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001) (rho -0.463). Years of computer exposure and staining of the ocular surface showed a significant positive correlation (p <0 0.001; rho 0.404). The accumulated exposure time was negatively correlated with TBUT (p <0.001; rho -0.376) and positively with OSS (p <0.001; rho 0.433). Schirmer test did not correlate with computer exposure time.

The prolonged time of exposure to the computer in subjects with CVS was significantly correlated with the DED tests, in the different ways of measuring it; but not with the Schirmer test.

The prolonged time of exposure to the computer in subjects with CVS was significantly correlated with the DED tests, in the different ways of measuring it; but not with the Schirmer test.The generative approach to social science, in which agent-based simulations (or other complex systems models) are executed to reproduce a known social phenomenon, is an important tool for realist explanation. However, a generative model, when suitably calibrated and validated using empirical data, represents just one viable candidate set of entities and mechanisms. The model only partially addresses the needs of an abductive reasoning process - specifically it does not provide insight into other viable sets of entities or mechanisms, nor suggest which of these are fundamentally constitutive for the phenomenon to exist. In this paper, we propose a new model discovery framework that more fully captures the needs of realist explanation. The framework exploits the implicit ontology of an existing human-built generative model to propose and test a plurality of new candidate model structures. Genetic programming is used to automate this search process. A multi-objective approach is used, which enables multiple perspectives on the value of any particular generative model - such as goodness-of-fit, parsimony, and interpretability - to be represented simultaneously. We demonstrate this new framework using a complex systems modeling case study of change and stasis in societal alcohol use patterns in the US over the period 1980-2010. The framework is successful in identifying three competing explanations of these alcohol use patterns, using novel integrations of social role theory not previously considered by the human modeler. Practitioners in complex systems modeling should use model discovery to improve the explanatory utility of the generative approach to realist social science.Pediatric trigger thumb is the new terminology for the so-called congenital trigger thumb. This change in appellation was suggested based on recent knowledge acquired through prospective studies of a large number of newborns for the presence of trigger thumb at birth across many centers. In this background, we came across a newborn with trigger thumb which was diagnosed right after birth, putting aside all theories of nonexistence of congenital trigger thumb. We report a case of congenital trigger thumb diagnosed at birth, which was managed surgically at 9 months of age, who has good clinical and functional outcomes at 1-year follow-up. Herewith, we would like to submit that congenital trigger thumb does exist, though might be a very rare occurrence.Introduction  We review the benefits of early motion protocols following replantation of a total right hand amputation at 1 and 2 years after replantation, and provide recommendations for postoperative management. Materials and Methods  Replantation of the entire right hand in zone-4 was performed and supported by rigid external fixation spanning the forearm and hand. https://www.selleckchem.com/products/r-hts-3.html An early active "place-and-hold" motion protocol was initiated within the first 3 postoperative days. Metacarpophalangeal joint extensors were tethered by the pins, limiting full excursion. This resulted in stiffness and extensor adhesions that required a staged extensor tenolysis; however, all joints remained supple. The early motion protocol prevented the need for significant flexor tenolysis and joint releases. Results  Early motion rehabilitation protocols can produce very successful results in complex replantation. The enhanced stability afforded by external fixation of the wrist allowed us to perform aggressive early rehabilitation. Conclusion  This case highlights the benefits of early active motion (limiting the need for complex joint and flexor tendon releases) and demonstrates the degree of extensor adhesions caused by even minor extensor tendon tethering. This aggressive rehabilitation approach can produce excellent range of motion, and likely limit the need for secondary tenolysis and joint release procedures.Background  Eosinophilic polymyositis is a rare disorder in which eosinophils infiltrate muscle and supporting connective tissue structures, resembling autoimmune or immunologically mediated disease. This disorder can be associated with muscle inflammation and death, and can be a cause of atraumatic compartment syndrome. Methods  This is a retrospective chart review of a case report as well as review of pertinent literature. Results  This report presents a rare case of atraumatic compartment syndrome of the forearm caused by eosinophilic polymyositis. It provides a case summary and histological examination of this patient. Conclusion  This is an important case to report because it highlights eosinophilic polymyositis as a unique etiology of compartment syndrome. In appropriate clinical situations where patients do not improve despite standard interventions, one should consider the rare and unusual etiology of compartment syndrome due to eosinophilic polymyositis. Furthermore, primary surgical intervention should not be delayed while waiting to ascertain a definitive diagnosis.Ehlers-Danlos syndrome (EDS) is a disorder that presents with a heterogeneous constellation of symptoms, ranging from clinically silent to rapidly deteriorating. It is a multisystemic connective tissue disorder that may result in any number of manifestations, with joint hypermobility being a classic manifestation. We present a case of a 58-year-old woman, with suspected EDS, who presented with several years' history of bilateral thumb pain, with imaging and physical examination findings consistent with bilateral thumb carpometacarpal (CMC) arthritis with metacarpophalangeal joint (MPJ) hypermobility. The Beighton hypermobility score was consistent with suspected EDS. Our patient underwent thumb CMC arthroplasty with ulnar collateral ligament (UCL) reconstruction.