Sumnermangum5737

As a consequence, there is a reduction in epithelial cell-derived antimicrobial peptide, but enhanced expression of lipid-binding proteins and transporters8. During food consumption, activation of VIPergic neurons thus enhances growth of epithelial-associated SFB and increases lipid absorption. Our results reveal a feeding- and circadian-regulated dynamic intestinal neuro-immune circuit that promotes a trade-off between IL-22-mediated innate immune protection and efficiency of nutrient absorption. Modulation of this pathway may hence be effective for enhancing resistance to enteropathogen2,3,9 and for treatment of metabolic diseases.BACKGROUND Screen-based media use is prevalent in children and is associated with health risks. American Academy of Pediatrics (AAP) recommendations involve access to screens, frequency, content, and co-viewing. The aim of this study was to test the ScreenQ, a composite measure of screen-based media use. METHODS ScreenQ is a 15-item parent report measure reflecting AAP recommendations. Range is 0-26, higher scores reflecting greater non-adherence. With no "gold standard" available, four validated measures of skills and parenting practices cited as influenced by overuse were applied as the external criteria, including expressive language, speed of processing, emergent literacy, and cognitive stimulation at home. Psychometric analyses involved Rasch methods and Spearman's ρ correlations. RESULTS Sixty-nine families were administered ScreenQ. Child age ranged from 36 to 63 months old (52 ± 8; 35 girls). Mean ScreenQ score was 9.6 (±5.0; 1-22). Psychometric properties were strong (rCo-α = 0.74). ScreenQ scores were negatively correlated with CTOPP-2 (Comprehensive Test of Phonological Processing, Second Edition) (rρ = -0.57), EVT-2 (Expressive Vocabulary Test, Second Edition) (rρ = -0.45), GRTR (Get Ready to Read!) (rρ = -0.30) and StimQ-P (rρ = -0.42) scores (all p ≤ 0.01). CONCLUSIONS ScreenQ shows potential as a composite measure of screen-based media use in young children in the context of AAP recommendations. ScreenQ scores were correlated with lower executive, language and literacy skills, and less stimulating home cognitive environment.BACKGROUND Obesity has been associated with earlier thelarche, whereas other predictors for it remain unclear. METHODS We studied child-related and parental predictors for earlier thelarche in 195 girls aged 6-8 years followed up for 2 years. A physician evaluated breast development by inspection and palpation. Body fat percentage (BF%) was measured by dual-energy X-ray absorptiometry, diet by food records, and physical activity and sedentary time by body movement and heart rate monitors. Parental education, smoking, and alcohol consumption and household income were assessed by questionnaires. Gestational age, birth weight, and maternal prepregnancy BMI were obtained from hospital registers. Predictors for thelarche were examined using logistic regression analysis adjusted for age and follow-up time. RESULTS The incidence of thelarche during 2 years increased by 11% (OR 1.11, CI 1.06-1.17, p  less then  0.001) for 1 unit increase in baseline BF%. Girls with a smoking parent had a 2.64 (95% CI 1.21-5.77, p = 0.015) times higher incidence of thelarche than other girls. The associations of lower parental education and higher maternal prepregnancy BMI with the higher incidence of thelarche were largely explained by BF%. Other possible predictors were not associated with thelarche. CC-4047 ic50 CONCLUSIONS Higher BF% and exposure to tobacco smoke are independent predictors for earlier thelarche.BACKGROUND We examined how specific cognitive behavioral impairments impacted quality of life (QoL) within a large multicenter cohort of 7-10 year olds surviving extremely preterm (EPT) without major neurodevelopmental disability. METHODS Between 7 and 10 years of age, two generic, self-proxy, and parental evaluations were obtained. QoL measurement questionnaires (Kidscreen-10/VSPA (Vécu et Santé Perçue de l'Enfant et de l'Adolescent)) were used and compared to a reference population. The general and specific cognitive functions, such as executive functions, behavior and anxiety, and clinical neurologic examination, were also assessed. RESULTS We analyzed 211 school-aged EPT children. The mean gestational age was 26.2 (±0.8) weeks, birth weight was 879 g (±181) and the mean age was 8.4 years (±0.87). Children with a Full-Scale Index Quotient ≥89, who were considered as normal, had a lower QoL. Specific cognitive impairments comprehensive language delay, visuo-spatial integration defect, and dysexecutive disorders) were the QoL correlates in the domains of school performance and body image. CONCLUSIONS School and health care professionals need to increase their focus on EPT children's lower so as to recognize the preterm behavioral/cognitive phenotype and their potential need for supportive measures. Research on preventive interventions is warranted to investigate if these long-term effects of an EPT birth can be attenuated in neonatal period and after.A 36-year-old highly myopic woman was referred for management of both cataract and glaucoma. Her ocular history included retinal detachment repair in each eye, 9 years earlier in the right eye and 7 years earlier in the left eye. Although the patient did not remember specific details of the retinal surgery, she recalled that she had a "gas bubble" postoperatively in the right eye, but not the left eye. She also had a very dense nuclear cataract in the right eye, but only mild nuclear sclerosis in the left eye.At presentation, the patient's corrected distance visual acuity (CDVA) was 20/125 in the right eye, with a large myopic shift (-18.25 + 2.00 × 175). Her CDVA in the left eye was 20/20 (-11.00 + 1.00 × 20). It is notable that she is contact lens-intolerant.Her angle was wide open in each eye, and each optic nerve had severe myopic saucerization and cupping. link2 The axial length was 28.5 mm and 28.7 mm in the right eye and left eye, respectively.The intraocular pressure (IOP) at presentation was 18 mm Hg in thOL) placed in the capsular bag with perfect centration. It was unclear whether the loose zonule was a consequence of the patient's vitreoretinal surgery or whether there was a systemic cause for her zonulopathy. Although it was not suspected before the surgery, in retrospect, this patient had the classic body habitus of Marfan syndrome. Moreover, subsequent surgery in the fellow left eye found the zonule to be quite loose, but not as severe as in the right eye.How would you manage this patient's glaucoma? Given the finding of very loose zonular fibers, would you initiate a workup for Marfan syndrome? Certain microinvasive glaucoma surgery (MIGS) procedures are labeled for mild-to-moderate glaucoma. How strictly do you adhere to such labeling? Do you ever use a MIGS device in severe glaucoma?We report a case of transient corneal ectasia developed after phacoemulsification in an eye previously treated with INTRACOR. There was a myopic refractive surprise after cataract surgery. Corneal tomography showed an increase in keratometry and elevation profile compared with preoperative examination. Soft contact lenses and intraocular pressure-lowering medications were prescribed as interim treatment. Clinical improvement was seen gradually, and the resolution of myopia and ectasia was achieved at 3 months. We believe that high intraocular pressure during phacoemulsification and the weakening effect of femtosecond intrastromal presbyopic treatment can be the culprits.Three patients using a postoperative combination of topical ketorolac (Acular) and neomycin/polymyxin B sulfate/dexamethasone (Maxitrol) were diagnosed with atypical keratopathy soon after routine cataract surgery. An immediate retrospective analysis of hospital patients who had used this topical drug combination in the previous year identified 10 other patients who also had significant corneal pathology after uneventful cataract surgery. Five of the 13 affected patients had corneal melting and 1 patient had corneal perforation and endophthalmitis. link3 At the last recorded follow-up appointment, 8 of the 13 patients had a visual acuity of 6/36 or worse. Corneal melting is a rare complication of topical nonsteroidal anti-inflammatory drugs (NSAIDs). We propose that the combined use of topical NSAIDs and other agents, such as neomycin and benzalkonium, that further compromise the corneal epithelium, should be used with vigilance and increased awareness of potential keratopathy and permanent visual morbidity.The iris-fixated phakic intraocular lens (pIOL) has been available for over 25 years. To provide a clear picture of outcomes and risks, for this systematic review and meta-analysis, the literature was searched for reports on middle- and long-term effects. The iris-fixated phakic intraocular lens (pIOL) has been available for over 25 years. To provide a clear picture of outcomes and risks, for this systematic review and meta-analysis, the literature was searched for reports on middle- and long-term effects of iris-fixated pIOLs on myopic and hyperopic eyes with a follow-up of at least 2 to 4 years. Visual and refractive results after implantation for correction of myopia are positive and the complication rate is low. Endothelial cell loss appears to be at an acceptable rate, although the range of endothelial cell change is too wide to draw firm conclusions. Care should be taken when considering an iris-fixated pIOL for hyperopic eyes because complication rates, particularly pigment dispersion, might be higher than those in myopic eyes. More well-designed, long-term studies are needed, especially in hyperopic eyes. The authors advocate for standardized reporting of refractive surgery data. Initiatives proposed by journal authors and editors to achieve uniformity should be supported.PURPOSE To perform ex vivo and in vivo validation of a manufactured, optimized shape-memory pupil expander and compare its performance to that of existing devices. SETTING National University of Singapore and SingHealth Academy. DESIGN Prospective randomized blinded assessment. METHODS Shape-memory expanders were manufactured by overmolding and were inserted into ex vivo porcine eyes and in vivo monkey eyes for validation. The shape-memory expander was compared to the Malyugin ring, OASIS iris expander, and iris hook. After insertion and removal of the devices, the eyes were fixed, and the iris images were analyzed. RESULTS The shape-memory was successful in pupil expansion for both in vivo and ex vivo experiments. Subsequent ex vivo device comparison revealed iris pigment epithelial loss in 36.4% of eyes for the iris hooks, 30.8% for the iris expander, and 20.0% for the Malyugin ring. Sphincter tears were observed in 27.3% of eyes for the iris hooks and 10.0% for the Malyugin ring. No observable tissue irregularities were observed in the shape-memory expander. CONCLUSION The shape-memory expander was optimized to minimize stress exerted onto the iris tissue. The in vivo and ex vivo experimental validation demonstrate efficacy in engineering design and further highlight the translational potential of smart materials in implant development to improve patient healthcare.