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Furthermore, Pearson's coefficient test revealed statistically significant correlations between salivary α-AMY diurnal percentage variation and selected choroidal imaging biomarkers (FCT, CVI, and flow signal void area). Finally, multiple linear regression analysis identified salivary α-AMY diurnal percentage production as the sole predictor of the CVI and flow signal void area in the study population.

Autonomic nervous system dysregulation was highlighted in CSC patients.

Autonomic nervous system dysregulation was highlighted in CSC patients.

It has been suggested that amblyopes present impaired motion extrapolation mechanisms. In this study, we used the flash grab effect (FGE), the illusory mislocalization of a briefly flashed stimulus in the direction of a reversing moving background, to investigate whether the amblyopic visual system can correct overextrapolation.

Thirteen amblyopes and 13 control subjects participated in the experiment. We measured the monocular FGE magnitude for each subject. Two spatial frequency (2 and 8 cycles), two texture configurations (square wave or sine wave), and two speed conditions (270 degrees/s and 67.5 degrees/s) were tested. In addition, control subjects were further tested in reduced luminance conditions.

Compared with controls, amblyopes exhibited a larger FGE magnitude both in their fellow eye (FE) and amblyopic eye (AE). The FGE magnitude of their AE was significantly larger than that of the FE. In a control experiment, we observed that the FGE magnitude increases with the decreasing of the luminance. The FGE magnitude of amblyopes fall into the same range as that of controls under reduced luminance conditions.

We observed a lager FGE in patients with amblyopia, which indicates that the amblyopic visual system does not accurately correct the overextrapolation when a moving object abruptly reverses its direction. This spatiotemporal processing deficit could be ascribed to delayed visual processing in the amblyopic visual system.

We observed a lager FGE in patients with amblyopia, which indicates that the amblyopic visual system does not accurately correct the overextrapolation when a moving object abruptly reverses its direction. This spatiotemporal processing deficit could be ascribed to delayed visual processing in the amblyopic visual system.This study examined the environmental and geological determinants of radon concentration in subway stations by applying a spatial statistical model to the integrated GIS database. PF2545920 The data were collected for 237 underground subway stations located inside the city of Seoul, South Korea and used for mapping to illustrate the spatial distribution of airborne radon exposure and analysis of potential contribution of station-specific and geological determinants. A Bayesian conditional autoregressive regression (CAR) model was developed to explain the radon concentrations, and the predicted radon surface was generated and visualized to identify hotspot regions where elevated radon exposure is likely to be present in underground settings. The findings include (1) subway stations located within granite bedrock maintained relatively higher radon concentrations; (2) underground radon emanation is not only controlled by lithology and the associated uranium content of the rocks and soil, but also by structural factors which facilitate easy migration of radon from deeper parts of the earth's crust; (3) radon risks would be elevated if the underground facility is constructed too deep without any control measure; and (4) not only the foundation of an underground facility but also the nature of the soil and rocks in the vicinity helps determine whether or not dangerous levels of radon gas are likely to accumulate inside. This modeling effort is expected to provide guidelines regarding the identification of future station locations with a lower radon risk and the mandatory installation of adequate radon reduction systems for the underground space where people stay or commute for long periods of time.The linear elasticity of dilute colloidal gels formed from discoidal latex particles is quantified as a function of aspect ratio and modeled by confocal microscopy characterization of their fractal cluster microstructure. Colloidal gels are of fundamental interest because of their widespread use to stabilize complex fluids in industry. Technological interest in producing gels of desired moduli using the least number of particles drives formulators to produce gels at dilute concentrations. However, dilute gels self-assembled from isotropic spheres offer limited scope for rheological tunability due to the universal characteristics of their fractal microstructure. Our results show that changing the building block shape from sphere to discoid yields very large shifts in gel elasticity relative to the universal behavior reported for spheres. This shift - tunable through aspect ratio - yields up to a 100-fold increase in elastic modulus at a fixed volume fraction. From modeling the results using the theory for fractal cluster gel rheology, which is applicable at the dilute conditions of this study, we reveal that the efficient generation of elasticity by the colloidal discoids is the consequence of the combined effects of shape anisotropy on the fractal microstructure of the gel network, the anisotropy of the attractive interparticle pair potentials, and the volumetric compactness of the fractal cluster. These results extend prior characterizations of the rheology of non-spherical particulate gels by providing quantitative estimates of how the specific mechanisms of fractality, pair potential, and clustering mediate the profound effects of particle shape anisotropy on the elastic rheology of colloidal gels.Reservoir computing (RC), as a brain-inspired neuromorphic computing algorithm, is capable of fast and energy-efficient temporal data analysis and prediction. Hardware implementation of RC systems can significantly reduce the computing time and energy, but it is hindered by current physical devices. Recently, dynamic memristors have proved to be promising for hardware implementation of such systems, benefiting from their fast and low-energy switching, nonlinear dynamics, and short-term memory behavior. In this work, we review striking results that leverage dynamic memristors to enhance the data processing abilities of RC systems based on resistive switching devices and magnetoresistive devices. The critical characteristic parameters of memristors affecting the performance of RC systems, such as reservoir size and decay time, are identified and discussed. Finally, we summarize the challenges this field faces in reliable and accurate task processing, and forecast the future directions of RC systems.The indolyl-4(3H)-quinazolinone core is an important structural motif in functional molecules. However, few methods exist for its direct modification, which limits its potential application. Reported herein is a palladium-mediated amination of halogen-containing indolyl-4(3H)-quinazolinones with a variety of primary and secondary amines via the corresponding palladium oxidative addition complexes. The protocol allows the facile synthesis of indolyl-4(3H)-quinazolinone derivatives with amino groups at all the positions of the benzene ring in moderate to good yields with mild reaction conditions and good functional group tolerance. Furthermore, the antitumor activity of these products was evaluated.Printed electronics based on liquid-exfoliated nanosheet networks are limited by inter-nanosheet junctions and thick films which hinder field-effect gating. Here, few-layer molybdenum disulfide nanosheets are assembled by Langmuir deposition into thin films, and size selection is shown to lead to a thousandfold conductivity enhancement with potential applicability to all nanosheet networks.Obesity-induced colonic inflammation-stimulated colitis is one of the main causes of colorectal cancer. Dietary polysaccharides are considered an effective agent for relieving obesity-induced inflammatory diseases such as diabetes and colitis. In this work, the protective effects of a polysaccharide (RTFP) extracted from Rosa roxburghii Tratt fruit on barrier dysfunction and inflammation were investigated using obesity-induced colitis model mice. RTFP treatment repaired intestinal barrier dysfunction by increasing the expression of tight junction proteins (ZO-1, claudin-1, and occludin) and reducing the levels of inflammatory cytokines, intestinal permeability, and colonic oxidative stress in mice fed a high-fat diet. Most significantly, RTFP decreased gut inflammation and ameliorated the metabolic dysbiosis of intestinal microflora by decreasing the Firmicutes/Bacteroidetes ratio, reducing the levels of serum D-lactic acid and lipopolysaccharides, and inhibiting the TLR4/NF-κB signaling pathway. Furthermore, RTFP significantly increased the abundance of beneficial bacteria (Ruminococcaceae, Muribaculaceae, Akkermansiaceae, etc.) but decreased the abundance of pathogenic bacteria. These findings indicate that RTFP can be used as a natural anti-inflammatory agent to reduce chronic obesity-induced colitis.In this study, a new series of extended linkers containing different polyaromatic chromophores (biphenyl, naphthalene, anthracene, fluorene, 9,9-dimethylfluorene and fluorenone) functionalized with isonicotinoyl moieties have been synthesized by Pd-catalyzed cross-coupling reactions involving isonicotinamide and the appropriate aromatic dibromide. The optimized protocol led to the isolation of the target molecules in good yield and with high purity. These were characterized by 1H NMR, FTIR, MS, and elemental analysis and their solid state structures were solved by single-crystal X-ray diffraction analysis. Electronic absorption and emission spectra were collected both in solution (DMF) and in the solid state. TDDFT calculations were carried out to investigate the effect of the isonicotinoyl moieties on the spectral features of the central chromophores. Although in solution only the linker containing a fluorenone scaffold shows a weak fluorescence, all the isolated linkers turned out to be fluorescent in the solid state, thus paving the way for their use for the fabrication of fluorescent MOFs.The rational synthesis of thiophene-based cross-coupled polymers on surfaces has been attracting more attention recently. Here, we report the stepwise activation of 5,5'-(2,3-difluoro-1,4-phenylene)bis(2-bromothiophene) as a precursor to synthesize thiophene-based polymeric ribbons on the Au(111) surface. Scanning tunneling microscopy studies showed that the precursor adopted different conformations in the self-assembled structure, organometallic species, and covalent polymers. On annealing the sample at a relatively low temperature (150 °C), the conversion of the organometallic structure into a covalent product with straight lines was observed, in which the Br adatoms arranged between the neighboring chains. On further annealing the sample at 270 °C, the detached Br adatoms played a key role in promoting the C-H bond activation. The cross-linked polymer was achieved by a combination of Ullmann and dehydrogenative coupling. When the annealing temperature was up to 390 °C, the C-F bond activation was triggered, which led to the formation of polymeric ribbons resulting from the cyclodehydrogenation of the fluorinated polymer.