Stillingdalsgaard3756

65 per person-year) and 136 among 129 intervention patients (IR, 1.09 per person-year; fully adjusted IR ratio [IRR], 0.79; 95% CI, 0.52-1.18). ED presentation incidence (fully adjusted IRR, 0.46; 95% CI, 0.22-0.94) and combined re-admission and ED presentation incidence (fully adjusted IRR, 0.69; 95% CI, 0.48-0.99) were significantly lower for intervention patients. The estimated incremental net cost benefit of the intervention was $5072 per patient, with a benefit-cost ratio of 311.

A collaborative pharmacist-GP model of post-hospital discharge medicines management can reduce the incidence of hospital re-admissions and ED presentations, achieving substantial cost savings to the health system.

Australian New Zealand Clinical Trials Registry, ACTRN12616001627448 (prospective).

Australian New Zealand Clinical Trials Registry, ACTRN12616001627448 (prospective).Switchable polymerization is an attractive strategy to enable the sequential selectivity of multi-block polyesters. Besides, these well-defined multi-block polyesters could enable further modification for wider applications. Herein, based on the reversible insertion of CO2 by Salen-MnIII , a new monomer controlled self-switchable polymerization route was developed. Chemoselective ring opening copolymerization of O-carboxyanhydrides (OCAs) and lactide (LA) was explored without cocatalyst. The sequential conversion of OCAs and LA into the polymer chain could form multi-block polyesters. Based on this strategy, a series of multi-block polyesters with different pendant groups were synthesized. Furthermore, by modifying the propargyl-containing copolymers with quaternary ammonium groups, we have realized antibacterial functionalization of PLA. These results imply the potential application of this strategy for the fabrication of functional polymers for biomedical applications.

Magnetic Resonance Imaging (MRI) being a noninvasive modality may help in preoperative evaluation of intratumoral fat in hepatocellular carcinoma (HCC) using chemical shift encoded (CSE) MRI and in-/opposed-phase (IOP) imaging sequences.

To compare the diagnostic accuracy of chemical shift encoded fat fraction at three different flip angles (FAs) using quantitative chemical shift encoded MRI (CSE-MRI) with in-/opposed phase (IOP) imaging to evaluate intratumoral fat in HCC.

Retrospective.

Eighty-six patients with 87 pathology proven HCCs.

IOP (LAVA-Flex) and CSE-MRI (IDEAL IQ) a three-dimensional spoiled gradient-echo pulse sequences acquired at 3 T.

Regions of interest (ROIs) were manually drawn by two observers in the tumors to measure mean fat fractions. Surgical specimens were reassessed for intratumoral fat content. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were assessed for CSE-MRI sequence at FA 3°, 8°, and 9°.

Intraclass correlation coefficient (ICC) was expressed in terms of inter- and intra-observer agreements. Receiver operating characteristic curve analysis was performed for the diagnostic performance followed by combined metric of both. SNR/CNR were analyzed by Kruskal-Wallis test.

Excellent inter- and intra-observer agreements (ICC >0.95, P < 0.001) were observed for both IOP and CSE-MRI. IOP (86.4%) showed higher sensitivity than CSE-MRI at FA 3° (72.5%), FA 8° (76.4%) and FA 9° (76.3%). In contrast, the specificity for CSE-MRI at FA 3° (86%), FA 8° (87%), and FA 9° (87%) were greater than IOP (72%). A combined metric of IOP and CSE-MRI derived fat fractions at FA 8° gave highest AUC of 87% and accuracy of 86%. SNR and CNR for CSE-MRI were significantly higher at FA 8° and FA 9° than FA 3° (P < 0.05).

IOP and quantitative CSE-MRI are both feasible methods to detect intratumoral fat in HCC with higher accuracy and SNR for CSE-MRI at FA 8° and 9°.

3 TECHNICAL EFFICACY Stage 2.

3 TECHNICAL EFFICACY Stage 2.

To quantitatively access penumbra sharpening and scattering by adaptive aperture (AA) under various beam conditions and clinical cases for a Mevion S250i compact pencil beam scanning proton therapy system.

First, in-air measurements were performed using a scintillation detector for single spot profile and lateral penumbra for five square field sizes (3×3 to 18×18cm

), three energies (33.04, 147.36, and 227.16MeV), and three snout positions (5, 15, and 33.6cm) with Open and AA field. Second, treatment plans were generated in RayStation treatment planning system (TPS) for various combination of target size (3- and 10-cm cube), target depth (5, 10, and 15cm) and air gap (5-20cm) for both Open and AA field. These plans were delivered to EDR2 films in the solid water and penumbra reduction by AA was quantified. Third, the effect of the AA scattered protons on the surface dose was studied at 5mm depth by EDR2 film and the RayStation TPS computation. Finally, dosimetric advantage of AA over Open field was studo to three depending upon the beam condition. The absolute penumbra reduction with AA was more noticeable for shallower target, smaller target, and larger air gap. check details The AA-scattered protons contributed to increase in surface dose. Clinically, AA reduced the doses to critical structures.The effects of fluorescence light irradiation on the changes in the levels of volatiles, especially acetaldehyde and formaldehyde, were determined in red and white wines. Three different red or white wine brands were mixed and subjected to light irradiation for 5 days. Generally, the levels of total volatiles in white wine were higher than those in red wine were and decreased during light irradiation. The level of 1,1,6-trimethyl-1,2-dihydronaphthalene, an aromatic compound commonly found in aging wine, decreased significantly following light irradiation (p less then 0.05), whereas those of acetaldehyde and formaldehyde increased significantly in white wine (p less then 0.05). Furthermore, the formaldehyde content in white wine was higher than that in red wine. Thus, light irradiation promotes the decomposition of major volatiles to a greater degree in white wine than in red wine. This implies that white wine may require more attention and caution against light exposure than red wine. PRACTICAL APPLICATION Red and white wines are two globally consumed alcoholic beverages; several factors influence their quality.