Storgaardbilde6036

000) and OC (p = 0.016). FW-W-30 µm showed a significantly smaller space than that for the L in MO (p = 0.000), CH (p = 0.000), AXE (p = 0.000), and OC (p = 0.002). CONCLUSIONS The design and CS of the FDPs affected the fit. FDPs with single-layer zirconia showed better fit than that obtained with multi-layer zirconia. BACKGROUND Exacerbations are crucial events during bronchiectasis progression. OBJECTIVES To explore the associations between bacterial, viral, and bacterial plus viral isolations and bronchiectasis exacerbations. METHODS In this prospective study, we enrolled 108 patients who were followed up every 3-6 months and at onset of exacerbations between March 2017 and November 2018. Spontaneous sputum was split for detection of bacteria (routine culture) and viruses (quantitative polymerase chain reaction). Symptoms and lung function were assessed during exacerbations. RESULTS The median exacerbation rate was 2.0 (interquartile range 1.0-2.5) per patient-year. At any visit, viral isolations (V+) occurred more frequently during onset of exacerbations [odds ratio (OR) 3.28, 95% confidence interval (95%CI) 1.76-6.12], as did isolation of new bacteria (NB+) (OR 2.52, 95%CI 1.35-4.71) and bacterial plus viral isolations (OR 2.24, 95%CI 1.11-4.55). Whilst coryza appeared more common in exacerbations with V+ than in exacerbations with no pathogen isolations and those with NB+, lower airway symptoms were more severe in exacerbations with NB+ (P less then .05). Sputum interleukin-1β levels were higher in exacerbations with NB+ than in exacerbations with no pathogen isolations and those with V+ (both P less then .05). Significantly more coryza symptoms correlated with bacterial plus viral isolations at exacerbations (P=.019). Compared with V+ alone, bacterial with and without viral isolations tended to yield more severe lower airway symptoms, but not sputum cytokine levels at exacerbations. CONCLUSIONS Viral isolations, isolation of new bacteria and bacterial plus viral isolation are associated with bronchiectasis exacerbations. Symptoms at exacerbations might inform clinicians the possible culprit pathogens. L.U.Stress cardiomyopathy (SC) is an increasingly recognized form of acute heart failure, which has been linked to a wide variety of emotional and physical triggers. The pathophysiological mechanisms of the disease remain incompletely understood, however, inflammation has been recently shown to play a pivotal role. This review summarizes the most notable findings of myocardial inflammation, demonstrated from biopsies and cardiac magnetic resonance imaging in humans. In the acute stage macrophage infiltration appears to represent the substrate for myocardial edema, together defining the local myocardial inflammation. This appears to evolve into a low grade systemic chronic inflammation which could explain the protracted clinical course of these patients and raises hope for finding a specific SC cardiac biomarker as well as a therapeutic breakthrough. As a parallel to the human findings the review covers some of the emerging mechanistic insights from experimental models, which, albeit not proven in the human condition, highlight the possible importance in pursuing distinct paths of investigation such as the beta-receptor signaling, aberrations of nitric oxide generation and signaling and the contribution of the vascular endothelium/permeability to edema and inflammation during the acute stage. STATEMENT OF PROBLEM Conventional fabrication of complete denture metal bases is being replaced by the computer-aided design and computer-aided manufacturing (CAD-CAM) systems. However, a comparative analysis of subtractive and additive CAD-CAM manufacturing techniques is lacking. PURPOSE The purpose of this in vitro study was to compare the adaptation of complete denture metal bases fabricated by milling (subtractive manufacturing) and stereolithography apparatus (SLA) and digital light processing (DLP) (additive manufacturing). MATERIAL AND METHODS Thirty metal bases were manufactured by using the milling (MIL group), SLA (SLA group), and DLP (DLP group) techniques. The silicone replica technique was used to evaluate the adaptation of the complete denture metal bases, and 30 silicone blocks were fabricated. The silicone block was cut equally in the canine, first molar, and second molar areas. The gap between the model and the metal base was measured by using a digital microscope at the 3 locations, and the measured data were statistically analyzed by using a statistical software program (α=.05). RESULTS The gaps measured at the 3 areas showed significant differences in all 3 groups (P less then .05). At the anterior, middle, and posterior areas, the SLA group showed the narrowest gap (302 ±31 μm, 241 ±39 μm, 201 ±43 μm, respectively). The SLA group also had the narrowest total gap of the metal bases (218 ±33 μm). CONCLUSIONS The adaptation of the fabricated metal bases varied significantly across the techniques used but fell within a clinically allowable range. The SLA group was the most precise in the fabrication of complete denture metal bases. Further studies are required to analyze the effects of the layer thickness setting, wax elimination, and casting temperature on the adaptation of metal bases manufactured by using SLA. STATEMENT OF PROBLEM The current trend is to shorten the loading times of dental implants. However, information about the risk of early loss of implants that have been loaded immediately is scant if compared with data available for those conventionally loaded. PURPOSE The purpose of this systematic review and meta-analysis was to study immediate (IL) and delayed loading (DL) protocols in edentulous mandibles to determine whether differences exist in implant success and crestal bone loss and to evaluate these possible differences in relation to the type of prosthesis and the splinting of the implants. MATERIAL AND METHODS The literature review was conducted in PubMed, Scopus, and the Cochrane Library. Nine randomized clinical trials were included. RESULTS The result of a meta-analysis of implant loss before 1 year was 2.63 (95% CI 1.22, 5.68), favoring the DL control group, while the outcome for crestal bone loss at the observation year was 0.42 (95% CI -0.35, 1.20), with a tendency toward reduced bone loss for DL. CONCLUSIONS The risk of early loss in the IL group was higher than that in the DL group. For removable prostheses and nonsplinted implants, DL was preferred. The quality of scientific evidence significantly favors DL. BACKGROUND Femorotibial rotational mismatch has been reported to cause unsatisfactory outcomes after total knee arthroplasty. However, to our knowledge, no previous reports have described the relationship between the femorotibial rotational mismatch and clinical outcomes of Oxford unicompartmental knee arthroplasty (UKA). METHODS In total, we studied 52 knees with primary varus knee osteoarthritis that underwent Oxford UKA with a navigation system. Tibial component internal rotation angles relative to the femoral component at extension and flexion angle of 90° were measured using a navigation system. We evaluated the relationship between the clinical outcomes and femorotibial rotational mismatch angles. Additionally, we evaluated the relationships between the outcomes and rotational alignments of the femur and tibial components measured by computed tomography (CT). RESULTS The tibial component internal rotational angle relative to the femoral component was significantly larger at a flexion angle of 90° than on extension (P  less then  .001) and showed negative correlations with the Knee Society Functional Score and the pain and sports subscales of the Knee Injury and Osteoarthritis Outcome Score. Rotational alignment of the femur and tibial components on computed tomography was not associated with clinical outcomes. CONCLUSION The tibial component internal rotational angle relative to the femoral component in the flexion position was negatively correlated with clinical outcome. Surgeons should pay attention to a rotational mismatch between components in the flexion position during the Oxford UKA procedure. Navigation systems will be effective in reducing the femorotibial rotational mismatch and improving clinical outcomes. PURPOSE To compare flexor tendon repair strength and speed between a tendon coupler and a standard-core suture in a cadaver model. ULK activator METHODS In 5 matched-pair fresh cadaver hands, we cut the flexor digitorum profundus tendon of each finger in zone 2 and assigned 20 tendons to both the coupler and the suture groups. Coupler repair was with low-profile stainless steel staple plates in each tendon stump, bridged by polyethylene thread. Suture repair was performed using an 8-strand locking-cruciate technique with 4-0 looped, multifilament, polyamide suture. One surgeon with the Subspecialty Certificate in Surgery of the Hand performed all repairs. Via a load generator, each flexor digitorum profundus was loaded at 5 to 10 N and cycled through flexion just short of tip-to-palm and full extension at 0.2 Hz for 2,000 cycles to simulate 6 weeks of rehabilitation. We recorded repair gapping at predetermined cycle intervals. Our primary outcome was repair gapping at 2,000 cycles. Tendons that had not catastrophically failed by 2,000 cycles were loaded to failure on a servohydraulic frame at 1 mm/s. RESULTS Tendon repair gapping was similar between coupled and sutured tendons at 2,000 cycles. Tendons repaired with the coupler had higher residual load to failure than sutured tendons. Mean coupler repair time was 4 times faster than suture repair. CONCLUSIONS Zone 2 flexor repair with a coupler withstood simulated early active motion in fresh cadavers. Residual load to failure and repair speed were better with the coupler. CLINICAL RELEVANCE This tendon coupler may eventually be an option for strong, reproducible, rapid flexor tendon repair. The primary cause of cyanide intake is suicidal attempts, most of which result in death. People who interfere with suspicion of cyanide intoxication may also be exposed to cyanide poisoning. During the autopsy of the corpse in the morning of that day, five people in the autopsy room within the hospital were admitted to the ED with suspicion of cyanide intoxication. Meanwhile, a 36-year-old patient who had come into contact with the patient at night also presented to the ED. Some of the precautionary measures to be taken against inhalation of cyanide may be wearing appropriate masks as well as suitable clothes and keeping the surroundings below 28 °C when exposed to cyanide. BACKGROUND Whether the ramped or sniffing laryngoscopy position is better for tracheal intubation is unclear. This study aimed to determine the efficacy and safety of tracheal intubation in the ramped versus sniffing position. METHODS We conducted a systematic review and meta-analysis of randomized clinical trials to compare the ramped position with the sniffing position for tracheal intubation. We searched the databases of Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Excerpta Medica Database (Embase), ClinicalTrials.gov, and World Health Organization Clinical Trials Registry Platform up to December 2018. We included randomized-controlled trials, trials of participants who required tracheal intubation in any setting, and that compared tracheal intubation in the ramped and the sniffing positions. Two authors independently screened the trials, extracted the data, and assessed the risk of bias. We conducted the meta-analysis using the random-effects model to calculate the pooled risk ratio with 95% confidence interval.