Staffordgrimes5448

Motion-onset visual evoked potentials (mVEPs)-based spellers, also known as N200 spellers, have been successfully implemented, avoiding flashing stimuli that are common in visual brain-computer interface (BCI). However, their information transfer rates (ITRs), typically below 50 bits/min, are lower than other visual BCI spellers. In this study, we sought to improve the speed of N200 speller to a level above the well-known P300 spellers.

Based on our finding of the spatio-temporal asymmetry of N200 response elicited by leftward and rightward visual motion, a novel dual-directional N200 speller was implemented. By presenting visual stimuli moving in two different directions simultaneously, the new paradigm reduced the stimuli presentation time by half, while ensuring separable N200 features between two visual motion directions. Furthermore, a probability-based dynamic stopping algorithm was also proposed to shorten the decision time for each output further. Both offline and online tests were conducted to evaluate the performance in ten participants.

Offline results revealed contralateral dominant temporal and spatial patterns in N200 responses when subjects attended to stimuli moving leftward or rightward. In online experiments, the dual-directional paradigm achieved an average ITR of 79.8 bits/min, with the highest ITR of 124.8 bits/min. Compared with the traditional uni-directional N200 speller, the median gain on the ITR was 202%.

The proposed dual-directional paradigm managed to double the speed of the N200 speller. Together with its non-flashing characteristics, this dual-directional N200 speller is promising to be a competent candidate for fast and reliable BCI applications.

The proposed dual-directional paradigm managed to double the speed of the N200 speller. Together with its non-flashing characteristics, this dual-directional N200 speller is promising to be a competent candidate for fast and reliable BCI applications.

Tendons are essential components of the musculoskeletal system and, as with any mechanical structure, can fail under load. Tendon injuries are common and can be debilitating, and research suggests that a better understanding of their loading conditions could help mitigate injury risk and improve rehabilitation. To that end, we present a novel method of noninvasively assessing parameters related to mechanical load in the Achilles tendon using burst vibrations.

These vibrations, produced by a small vibration motor on the skin superficial to the tendon, are sensed by a skin-mounted accelerometer, which measures the tendon's response to burst excitation under varying tensile load. In this study, twelve healthy subjects performed a variety of everyday tasks designed to expose the Achilles tendon to a range of loading conditions. To approximate the vibration motor-tendon system and provide an explanation for observed changes in tendon response, a 2-degree-of-freedom mechanical systems model was developed.

Relining, and the study of human movement.The current challenge in the field of thermo-ablative treatments of tumors is to achieve a balance between complete destruction of malignant cells and safeguarding of the surrounding healthy tissue. VPA inhibitor Blood perfusion plays a key role for thermal ablation success, especially in the case of highly vascularized organs like liver. This work aims at monitoring the temperature within perfused swine liver undergoing laser ablation (LA). Temperature was measured through seven arrays of Fiber Bragg Grating sensors (FBGs) around the laser applicator. To mimic reality, blood perfusion within the ex-vivo liver was simulated using artificial vessels. The influence of blood perfusion on LA was carried out by comparing the temperature profiles in two different spatial configurations of vessels and fibers. The proposed setup permitted to accurately measure the heat propagation in real-time with a temperature resolution of 0.1 °C and to observe a relevant tissue cooling near to the vessel up to 65%.

Although spirometry is the most common pulmonary function test, there is no method to quantitatively infer about airway resistance or other properties from the flow-volume curves. Recently, an identifiable inverse model for forced expiration was proposed, as well as the idea to deduce changes in airway resistances and compliances from spirometric curve evolution. The aim of this work was to combine the above advances in a method for assessing the airway response to bronchial tests from a spirometric curve shift.

The approach is based on the differential measurement of the degree, site of maximal effect and width of changes, further recalculated into relative changes in the distribution of airway resistances (δR

) and compliances (δC

) along the bronchial tree. To this end, appropriate models were identified using the pre- and post-test spirometry data. The accuracy was validated using sets of data simulated by the anatomy and physiology based models. Finally, the method was used to analyze the bronchodilation tests of three asthmatic subjects.

The expected errors in assessing the degree, site and width of changes in the zone of conducting airways were 6.3%, 2.4 generations and 22%, respectively, and for δR

and δC

were 5-10% and 13-16%, respectively. The analyses of clinical data indicated a significant reduction in resistances and an increase in compliances of airway generations 8-12, consistent with clinical knowledge.

An unprecedented method to plausibly transforming the spirometry data into the site and degree of changes in airway properties has been proposed.

The method can be used to deduce about the effects of bronchial tests, as well as to monitor changes in the airways between visits or to investigate how inhaled pharmaceuticals affect the bronchi.

The method can be used to deduce about the effects of bronchial tests, as well as to monitor changes in the airways between visits or to investigate how inhaled pharmaceuticals affect the bronchi.A method for deriving respiratory rate from an armband, which records three-channel electrocardiogram (ECG) using three pairs of dry (no hydrogel) electrodes, is presented. The armband device is especially convenient for long-term (months-years) monitoring because it does not use obstructive leads nor hydrogels/adhesives, which cause skin irritation even after few days. An ECG-derived respiration (EDR) based on respiration-related modulation of QRS slopes and R-wave angle approach was used. Moreover, we modified the EDR algorithm to lower the computational cost. Respiratory rates were estimated with the armband-ECG and the reference plethysmography-based respiration signals from 15 subjects who underwent breathing experiment consisting of five stages of controlled breathing (at 0.1, 0.2, 0.3, 0.4, and 0.5 Hz) and one stage of spontaneous breathing. The respiratory rates from the armband obtained a relative error with respect to the reference (respiratory rate estimated from the plethysmography-based respiration signal) that was not higher than 2.