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Differences in study design, control groups and clinical parameters between studies, however, affect sensitivity, specificity and cutoff values, underlining the need of further studies to address these issues and pave the way for a generalized clinical practice.Aim We investigated the direct effects of sevoflurane on angiogenesis and a variety of tumor cells. Materials & methods The antiangiogenic activity of sevoflurane was determined using angiogenesis and biochemical assays. Results Sevoflurane at low doses inhibits capillary network formation. Sevoflurane inhibited VEGF- and bFGF-stimulated migration, adhesion and growth in endothelial cells and induced apoptosis. Sevoflurane only at high doses inhibited growth and migration of tumor cells, suggesting differential effects of sevoflurane between endothelial and tumor cells. Mechanistically, sevoflurane decreased growth factors-induced Ras and Rac1 activation, and suppressed Ras and Rac1 signaling. Conclusion We demonstrate the antiangiogenic effects of sevoflurane and provide preclinical evidence into the potential mechanisms by which sevoflurane may negatively affect cancer growth and metastasis.Objectives The evidence for diagnostic accuracy using cone beam computed tomography (CBCT) for dental applications depends heavily on ex vivo research, but there is little knowledge of whether the model used affects the diagnostic accuracy results. The objective of this study was to determine the impact of different designs of anthropomorphic models on diagnostic accuracy for the specific task of dental root fracture detection. Methods Horizontal or oblique root fracture was induced in 24 of 48 permanent maxillary incisors. The 48 teeth were scanned by CBCT using standard clinical exposure factors on five occasions, each with a different model design. Scans were viewed by five dental and maxillofacial radiologists, who each made a forced diagnosis of fracture or no fracture in each root and a judgment on root fracture using a five-point confidence scale. Sensitivity (Se), specificity (Sp) and areas under receiver operating characteristic (ROC) curve (Az) were calculated for each observer for each model. Results There were no significant differences between the diagnostic accuracy measurements recorded using different models. There were, however, numerous significant differences between observers using the same anthropomorphic model. Conclusions Despite the differences in X-ray attenuation between the five model designs, the results suggest that the anthropomorphic model does not affect the results of diagnostic accuracy studies on root fracture using this CBCT machine at standard clinical exposures. This provides some confidence in the previously published evidence. The interobserver diagnosis differences indicate that research using only two observers could provide misleading results.Introduction The aim of this paper was to perform a narrative review of the literature on the available approaches in the treatment of two emerging subpopulations of metastatic renal cell carcinoma (mRCC) patients the oligometastatic disease (less than 5 metastasis) and the oligoprogressive disease, defined as worsening in maximum 3-5 sites while all other tumor sites are controlled by systemic therapy. Areas covered We explore all possible approaches in these settings of patients the role of local therapies, considering both surgical metastasectomy and/or ablative techniques, the efficacy of systemic therapies and the rationale behind active surveillance. We also discuss ongoing clinical trials in these settings. Expert opinion Two different strategies are emerging as the most promising for the approach to the oligometastatic/oligoprogressive mRCC patient (1) the use of immunocheckpoint inhibitors following metastasectomy; (2) the use of stereotactic radiotherapy alone or combined with immunotherapy for oligometastatic disease. The lack of validated biomarkers of response in these mRCC patient subpopulations is opening the way to the employment of novel technologies. Among them, the use of artificial intelligence seems to be the candidate to contribute to precision oncology in patients with mRCC.Immune checkpoint inhibition completely changed our approach of cancer therapeutics and led to interesting response rate in a wide spectrum of tumors. However, only a portion of patients benefits from immune checkpoint blockers. To improve response rates, monoclonal antibodies targeting costimulatory receptors called PD-1 or CTLA-4 are combined together or with different therapies such as chemotherapy or antiangiogenic drugs. Some of these combinations are already approved and used in daily practice, but the safety and efficacy in particular populations such as older patients, Eastern Cooperative Organization performance status 2 or patients taking corticosteroids or antibiotics remain unclear. This special report focuses on the data available for these populations with a focus on non-small-cell lung cancer.Sexual violence or misconduct can occur at any age, yet sexual consent understanding is not well studied, especially beyond early adulthood. This project aimed to describe how sexual consent is conceptualized across the adult lifespan, drawing comparisons between young, middle-aged, and older adults. Additionally, we examined variables that may differ by age group and influence sexual consent conceptualization. In a survey, young adults (n= 266), middle-aged adults (n= 236), and older adults (n= 51) were asked to define sexual consent and complete a measure on the appropriateness of giving and receiving consent in different types of sexual relationships. Participants also reported on their exposure to formal sex education and their current sexual relationship status. More than half (57.4%) of participants included basic elements of a simple core definition (agreement in reference to sexual acts), and most (63.3%) expanded beyond a simple definition. Age groups differed significantly on variables expected to influence sexual consent definitions, including exposure to sexual education and sexual consent attitudes. Age group differences were not found when examining the simple core definition, but young adults and middle-aged adults differed significantly in their expansion on the definition. https://www.selleckchem.com/products/tng908.html Sexual consent attitudes were also significantly related to the scope of the supplied definition. These findings suggest that sexual consent definitions vary in scope across at least a portion of the lifespan and that the importance placed on sexual consent may be a reasonable intervention target regardless of age differences in sexual experience and education.