusion volume, post-operative blood loss, operative time, complication rate, and mortality.

Across studies, IABO was associated with a large, significant reduction in intraoperative blood loss (SMD -0.81, 95% CI -1.01 to -0.60, P<0.0001) and transfused red blood cell volume (SMD 0.92, 95% CI -1.30 to -0.53, P<0.0001). Two studies reported that complication rates were comparable between patients receiving IABO and patient receiving conventional surgery (Odds ratio=1.29, 95% CI 0.59 to 2.83, P=0.52). All studies descriptively reported improved visualization of the operative field with IABO.

Our findings demonstrated that IABO is an effective technique to decrease blood loss and transfusion requirements during sacral and pelvic tumor surgery. Future clinical trials should be conducted to establish the safety of this method and explore potential contraindications.

Our findings demonstrated that IABO is an effective technique to decrease blood loss and transfusion requirements during sacral and pelvic tumor surgery. Future clinical trials should be conducted to establish the safety of this method and explore potential contraindications.

Inguinofemoral lymphadenectomy (IFL) is part of the surgical treatment of different malignancies of the genital tract and/or the lower limb including vulvar carcinoma, penile carcinoma and melanoma. IFL is associated with morbidity in up to 85% of the patients. The aims of this MAMBO-IC study (Morbidity And Measurement of the Body) are to study the feasibility of using LigaSure for IFL and to assess the differences in the incidence of short-term complications using LigaSure versus conventional IFL randomized within each individual patient.

In this multicenter randomized controlled trial (RCT), women diagnosed with squamous cell carcinoma of the vulva with an indication for bilateral IFL were included. It was randomly assigned for which groin the LigaSure was used; the other groin was treated with conventional IFL (sharp/diathermia). We estimated the incidence of ≥1 complication(s) per groin using logistic regression and compared this between the two surgical methods, adjusting for possible confounders.

We included 40 groins of 20 patients. The estimated incidence of ≥1 complication(s) was 29% after LigaSure versus 70% after conventional IFL (risk difference 41% (95% CI 19-62), p<0.001). Patients' reported restriction of daily living activities and maximum pain score were equal for both treatment methods. There were no differences in the surgeon reported workload scores.

This RCT shows that LigaSure for IFL is feasible and associated with significantly less short-term surgical complications compared to conventional IFL. Further studies with a larger sample size are needed to validate our findings. ISRCTN15057626.

This RCT shows that LigaSure for IFL is feasible and associated with significantly less short-term surgical complications compared to conventional IFL. Further studies with a larger sample size are needed to validate our findings. ISRCTN15057626.Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) with favorable pathological and clinical features may be considered as indolent lesions, and therefore be amenable to conservative management. According to the primary tumor site, different non-aggressive approaches, based on endoscopic resection or simple active surveillance, can be proposed to selected patients fulfilling specific criteria. Tumor size, Ki67 proliferative index and depth of invasion are markers that can be used in order to identify these subjects. Patients with type I gastric NENs less then 1 cm as well as those with non-ampullary duodenal NENs less then 1 cm with no associated syndrome can be safely managed by endoscopic resection. On the other hand, an active surveillance approach is preferred over surgery for patients with asymptomatic, non-functioning pancreatic NENs ≤2 cm without dilation of the main pancreatic duct or bile duct. As far as NENs of the appendix are concerned, appendectomy should be considered as curative when a R0 resection has been achieved in the presence of a tumor ≤1.5 cm, graded as G1 and without lymphovascular invasion. Finally, G1 rectal NENs ≤1 cm without invasion of the muscular layer can be safely treated by endoscopic resection. Therefore, surgeons should be aware of the existence of indolent GEP-NENs, in order to avoid unnecessary operations with associated postoperative complications.

Exposing the middle hepatic vein (MHV) is required in left hemihepatectomy [1]. Laparoscopy enables us to perform unique approach in performing hepatectomy [2,3]. Herein we show a video of dorsal approach in left hemihepatectomy and measure anatomical parameters useful for approaching to the MHV.

A 79-year-old man with colorectal liver metastasis underwent laparoscopic left hemihepatectomy.

After mobilizing left lateral section and encircling left Glissonian trunk, we firstly flipped up left lateral section inside and began parenchymal transection from dorsal surface around the root of left hepatic vein (LHV). Immediately we touched the MHV and, by cutting the left Glissonian trunk, could extend complete MHV exposure in central-to-peripheral direction without split injuries of MHV branches [2]. Next, we flipped down the left lateral section and divided ventral remaining parenchyma in caudal-to-cranial direction without risk of MHV injury. As this is not one-way procedure [4], as if open a book, we adjusted the ventral cutting plane to match with the dorsal one.