Stentoftfulton4990

Bland-Altman analysis revealed a bias toward larger CT value for SMA (1.35 %), linear muscle measures (2.79 %), and SFA (10.34 %), and toward larger MRI values for IMFA (0.75 %) and VFA (5.81 %). ECOG ≥ 1 was associated with lower skeletal muscle than ECOG 0 for all measurements.

Strong correlation of CT and MRI cross sectional measurements of skeletal muscle and adipose tissues supports the use of axial MRI images for comprehensive measurement of body composition. This has widespread implications for body composition research and cancer patient care.

Strong correlation of CT and MRI cross sectional measurements of skeletal muscle and adipose tissues supports the use of axial MRI images for comprehensive measurement of body composition. This has widespread implications for body composition research and cancer patient care.

To examine the association of diabetes and prediabetes with suicide deaths in a Japanese working population.

A nested case-control study was conducted using data from the Japan Epidemiology Collaboration on Occupational Health Study. During 8years of follow-up, we identified 56 registered cases of suicide death that had information on fasting plasma glucose or glycated hemoglobin A1c at any health check-up during the past 3years prior to suicide. For each case, we randomly selected five controls matched for age, sex, and worksite. We used the latest health check-up data for analysis. We defined diabetes status based on the American Diabetes Association criteria and used a conditional logistic regression model to investigate the association.

Adjusted odds ratios and 95% confidence intervals for suicide death were 0.67 (0.32-1.41) and 3.53 (1.05-11.91) for prediabetes and diabetes, respectively, compared to normoglycemia. Similar results were obtained when diabetes status was exclusively defined by the fasting plasma glucose or glycated hemoglobin A1c level.

Diabetes, but not prediabetes, was associated with a higher risk of suicide death, compared with normoglycemia, among a Japanese working population.

Diabetes, but not prediabetes, was associated with a higher risk of suicide death, compared with normoglycemia, among a Japanese working population.Mesenchymal stem cells (MSCs) are recognized as a valuable source of cells in clinical treatment and tissue engineering applications. In this study, we created human induced pluripotent stem cells (hiPSCs) from different MSC sources to evaluate the capacity of MSC-derived iPSCs to differentiate into any cell type of the human body and to serve as an alternative source for iPSC generation. Here in, the generated hiPSC lines retained their normal karyotype and showed similar STR-based identities to the parental cells. Reprogrammed cells also showed positive expression of the pluripotency markers and the ability to differentiate into the three germ layers.Epidemiological studies suggest that about 95% of PD have a sporadic component. We have generated induced pluripotent stem cells (iPSCs) using Sendai-virus reprogramming-method from peripheral blood mononuclear cells of two sporadic PD-patient of East-Indian ethnicity carrying no PD-related gene mutations. PD diagnosis was performed using Unified Parkinson's Disease rating scale (UPDRS) score and confirmed by [18F]fluoro-L-dopa [F-DOPA] positron emission tomography (F-DOPA PET). The iPSC lines were characterized for self-renewal and pluripotency. These generated lines will provide a valuable resource to understand the pathophysiology of this disease and a drug-screening platform.We have generated new disease-specific induced pluripotent stem cell (iPSC) lines from skin fibroblasts obtained from a female patient with Joubert syndrome (JS) caused by compound heterozygous mutations in C5orf42 gene. The generated iPSCs offer an unprecedented opportunity to obtain iPSC-derived neurons to investigate the pathogenesis of JS in vitro and to develop therapeutic strategies.Thiosulfate is frequently used as an energy source and electron donor in autotrophic denitrification (AD) for removing nitrate from wastewater. However, transforming pathways of S2O32- in this process is unclear. Herein, the aim of this study is to explore possible transforming pathways of sulfur compounds in thiosulfate-based AD process. After measuring the variation of NO3-, NO2-, and various sulfur compounds such as S0, SO42-, S2O32-, acid volatile sulfide (AVS), and S2- in the presence and absence of S2O32-, the variation process of S2O32- and the contribution of various sulfur compounds were analyzed. The results indicated that S0, AVS, and S2- were the intermediate products when S2O32- was applied as an electron donor. All S2O32-, S0, AVS, and S2- could act as electron donors in the nitrate removal process with the final products of SO42-. The utilization priority of these four sulfur sources was presumed in the following order S2- > S2O32- > AVS ≈ S0. Furthermore, sulfur transformation and balance in nitrate removal process was also investigated. This suggests the transforming pathways of sulfur compounds in denitrification process. Nitrogen removal and sulfur conversion process are dependent on the presence of microorganisms in the sludge.Metal pollution is a great concern worldwide and the development of new technologies for more sustainable extraction methods as well as for the remediation of polluted sites is essential. Extremophilic microorganisms are attractive for this purpose since they have poly-resistance mechanisms which make them versatile. In this work, we sampled an acidic river and a hot spring of Caviahue-Copahue volcanic environment. The indigenous microbial communities were exposed to five heavy metals (Cd, Co, Cu, Ni and Zn) in batch-cultures favouring different metabolisms of biotechnological interest. Remarkably, high tolerance values were reached in all the cultures, even though most of the metals studied were not present in the environmental sample. Particularly, outstanding tolerances were exhibited by acidophiles, which grew at concentrations as high as 400 mM of Zn and Ni. High-throughput amplicon sequencing of 16S rRNA gene was used to study the indigenous communities and the resistant consortia. We took three approaches for the analysis phylotypes, OTUs and amplicon sequence variants (ASVs). Interestingly, similar conclusions were drawn in all three cases. Analysing the phylogenetic structure and functional potential of the adapted consortia, we found that the strongest selection was exerted by the culture media. Notably, there was a poor correlation between alpha diversity and metal stress; furthermore, metal stress did not seem to harm the functional potential of the consortia. All these results reveal a great adaptability and versatility. At the end, 25 metal-resistant extremophilic consortia with potential uses in bioremediation, bioleaching or biomonitoring processes were obtained.Nitrate leaching caused by overusing or misusing nitrogen (N) fertilizers in field vegetable cropping systems in China is a leading contributor to nitrate contamination of groundwater. Identification of the critical fertilizer N input rate could support management decisions that maintain yields while reducing the impact of nitrate leaching on groundwater. A four-season field experiment involving six N treatments (0, 60, 120, 180, 240, and 300 kg N ha-1) was undertaken to investigate the impacts of various N rates on N use efficiency (NUE), seasonal nitrate leaching loss (SNLL), nitrate residue (NR), and radish yield, and to identify the critical N fertilizer rate for both optimum yield and minimum nitrate leaching loss in a field vegetable (radish, Raphanus sativus L.) cropping system in northern China. The results showed that radish yield enhanced quadratically and NUE reduced linearly with increasing N addition, while the NR and SNLL increased exponentially. The yield did not increase markedly when N fertilization exceeded 180 kg N ha-1. SNLL and nitrate concentrations in the leachate averaged 11.5-71.5 kg N ha-1 and 5.1-35.6 mg N L-1, respectively, under N rates of 60-300 kg N ha-1. The results showed that N fertilizer rate ranging from 180 to 196 kg N ha-1 resulted in high yields and low nitrate leaching losses. Compared with those in response to the N fertilizer amount applied by local farmers, the NUE, NR, and SNLL in response to the N fertilizer amount identified in this study increased, decreased by 30.9%-35.0%, and decreased by 49.9%-55.7%, respectively, without any yield loss. Thus, a critical N fertilizer rate ranging from 180 to 196 kg N ha-1 is recommended to obtain optimum yields with minimal environmental risks in radish fields in northern China.Heterogeneous photochemical reaction of O3 with humic acid (HA) under simulated sunlight was performed using a flow tube reactor coupled to an O3 analyzer at ambient pressure. It was confirmed that light significantly enhanced the uptake of O3 on HA. The initial uptake coefficient (γi) and the steady-state uptake coefficient (γss) of O3 under irradiation increased by 1.6 and 3.8 times compared to those in the dark, respectively. The γi and γss on HA varied in the range of 0.76-2.77 × 10-5 and 1.50-9.55 × 10-6, respectively, which were dependent on various environmental factors including HA mass, total irradiance, initial O3 concentration, O2 content, temperature, relative humidity (RH) and HA solution pH. Both γi and γss showed linear dependence on the total irradiance (0-2.07 × 1016 photons/(cm2⋅s)) of the light source, and increased with the HA mass (0-3.2 μg/cm2), temperature (278-298 K) and HA solution pH (4.0-9.6). However, they showed negative correlations with the initial O3 concentration and O2 content. The γi remained constant in the RH range of 7%-60%, while γss exhibited the maximum value at RH = 20%. During the ozonization of HA under irradiation, some functional groups were consumed, including CH2, CH3, aromatic CC, OH, CO, COOH and COO-. HA aged by O3 exhibited a decrease in the mass absorption efficiency (MAE) and a small increase in the absorption Ångström exponent between 300 and 600 nm wavelength (AAE300,600), which was ascribed to changes in the composition of HA during the photochemical ozonization process.We aimed to detail language profiles, brain metabolic patterns and proportion of Alzheimer's disease biomarkers in a cohort of patients with mixed primary progressive aphasia (mPPA). We considered 58 patients with PPA 10 with non-fluent/agrammatic variant (nfvPPA), 16 with semantic variant (svPPA), 21 with logopenic variant (lvPPA) and 9 with mPPA. Patients with mPPA were further classified as 4 nf/lvPPA (with prevailing features for nfvPPA and lvPPA) and 5 s/lvPPA (with prevailing features for svPPA and lvPPA). Nf/lvPPA patients were characterized by higher proportion of Naming impairment compared to nfvPPA and more frequent Grammatical Errors and Phonologic Errors than lvPPA. S/lvPPA had higher proportion of impairment in Sentences Repetition compared to svPPA and in Single-word Comprehension compared to lvPPA. 100% of nf/lvPPA and 40% of s/lvPPA had Aβ positive biomarkers. Brain hypometabolic pattern in Nf/lvPPA was consistent with lvPPA, while s/lvPPA had a brain metabolism resembling svPPA. We concluded that nf/lvPPA patients might be considered as PPA variant due to Alzheimer's disease and s/lvPPA group mainly included patients with svPPA.