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Mitotic count is an important indicator for assessing the invasiveness of breast cancers. Currently, the number of mitoses is manually counted by pathologists, which is both tedious and time-consuming. To address this situation, we propose a fast and accurate method to automatically detect mitosis from the histopathological images. The proposed method can automatically identify mitotic candidates from histological sections for mitosis screening. Specifically, our method exploits deep convolutional neural networks to extract high-level features of mitosis to detect mitotic candidates. Then, we use spatial attention modules to re-encode mitotic features, which allows the model to learn more efficient features. Finally, we use multi-branch classification subnets to screen the mitosis. Compared to existing related methods in literature, our method obtains the best detection results on the dataset of the International Pattern Recognition Conference (ICPR) 2012 Mitosis Detection Competition. Code has been made available at https//github.com/liushaomin/MitosisDetection.Non-small cell lung cancer (NSCLC) caused by the mutation of epidermal growth factor receptor (EGFR) is a major cause of death worldwide. EGFR Tyrosine kinase inhibitors (TKIs) have been developed against the EGFR. These TKIs produce promising results at initial stage of therapy, but the efficacy becomes limited due to the emergence of drug resistance in most cases after about an year, due to a secondary point mutation. #link# In this work, we investigated the drug resistance mechanism due to the EGFR mutations. We performed molecular dynamics (MD) simulation for EGFR-drug interactions complexes. Euclidean distance and binding free energy are used for drug resistance analysis and drug-protein interactions visualization. A PCA-based method is proposed to find normal, rigid, flexible, and critical residues. Overall, we have established a systematic method for the visualization of protein-drug interactions, which provides an effective framework for the analysis of lung cancer drug resistance at atomic level.Reinforcement learning is a powerful tool for developing personalized treatment regimens from healthcare data. Yet training reinforcement learning agents through direct interactions with patients is often impractical for ethical reasons. One solution is to train reinforcement learning agents using an 'environment model,' which is learned from retrospective patient data and can simulate realistic patient trajectories. In this study, we propose transitional variational autoencoders (tVAE), a generative neural network architecture that learns a direct mapping between distributions over clinical measurements at adjacent time points. Unlike other models, the tVAE requires few distributional assumptions and benefits from identical training and testing architectures. This model produces more realistic patient trajectories than state-of-the-art sequential decision-making models and generative neural networks, and can be used to learn effective treatment policies.With the soaring development of body sensor network (BSN)-based health informatics, information security in such medical devices has attracted increasing attention in recent years. Employing the biosignals acquired directly by the BSN as biometrics for personal identification is an effective approach. Noncancelability and cross-application invariance are two natural flaws of most traditional biometric modalities. Once the biometric template is exposed, it is compromised forever. Even worse, because the same biometrics may be employed as tokens for different accounts in multiple applications, the exposed template can be used to compromise other accounts. In this work, we propose a cancelable and cross-application discrepant biometric approach based on high-density surface electromyogram (HD-sEMG) for personal identification. We enrolled two accounts for each user. HD-sEMG signals from the right dorsal hand under isometric contractions of different finger muscles were employed as biometric tokens. Since isometric contraction, in contrast to dynamic contraction, requires no actual movement, the users' choice to login to different accounts is greatly protected against impostors. link2 We realized a promising identification accuracy of 85.8% for 44 identities (22 subjects × 2 accounts) with training and testing data acquired 9 days apart. The high identification accuracy of different accounts for the same user demonstrates the promising cancelability and cross-application discrepancy of the proposed HD-sEMG-based biometrics. To the best of our knowledge, this is the first study to employ HD-sEMG in personal identification applications, with signal variation across days considered.Kidney development is key to the long-term health of the fetus. Renal volume and vascularity assessed by 3D ultrasound (3D-US) are known markers of wellbeing, however, a lack of real-time image segmentation solutions preclude these measures being used in a busy clinical environment. In this work, we aimed to automate kidney segmentation using fully convolutional neural networks (fCNN). We used multi-parametric input fusion incorporating 3D B-Mode and power Doppler (PD) volumes, aiming to improve segmentation accuracy. Three different fusion strategies and their performance were assessed versus a single input (B-Mode) network. Early input-level fusion provided the best segmentation accuracy with an average Dice similarity coefficient (DSC) of 0.81 and Hausdorff distance (HD) of 8.96 mm, an improvement of 0.06 DSC and reduction of 1.43mm HD compared to our baseline network. Compared to manual segmentation for all models, repeatability was assessed by intra-class correlation coefficients (ICC) indicating good to excellent reproducability (ICC >= 0.93). The framework was extended to support multiple graphics processing units (GPUs) to better handle volumetric data, dense fCNN models, batch normalisation and complex fusion networks. This work and available source code provides a framework to increase the parameter space of encoder-decoder style fCNNs across multiple GPUs and shows that application of multi-parametric 3D-US in fCNN training improves segmentation accuracy.Bilateral rehabilitation allows patients with hemiparesis to exploit the cooperative capabilities of both arms to promote the recovery process. Although various approaches have been proposed to facilitate synchronized robot-assisted bilateral movements, few studies have focused on addressing the varying joint stiffness resulting from dynamic motions. This paper presents a novel bilateral rehabilitation system that implements a surface electromyography (sEMG)-based stiffness control to achieve real-time stiffness adjustment based on the user's dynamic motion. An sEMG-driven musculoskeletal model that incorporates muscle activation and muscular contraction dynamics is developed to provide reference signals for the robot's real-time stiffness control. Preliminary experiments were conducted to evaluate the system performance in tracking accuracy and comfortability, which showed the proposed rehabilitation system with sEMG-based real-time stiffness variation achieved fast adaption to the patient's dynamic movement as well as improving the comfort in robot-assisted bilateral training.The neuron behavioral models are inspired by the principle of the firing of neurons, and weighted accumulation of charge for a given set of input stimuli. Biological neurons show dynamic behavior through its feedback and feedforward time-dependent responses. link3 The principle of the firing of neurons inspires threshold logic design by applying threshold functions on the weight summation of inputs. In this article, we present a recursive threshold logic unit that uses the output feedback from standard threshold logic gates to emulate Boolean expressions in a time-sequenced manner. The Boolean expression is implemented with an analog resistive divider in memristive crossbars and a hard-threshold function designed with CMOS comparator for realizing the sums (OR) and products (AND) operators. The method benefits from reliable programming of the memristors in 1T1R crossbar configuration to suppress sneak path currents and thus enable larger crossbar sizes, which in turn allow a higher number of Boolean inputs. The reference threshold voltage for the decision comparators is tuned to implement AND and OR logic. selleckchem is limited by the number of inputs to the crossbar. Simultaneously, the resistance of the memristors is kept constant at RON. The circuit's tolerance to the memristor variability and aging are analyzed, showing sufficient resilience. Also, the proposed recursive logic uses fewer cross-points, and has lower power dissipation than other memristive logic and CMOS implementation.The tracking of eye gesture movements using wearable technologies can undoubtedly improve quality of life for people with mobility and physical impairments by using spintronic sensors based on the tunnel magnetoresistance (TMR) effect in a human-machine interface. Our design involves integrating three TMR sensors on an eyeglass frame for detecting relative movement between the sensor and tiny magnets embedded in an in-house fabricated contact lens. Using TMR sensors with the sensitivity of 11 mV/V/Oe and ten less then 1 mm3 embedded magnets within a lens, an eye gesture system was implemented with a sampling frequency of up to 28 Hz. Three discrete eye movements were successfully classified when a participant looked up, right or left using a threshold-based classifier. Moreover, our proof-of-concept real-time interaction system was tested on 13 participants, who played a simplified Tetris game using their eye movements. Our results show that all participants were successful in completing the game with an average accuracy of 90.8%.Lung cancer is the leading cause of cancer deaths. Low-dose computed tomography (CT) screening has been shown to significantly reduce lung cancer mortality but suffers from a high false positive rate that leads to unnecessary diagnostic procedures. The development of deep learning techniques has the potential to help improve lung cancer screening technology. Here we present the algorithm, DeepScreener, which can predict a patient's cancer status from a volumetric lung CT scan. DeepScreener is based on our model of Spatial Pyramid Pooling, which ranked 16th of 1972 teams (top 1%) in the Data Science Bowl 2017 (DSB2017) competition, evaluated with the challenge datasets. Here we test the algorithm with an independent set of 1449 low-dose CT scans of the National Lung Screening Trial (NLST) cohort, and we find that DeepScreener has consistent performance of high accuracy. Furthermore, by combining Spatial Pyramid Pooling and 3D Convolution, it achieves an AUC of 0.892, surpassing the previous state-of-the-art algorithms using only 3D convolution. The advancement of deep learning algorithms can potentially help improve lung cancer detection with low-dose CT scans.Numerous studies have shown that microRNAs are associated with the occurrence and development of human diseases. Thus, studying disease-associated miRNAs is significantly valuable to the prevention, diagnosis and treatment of diseases. In this paper, we proposed a novel method based on matrix completion and non-negative matrix factorization (MCNMF) for predicting disease-associated miRNAs. Due to the information inadequacy on miRNA similarities and disease similarities, we calculated the latter via two models, and introduced the Gaussian interaction profile kernel similarity. In addition, the matrix completion (MC) was employed to further replenish the miRNA and disease similarities to improve the prediction performance. And to reduce the sparsity of miRNA-disease association matrix, the method of weighted K nearest neighbor (WKNKN) was used, which is a pre-processing step. We also utilized non-negative matrix factorization (NMF) using dual L2,1-norm, graph Laplacian regularization, and Tikhonov regularization to effectively avoid the overfitting during the prediction.