Stricklandrosenkilde4839

If pleural effusion occurs in hypertensive patients administered amlodipine, it should be considered as the potential cause.

Pleural effusion resolved within 24 h of reducing the dosage of amlodipine. Hence, the dog was diagnosed with amlodipine-induced pleural effusion. Rarely, amlodipine can cause pleural effusion after high-dose administrations in humans, but only two cases of peripheral edema have been reported in animals. If pleural effusion occurs in hypertensive patients administered amlodipine, it should be considered as the potential cause.

We aimed to determine the psychometric properties and factor structure of the 19-item Female Sexual Function Index (FSFI) in 132sexually active women previously treated for breast cancer.

Confirmatory factor analysis explored three models (a) second-order six-factor, (b) six-factor, and (c) five-factor models combining the desire and arousal subscales.

Results revealed excellent reliability for the total score (Cronbach's α=0.94), and domain scores (all Cronbach's αs>0.90), and good convergent and discriminant validity. The six-factor model provided the best fit of the models assessed, but a marginal overall fit (Tucker-Lewis index=0.91, comparative fit index=0.93, root mean square error of approximation=0.09). Exploratory factor analyses (EFA) supported a four-factor structure, revealing an arousal/orgasm factor alongside the original pain, lubrication, and satisfaction domains.

The arousal/orgasm factor suggests a "sexual response" construct, potentially arising from an underlying latent factor icancer. Finally, the EFA failed to capture an underlying desire factor, potentially due to measurement error associated with the small number of items (two) in this domain. Despite evidence that the FSFI has sound psychometric properties, our results suggest that the current conceptualizations of the FSFI might not accurately represent sexual functioning in women previously treated for breast cancer. Further research is required to elucidate the factors that influence desire, arousal, and orgasm in sexually active women in this population, and the reasons underlying sexual inactivity. Practical and theoretical implications for FSFI use in this population are discussed.All-solid-state batteries (ASSBs) have become an important technology because of their high performance and low-risk operation. However, the high interface resistance and low ionic conductivity of ASSBs hinder their application. In this study, a self-developed electrochemical model based on an open-source computational fluid dynamics platform is presented. The effect of contact area reduction at the electrode/solid-state electrolyte interface is investigated. Then, a new conceptual 3D structure is introduced to circumvent the existing barriers. The results demonstrate that the discharge time is shortened by over 20% when the area contact ratio reduces from 1.0 to 0.8 at 1 C-rate, owing to the increased overpotential. By adopting the new 3D pillar design, the energy density of ASSBs can be improved. However, it is only when a 3D current collector is contained in the cathode that the battery energy/power density, capacity, and material utilization can be greatly enhanced without being limited by pillar height issues. Therefore, this work provides important insight into the enhanced performance of 3D structures.Blunt or penetrating trauma resulting in injury or rupture of the diaphragm is rare and constitutes about 1% to 3.9% of all thoraco-abdominal injuries. It is often regarded as a marker of severe trauma. Unfortunately about half of these injuries can be missed during the index admission. Contrast-enhanced computed tomography is the best modality to assess the extent, size of diaphragmatic defect and nature of hernial contents. Surgery is mandatory once the diagnosis is made to prevent future strangulation of hernial contents. Although technically challenging, laparoscopic reduction and mesh repair is feasible in expert hands. We report our experience with laparoscopic repair and mesh re-enforcement in a patient who had a large right diaphragmatic hernia with part of liver, gallbladder, small bowel and omentum within the right hemithorax secondary to a penetrating trauma he had incurred 29 years earlier.Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient uptake by recipient cells remain critical barriers for their theranostic applications. To address these critical issues, multifunctional nanomaterials, such as magnetic nanomaterials, with their tunable physical, chemical, and biological properties, may play crucial roles in next-generation extracellular vesicles (EV)-based disease diagnosis, drug delivery, tissue engineering, and regenerative medicine. As such, one aims to provide cutting-edge knowledge pertaining to magnetic nanomaterials-facilitated isolation, detection, and delivery of extracellular vesicles and their associated biomolecules. By engaging the fields of extracellular vesicles and magnetic nanomaterials, it is envisioned that their properties can be effectively combined for optimal outcomes in biomedical applications.Intestinal ultrasound (IUS) is a non-invasive and accurate tool to assess inflammatory bowel disease. The ECCO-ESGAR guideline recommends the use of IUS for the assessment of disease activity and complications in Crohn's disease (CD). In addition, an increasing body of evidence suggests the use of IUS as alternative to colonoscopy in monitoring CD and in assessing disease activity of ulcerative colitis. learn more Early responsiveness of IUS findings by the first weeks of treatment and the advantage to perform the procedure in real time may dramatically change frequency of the assessment of treatment response in the future and speed up the clinical decision-making process. Development of validated and reproducible sonographic scores to measure disease activity and therapeutic response and spread of knowledge of IUS remain relevant issues for the future in which current researchers and the International Bowel Ultrasound (IBUS) Group are actively engaged.

This study aimed to evaluate the outcome and prognostic factors in patients with dilated cardiomyopathy (DCM) and long-standing heart failure (LDCM) vs. recent-onset heart failure (RODCM).

We compared 2019 patients with RODCM (duration <6months, mean age 58.6years, 70.7% male) with 1714 patients with LDCM (duration ≥6months, median duration 3.5years, mean age 62.5years, 73.7% male) included in the Swedish Heart Failure Registry in the years 2003-16. Outcome measures were all-cause, cardiovascular (CV), and non-CV death and hospitalizations; heart transplantation; and a combined outcome of all-cause death, heart transplantation, or heart failure (HF) hospitalization. Multivariable risk factor analyses were performed for the combined endpoint. All outcomes were more frequent in LDCM than in RODCM. The multivariable-adjusted hazard ratios (HRs) (95% confidence interval) for LDCM vs. RODCM were 1.56 (1.34-1.82), P<0.0001, for all-cause death over a median follow-up of 4.2 and 5.0years, respectively; 1.6o co-morbid conditions in patients with DCM.Molecular solar thermal (MOST) systems have attracted tremendous attention for solar energy conversion and storage, which can generate high-energy metastable isomers upon capturing photon energy, and release the stored energy as heat on demand during back conversion. However, the pristine molecular photoswitches are limited by low storage energy density and UV light photon energy storage. Recently, numerous pioneering works have been focused on the development of MOST systems towards phase change (PC) and visible light photon energy storage to increase their properties. On the one hand, the strategy of simultaneously capturing isomerization enthalpy and PC energy between solid and liquid can not only offer high latent heat, but also promote the development of sustainable energy systems. On the other hand, the efficient photon energy storage in the visible light range opens a tremendously fascinating avenue to fabricate MOST systems powered under natural sunlight. Here, the recent advances of MOST systems towards PC and visible light photon energy storage are systematically summarized, the most promising advantages and current challenges are analyzed, and emerging strategies and future research directions are proposed.The last decade has seen a robust increase in various types of novel RNA molecules and their complexity in gene regulation. RNA molecules play a critical role in cellular events by interacting with other biomolecules, including protein, DNA, and RNA. It has been established that RNA-RNA interactions play a critical role in several biological processes by regulating the biogenesis and function of RNA molecules. Interestingly, RNA-RNA interactions regulate the biogenesis of diverse RNA molecules, including mRNAs, microRNAs, tRNAs, and circRNAs, through splicing or backsplicing. Structured RNAs like rRNA, tRNA, and snRNAs achieve their functional conformation by intramolecular RNA-RNA interactions. In addition, functional consequences of many intermolecular RNA-RNA interactions have been extensively studied in the regulation of gene expression. Hence, it is essential to understand the mechanism and functions of RNA-RNA interactions in eukaryotes. Conventionally, RNA-RNA interactions have been identified through diverse biochemical methods for decades. The advent of high-throughput RNA-sequencing technologies has revolutionized the identification of global RNA-RNA interactome in cells and their importance in RNA structure and function in gene expression regulation. Although these technologies revealed tens of thousands of intramolecular and intermolecular RNA-RNA interactions, we further look forward to future unbiased and quantitative high-throughput technologies for detecting transcriptome-wide RNA-RNA interactions. With the ability to detect RNA-RNA interactome, we expect that future studies will reveal the higher-order structures of RNA molecules and multi-RNA hybrids impacting human health and diseases. This article is categorized under RNA Methods > RNA Analyses In Vitro and In Silico RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems.For a heterogeneous catalytic process, the performance of catalysts could be improved by modifying the active metal with a second element. Determining the enhanced mechanism of the second element is essential to the rational design of catalysts. In this work, Zn was introduced as a second element into Ni/ZrO2 for CO2 hydrogenation. In contrast to Ni/ZrO2 , the selectivity of NiZn/ZrO2 is observed to shift from CH4 to CO. A series of structural characterization results reveals that Zn is atomically dispersed in the NiO and ZrO2 phases as NiZnOx and ZnZrOx , respectively during CO2 hydrogenation, stabilizing a higher valence state of Ni (Niδ+ ) under a hydrogenation atmosphere over Ni-O-Zn site and thus promoting the generation of CO. These findings shed light on the O-mediated bimetallic effect of NiZn/ZrO2 and bring new insight into the rational design of more efficient heterogeneous catalysts.