Svendsenschaefer6211

Transforming growth factor-β1 (TGF-β1), collagen IV (Col-IV) and fibronectin (FN) expressions in UUO group were significantly up-regulated, whereas Angpt-1 expression was significantly down-regulated compared with the SHO group. ATRA treatment reduced TGF-β1, Col-IV and FN expressions and improved Angpt-1 expression compared with the UUO group. The protein expression of Angpt-1 in kidney tissue of UUO group was negatively correlated with RIF index and protein expressions of Col-IV, FN and TGF-β1. In conclusion, low expression of Angpt-1 was associated with the RIF disease and ATRA treatment can increase the Angpt-1 and alleviate the RIF lesion in UUO rats.Since December 2019, the outbreak of the novel coronavirus disease (COVID-19) in China has rapidly spread throughout the world. During the course of the COVID-19 pandemic, thrombotic complications have emerged as an important issue. We present two cases of symptomatic arterial thrombosis in patients with confirmed COVID-19. learn more The first patient presented with digital ischemia due to distal embolization from a floating thrombus in the proximal left subclavian artery, and the second one with bilateral acute limb ischemia due to thrombosis of the right popliteal artery and left tibioperoneal trunk. This case report illustrates that arterial thrombosis associated with COVID-19 can occur even in the absence of severe respiratory disease and clinically relevant peripheral arterial disease.Single-vehicle crashes are of major concern in both developed as well as in Low Middle Income Countries due to the severity of injuries, particularly fatal accidents. In India, a significant proportion of crashes are single-vehicle crashes. The vehicles which are involved in accidents due to causes such as self skidding, hitting stationary objects, trees that are simply contributed by the drivers themselves are referred to as out-of-control single-vehicle crashes. The main objective of this study is to evaluate the risk factors associated with single-vehicle motorcycle collisions in Tamilnadu, India and identifies the unique characteristics and injury outcomes associated with these collisions. Crash dataset for the present study was prepared from the police-reported crashes for the past nine years that occurred within the state of Tamilnadu between 2009 and 2017. The identified contributory factors which influence injury severity include driver characteristics, crash-related factors, traffic-related factors, injury severity of the drivers with respect to single-vehicle crashes also. This study provides useful insights for reducing injury severity in single-vehicle motorcycle crashes.Nanotechnology has many potential applications in cancer treatment. For example, nano-drug delivery systems (NDDS) with high bioavailability, biodegradability, and biocompatibility have been developed, in order to increase the therapeutic effects of anticancer drugs. Among these NDDS, high-performance hydroxyapatite (HA) nanoparticles are rapidly advancing in the targeted cancer treatment due to their numerous benefits. Curcumin is an herbal metabolite that acts as a chemical inhibitor through the inhibition of tumor cells and the progression of many cancers. However, the poor bioavailability of curcumin is the most important challenge in using this substance. In this study, HA nanoparticles coated by chitosan were used as a pH-sensitive biopolymer to improve the efficiency and bioavailability of curcumin. For this purpose, HA nanoparticles were first synthesized by the sol-gel method. Then, a layer of chitosan was coated on it, and the curcumin drug was encapsulated in the nanocarrier, under controlled conditions. Techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) were used to characterize the nanocarriers. In the second part, nano-drugs prepared by various bioassays were examined. For this purpose, the rate of cytotoxicity by the methyl-thiazol-tetrazolium (MTT) assay and the rate of apoptosis induction by the acridine orange and ethidium bromide (AO/EB) staining method on the brain carcinoma U87MG cell line were investigated.Background In Asian countries, clinical practice places little emphasis on developing the clinical decision-making skills and social problem-solving abilities of nursing students.Objective This study explored whether a 3-months-in-1-unit training program improved nursing students' clinical decision-making skills and social problem-solving abilities compared to the 1-month-in-1-unit rotation program.Methods A quasi-experimental study was conducted. A 3-months-in-1-unit training program was conducted in the intervention group (n = 77), rountine1-month-in-1-unit rotation was conducted in the control group (n = 73). Clinical decision-making skills and problem-solving abilities were measured using the Chinese version of the Clinical Decision-Making Nursing Scale and the Social Problem-Solving Inventory-Revised.Results Nursing students in the intervention group scored higher clinical decision-making skills (t = 7.677, p  less then  0.05), positive problem orientation (t = 18.359, p  less then  0.05), negative problem orientation (t = -3.711, p  less then  0.05), and rational problem-solving (t = 2.312, p  less then  0.05) than the control group.Conclusions The 3-months-in-1-unit specialized training program had a significant positive impact on students' clinical decision-making skills and social problem-solving abilities.A new type of photocatalysts, nanocrystalline titanium dioxide (TiO2) doped with Co and I, were synthesized and modified via the sol-gel method to enhance the utilization of visible light. Herein, mono- and co-doped TiO2 (i.e. Co-TiO2, I-TiO2, Co-I-TiO2) were employed as the photocatalysts to investigate the photocatalytic performance on gaseous benzene removal. The prepared photocatalysts were characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET)-specific surface areas, Raman spectroscopy, UV-visible diffuse reflectance spectroscopy (UV-vis-DRS), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL), and electrochemical impedance spectroscopy (EIS). Results indicated that both particle sizes and band gaps of TiO2 were significantly reduced by doping with Co/I. Also, the lattice defects and the specific surface areas of TiO2 were substantially augmented by adding Co/I because of the increase of oxygen vacancies, especially for Co-I-TiO2. Meanwhile, Co and I were distributed on the titanium base with the existence of multivalent states.