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Finally, the good performance of GMM-SOM is evaluated on a coastline map.Small aerial object detection plays an important role in numerous computer vision tasks, including remote sensing, early warning systems, and visual tracking. Despite existing moving object detection techniques that can achieve reasonable results in normal size objects, they fail to distinguish the small objects from the dynamic background. To cope with this issue, a novel method is proposed for accurate small aerial object detection under different situations. Initially, the block segmentation is introduced for reducing frame information redundancy. Meanwhile, a random projection feature (RPF) is proposed for characterizing blocks into feature vectors. Subsequently, a moving direction estimation based on feature vectors is presented to measure the motions of blocks and filter out the major directions. Finally, variable search region clustering (VSRC), together with the color feature difference, is designed for extracting pixelwise targets from the remaining moving direction blocks. The comprehensive experiments demonstrate that our approach outperforms the level of state-of-the-art methods upon the integrity of small aerial objects, especially on the dynamic background and scale variation targets.In this article, considering the supervised dimensionality reduction, we first propose a model, called infinite Bayesian max-margin linear discriminant projection (iMMLDP), by assembling a set of local regions, where we make use of Bayesian nonparametric priors to handle the model selection problem, for example, the underlying number of local regions. In each local region, our model jointly learns a discriminative subspace and the corresponding classifier. Under this framework, iMMLDP combines dimensionality reduction, clustering, and classification in a principled way. selleckchem Moreover, to deal with more complex data, for example, a local nonlinear separable structure, we extend the linear projection to a nonlinear case based on the kernel trick and develop an infinite kernel max-margin discriminant projection (iKMMDP) model. Thanks to the conjugate property, the parameters in these two models can be inferred efficiently via the Gibbs sampler. Finally, we implement our models on synthesized and real-world data, including multimodally distributed datasets and measured radar image data, to validate their efficiency and effectiveness.This article is concerned with the event-triggered output consensus problem for heterogeneous multiagent systems (MASs) with nonuniform communication delays. Unlike the existing event-triggered consensus results, more general heterogeneous linear MASs and nonuniform communication delays are considered. To reduce communication among subsystems, novel dynamic periodic event-triggered mechanisms are proposed. By using the event-triggered signals at the previous sampling instant, new distributed observers are designed to eliminate asynchronous behavior caused by nonuniform communication delays. Based on the developed observers, the observer error system is converted into a time-delay system with interval time-varying delays. Besides, a controller is designed by using the states of observers. It is shown that the consensus problem can be solved by the proposed method. Finally, an illustrative example is provided to verify the effectiveness of the developed method.Long noncoding RNAs (lncRNAs) have emerged as potential prognostic markers in various human cancers as they participate in many malignant behaviors. However, the value of lncRNAs as prognostic markers among diverse human cancers is still under investigation, and a systematic signature based on these transcripts that related to pan-cancer prognosis has yet to be reported. In this study, we proposed a framework to incorporate statistical power, biological rationale and machine learning models for pan-cancer prognosis analysis. The framework identified a 5-lncRNA signature (ENSG00000206567, PCAT29, ENSG00000257989, LOC388282, and LINC00339) from TCGA training studies (n=1,878). The identified lncRNAs are significantly associated (all P1.48E-11) with overall survival (OS) of the TCGA cohort (n=4,231). The signature stratified the cohort into low- and high-risk groups with significantly distinct survival outcomes (median OS of 9.84 years versus 4.37 years, log-rank P=1.48E-38) and achieved a time-dependent ROC/AUC of 0.66 at 5 years. After routine clinical factors involved, the signature demonstrated a better performance for long-term prognostic estimation (AUC of 0.72). Moreover, the signature was further evaluated on two independent external cohorts (TARGET, n=1,122; CPTAC, n=391; National Cancer Institute) which yielded similar prognostic values (AUC of 0.60 and 0.75; log-rank P=8.6E-09 and P=2.7E-06). An indexing system was developed to map the 5-lncRNA signature to prognoses of pan-cancer patients. In silico functional analysis indicated that the lncRNAs are associated with common biological processes driving human cancers. The five lncRNAs, especially ENSG00000206567, ENSG00000257989 and LOC388282 that never reported before, may serve as viable molecular targets common among diverse cancers.Mitotic count is an important indicator for assessing the invasiveness of breast cancers. Currently, the number of mitoses is manually counted by pathologists, which is both tedious and time-consuming. To address this situation, we propose a fast and accurate method to automatically detect mitosis from the histopathological images. The proposed method can automatically identify mitotic candidates from histological sections for mitosis screening. Specifically, our method exploits deep convolutional neural networks to extract high-level features of mitosis to detect mitotic candidates. Then, we use spatial attention modules to re-encode mitotic features, which allows the model to learn more efficient features. Finally, we use multi-branch classification subnets to screen the mitosis. Compared to existing related methods in literature, our method obtains the best detection results on the dataset of the International Pattern Recognition Conference (ICPR) 2012 Mitosis Detection Competition. Code has been made available at https//github.

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