Stougaardvestergaard4807

In the case of clusterin, this upregulation was also observed in the cytosolic fraction of the nucleus accumbens. When undernourishment was limited to gestation and lactation the two proteins appeared downregulated with respect to controls.

The results are consistent with the idea that perinatal malnutrition provokes marked changes in brain neurochemistry that are not fully corrected by the rehabilitation of normal feeding and could be linked to behavioural disturbances in the adulthood, that is, increased vulnerability to addiction.

The results are consistent with the idea that perinatal malnutrition provokes marked changes in brain neurochemistry that are not fully corrected by the rehabilitation of normal feeding and could be linked to behavioural disturbances in the adulthood, that is, increased vulnerability to addiction.Purpose This review provides an overview of the causes and treatment of neurotrophic keratopathy in the pediatric population.Methods A thorough review of the current literature discussing neurotrophic keratopathy was conducted then summarized.ResultsFourty-nine papers were reviewed. Congenital and acquired causes of neurotrophic keratopathy exist in the pediatric population. Both medical and surgical approaches to treatment have been trialed, albeit to a limited extent, in pediatric patients. Conservative treatment includes topical lubrication and antibiotics to prevent concurrent infectious ulcer formation. Various neurotrophic factors have been trialed in the form of serum drops to restore corneal sensation when conservative measures fail. Surgically, different corneal neurotization techniques have been developed whereby a donor nerve is routed to the anesthetized cornea to restore innervation and sensation. Conclusions Advances in the treatment of neurotrophic keratopathy have made corneal reinnervation and restoration of vision more easily attainable in pediatric patients.Spurred by the coronavirus disease pandemic and shortage of eye care providers, telemedicine is transforming the way ophthalmologists care for their patients. Video conferencing, ophthalmic imaging, hybrid visits, intraocular inflammation quantification, and portable technology are evolving areas that may allow more uveitis patients to be evaluated via telemedicine. Despite these promising disruptive technologies, there remain significant technological limitations, legal barriers, variable insurance coverage for virtual visits, and lack of clinical trials for uveitis specialists to embrace telemedicine.Objectives The goal of this study was to investigate diversity in stakeholders' perspectives on how best to maximize older adults' well-being when they use long-term services and supports (LTSS).Methods We used Q methodology, an exploratory method, to investigate preference patterns among a purposive sample of older adults, family members, and leadership professionals (n = 57). Participants categorized 52 items related to 9 domains of LTSS quality relevant to well-being into categories of importance. We used factors analysis and qualitative methods to identify groups of individuals who identified similar priorities.Results The analysis identified four shared viewpoints, each prioritizing different aspects of well-being 1) physical health and safety; 2) independence; 3) emotional well-being; and 4) social engagement. Individual and contextual factors, including stakeholder role, care needs, and expectations for LTSS, appeared to influence participants' perspectives.Conclusions Distinct viewpoints on how to maximize well-being when older adults use LTSS exist. Our results affirm the importance of person-centered care yet demonstrate that shared preference patterns LTSS exist.Clinical Implications Engaging with older adults' values and preferences is critical to improving their experiences with LTSS. Better understanding common preference patterns could help providers deliver person-centered care more efficiently and effectively.Purpose To test the hypothesis of a possible association between platelet reactivity and the severity of diabetic retinopathy using Multiplate whole blood aggregometry in type 2 diabetes mellitus patients. Methods Of 157 patients were divided to three groups based on the severity of diabetic retinopathy (normal, non-proliferative and proliferative [ordinal among group 1-2-3]). Platelet reactivity was measured using arachidonic acid response to the ASPI and ADP platelet test. The association between DR stage and the degree of platelet reactivity (predictor variable) ASPI, ADP, systolic blood pressure, age, hypertension, body mass index (BMI), HbA1c, creatinine, Microalbumin, platelet, triglyceride/HDL and Hscrp variables were evaluated using ordinal logistic regression models (Model 1). The association between DR presence (outcome variable (group 1 vs group 2 and 3)) and the presence of variables was evaluated using binary logistic regression models (Model 2). Results A comparison of the laboratory parameters of the three groups revealed that the ASPI, ADP, glucose and HbA1c values were significantly higher in Group-3 than Group-1. ASPI (odds-ratio OR 1.044[1.021-1.09], p less then .001], ADP (OR 1.033[1.010-1.10], p 0.002] and HbA1c (OR 2.42(1.22, 4.94), p less then .001) were demonstrated to be associated with stage of DR while the other variables were not. In binary logistic regression (model-2) analysis; ASPI (OR 1.061[1.031-1.1], p less then .001], ADP (OR 1.03(1.01, 1.06), p 0.045] and HbA1c (OR 4.37 (1.67, 11.36)], p 0.002) were associated with DR while the other variables were not. Conclusion Herewith, we demonstrated that higher platelet reactivity measured by multiplate ASPI and ADP was significantly associated with stages of DR. Therefore, these measurements may be useful to predict the severity of DR in the clinical practice of physicians.Objectives. This study assessed musculoskeletal disorders (MSDs) and their correlates among heavy load carriers in Yaounde city, Cameroon. Methods. A descriptive cross-sectional study was conducted on 301 healthy male handlers. Descriptive statistics were used to determine prevalence while logistic regression was performed to determine associated factors. Results. MSD prevalence was 100 and 87.7% during the last 12 months and 7 days, respectively. find more Main sites affected were, respectively, the lower back (84.1 and 61.1%), hips/thighs (81.1 and 47.2%) and neck (74.7 and 43.2%). MSD risk factors were age 25-30 years during the last 12 months (odds ratio [OR] = 2.8; 95% confidence interval [CI] [-1.2, 6.5]) and 7 days (OR = 4.2; 95% CI [-1.7, 10.7]) for the neck and the last 12 months (OR = 2.6; 95% CI [-1.1, 5.8]) for shoulders. Overweight was a risk factor for wrists/hands in the last 12 months (OR = 2.7; 95% CI [-11.0, 7.2]). Seniority of 5-10 years was a risk factor for the lower back (OR = 1.8; 95% CI [-1.0, 3.