Stewartguy7945

Doubling the perovskite cell (double perovskite) has been found to open new possibilities for engineering functional materials, magnetic materials in particular. This route should be applicable to the antiperovskite (aPV) class. In the pnictide based double aPV (2aPV) class introduced here magnetism is very rare, and we address them as new topological materials, possibly with thermoelectric interest. We have found that the 2aPV supercell provides a systematically larger band gap that can serve to inhibit bulk conductivity, and also large spin-orbit coupling (SOC) for band inversion. We present examples from a broad study of double antiperovskites focusing on the X$_6$AA$'$B$_2$ configuration, where X is the alkaline earth element and A and B are the group 5A pnictogens. We find that an ``extended s state at the valence band minimum, described alternatively as a cation valence state or a modulated interstitial planewave state, plays a crucial role in both topological and thermoelectric properties. Several of these compounds may house topological phases, while transport calculations indicate they may also find themselves useful in thermoelectric applications. © 2020 IOP Publishing Ltd.Materials based on the cubic perovskite unit cell continue to provide the basis for technologically important materials with two notable recent examples being lead based relaxor piezoelectrics and lead based organic-inorganic halide photovoltaics. While these materials carry considerable disorder owing to site substitution in relaxors and molecular vibrations in the organic-inorganics, much of the understanding of these materials derives from the initial classic work on lattice vibrations in SrTiO$_3$ performed by Prof. R. A. Cowley applying both theory and neutron scattering experiments at Chalk River Laboratories. Neutron scattering continues to play an important role in understanding lattice vibrations in perovskites owing to the cross section and also the appropriate energy resolution achievable with current neutron instrumentation. We discuss the dynamics that drive the phase transitions in the relaxors and organic-inorganic lead halides as probed through neutron scattering and compare the dynamics to those phase transitions that derive from a ``central peak" and also a soft mode. We review some of the past experimental work on these materials and illustrate new data using high resolution time of flight backscattering spectroscopy on organic-inorganic perovskites. We will show that the structural transitions in disordered lead based perovskites are driven by a broad frequency band of excitations. Creative Commons Attribution license.We predict a high thermoelectric efficiency of HfTe5, based on the first-principles calculations of the electronic structure and thermal conductivity, and the transport coefficients obtained by using the semi-classical Boltzmann transport theory in a wide temperature and carrier concentration range. The lattice thermal conductivity is calculated based on the Slack model and the result is in good agreement with the experimental value. The results of all the thermoelectric transport coefficients demonstrate anisotropic characteristics with the obvious small values along with the b direction. The figure of merit ZT computed with a temperature-dependent relaxation time can reach 2.68 along with the c direction of the n-type HfTe5 at 300 K and an optimal carrier concentration of 5.801019 cm-3. The Seebeck thermopower coefficients are between 100 and 300 μV/K at the optimal carrier concentration, but can reach nearly 1000 μV/K at low concentration. Therefore, HfTe5could achieve high thermoelectric performance at room temperature by controlling the transport direction and carrier concentration. © 2020 IOP Publishing Ltd.In this paper, amphiphilic conjugated triphenylamine-porphyrins TPA-Por-TPA and TPA-Por were designed and synthesized. The water-soluble nanostructures TPA-Por-TPA NPs, TPA-Por NPs spontaneously assembled after π-π stacking, which can be changed by improving the internal transfer ability of electrons. The intercalation and external binding modes of these free porphyrins and nanoporphyrins interacting with ct-DNA were confirmed by UV-vis and fluorescence spectroscopy. Reactive oxygen species (ROS) production was studied by 2',7'-dichlorofluorescein diacetate, demonstrating that the rate of production of ROS is TPA-Por-TPA NPs>TPA-Por-TPA>TPA-Por NPs>TPA-Por. In addition, the structure of NP enhanced the acceptor-donor conjugated structure, resulting in fluorescence quenching and promoting non-radiative heat generation. The photothermal conversion efficiencies (PCE) of TPA-Por-TPA NPs, TPA-Por NPs were measured and calculated to be 34.89% and 37.99%, respectively. At the same time, the three nanomaterials showed good photocytotoxicity, the IC50 of TPA-Por-TPA NPs, TPA-Por NPs were 32.18 μg/mL, 36.62 μg/mL at 10 minutes after laser irradiation. The cellular uptake and subcellular localization of these NPs were further evaluated through a confocal laser scanning microscope. The results showed that the conjugated nanoparticles have good biocompatibility properties in the cancer cells. These properties make triphenylamine porphyrin nanoparticles possible to become photosensitizers for photodynamic and photothermal synergistic treatment of tumor, and have potential prospects for applications in cancer diagnosis and treatment. © 2020 IOP Publishing Ltd.The aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of World Health Organization classification of endocrine tumours. The carcinomas occur in 83 women and 34 men (female to male ratio is 2.4 to 1) and with median age at presentation of 64. read more Half of these squamous cell carcinomas of thyroid were moderately differentiated. PAX-8 protein is a sensitive marker for confirming the thyroid origin of the carcinoma. The carcinoma is also positive for p63, p40 cytokeratins 5/6, 7,19 and negative for cytokeratins 20 and 10/13. P53 overexpression is common. The most important differential diagnosis is direct infiltration or metastatic involvement by squamous cell carcinoma from other organs. Limited mutation analysis revealed BRAF mutation in some squamous cell carcinomas of the thyroid. The genetic profile appears to be different from anaplastic thyroid carcinomas. Primary squamous cell carcinoma of thyroid had lymph node involvement in 59% and distant metastases in 26%. The median survival of the patients was 8 months. Curative surgery offers the best survival for the patients with the carcinoma. To conclude, primary squamous cell carcinoma of the thyroid gland has distinctive clinical, pathological and molecular profiles. It is important to recognize this unique variant of thyroid carcinoma for possible curative surgical resection and to do more genomic works on the entity to uncover the molecular pathogenesis.Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great interest. Mutations in succinate dehydrogenase (SDH) subunits cause pheochromocytoma/paraganglioma (PCPG) and syndromically associated tumors, which differ phenotypically and clinically from more common SDH-intact tumors of the same types. Consequences of SDH deficiency include rewired metabolism, pseudohypoxic signaling and altered redox balance. PCPG with SDHB mutations are particularly aggressive, and development of treatments has been hampered by lack of valid experimental models. Attempts to develop mouse models have been unsuccessful. Using a new strategy, we developed a xenograft and cell line model of SDH-deficient pheochromocytoma from rats with a heterozygous germline Sdhb mutation. The genome, transcriptome and metabolome of this model, called RS0, closely resemble those of SDHB-mutated human PCPGs, making it the most valid model now available. Strategies employed to develop RS0 may be broadly applicable to other SDH-deficient tumors.Differentiated thyroid carcinoma (DTC) in children, adolescents, and young adults is associated with excellent prognosis. However, little is known about the long-term utilization of healthcare resources among survivors. The objective of this study was to compare utilization of healthcare resources among DTC survivors to the general population, with a focus on pulmonary-related resource utilization. Population-based linked data were used to retrospectively ascertain DTC patients from the Ontario Cancer Registry, age less then 30 years at diagnosis between 1992 and 2011. DTC cases were individually matched 110 to the general population on age, gender, diagnosis year, and rural status. Billing records for all-cause hospitalizations, emergency department visits, pulmonary subspecialist visits, and chest imaging were compared using incidence rate ratios (IRR). A total of 2456 individuals with DTC were identified, with women representing the majority (82.8%) of cases. Compared to controls, hospitalization and emergency department visit IRRs were 2.56 (95%CI, 2.49-2.63) and 2.22 (95%CI, 2.18-2.26), respectively. An excess of pulmonary diagnostic imaging was observed for chest radiography (IRR, 2.7; 95%CI, 2.6-2.8) and pulmonary CT's (IRR, 17.5; 95%CI, 15.8-19.3). Patients who underwent radioactive iodine therapy had a higher incidence of pulmonary-related healthcare utilization than those who did not. The highest healthcare utilization for all modalities was observed in the 30-to-90 days after DTC diagnosis with a steady decline further from diagnosis; however, elevated utilization was observed throughout the observation period. Health services utilization is high for primary DTC survivors, irrespective of the time since diagnosis. Radioactive iodine therapy is associated with higher rates of utilization. These findings have ramifications for treatment, surveillance and for policy-formulation.Neuroendocrine tumors (NETs) are a class of rare and heterogeneous neoplasms that originate from the neuroendocrine system. In several cases these neoplasms can release bioactive hormones leading to characteristic clinical syndromes and hormonal dysregulations with detrimental impact on the quality of life and survival of these patients. Only few animal models are currently available to investigate pathogenesis, progression and functional syndromes in NETs and to identify new therapeutic strategies. The tropical teleost zebrafish (Danio rerio) is a popular vertebrate model system that offers unique advantages for the study of several biological processes, ranging from embryonic development to human diseases such as cancer. In this review, we summarize recent advances on zebrafish models for NET preclinical research, that take advantage of modern genetic and transplantable technologies. In future these tools may have a role in the treatment decision-making and tertiary prevention of NETs.Nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide, which is featured by liver steatosis and often accompanied with other pathology characters such as insulin resistance. However, the underlying mechanisms and specific pharmacological agents are needed to be deeply developed. Here, we recognized microRNA-188 (miR-188) as a negative regulator in hepatic glucose and lipid metabolism. miR-188 was upregulated in the liver of obese mice. Loss of miR-188 alleviated diet-induced hepatosteatosis and insulin resistance. In contrast, liver-specific overexpression of miR-188 aggravated hepatic steatosis and insulin resistance during high fat diet feeding. Mechanistically, we found that the negative effects of miR-188 on lipid and glucose metabolism was mediated by autophagy pathway via targeting autophagy-related gene 12 (Atg12). Furthermore, suppressing miR-188 in the liver of obese mice improved liver steatosis and insulin resistance. Taken together, our findings revealed a new regulatory role of miR-188 in glucose and lipid metabolism through autophagy pathway, and provides a therapeutic insights for NAFLD.