Suttonsonne4371

Due to the large scale of the considered problems and the resulting computational complexity of the employed networks, the priors are obtained by processing the images or volumes as patches or slices. We evaluated the method for the cases of 3D cone-beam low dose CT and undersampled 2D radial cine MRI and compared it to a total variation-minimization-based reconstruction algorithm as well as to a method with regularization based on learned overcomplete dictionaries. The proposed method outperformed all the reported methods with respect to all chosen quantitative measures and further accelerates the regularization step in the reconstruction by several orders of magnitude.We synthesized the alkaline-earth metal-doped FeSe compounds (NH3) y AE x FeSe (AE Ca, Sr and Ba), using the liquid NH3 technique, to determine their superconducting properties and crystal structures. Multiple superconducting phases were obtained in each sample of (NH3) y Ca x FeSe and (NH3) y Ba x FeSe, which showed two superconducting transition temperatures (T c's) as high as 37-39 K and 47-48 K at ambient pressure, hereinafter referred to as the 'low-T c phase' and 'high-T c phase', respectively. The high-T c phases in (NH3) y Ca x FeSe and (NH3) y Ba x FeSe were metastable, and rapidly converted to their low-T c phases. However, T c values of 38.4 K and 35.6 K were recorded for (NH3) y Sr x FeSe, which displayed different behavior than (NH3) y Ca x FeSe and (NH3) y Ba x FeSe. The Le Bail fitting of x-ray diffraction (XRD) patterns provided lattice constants of c = 16.899(1) Å and c = 16.8630(8) Å for the low-T c phases of (NH3) y Ca x FeSe and (NH3) y Ba x FeSe, respectively. The lattice constants of their high-T c phases could not be determined due to the disappearance of the high T c phase within a few days. The XRD pattern for (NH3) y Sr x FeSe indicated the coexistence of two phases with c = 16.899(3) Å and c = 15.895(4) Å. The former value of c in (NH3) y Sr x FeSe is almost the same as those of the low-T c phases in (NH3) y Ca x FeSe and (NH3) y Ba x FeSe. Therefore, the phase with c = 16.899(3) Å in (NH3) y Sr x FeSe must correspond to the superconducting phase with the T c of 38.4 K, while the superconducting phase with T c = 35.6 K is assigned to the crystal phase with c = 15.895(4) Å. For (NH3) y Sr x FeSe, a high-T c phase with T c = 47-48 K has not yet been obtained, but a new phase showing the T c value of 35.6 K was clearly obtained. This is the first systematic study of the preparation, crystal structure, and superconductivity of alkaline-earth metal-doped FeSe, (NH3) y AE x FeSe.Objective Developing a new neuromodulation method for epilepsy treatment requires a large amount of time and resources to find effective stimulation parameters and often fails due to inter-subject variability in stimulation effect. As an alternative, we present a novel data-driven surrogate approach which can optimize the neuromodulation efficiently by investigating the stimulation effect on surrogate neural states. Approach Medial septum (MS) optogenetic stimulation was applied for modulating electrophysiological activities of the hippocampus in a rat temporal lobe epilepsy model. For the new approach, we implemented machine learning techniques to describe the pathological neural states and to optimize the stimulation parameters. Specifically, first, we found neural state surrogates to estimate a seizure susceptibility based on hippocampal local field potentials. Second, we modulated the neural state surrogates in a desired way with the subject-specific optimal stimulation parameters found by in vivo Bayesiaand further improve therapeutic effectiveness. This approach also can be used for improving neuromodulation treatment of other neurological or psychiatric diseases.Acute kidney injury (AKI) is a common renal dysfunction. Renal ischemia-reperfusion (I/R) injury contributes to AKI progression. The microRNA miR-195-5p can act as a crucial tumor inhibitor in various cancers. However, the potential biological effects of miR-195-5p on AKI are not well-understood. We found that miR-195-5p levels were decreased in the serum samples of patients with AKI. Next, we determined miR-195-5p expression in the renal tissues of the rats and found that it was downregulated. Renal function was evaluated and confirmed using blood urea nitrogen and serum Cr levels. Vismodegib ic50 In parallel, the hypoxia-induced NRK-52E cell model was employed, and miR-195-5p was found to be markedly reduced under hypoxic conditions. Furthermore, miR-195-5p was modulated in NRK-52E cells. miR-195-5p induced NRK-52E cell proliferation and protected NRK-52E cells against hypoxia-triggered apoptosis. In an I/R mouse model, miR-195-5p alleviated renal injury triggered by I/R. In addition, oxidative stress and inflammatory factor concentrations were assessed using ELISA. The results showed that miR-195-5p mimicked attenuated oxidative stress induced by I/R injury and downregulated the protein expression of inflammatory factors. Moreover, we identified that vascular endothelial growth factor A (VEGFA) was a target gene of miR-195-5p, which could negatively regulate VEGFA expression in vitro. Inhibitors of miR-195-5p subsequently contributed to renal injury, which was reversed by VEGFA loss. In conclusion, miR-195-5p may repress AKI by targeting VEGFA.Background TP53 plays critical roles in sensitivity to chemotherapy, and aging. Collagen is very important in aging. The molecular structure and biochemical properties of collagen changes during aging. The discoidin domain receptor (DDR1) is regulated in part by collagen. Elucidating the links between TP53 and DDR1 in chemosensitivity and aging could improve therapies against cancer and aging. Results Restoration of WT-TP53 activity resulted in increased sensitivity to chemotherapeutic drugs and elevated expression of key components of the Raf/MEK/ERK, PI3K/Akt and DDR1 pathways. DDR1 could modulate the levels of Raf/MEK/ERK and PI3K/Akt pathways as well as sensitize the cells to chemotherapeutic drugs. In contrast, suppression of WT TP53 with a dominant negative (DN) TP53 gene, suppressed DDR1 protein levels and increased their chemoresistance. Conclusion Restoration of WT TP53 activity or increased expression of the anti-aging DDR1 collagen receptor can result in enhanced sensitivity to chemotherapeutic drugs.